JP2017522871A5 - - Google Patents
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- JP2017522871A5 JP2017522871A5 JP2017501287A JP2017501287A JP2017522871A5 JP 2017522871 A5 JP2017522871 A5 JP 2017522871A5 JP 2017501287 A JP2017501287 A JP 2017501287A JP 2017501287 A JP2017501287 A JP 2017501287A JP 2017522871 A5 JP2017522871 A5 JP 2017522871A5
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- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims description 200
- 102100037236 Tyrosine-protein kinase receptor UFO Human genes 0.000 claims description 45
- 229940127121 immunoconjugate Drugs 0.000 claims description 38
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 10
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- IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims description 8
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- GTBCXYYVWHFQRS-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-(pyridin-2-yldisulfanyl)pentanoate Chemical group C=1C=CC=NC=1SSC(C)CCC(=O)ON1C(=O)CCC1=O GTBCXYYVWHFQRS-UHFFFAOYSA-N 0.000 claims description 2
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- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims description 2
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201400380 | 2014-07-11 | ||
| DKPA201400380 | 2014-07-11 | ||
| DKPA201400489 | 2014-09-01 | ||
| DKPA201400489 | 2014-09-01 | ||
| DKPA201400746 | 2014-12-22 | ||
| DKPA201400746 | 2014-12-22 | ||
| DKPA201500283 | 2015-05-12 | ||
| DKPA201500283 | 2015-05-12 | ||
| PCT/EP2015/065900 WO2016005593A1 (en) | 2014-07-11 | 2015-07-10 | Antibodies binding axl |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080943A Division JP2020141682A (ja) | 2014-07-11 | 2020-05-01 | Ａｘｌに結合する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017522871A JP2017522871A (ja) | 2017-08-17 |
| JP2017522871A5 true JP2017522871A5 (cg-RX-API-DMAC7.html) | 2018-08-16 |
| JP6701162B2 JP6701162B2 (ja) | 2020-05-27 |
Family
ID=53673928
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017501287A Active JP6701162B2 (ja) | 2014-07-11 | 2015-07-10 | Ａｘｌに結合する抗体 |
| JP2020080943A Pending JP2020141682A (ja) | 2014-07-11 | 2020-05-01 | Ａｘｌに結合する抗体 |
| JP2023198745A Pending JP2024026158A (ja) | 2014-07-11 | 2023-11-24 | Ａｘｌに結合する抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080943A Pending JP2020141682A (ja) | 2014-07-11 | 2020-05-01 | Ａｘｌに結合する抗体 |
| JP2023198745A Pending JP2024026158A (ja) | 2014-07-11 | 2023-11-24 | Ａｘｌに結合する抗体 |
Country Status (27)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114621347A (zh) | 2014-07-11 | 2022-06-14 | 根马布股份公司 | 结合axl的抗体 |
| PT3319993T (pt) * | 2015-07-10 | 2020-04-22 | Genmab As | Conjugados de anticorpo-fármaco específicos de axl para tratamento de cancro |
| KR20180101479A (ko) | 2016-01-13 | 2018-09-12 | 젠맵 에이/에스 | 항체 및 그의 약물 접합체를 위한 제제 |
| WO2017180842A1 (en) * | 2016-04-15 | 2017-10-19 | Bioatla, Llc | Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof |
| WO2017200493A1 (en) | 2016-05-20 | 2017-11-23 | Agency For Science, Technology And Research | Anti-axl tyrosine kinase receptor antibodies and uses thereof |
| JP7030066B2 (ja) | 2016-05-26 | 2022-03-04 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | Ｅｇｆｒ阻害剤化合物 |
| WO2018007592A1 (en) | 2016-07-08 | 2018-01-11 | Genmab A/S | New dosage regimens for antibody drug conjugates based on anti-axl antibodies |
| EP3507601B1 (en) * | 2016-08-31 | 2023-08-16 | Agency for Science, Technology and Research | Methods for the identification, targeting and isolation of human dendritic cell (dc) precursors "pre-dc" |
| CN108285487B (zh) * | 2017-01-08 | 2021-02-19 | 浙江昭华生物医药有限公司 | 抗5t4抗体-药物偶联物及其应用 |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| WO2019051586A1 (en) | 2017-09-13 | 2019-03-21 | National Research Council Of Canada | AXL SPECIFIC ANTIBODIES AND USES THEREOF |
| CN107987163B (zh) * | 2017-12-04 | 2018-11-20 | 杭州尚健生物技术有限公司 | 单克隆抗体9a及其应用 |
| WO2019197506A1 (en) | 2018-04-10 | 2019-10-17 | Genmab A/S | Axl-specific antibodies for cancer treatment |
| CN110483639A (zh) * | 2018-05-15 | 2019-11-22 | 复旦大学 | 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 |
| CA3104390A1 (en) | 2018-06-22 | 2019-12-26 | Genmab A/S | Method for producing a controlled mixture of two or more different antibodies |
| EP3856783A1 (en) * | 2018-09-26 | 2021-08-04 | Genmab A/S | Axl-specific antibodies for treatment of non-small cell lung cancer |
| WO2020093024A2 (en) * | 2018-11-01 | 2020-05-07 | Merck Patent Gmbh | Methods of administering anti-tim-3 antibodies |
| WO2020227574A2 (en) * | 2019-05-07 | 2020-11-12 | Board Of Regents, The University Of Texas System | Methods for predicting drug responsiveness in samples from cancer subjects |
| WO2021013746A1 (en) | 2019-07-19 | 2021-01-28 | Genmab A/S | Axl antibody-drug conjugates for use in treating cancer |
| CN118465272B (zh) * | 2019-12-04 | 2025-08-19 | 珠海泰诺麦博制药股份有限公司 | 抗人巨细胞病毒抗体及其用途 |
| EP4087657A1 (en) | 2020-01-08 | 2022-11-16 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
| CA3192239A1 (en) * | 2020-08-19 | 2022-02-24 | Pharmabcine Inc. | Modified antibody and method for manufacturing same |
| JP2024505935A (ja) | 2021-01-29 | 2024-02-08 | イリミス セラピューティクス インコーポレーテッド | 非炎症性食細胞作用誘導活性を有する融合分子 |
| WO2022261846A1 (zh) * | 2021-06-16 | 2022-12-22 | 上海鑫湾生物科技有限公司 | 靶向axl蛋白的抗体及其抗原结合片段、其制备方法和应用 |
| EP4359439A1 (en) | 2021-06-24 | 2024-05-01 | Yeda Research and Development Co. Ltd | Combination therapy for the treatment of cancer comprising an anti-egfr antibody and an axl-inhibitor |
| EP4572854A2 (en) * | 2022-08-18 | 2025-06-25 | Biolegend, Inc. | Anti-axl antibodies, antigen-binding fragments thereof and methods for making and using the same |
| PL446349A1 (pl) * | 2023-10-11 | 2025-04-14 | Celon Pharma Spółka Akcyjna | Przeciwciała bispecyficzne anty-AXL i anty-PD-L1 oraz ich zastosowanie w terapii, zwłaszcza w leczeniu nowotworu |
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| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| DE3380726D1 (en) | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
| US4681581A (en) | 1983-12-05 | 1987-07-21 | Coates Fredrica V | Adjustable size diaper and folding method therefor |
| US4699880A (en) | 1984-09-25 | 1987-10-13 | Immunomedics, Inc. | Method of producing monoclonal anti-idiotype antibody |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
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