JP2017526716A5 - - Google Patents
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- Publication number
- JP2017526716A5 JP2017526716A5 JP2017513658A JP2017513658A JP2017526716A5 JP 2017526716 A5 JP2017526716 A5 JP 2017526716A5 JP 2017513658 A JP2017513658 A JP 2017513658A JP 2017513658 A JP2017513658 A JP 2017513658A JP 2017526716 A5 JP2017526716 A5 JP 2017526716A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- compound
- pharmaceutically acceptable
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- QMBZVWHMCQUVTP-DSYKOEDSSA-N C[C@H]1N[C@H]2C[C@@H]1CC2 Chemical compound C[C@H]1N[C@H]2C[C@@H]1CC2 QMBZVWHMCQUVTP-DSYKOEDSSA-N 0.000 description 2
- 0 *C1(CC2)NCC2CC1 Chemical compound *C1(CC2)NCC2CC1 0.000 description 1
- QOQFIGTUFLXDFE-UHFFFAOYSA-N CC1(CC2)NCC2CC1 Chemical compound CC1(CC2)NCC2CC1 QOQFIGTUFLXDFE-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14184613.9 | 2014-09-12 | ||
| EP14184613 | 2014-09-12 | ||
| PCT/EP2015/070449 WO2016038007A1 (en) | 2014-09-12 | 2015-09-08 | Spirocyclic inhibitors of cathepsin c |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017246001A Division JP6360961B2 (ja) | 2014-09-12 | 2017-12-22 | カテプシンcのスピロ環状阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017526716A JP2017526716A (ja) | 2017-09-14 |
| JP2017526716A5 true JP2017526716A5 (OSRAM) | 2017-10-26 |
Family
ID=51535355
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017513658A Ceased JP2017526716A (ja) | 2014-09-12 | 2015-09-08 | カテプシンcのスピロ環状阻害剤 |
| JP2017246001A Active JP6360961B2 (ja) | 2014-09-12 | 2017-12-22 | カテプシンcのスピロ環状阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017246001A Active JP6360961B2 (ja) | 2014-09-12 | 2017-12-22 | カテプシンcのスピロ環状阻害剤 |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US9540373B2 (OSRAM) |
| EP (2) | EP3511331A1 (OSRAM) |
| JP (2) | JP2017526716A (OSRAM) |
| KR (1) | KR102510588B1 (OSRAM) |
| CN (2) | CN107074870B (OSRAM) |
| AP (1) | AP2017009733A0 (OSRAM) |
| AU (1) | AU2015314355B2 (OSRAM) |
| BR (1) | BR112017003433B1 (OSRAM) |
| CA (1) | CA2960916C (OSRAM) |
| CL (1) | CL2017000432A1 (OSRAM) |
| CO (1) | CO2017002268A2 (OSRAM) |
| CY (1) | CY1123033T1 (OSRAM) |
| DK (1) | DK3191487T3 (OSRAM) |
| EA (1) | EA031376B1 (OSRAM) |
| ES (1) | ES2749009T3 (OSRAM) |
| HK (1) | HK1255362A1 (OSRAM) |
| HR (1) | HRP20191756T1 (OSRAM) |
| HU (1) | HUE047208T2 (OSRAM) |
| IL (1) | IL250262B (OSRAM) |
| LT (1) | LT3191487T (OSRAM) |
| MX (2) | MX378099B (OSRAM) |
| MY (1) | MY188382A (OSRAM) |
| NZ (1) | NZ728684A (OSRAM) |
| PE (1) | PE20170438A1 (OSRAM) |
| PH (1) | PH12017500453B1 (OSRAM) |
| PL (1) | PL3191487T3 (OSRAM) |
| PT (1) | PT3191487T (OSRAM) |
| RS (1) | RS59444B1 (OSRAM) |
| SA (1) | SA517381064B1 (OSRAM) |
| SG (1) | SG11201701633SA (OSRAM) |
| SI (1) | SI3191487T1 (OSRAM) |
| TW (1) | TWI687424B (OSRAM) |
| UA (1) | UA118610C2 (OSRAM) |
| WO (1) | WO2016038007A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9018227B2 (en) | 2010-03-19 | 2015-04-28 | Indiana State University | Nicotinic acetylcholine receptor agonists |
| NO2699580T3 (OSRAM) | 2014-01-24 | 2018-02-24 | ||
| WO2016016242A1 (en) * | 2014-08-01 | 2016-02-04 | Boehringer Ingelheim International Gmbh | Substituted oxetanes and their use as inhibitors of cathepsin c |
