JP2016528882A5 - - Google Patents
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- JP2016528882A5 JP2016528882A5 JP2016521907A JP2016521907A JP2016528882A5 JP 2016528882 A5 JP2016528882 A5 JP 2016528882A5 JP 2016521907 A JP2016521907 A JP 2016521907A JP 2016521907 A JP2016521907 A JP 2016521907A JP 2016528882 A5 JP2016528882 A5 JP 2016528882A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- sequence
- hvr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001413 amino acids Chemical class 0.000 claims 99
- 229940127121 immunoconjugate Drugs 0.000 claims 33
- 101000846908 Homo sapiens Fc receptor-like protein 5 Proteins 0.000 claims 26
- 102100031507 Fc receptor-like protein 5 Human genes 0.000 claims 24
- 239000003814 drug Substances 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 125000005647 linker group Chemical group 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 4
- 102000001708 Protein Isoforms Human genes 0.000 claims 3
- 108010029485 Protein Isoforms Proteins 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 108010016626 Dipeptides Proteins 0.000 claims 2
- 108010044540 auristatin Proteins 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 102000044694 human FCRL5 Human genes 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- CTMCWCONSULRHO-UHQPFXKFSA-N nemorubicin Chemical class C1CO[C@H](OC)CN1[C@@H]1[C@H](O)[C@H](C)O[C@@H](O[C@@H]2C3=C(O)C=4C(=O)C5=C(OC)C=CC=C5C(=O)C=4C(O)=C3C[C@](O)(C2)C(=O)CO)C1 CTMCWCONSULRHO-UHQPFXKFSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical compound C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- AGGWFDNPHKLBBV-YUMQZZPRSA-N (2s)-2-[[(2s)-2-amino-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoic acid Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=O AGGWFDNPHKLBBV-YUMQZZPRSA-N 0.000 claims 1
- 125000001963 4 membered heterocyclic group Chemical group 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
- 102100031517 Fc receptor-like protein 1 Human genes 0.000 claims 1
- 101710120224 Fc receptor-like protein 1 Proteins 0.000 claims 1
- 102100031511 Fc receptor-like protein 2 Human genes 0.000 claims 1
- 102100031512 Fc receptor-like protein 3 Human genes 0.000 claims 1
- 102100031513 Fc receptor-like protein 4 Human genes 0.000 claims 1
- 101000846911 Homo sapiens Fc receptor-like protein 2 Proteins 0.000 claims 1
- 101000846910 Homo sapiens Fc receptor-like protein 3 Proteins 0.000 claims 1
- 101000846909 Homo sapiens Fc receptor-like protein 4 Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 101000846907 Mus musculus Fc receptor-like protein 5 Proteins 0.000 claims 1
- VDYZJHUMTCUMFF-RVYSEXHFSA-N N[C@@H](CCCCCN)C(=O)O.N[C@@H](CC1=CC=CC=C1)C(=O)O Chemical compound N[C@@H](CCCCCN)C(=O)O.N[C@@H](CC1=CC=CC=C1)C(=O)O VDYZJHUMTCUMFF-RVYSEXHFSA-N 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical group CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 1
- 229930195731 calicheamicin Natural products 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960002173 citrulline Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- -1 fluoro-substituted phenyl Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 150000007857 hydrazones Chemical class 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- YCBIWVHDKSQGFJ-UHFFFAOYSA-N C(C1)C11OCCCC1 Chemical compound C(C1)C11OCCCC1 YCBIWVHDKSQGFJ-UHFFFAOYSA-N 0.000 description 2
- BVJWKTOWLQBIRD-UHFFFAOYSA-N C1OC11NCCOC1 Chemical compound C1OC11NCCOC1 BVJWKTOWLQBIRD-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361838534P | 2013-06-24 | 2013-06-24 | |
| US61/838,534 | 2013-06-24 | ||
| PCT/US2014/043952 WO2014210064A1 (en) | 2013-06-24 | 2014-06-24 | Anti-fcrh5 antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019192491A Division JP2020048559A (ja) | 2013-06-24 | 2019-10-23 | 抗ＦｃＲＨ５抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016528882A JP2016528882A (ja) | 2016-09-23 |
| JP2016528882A5 true JP2016528882A5 (OSRAM) | 2017-08-10 |
| JP6684208B2 JP6684208B2 (ja) | 2020-04-22 |
Family
ID=51212984
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016521907A Active JP6684208B2 (ja) | 2013-06-24 | 2014-06-24 | 抗ＦｃＲＨ５抗体 |
| JP2019192491A Pending JP2020048559A (ja) | 2013-06-24 | 2019-10-23 | 抗ＦｃＲＨ５抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019192491A Pending JP2020048559A (ja) | 2013-06-24 | 2019-10-23 | 抗ＦｃＲＨ５抗体 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10435471B2 (OSRAM) |
| EP (3) | EP3336106B1 (OSRAM) |
| JP (2) | JP6684208B2 (OSRAM) |
| KR (1) | KR20160022912A (OSRAM) |
