JP2017526675A5 - - Google Patents
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- Publication number
- JP2017526675A5 JP2017526675A5 JP2017510881A JP2017510881A JP2017526675A5 JP 2017526675 A5 JP2017526675 A5 JP 2017526675A5 JP 2017510881 A JP2017510881 A JP 2017510881A JP 2017510881 A JP2017510881 A JP 2017510881A JP 2017526675 A5 JP2017526675 A5 JP 2017526675A5
- Authority
- JP
- Japan
- Prior art keywords
- cycloalkyl
- solvate
- alkyl
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 **N(*)C(*)c1nc(*)nc(O)c1 Chemical compound **N(*)C(*)c1nc(*)nc(O)c1 0.000 description 1
- RASVGFMDDLVZSK-UHFFFAOYSA-N CCc1cnc(CNCc2nc(C)cc(C(O)=O)c2)[n]1CCc1ccccc1 Chemical compound CCc1cnc(CNCc2nc(C)cc(C(O)=O)c2)[n]1CCc1ccccc1 RASVGFMDDLVZSK-UHFFFAOYSA-N 0.000 description 1
- ORTZUFGQPDXCIN-UHFFFAOYSA-N Cc1cc(C(O)=O)cc(CNCc2ncc(CC#CC)[n]2Cc(cc2)ccc2F)n1 Chemical compound Cc1cc(C(O)=O)cc(CNCc2ncc(CC#CC)[n]2Cc(cc2)ccc2F)n1 ORTZUFGQPDXCIN-UHFFFAOYSA-N 0.000 description 1
- DTDVJXFGJQBRLW-UHFFFAOYSA-N Cc1cc(C(O)=O)cc(CNCc2nnc[n]2CCc2cccc(Cl)c2)n1 Chemical compound Cc1cc(C(O)=O)cc(CNCc2nnc[n]2CCc2cccc(Cl)c2)n1 DTDVJXFGJQBRLW-UHFFFAOYSA-N 0.000 description 1
- XNAUNIHPQIPVLW-UHFFFAOYSA-N Cc1nc(CNCc2nnc(CNC3)[n]2C3c2ccccc2)cc(C(O)=O)c1 Chemical compound Cc1nc(CNCc2nnc(CNC3)[n]2C3c2ccccc2)cc(C(O)=O)c1 XNAUNIHPQIPVLW-UHFFFAOYSA-N 0.000 description 1
- HITBOZDUYVYOEN-UHFFFAOYSA-N OCc1cc(C(O)=O)cc(CNCc2nc(C=O)c[n]2Cc(cc2)ccc2F)n1 Chemical compound OCc1cc(C(O)=O)cc(CNCc2nc(C=O)c[n]2Cc(cc2)ccc2F)n1 HITBOZDUYVYOEN-UHFFFAOYSA-N 0.000 description 1
- CGFCQTHVWSBUDP-UHFFFAOYSA-N OCc1cc(C(O)=O)cc(CNCc2nnc[n]2CCc2cc(Cl)cc(Cl)c2)n1 Chemical compound OCc1cc(C(O)=O)cc(CNCc2nnc[n]2CCc2cc(Cl)cc(Cl)c2)n1 CGFCQTHVWSBUDP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462042717P | 2014-08-27 | 2014-08-27 | |
| US62/042,717 | 2014-08-27 | ||
| PCT/US2015/046921 WO2016033169A1 (en) | 2014-08-27 | 2015-08-26 | Compounds and methods for inhibiting histone demethylases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017526675A JP2017526675A (ja) | 2017-09-14 |
| JP2017526675A5 true JP2017526675A5 (enExample) | 2018-09-27 |
Family
ID=54062822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017510881A Withdrawn JP2017526675A (ja) | 2014-08-27 | 2015-08-26 | ヒストンデメチラーゼを阻害するための化合物および方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9802941B2 (enExample) |
| EP (1) | EP3186238A1 (enExample) |
| JP (1) | JP2017526675A (enExample) |
| KR (1) | KR20170040805A (enExample) |
| CN (1) | CN107074807A (enExample) |
| AR (1) | AR101692A1 (enExample) |
| AU (1) | AU2015306662A1 (enExample) |
| BR (1) | BR112017003442A2 (enExample) |
| CA (1) | CA2957947A1 (enExample) |
| EA (1) | EA201790154A1 (enExample) |
| IL (1) | IL250355A0 (enExample) |
| MA (1) | MA40470A (enExample) |
| MX (1) | MX2017002451A (enExample) |
| SG (1) | SG11201701182VA (enExample) |
| TW (1) | TW201625536A (enExample) |
| WO (1) | WO2016033169A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017198785A1 (en) * | 2016-05-18 | 2017-11-23 | Ieo - Istituto Europeo Di Oncologia S.R.L. | Oxime derivatives useful as inhibitors of histone demethylase kdm4c |
