JP2014531434A5 - - Google Patents
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- JP2014531434A5 JP2014531434A5 JP2014529919A JP2014529919A JP2014531434A5 JP 2014531434 A5 JP2014531434 A5 JP 2014531434A5 JP 2014529919 A JP2014529919 A JP 2014529919A JP 2014529919 A JP2014529919 A JP 2014529919A JP 2014531434 A5 JP2014531434 A5 JP 2014531434A5
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- 125000001072 heteroaryl group Chemical group 0.000 claims 26
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- 150000002431 hydrogen Chemical group 0.000 claims 24
- 125000004122 cyclic group Chemical group 0.000 claims 20
- 125000000623 heterocyclic group Chemical group 0.000 claims 20
- 125000004452 carbocyclyl group Chemical group 0.000 claims 15
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 15
- 125000000547 substituted alkyl group Chemical group 0.000 claims 15
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 15
- 125000003107 substituted aryl group Chemical group 0.000 claims 15
- 101000651021 Homo sapiens Splicing factor, arginine/serine-rich 19 Proteins 0.000 claims 14
- 102100027779 Splicing factor, arginine/serine-rich 19 Human genes 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 12
- 239000002872 contrast media Substances 0.000 claims 12
- 238000003384 imaging method Methods 0.000 claims 12
- 125000002950 monocyclic group Chemical group 0.000 claims 10
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 150000003839 salts Chemical group 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 230000030214 innervation Effects 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 230000010412 perfusion Effects 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000002015 acyclic group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 239000002738 chelating agent Substances 0.000 claims 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000006239 protecting group Chemical group 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 208000010125 myocardial infarction Diseases 0.000 claims 3
- 125000001845 4 membered carbocyclic group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 230000000747 cardiac effect Effects 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004011 3 membered carbocyclic group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000002638 denervation Effects 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017131851A JP6964450B2 (ja) | 2011-09-09 | 2017-07-05 | 造影剤の合成および使用のための組成物、方法およびシステム |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161533133P | 2011-09-09 | 2011-09-09 | |
| US61/533,133 | 2011-09-09 | ||
| US201261656489P | 2012-06-06 | 2012-06-06 | |
| US201261656492P | 2012-06-06 | 2012-06-06 | |
| US61/656,492 | 2012-06-06 | ||
| US61/656,489 | 2012-06-06 | ||
| PCT/US2012/054309 WO2013036869A2 (en) | 2011-09-09 | 2012-09-07 | Compositions, methods, and systems for the synthesis and use of imaging agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017131851A Division JP6964450B2 (ja) | 2011-09-09 | 2017-07-05 | 造影剤の合成および使用のための組成物、方法およびシステム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014531434A JP2014531434A (ja) | 2014-11-27 |
| JP2014531434A5 true JP2014531434A5 (enExample) | 2015-11-05 |
| JP6174026B2 JP6174026B2 (ja) | 2017-08-02 |
Family
ID=47832802
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529919A Active JP6174026B2 (ja) | 2011-09-09 | 2012-09-07 | 造影剤の合成および使用のための組成物、方法およびシステム |
| JP2017131851A Expired - Fee Related JP6964450B2 (ja) | 2011-09-09 | 2017-07-05 | 造影剤の合成および使用のための組成物、方法およびシステム |
| JP2019147621A Withdrawn JP2019218371A (ja) | 2011-09-09 | 2019-08-09 | 造影剤の合成および使用のための組成物、方法およびシステム |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017131851A Expired - Fee Related JP6964450B2 (ja) | 2011-09-09 | 2017-07-05 | 造影剤の合成および使用のための組成物、方法およびシステム |
| JP2019147621A Withdrawn JP2019218371A (ja) | 2011-09-09 | 2019-08-09 | 造影剤の合成および使用のための組成物、方法およびシステム |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US9550000B2 (enExample) |
| EP (2) | EP3567029A1 (enExample) |
| JP (3) | JP6174026B2 (enExample) |
| KR (4) | KR20190015765A (enExample) |
| CN (2) | CN104159890B (enExample) |
| AU (3) | AU2012304359B2 (enExample) |
| BR (2) | BR122019017259B1 (enExample) |
| CA (2) | CA3123737A1 (enExample) |
| DK (1) | DK2753605T3 (enExample) |
| ES (1) | ES2731471T3 (enExample) |
| IL (2) | IL231414B (enExample) |
| SG (2) | SG10201607437QA (enExample) |
| TW (2) | TWI568714B (enExample) |
| WO (1) | WO2013036869A2 (enExample) |
| ZA (2) | ZA201401940B (enExample) |
Families Citing this family (36)
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| US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| DK2474523T3 (da) | 2006-12-26 | 2020-07-13 | Lantheus Medical Imaging Inc | Ligander til billeddannelse af hjerte-innervation |
| KR101616139B1 (ko) | 2008-02-29 | 2016-04-27 | 랜티우스 메디컬 이메징, 인크. | 관류 영상화를 포함하는 용도를 위한 조영제 |
| CN102458396B (zh) | 2009-04-15 | 2017-05-10 | 兰休斯医疗成像公司 | 使用抗坏血酸稳定化放射性药物组合物 |
| AU2011213568B2 (en) | 2010-02-08 | 2016-05-12 | Lantheus Medical Imaging, Inc. | Methods and apparatus for synthesizing imaging agents, and intermediates thereof |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| RU2569678C2 (ru) | 2010-04-22 | 2015-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| CN106977429B (zh) | 2010-05-11 | 2021-08-24 | 蓝瑟斯医学影像公司 | 用于合成和使用造影剂的组合物、方法和系统 |
| CA2852395C (en) * | 2011-10-21 | 2020-04-28 | Lantheus Medical Imaging, Inc. | Compositions comprising ascorbic acid and pyridaben and pyridaben analogs attached to an imaging moiety and related methods |
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| US10646183B2 (en) | 2014-01-10 | 2020-05-12 | Tylerton International Inc. | Detection of scar and fibrous cardiac zones |
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