JP2015528818A5 - - Google Patents

Info

Publication number

JP2015528818A5

JP2015528818A5 JP2015525600A JP2015525600A JP2015528818A5 JP 2015528818 A5 JP2015528818 A5 JP 2015528818A5 JP 2015525600 A JP2015525600 A JP 2015525600A JP 2015525600 A JP2015525600 A JP 2015525600A JP 2015528818 A5 JP2015528818 A5 JP 2015528818A5

Authority

JP

Japan

Prior art keywords

seq

sequence

immunoconjugate

hvr

antibody

Prior art date

2013-08-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 229940127121 immunoconjugate Drugs 0.000 claims 14
• 125000003275 alpha amino acid group Chemical group 0.000 claims 12
• 239000003814 drug Substances 0.000 claims 9
• 229940124597 therapeutic agent Drugs 0.000 claims 8
• 125000005843 halogen group Chemical group 0.000 claims 5
• 101000620359 Homo sapiens Melanocyte protein PMEL Proteins 0.000 claims 4
• 102100022430 Melanocyte protein PMEL Human genes 0.000 claims 4
• 229940127089 cytotoxic agent Drugs 0.000 claims 4
• 239000002254 cytotoxic agent Substances 0.000 claims 4
• 231100000599 cytotoxic agent Toxicity 0.000 claims 4
• 125000005647 linker group Chemical group 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 239000000427 antigen Substances 0.000 claims 3
• 102000036639 antigens Human genes 0.000 claims 3
• 108091007433 antigens Proteins 0.000 claims 3
• 125000003118 aryl group Chemical group 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 3
• 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 claims 2
• 102000008203 CTLA-4 Antigen Human genes 0.000 claims 2
• 108010021064 CTLA-4 Antigen Proteins 0.000 claims 2
• 101000904724 Homo sapiens Transmembrane glycoprotein NMB Proteins 0.000 claims 2
• 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 claims 2
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 2
• 108010044540 auristatin Proteins 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• CTMCWCONSULRHO-UHQPFXKFSA-N nemorubicin Chemical class C1CO[C@H](OC)CN1[C@@H]1[C@H](O)[C@H](C)O[C@@H](O[C@@H]2C3=C(O)C=4C(=O)C5=C(OC)C=CC=C5C(=O)C=4C(O)=C3C[C@](O)(C2)C(=O)CO)C1 CTMCWCONSULRHO-UHQPFXKFSA-N 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical compound C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 2
• 108010014402 tyrosinase-related protein-1 Proteins 0.000 claims 2
• AGGWFDNPHKLBBV-YUMQZZPRSA-N (2s)-2-[[(2s)-2-amino-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoic acid Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=O AGGWFDNPHKLBBV-YUMQZZPRSA-N 0.000 claims 1
• SLURUCSFDHKXFR-WWMWMSKMSA-N (7s,9s)-7-[[(1s,3r,4as,9s,9ar,10as)-9-methoxy-1-methyl-3,4,4a,6,7,9,9a,10a-octahydro-1h-pyrano[1,2][1,3]oxazolo[3,4-b][1,4]oxazin-3-yl]oxy]-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical group O=C1C2=CC=CC(OC)=C2C(=O)C(C(O)=C23)=C1C(O)=C3C[C@@](O)(C(=O)CO)C[C@@H]2O[C@H]1C[C@@H]2N3CCO[C@H](OC)[C@H]3O[C@@H]2[C@H](C)O1 SLURUCSFDHKXFR-WWMWMSKMSA-N 0.000 claims 1
• 125000001963 4 membered heterocyclic group Chemical group 0.000 claims 1
• 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
• 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
• 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
• 108010016626 Dipeptides Proteins 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 125000002947 alkylene group Chemical group 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 150000001768 cations Chemical class 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• -1 fluoro-substituted phenyl Chemical group 0.000 claims 1
• 125000005842 heteroatom Chemical group 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 239000002184 metal Substances 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1