| ES2969239T3 (es) | 2016-05-27 | 2024-05-17 | Gilead Sciences Inc | Combinación de ledipasvir y sofosbuvir para su uso en el tratamiento de infecciones por el virus de la hepatitis B en humanos |
| BR102017010009A2 (pt) | 2016-05-27 | 2017-12-12 | Gilead Sciences, Inc. | Compounds for the treatment of hepatitis b virus infection |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| SI3507276T1 (sl) | 2016-09-02 | 2022-01-31 | Gilead Sciences, Inc. | Spojine modulatorja toličnih receptorjev |
| WO2018045150A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| KR20230010826A (ko) | 2016-10-14 | 2023-01-19 | 프리시젼 바이오사이언시스 인코포레이티드 | B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제 |
| TWI714820B (zh) | 2017-01-31 | 2021-01-01 | 美商基利科學股份有限公司 | 替諾福韋艾拉酚胺(tenofovir alafenamide)之晶型 |
| UY37581A (es) | 2017-02-02 | 2018-08-31 | Gilead Sciences Inc | Compuestos para el tratamiento de la infección por virus de la hepatitis b |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| WO2018222831A1 (en) * | 2017-05-31 | 2018-12-06 | The Children's Medical Center Corporation | TARGETING LYSINE DEMETHYLASES (KDMs) AS A THERAPEUTIC STRATEGY FOR DIFFUSE LARGE B-CELL LYMPHOMA |
| US11203610B2 (en) | 2017-12-20 | 2021-12-21 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| JP7037667B2 (ja) | 2017-12-20 | 2022-03-16 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． | Ｓｔｉｎｇアダプタータンパク質を活性化するホスホン酸結合を有する３’３’環状ジヌクレオチド |
| WO2019154261A1 (zh) * | 2018-02-09 | 2019-08-15 | 南京明德新药研发股份有限公司 | 与kmd5通路相关的吡啶衍生物 |
| WO2019160882A1 (en) | 2018-02-13 | 2019-08-22 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| JP7050165B2 (ja) | 2018-02-26 | 2022-04-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｂｖ複製阻害剤としての置換ピロリジン化合物 |
| WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| WO2019211799A1 (en) | 2018-05-03 | 2019-11-07 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide |
| PE20210642A1 (es) | 2018-07-13 | 2021-03-23 | Gilead Sciences Inc | Inhibidores de pd-1/pd-l1 |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| AU2019318046B2 (en) * | 2018-08-06 | 2025-02-13 | Dana-Farber Cancer Institute, Inc. | Histone demethylase 5 inhibitors and uses thereof |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| EP3873608A1 (en) | 2018-10-31 | 2021-09-08 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| EP4371987B9 (en) | 2018-10-31 | 2025-11-26 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds as hpk1 inhibitors |
| WO2020178769A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| CN113574063B (zh) | 2019-03-07 | 2025-03-18 | 捷克共和国有机化学与生物化学研究所 | 3’3’-环二核苷酸及其前药 |
| WO2020178768A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| US11453681B2 (en) | 2019-05-23 | 2022-09-27 | Gilead Sciences, Inc. | Substituted eneoxindoles and uses thereof |
| CN114245807B (zh) | 2019-06-25 | 2025-05-02 | 吉利德科学公司 | Flt3l-fc融合蛋白和使用方法 |
