JP2017527341A5 - - Google Patents
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- Publication number
- JP2017527341A5 JP2017527341A5 JP2017504425A JP2017504425A JP2017527341A5 JP 2017527341 A5 JP2017527341 A5 JP 2017527341A5 JP 2017504425 A JP2017504425 A JP 2017504425A JP 2017504425 A JP2017504425 A JP 2017504425A JP 2017527341 A5 JP2017527341 A5 JP 2017527341A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- copolymer
- lactide
- orthopedic implant
- glycolide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007943 implant Substances 0.000 claims 17
- 229920001577 copolymer Polymers 0.000 claims 15
- 230000000399 orthopedic effect Effects 0.000 claims 14
- 239000012890 simulated body fluid Substances 0.000 claims 8
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 7
- 239000000463 material Substances 0.000 claims 7
- 239000012783 reinforcing fiber Substances 0.000 claims 7
- 239000011173 biocomposite Substances 0.000 claims 6
- 229920002988 biodegradable polymer Polymers 0.000 claims 6
- 239000004621 biodegradable polymer Substances 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 6
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 5
- 229920001432 poly(L-lactide) Polymers 0.000 claims 5
- 229920000747 poly(lactic acid) Polymers 0.000 claims 5
- OZJPLYNZGCXSJM-UHFFFAOYSA-N 5-valerolactone Chemical compound O=C1CCCCO1 OZJPLYNZGCXSJM-UHFFFAOYSA-N 0.000 claims 4
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 4
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 4
- 239000004633 polyglycolic acid Substances 0.000 claims 4
- 229950008885 polyglycolic acid Drugs 0.000 claims 4
- 230000000717 retained effect Effects 0.000 claims 4
- VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 claims 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- 239000002131 composite material Substances 0.000 claims 3
- -1 etc.) Chemical compound 0.000 claims 3
- 239000000835 fiber Substances 0.000 claims 3
- 229920001610 polycaprolactone Polymers 0.000 claims 3
- 229920001897 terpolymer Polymers 0.000 claims 3
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims 2
- 229920001710 Polyorthoester Polymers 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- 230000002745 absorbent Effects 0.000 claims 2
- 239000002250 absorbent Substances 0.000 claims 2
- 238000005452 bending Methods 0.000 claims 2
- 239000001913 cellulose Chemical class 0.000 claims 2
- 229920002678 cellulose Chemical class 0.000 claims 2
- 235000010980 cellulose Nutrition 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920000117 poly(dioxanone) Polymers 0.000 claims 2
- 239000002745 poly(ortho ester) Substances 0.000 claims 2
- 239000004632 polycaprolactone Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 239000004814 polyurethane Substances 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000012763 reinforcing filler Substances 0.000 claims 2
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims 2
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- NENKKJDNYSKDBT-UHFFFAOYSA-N 1,3-dioxan-4-one Chemical compound O=C1CCOCO1 NENKKJDNYSKDBT-UHFFFAOYSA-N 0.000 claims 1
- VKSWWACDZPRJAP-UHFFFAOYSA-N 1,3-dioxepan-2-one Chemical compound O=C1OCCCCO1 VKSWWACDZPRJAP-UHFFFAOYSA-N 0.000 claims 1
- ZAJGKKXBKLVSKW-UHFFFAOYSA-N 3,6-dimethyl-1,4-dioxane-2,5-dione;oxepan-2-one Chemical compound O=C1CCCCCO1.CC1OC(=O)C(C)OC1=O ZAJGKKXBKLVSKW-UHFFFAOYSA-N 0.000 claims 1
- ALRHLSYJTWAHJZ-UHFFFAOYSA-N 3-hydroxypropionic acid Chemical compound OCCC(O)=O ALRHLSYJTWAHJZ-UHFFFAOYSA-N 0.000 claims 1
- FMHKPLXYWVCLME-UHFFFAOYSA-N 4-hydroxy-valeric acid Chemical compound CC(O)CCC(O)=O FMHKPLXYWVCLME-UHFFFAOYSA-N 0.000 claims 1
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 claims 1
- 229930185605 Bisphenol Natural products 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 229920001651 Cyanoacrylate Polymers 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 102000009123 Fibrin Human genes 0.000 claims 1
- 108010073385 Fibrin Proteins 0.000 claims 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 239000004642 Polyimide Substances 0.000 claims 1
- 229920000388 Polyphosphate Polymers 0.000 claims 1
- 229920002472 Starch Chemical class 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229940061720 alpha hydroxy acid Drugs 0.000 claims 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims 1