| KR102510588B1 (ko) * | 2014-09-12 | 2023-03-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 카텝신 c의 스피로사이클릭 억제제 |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| WO2018162312A1 (en) * | 2017-03-10 | 2018-09-13 | Basf Se | Spirocyclic derivatives |
| EP3749326A4 (en) * | 2018-02-07 | 2021-11-03 | Insmed Incorporated | CERTAIN (2S) -N - [(1S) -1-CYANO-2-PHENYLETHYL] -1,4-OXAZEPAN-2-CARBOXAMIDE FOR THE TREATMENT OF VASCULITIDES ASSOCIATED WITH ANCA |
| PL3758708T3 (pl) | 2018-03-01 | 2025-03-31 | Astrazeneca Ab | Kompozycje farmaceutyczne zawierające (2s)-{(1s)-1-cyjano-2-[4-(3-metylo-2-okso-2,3-dihydro-1,3-benzoksazol-5-ilo)fenylo]etylo}-1,4-oksazepano-2-karboksyamid |
| EP3823627A4 (en) | 2018-07-17 | 2022-04-20 | Insmed Incorporated | CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES FOR THE TREATMENT OF LUPUS ENEHROPATHY |
| CN110256429B (zh) * | 2019-06-17 | 2021-06-22 | 广东药科大学 | 一种具有螺环结构的氨基嘧啶类化合物及其制备方法和应用 |
| CN110257504A (zh) * | 2019-06-30 | 2019-09-20 | 中南大学 | 一种难治性哮喘检测标记物的筛选方法及其应用 |
| JP2023535332A (ja) | 2020-07-20 | 2023-08-17 | インスメッド インコーポレイテッド | 好中球セリンプロテアーゼを抽出するおよびジペプチジルペプチダーゼ1媒介性病態を治療するための方法 |
| CN114106005B (zh) * | 2020-08-26 | 2025-08-01 | 西藏海思科制药有限公司 | 一种作为二肽基肽酶1抑制剂的腈衍生物及其用途 |
| EP4247490A2 (en) * | 2020-11-17 | 2023-09-27 | Vertex Pharmaceuticals Incorporated | Solid forms of 4-(5-(4-fluorophenyl)-6-tetrahydro-2h-pyran-4-yl)- 1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid |
| JP2023551488A (ja) * | 2020-12-04 | 2023-12-08 | 瑞石生物医薬有限公司 | カテプシンcの小分子阻害剤及びその医薬的使用 |
| CN114591315A (zh) * | 2020-12-04 | 2022-06-07 | 瑞石生物医药有限公司 | 一种组织蛋白酶c小分子抑制剂 |
| AU2023296161A1 (en) * | 2022-06-13 | 2025-01-02 | Alivexis, Inc. | Azacycloalkyl carbonyl cyclic amine compound |
| US20250250232A1 (en) | 2022-07-06 | 2025-08-07 | Chiesi Farmaceutici S.P.A. | Azetidine derivatives and use thereof as dipeptidyl peptidase 1 inhibitors |
| WO2024088307A1 (zh) * | 2022-10-26 | 2024-05-02 | 上海壹迪生物技术有限公司 | 一种新型肽基腈类化合物及其应用 |
| EP4646265A1 (en) | 2023-01-06 | 2025-11-12 | Insmed Incorporated | Novel, reversible dpp1 inhibitors and uses thereof |
| WO2025214464A1 (en) * | 2024-04-12 | 2025-10-16 | Insmed Incorporated | Crystalline forms of (s) -n- (1-cyano-2- (2-fluoro-4- (1' - (oxetan-3-yl) -3h-spiro [isobenzofuran-1, 4' -piperidin] -6-yl) phenyl) ethyl) -2-azabicyclo [2.2.2] octane-1-carboxamide |
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| US4125727A (en) | 1976-10-18 | 1978-11-14 | American Cyanamid Company | Method of preparing imidazoisoindolediones |
| GB8922355D0 (en) | 1989-10-04 | 1989-11-22 | British Telecomm | Sealing gland |
| GEP20012487B (en) | 1998-09-16 | 2001-07-25 | Merab Lomia | Use of Chemical Agent 5-carbarnoyl-5H-Dibenz (b,f) azepin, its Derivatives and Analogues by New Purpose |
| US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| EP1372655B1 (en) | 2001-03-02 | 2008-10-01 | Merck Frosst Canada Ltd. | Cathepsin cysteine protease inhibitors |
| TW200306189A (en) | 2002-03-21 | 2003-11-16 | Merz Pharma Gmbh & Co Kgaa | Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists |
| JP2006527704A (ja) | 2003-06-18 | 2006-12-07 | プロザイメックス・アクティーゼルスカブ | プロテアーゼ阻害剤 |
| TW200528440A (en) | 2003-10-31 | 2005-09-01 | Fujisawa Pharmaceutical Co | 2-cyanopyrrolidinecarboxamide compound |
| US20060223846A1 (en) | 2005-03-08 | 2006-10-05 | Dyatkin Alexey B | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists |
| WO2007137738A1 (de) * | 2006-06-01 | 2007-12-06 | Sanofi-Aventis | Spiro-cyclische nitrile als protease-inhibitoren |
