CA2957947A1 - Compounds and methods for inhibiting histone demethylases - Google Patents

Compounds and methods for inhibiting histone demethylases Download PDF

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Publication number
CA2957947A1
CA2957947A1 CA2957947A CA2957947A CA2957947A1 CA 2957947 A1 CA2957947 A1 CA 2957947A1 CA 2957947 A CA2957947 A CA 2957947A CA 2957947 A CA2957947 A CA 2957947A CA 2957947 A1 CA2957947 A1 CA 2957947A1
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Prior art keywords
alkyl
cycloalkyl
compound
aryl
heteroaryl
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CA2957947A
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English (en)
French (fr)
Inventor
Thomas Boesen
Marc Labelle
Ying Yang
Neerja Saraswat
Dastagiri Dudekula
Cyril John COOK
Ramkrishna Reddy VAKITI
Rui Zhang
Farman ULLAH
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Gilead Sciences Inc
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Gilead Sciences Inc
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Publication of CA2957947A1 publication Critical patent/CA2957947A1/en
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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CA2957947A 2014-08-27 2015-08-26 Compounds and methods for inhibiting histone demethylases Abandoned CA2957947A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462042717P 2014-08-27 2014-08-27
US62/042,717 2014-08-27
PCT/US2015/046921 WO2016033169A1 (en) 2014-08-27 2015-08-26 Compounds and methods for inhibiting histone demethylases

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US (1) US9802941B2 (enExample)
EP (1) EP3186238A1 (enExample)
JP (1) JP2017526675A (enExample)
KR (1) KR20170040805A (enExample)
CN (1) CN107074807A (enExample)
AR (1) AR101692A1 (enExample)
AU (1) AU2015306662A1 (enExample)
BR (1) BR112017003442A2 (enExample)
CA (1) CA2957947A1 (enExample)
EA (1) EA201790154A1 (enExample)
IL (1) IL250355A0 (enExample)
MA (1) MA40470A (enExample)
MX (1) MX2017002451A (enExample)
SG (1) SG11201701182VA (enExample)
TW (1) TW201625536A (enExample)
WO (1) WO2016033169A1 (enExample)

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MX2018014377A (es) 2016-05-27 2019-03-14 Gilead Sciences Inc Metodos para tratar infecciones por virus de hepatitis b usando inhibidores de proteina no estructural 5a (ns5a), proteina no estructural 5b (ns5b) o proteina no estructural 3 (ns3).
BR102017010009A2 (pt) 2016-05-27 2017-12-12 Gilead Sciences, Inc. Compounds for the treatment of hepatitis b virus infection
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
MA46093A (fr) 2016-09-02 2021-05-19 Gilead Sciences Inc Composés modulateurs du recepteur de type toll
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
FI3526323T3 (fi) 2016-10-14 2023-06-06 Prec Biosciences Inc Hepatiitti B -viruksen genomissa oleville tunnistussekvensseille spesifisiä muokattuja meganukleaaseja
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