- 229920000249 biocompatible polymer Polymers 0.000 claims 1
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 229940045110 chitosan Drugs 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 229960005188 collagen Drugs 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 210000002310 elbow joint Anatomy 0.000 claims 1
- 229950003499 fibrin Drugs 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 229920000578 graft copolymer Polymers 0.000 claims 1
- 210000004394 hip joint Anatomy 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 210000000629 knee joint Anatomy 0.000 claims 1
- 150000002596 lactones Chemical class 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 229920001308 poly(aminoacid) Polymers 0.000 claims 1
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920006149 polyester-amide block copolymer Polymers 0.000 claims 1
- 229920002643 polyglutamic acid Polymers 0.000 claims 1
- 229920000903 polyhydroxyalkanoate Polymers 0.000 claims 1
- 229920001721 polyimide Polymers 0.000 claims 1
- 239000001205 polyphosphate Substances 0.000 claims 1
- 235000011176 polyphosphates Nutrition 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 229920005604 random copolymer Polymers 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462047023P | 2014-09-07 | 2014-09-07 | |
| US62/047,023 | 2014-09-07 | ||
| PCT/IL2015/050903 WO2016035088A1 (en) | 2014-09-07 | 2015-09-07 | Anisotropic biocomposite material, medical implants comprising same and methods of treatment thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527341A JP2017527341A (ja) | 2017-09-21 |
| JP2017527341A5 true JP2017527341A5 (enExample) | 2018-10-11 |
| JP6719447B2 JP6719447B2 (ja) | 2020-07-08 |
Family
ID=55439212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017504425A Active JP6719447B2 (ja) | 2014-09-07 | 2015-09-07 | 異方性バイオ複合材料、異方性バイオ複合材料を含む医療用インプラント、および係る医療用インプラントの治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10869708B2 (enExample) |
| EP (2) | EP3188676B1 (enExample) |
| JP (1) | JP6719447B2 (enExample) |
| KR (1) | KR102504497B1 (enExample) |
| CN (2) | CN106687077B (enExample) |
| AU (1) | AU2015310510B2 (enExample) |
| BR (1) | BR112017001049B1 (enExample) |
| CA (1) | CA2955392C (enExample) |
| IL (2) | IL251003B (enExample) |
| MX (1) | MX384264B (enExample) |
| SG (2) | SG11201610671PA (enExample) |
| WO (2) | WO2016035088A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015095745A1 (en) | 2010-10-20 | 2015-06-25 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US20120101593A1 (en) | 2010-10-20 | 2012-04-26 | BIOS2 Medical, Inc. | Implantable polymer for bone and vascular lesions |
| US11291483B2 (en) | 2010-10-20 | 2022-04-05 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
| US10525169B2 (en) | 2010-10-20 | 2020-01-07 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US11207109B2 (en) | 2010-10-20 | 2021-12-28 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US11484627B2 (en) | 2010-10-20 | 2022-11-01 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US11058796B2 (en) | 2010-10-20 | 2021-07-13 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| EP2819620A4 (en) | 2012-02-29 | 2015-11-04 | 206 Ortho Inc | METHOD AND APPARATUS FOR TREATING BONE FRACTURES, INCLUDING THE USE OF COMPOSITE IMPLANTS |
| US10010609B2 (en) | 2013-05-23 | 2018-07-03 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
| CN106687077B (zh) | 2014-09-07 | 2021-07-27 | 奥西奥有限公司 | 各向异性生物复合材料、包含各向异性生物复合材料的医疗植入物及其治疗方法 |
| BR112017012508B1 (pt) | 2014-12-26 | 2022-04-12 | Ossio Ltd | Implante médico |
| EP3426312A4 (en) | 2016-03-07 | 2019-11-13 | Ossio Ltd. | SURFACE TREATED BIOVERAL MATERIAL, MEDICAL IMPLANTS THEREFOR AND TREATMENT METHOD THEREFOR |
| KR101949013B1 (ko) * | 2016-03-22 | 2019-02-18 | 한양대학교 에리카산학협력단 | 다중 약물 제어 방출을 위한 폴리락타이드 광학이성질체의 스테레오 복합체에 기초한 생분해성 이방성 나노입자 |
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| EP3643691B1 (en) * | 2018-10-24 | 2021-07-21 | Arctic Biomaterials Oy | Biodegradable, bioactive and biocompatible glass composition |
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| CN112245661B (zh) * | 2020-10-23 | 2021-09-10 | 湖南大学 | 一种tbj组织修复薄膜型支架及其制备方法 |
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| CN114272437A (zh) * | 2021-12-28 | 2022-04-05 | 同光(昆山)生物科技有限公司 | 一种医用复合材料及其制备方法和应用 |
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