| EP2072519A4 (en) | 2006-09-28 | 2009-10-21 | Banyu Pharma Co Ltd | DIARYLKETIMINDERIVAT |
| JP5240201B2 (ja) | 2007-10-12 | 2013-07-17 | 富士通株式会社 | Ip電話自動試験システム及び方法 |
| BRPI0820665A2 (pt) | 2007-12-12 | 2018-05-29 | Astrazeneca Ab | compostos de peptidil nitrilas, processos para fabricação dos mesmos, composição farmacêutica, combinação e uso de ditos compostos |
| BRPI1015540A2 (pt) | 2009-05-07 | 2019-09-24 | Astrazeneca Ab | ''composto de 1-cianoetil-heterociclilcarboxamida substituídos 750'' |
| WO2010142985A1 (en) | 2009-06-10 | 2010-12-16 | Astrazeneca Ab | Substituted n-[1-cyano-2-(phenyl)ethyl]piperidin-2-ylcarboxmide compounds 761 |
| WO2012119941A1 (en) | 2011-03-04 | 2012-09-13 | Prozymex A/S | Peptidyl nitrilcompounds as peptidase inhibitors |
| US8999975B2 (en) * | 2011-09-19 | 2015-04-07 | Boehringer Ingelheim International Gmbh | Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C |
| PE20142400A1 (es) | 2012-04-27 | 2015-02-04 | Glaxo Group Ltd | Compuestos novedosos |
| US9056874B2 (en) | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
| KR101719893B1 (ko) | 2012-05-22 | 2017-03-24 | 제넨테크, 인크. | N-치환된 벤즈아미드 및 통증의 치료에서 이들의 용도 |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| JO3459B1 (ar) | 2012-09-09 | 2020-07-05 | H Lundbeck As | تركيبات صيدلانية لعلاج مرض الزهايمر |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| NZ706857A (en) | 2012-09-28 | 2018-05-25 | Ignyta Inc | Azaquinazoline inhibitors of atypical protein kinase c |
| WO2014056942A1 (en) * | 2012-10-09 | 2014-04-17 | Boehringer Ingelheim International Gmbh | Use of selectively moisture-adjusted tabletting material in the production of mechanically stable tablets which contain at least one hydrate-forming active substance and/or adjuvant relevant to the mechanical stability of the tablets, particularly arginine-containing tablets |
| SG10201705989YA (en) | 2012-10-15 | 2017-08-30 | Epizyme Inc | Substituted benzene compounds |
| PE20150778A1 (es) | 2012-10-16 | 2015-05-23 | Janssen Pharmaceutica Nv | Moduladores de quinolinilo unidos a metileno de ror-gamma-t |
| CA2888816A1 (en) | 2012-11-01 | 2014-05-08 | Incyte Corporation | Tricyclic fused thiophene derivatives as jak inhibitors |
| US9233974B2 (en) | 2012-12-21 | 2016-01-12 | Gilead Sciences, Inc. | Antiviral compounds |
| BR112015014752B1 (pt) | 2012-12-21 | 2022-07-05 | Plexxikon, Inc | Compostos e seus uso para modulação de cinase |
| HK1210611A1 (en) | 2012-12-21 | 2016-04-29 | Quanticel Pharmaceuticals Inc | Histone demethylase inhibitors |
| WO2014124230A2 (en) | 2013-02-08 | 2014-08-14 | Celgene Avilomics Research, Inc. | Erk inhibitors and uses thereof |
| AR095426A1 (es) | 2013-03-14 | 2015-10-14 | Onyx Therapeutics Inc | Inhibidores tripeptídicos de la epoxicetona proteasa |
| JO3383B1 (ar) | 2013-03-14 | 2019-03-13 | Lilly Co Eli | مثبطات cdc7 |
| US8877775B2 (en) * | 2013-03-14 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C |
| TWI599567B (zh) | 2013-03-14 | 2017-09-21 | 健生藥品公司 | P2x7調節劑 |
| HK1213251A1 (zh) | 2013-03-14 | 2016-06-30 | Novartis Ag | 作为突变idh抑制剂的3-嘧啶-4-基-恶唑烷-2-酮化合物 |
| WO2014159248A1 (en) | 2013-03-14 | 2014-10-02 | Newlink Genetics Corporation | Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| DK2970283T3 (da) * | 2013-03-14 | 2021-01-25 | Boehringer Ingelheim Int | Substituerede 2-aza-bicyclo[2.2.1]heptan-3-carboxylsyre-(benzyl-cyano-methyl)-amider som inhibitorer af cathepsin-c |