| CN (2) | CN105473618A (OSRAM) |
| AR (1) | AR096687A1 (OSRAM) |
| AU (2) | AU2014302617B2 (OSRAM) |
| BR (1) | BR112015032224B1 (OSRAM) |
| CA (1) | CA2915480C (OSRAM) |
| DK (3) | DK3336106T3 (OSRAM) |
| ES (3) | ES2962874T3 (OSRAM) |
| FI (1) | FI3736291T3 (OSRAM) |
| HK (1) | HK1222663A1 (OSRAM) |
| HR (3) | HRP20180352T1 (OSRAM) |
| HU (3) | HUE036581T2 (OSRAM) |
| IL (2) | IL243129B (OSRAM) |
| LT (3) | LT3336106T (OSRAM) |
| MX (1) | MX376663B (OSRAM) |
| MY (2) | MY176285A (OSRAM) |
| NO (1) | NO2955475T3 (OSRAM) |
| PL (3) | PL3013861T3 (OSRAM) |
| PT (3) | PT3736291T (OSRAM) |
| RS (3) | RS56878B1 (OSRAM) |
| RU (2) | RU2687132C2 (OSRAM) |
| SG (2) | SG11201510653YA (OSRAM) |
| SI (3) | SI3736291T1 (OSRAM) |
| TW (1) | TWI725931B (OSRAM) |
| WO (1) | WO2014210064A1 (OSRAM) |
| ZA (2) | ZA201509261B (OSRAM) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR096687A1 (es) | 2013-06-24 | 2016-01-27 | Genentech Inc | Anticuerpos anti-fcrh5 |
| CN112390883A (zh) | 2013-12-17 | 2021-02-23 | 基因泰克公司 | 抗cd3抗体及使用方法 |
| DK3160513T3 (da) | 2014-06-30 | 2020-04-06 | Glykos Finland Oy | Saccharidderivat af en toksisk payload og antistofkonjugater deraf |
| MX2017000646A (es) | 2014-07-15 | 2017-04-27 | Juno Therapeutics Inc | Celulas geneticamente modificadas para terapia celular adoptiva. |
| CR20170095A (es) | 2014-09-12 | 2017-07-19 | Genentech Inc | Anticuerpos anti-cll-1 e inmunoconjugados referencias recíprocas con solicitudes relacionadas |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| SG11201704550XA (en) | 2014-12-05 | 2017-07-28 | Memorial Sloan Kettering Cancer Center | Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof |
| JP6932649B2 (ja) * | 2015-02-16 | 2021-09-08 | ロンザ リミテッドＬｏｎｚａ Ｌｉｍｉｔｅｄ | Ｃｌ及び／又はｃｈ１が突然変異された薬剤コンジュゲーションのための抗体 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN107847568B (zh) | 2015-06-16 | 2022-12-20 | 豪夫迈·罗氏有限公司 | 抗cll-1抗体和使用方法 |
| EP3310814B1 (en) * | 2015-06-16 | 2023-08-02 | F. Hoffmann-La Roche AG | Humanized and affinity matured antibodies to fcrh5 and methods of use |
| MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
| EP3383913A4 (en) | 2015-12-04 | 2019-10-30 | Memorial Sloan-Kettering Cancer Center | ANTIBODY AGAINST FC RECEPTOR LIKE 5 AND METHOD OF USE |
| KR20190074300A (ko) | 2016-11-15 | 2019-06-27 | 제넨테크, 인크. | 항-cd20/항-cd3 이중특이적 항체에 의한 치료를 위한 투약 |
| BR112019011186A2 (pt) | 2016-12-01 | 2019-10-08 | Regeneron Pharmaceuticals, Inc. | conjugado de anticorpo radiomarcado, composto, e, métodos de imageamento e para tratamento de um tumor. |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN110650974B (zh) | 2017-02-10 | 2024-04-19 | 瑞泽恩制药公司 | 用于免疫-pet成像的放射性标记的抗-lag3抗体 |
| JP7304846B2 (ja) | 2017-07-24 | 2023-07-07 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗ｃｄ８抗体およびその使用 |
| US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| WO2019090003A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for b-cell maturation antigen (bcma) |
| WO2019089969A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for b-cell maturation antigen |
| PL3704230T3 (pl) | 2017-11-01 | 2025-02-24 | Juno Therapeutics, Inc. | Proces wytwarzania kompozycji terapeutycznych z komórek zmodyfikowanych genetycznie |
| WO2019089858A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| CA3080509A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Process for producing a t cell composition |
| SG11202005005YA (en) | 2017-11-30 | 2020-06-29 | Novartis Ag | Bcma-targeting chimeric antigen receptor, and uses thereof |
| JP2021505615A (ja) | 2017-12-08 | 2021-02-18 | ジュノー セラピューティクス インコーポレイテッド | 細胞療法および関連方法のための表現型マーカー |
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| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| CA3089287A1 (en) | 2018-02-08 | 2019-08-15 | Genentech, Inc. | Bispecific antigen-binding molecules and methods of use |
| WO2019178362A1 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| JP7398396B2 (ja) | 2018-06-01 | 2023-12-14 | ノバルティス アーゲー | Ｂｃｍａに対する結合分子及びその使用 |
| US20210123075A1 (en) | 2018-06-08 | 2021-04-29 | Novartis Ag | Compositions and methods for immunooncology |
| AU2019297451A1 (en) | 2018-07-03 | 2021-01-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
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| JP7538109B2 (ja) | 2018-08-09 | 2024-08-21 | ジュノー セラピューティクス インコーポレイテッド | 組み込まれた核酸を評価するための方法 |
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| CN114007640A (zh) | 2019-05-01 | 2022-02-01 | 朱诺治疗学股份有限公司 | 从修饰的cd247基因座表达嵌合受体的细胞、相关多核苷酸和方法 |
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