| WO2021011891A1 (en) | 2019-07-18 | 2021-01-21 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| US20220296619A1 (en) | 2019-08-19 | 2022-09-22 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| HRP20241379T1 (hr) | 2019-09-30 | 2024-12-20 | Gilead Sciences, Inc. | Cjepiva za hbv i postupci za liječenje hbv |
| US12410418B2 (en) | 2019-12-06 | 2025-09-09 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| KR102987126B1 (ko) | 2020-03-20 | 2026-07-07 | 길리애드 사이언시즈, 인코포레이티드 | 4'-c-치환된-2-할로-2'-데옥시아데노신 뉴클레오시드의 프로드러그 및 이의 제조 및 사용 방법 |
| LT4192474T (lt) | 2020-08-07 | 2025-11-25 | Fosfonamidų nukleotidų analogų provaistai ir jų farmacinis panaudojimas | |
| TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| US20240269142A1 (en) | 2021-05-13 | 2024-08-15 | Gilead Sciences, Inc. | COMBINATION OF A TLR8 MODULATING COMPOUND AND ANTI-HBV siRNA THERAPEUTICS |
| EP4359413A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| MX2023014762A (es) | 2021-06-23 | 2024-01-15 | Gilead Sciences Inc | Compuestos moduladores de diacilglicerol quinasa. |
| JP7651018B2 (ja) | 2021-06-23 | 2025-03-25 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| CN117355531A (zh) | 2021-06-23 | 2024-01-05 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| CN114907317B (zh) * | 2022-06-01 | 2023-06-13 | 郑州大学 | 一种吡唑-乙烯基-异烟酸衍生物及其制备方法和应用 |
| CN117756794B (zh) * | 2023-12-18 | 2024-07-16 | 和径医药科技（上海）有限公司 | 一种含氮杂环类化合物及其制备方法和应用 |
| WO2025240246A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| US20250345390A1 (en) | 2024-05-13 | 2025-11-13 | Gilead Sciences, Inc. | Combination therapies |
| TW202608468A (zh) | 2024-05-13 | 2026-03-01 | 美商基利科學股份有限公司 | 組合療法 |
| WO2025240242A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
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| GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
| DE3372965D1 (en) | 1982-07-23 | 1987-09-17 | Ici Plc | Amide derivatives |
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-
2015
- 2015-08-26 JP JP2017510881A patent/JP2017526675A/ja not_active Withdrawn
- 2015-08-26 WO PCT/US2015/046921 patent/WO2016033169A1/en not_active Ceased
- 2015-08-26 CA CA2957947A patent/CA2957947A1/en not_active Abandoned
- 2015-08-26 CN CN201580046345.3A patent/CN107074807A/zh active Pending
- 2015-08-26 TW TW104127904A patent/TW201625536A/zh unknown
- 2015-08-26 AR ARP150102728A patent/AR101692A1/es unknown
- 2015-08-26 MA MA040470A patent/MA40470A/fr unknown
- 2015-08-26 AU AU2015306662A patent/AU2015306662A1/en not_active Abandoned
- 2015-08-26 MX MX2017002451A patent/MX2017002451A/es unknown
- 2015-08-26 SG SG11201701182VA patent/SG11201701182VA/en unknown
- 2015-08-26 EA EA201790154A patent/EA201790154A1/ru unknown
- 2015-08-26 EP EP15759595.0A patent/EP3186238A1/en not_active Withdrawn
- 2015-08-26 BR BR112017003442A patent/BR112017003442A2/pt not_active Application Discontinuation
- 2015-08-26 KR KR1020177006855A patent/KR20170040805A/ko not_active Withdrawn
- 2015-08-26 US US14/836,397 patent/US9802941B2/en active Active
-
2017
- 2017-01-30 IL IL250355A patent/IL250355A0/en unknown
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