| KR101886550B1 (ko) * | 2014-04-29 | 2018-08-07 | 케어베이 유럽 리미티드 | 바늘 삽입 깊이를 조정하기 위한 장치 |
| US20160001608A1 (en) | 2014-07-03 | 2016-01-07 | Bridgestone Americas Tire Operations, Llc | Sidewall decoration on rim guard |
| CN106687453B (zh) | 2014-09-12 | 2019-07-19 | 葛兰素史克知识产权第二有限公司 | 作为溴结构域抑制剂的四氢喹啉衍生物 |
| UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
| AR101696A1 (es) | 2014-09-12 | 2017-01-04 | Lilly Co Eli | Compuestos de azetidiniloxifenilpirrolidina |
| KR102510588B1 (ko) * | 2014-09-12 | 2023-03-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 카텝신 c의 스피로사이클릭 억제제 |
-
2015
- 2015-09-08 KR KR1020177009993A patent/KR102510588B1/ko active Active
- 2015-09-08 HU HUE15757523A patent/HUE047208T2/hu unknown
- 2015-09-08 WO PCT/EP2015/070449 patent/WO2016038007A1/en not_active Ceased
- 2015-09-08 DK DK15757523T patent/DK3191487T3/da active
- 2015-09-08 AU AU2015314355A patent/AU2015314355B2/en active Active
- 2015-09-08 LT LTEP15757523.4T patent/LT3191487T/lt unknown
- 2015-09-08 CN CN201580048467.6A patent/CN107074870B/zh active Active
- 2015-09-08 PE PE2017000400A patent/PE20170438A1/es unknown
- 2015-09-08 UA UAA201703350A patent/UA118610C2/uk unknown
- 2015-09-08 PT PT157575234T patent/PT3191487T/pt unknown
- 2015-09-08 CN CN201810030066.3A patent/CN108047240B/zh active Active
- 2015-09-08 AP AP2017009733A patent/AP2017009733A0/en unknown
- 2015-09-08 EP EP19155235.5A patent/EP3511331A1/en not_active Withdrawn
- 2015-09-08 MX MX2019009695A patent/MX378099B/es unknown
- 2015-09-08 PL PL15757523T patent/PL3191487T3/pl unknown
- 2015-09-08 ES ES15757523T patent/ES2749009T3/es active Active
- 2015-09-08 HR HRP20191756TT patent/HRP20191756T1/hr unknown
- 2015-09-08 MY MYPI2017000213A patent/MY188382A/en unknown
- 2015-09-08 EA EA201790576A patent/EA031376B1/ru not_active IP Right Cessation
- 2015-09-08 EP EP15757523.4A patent/EP3191487B1/en active Active
- 2015-09-08 SI SI201530977T patent/SI3191487T1/sl unknown
- 2015-09-08 SG SG11201701633SA patent/SG11201701633SA/en unknown
- 2015-09-08 NZ NZ728684A patent/NZ728684A/en unknown
- 2015-09-08 BR BR112017003433-6A patent/BR112017003433B1/pt active IP Right Grant
- 2015-09-08 MX MX2017003156A patent/MX367316B/es active IP Right Grant
- 2015-09-08 RS RSP20191350 patent/RS59444B1/sr unknown
- 2015-09-08 JP JP2017513658A patent/JP2017526716A/ja not_active Ceased
- 2015-09-08 CA CA2960916A patent/CA2960916C/en active Active
- 2015-09-10 US US14/849,710 patent/US9540373B2/en not_active Ceased
- 2015-09-11 TW TW104130165A patent/TWI687424B/zh active
-
2016
- 2016-11-29 US US15/362,949 patent/US9879026B2/en active Active
-
2017
- 2017-01-24 IL IL250262A patent/IL250262B/en active IP Right Grant
- 2017-02-23 CL CL2017000432A patent/CL2017000432A1/es unknown
- 2017-03-07 CO CONC2017/0002268A patent/CO2017002268A2/es unknown
- 2017-03-09 SA SA517381064A patent/SA517381064B1/ar unknown
- 2017-03-10 PH PH12017500453A patent/PH12017500453B1/en unknown
- 2017-11-30 US US15/827,433 patent/USRE47636E1/en active Active
- 2017-12-22 JP JP2017246001A patent/JP6360961B2/ja active Active
-
2018
- 2018-11-14 HK HK18114501.3A patent/HK1255362A1/zh unknown
-
2019
- 2019-11-06 CY CY20191101154T patent/CY1123033T1/el unknown
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