JP2017537893A - 抗ｃｓ１抗体および抗体薬結合体 - Google Patents

抗ｃｓ１抗体および抗体薬結合体 Download PDF

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JP2017537893A
JP2017537893A JP2017523295A JP2017523295A JP2017537893A JP 2017537893 A JP2017537893 A JP 2017537893A JP 2017523295 A JP2017523295 A JP 2017523295A JP 2017523295 A JP2017523295 A JP 2017523295A JP 2017537893 A JP2017537893 A JP 2017537893A
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antibody
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JP2017537893A5 (OSRAM
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カート シー． ギッシュ
カート シー． ギッシュ
ハン ケイ． キム
ハン ケイ． キム
ルイ ナウモフスキ
ルイ ナウモフスキ
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アッヴィ・バイオセラピューティクス・インコーポレイテッド
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
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  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
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  • Hematology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2017523295A 2014-10-31 2015-10-30 抗ｃｓ１抗体および抗体薬結合体 Withdrawn JP2017537893A (ja)

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US201462073824P 2014-10-31 2014-10-31
US62/073,824 2014-10-31
PCT/US2015/058389 WO2016070089A2 (en) 2014-10-31 2015-10-30 Anti-cs1 antibodies and antibody drug conjugates

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JP2017537893A5 JP2017537893A5 (OSRAM) 2018-07-26

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US (2) US10011657B2 (OSRAM)
EP (1) EP3212668B1 (OSRAM)
JP (2) JP2017537893A (OSRAM)
AU (1) AU2015339012B2 (OSRAM)
BR (1) BR112017008945A2 (OSRAM)
CA (1) CA2966005C (OSRAM)
ES (1) ES2832711T3 (OSRAM)
IL (1) IL251938A0 (OSRAM)
SG (1) SG11201703446RA (OSRAM)
WO (1) WO2016070089A2 (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023547557A (ja) * 2020-12-04 2023-11-10 シャンハイ フダン－チャンジャン バイオ－ファーマシューティカル カンパニー リミテッド 抗体薬物複合体、その中間体、製造方法及び使用
JP2023550532A (ja) * 2020-12-18 2023-12-01 シャンハイ フダン－チャンジャン バイオ－ファーマシューティカル カンパニー リミテッド Ｔｒｏｐ２を標的とする抗体薬物複合体、その製造方法及び使用
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