JP2017518306A5 - - Google Patents

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Publication number
JP2017518306A5
JP2017518306A5 JP2016570860A JP2016570860A JP2017518306A5 JP 2017518306 A5 JP2017518306 A5 JP 2017518306A5 JP 2016570860 A JP2016570860 A JP 2016570860A JP 2016570860 A JP2016570860 A JP 2016570860A JP 2017518306 A5 JP2017518306 A5 JP 2017518306A5
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JP
Japan
Prior art keywords
nicotinamide riboside
chloride
ion
tetrahydrofuran
isomerically pure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016570860A
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English (en)
Japanese (ja)
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JP2017518306A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2015/054181 external-priority patent/WO2015186068A1/en
Publication of JP2017518306A publication Critical patent/JP2017518306A/ja
Publication of JP2017518306A5 publication Critical patent/JP2017518306A5/ja
Pending legal-status Critical Current

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JP2016570860A 2014-06-02 2015-06-02 結晶性β−D−ニコチンアミドリボシドの製造および使用 Pending JP2017518306A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462006434P 2014-06-02 2014-06-02
US62/006,434 2014-06-02
PCT/IB2015/054181 WO2015186068A1 (en) 2014-06-02 2015-06-02 Preparation and use of crystalline beta-d-nicotinamide riboside

Publications (2)

Publication Number Publication Date
JP2017518306A JP2017518306A (ja) 2017-07-06
JP2017518306A5 true JP2017518306A5 (https=) 2018-07-12

Family

ID=53276953

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016570860A Pending JP2017518306A (ja) 2014-06-02 2015-06-02 結晶性β−D−ニコチンアミドリボシドの製造および使用

Country Status (10)

Country Link
US (1) US10316054B2 (https=)
EP (1) EP3149016A1 (https=)
JP (1) JP2017518306A (https=)
KR (1) KR20170012449A (https=)
CN (1) CN106536535A (https=)
AU (1) AU2015270130A1 (https=)
CA (1) CA2950727A1 (https=)
MX (1) MX2016015997A (https=)
RU (1) RU2016149764A (https=)
WO (1) WO2015186068A1 (https=)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106715454B (zh) 2014-07-24 2020-06-16 格雷斯公司 烟酰胺核苷的结晶形式
KR102629310B1 (ko) * 2015-03-09 2024-01-24 더블유.알. 그레이스 앤드 캄파니-콘. 니코틴아미드 리보사이드의 결정 형태
JP6949002B6 (ja) 2015-08-05 2021-11-17 メトロ インターナショナル バイオテック,エルエルシー ニコチンアミドモノヌクレオチド誘導体及びそれらの使用
EP3347024A2 (en) * 2015-09-08 2018-07-18 Ecole Polytechnique Federale de Lausanne (EPFL) Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
US10611790B2 (en) 2015-11-02 2020-04-07 Mitobridge, Inc. Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
CN115176998A (zh) 2016-04-14 2022-10-14 可劳迈戴斯有限公司 烟酰胺核苷、烟酸核苷、烟酰胺单核苷酸和烟碱基化合物衍生物在婴儿配方中的用途
GB2553001A (en) * 2016-08-19 2018-02-21 The Queen's Univ Of Belfast Lactone intermediates of nicotinamide riboside and nicotinate riboside
BR112019003579A2 (pt) 2016-08-22 2019-05-21 Elysium Health, Inc. Composições de ribosídeo de nicotinamida e pterostilbeno e métodos para o tratamento dedistúrbios neurodegenerativos
CA3045876A1 (en) 2016-11-11 2018-05-17 The Queen's University Of Belfast Scalable syntheses of nicotinoyl ribosides and reduced nic otinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
MX2019006278A (es) 2016-11-29 2019-08-21 Univ Iowa Res Found Uso de precursores de nad para mejorar la salud materna y/o salud de la descendencia.
WO2018132833A1 (en) * 2017-01-13 2018-07-19 The Regents Of The University Of Colorado, A Body Corporate Methods for treating hypertension and arterial stiffness
US20180303861A1 (en) * 2017-04-24 2018-10-25 Eric Marcotulli Treating and preventing kidney damage
US20200085849A1 (en) * 2017-05-18 2020-03-19 Elysium Health, Inc. Methods and compositions for improving sleep
EP3642214A2 (en) 2017-06-19 2020-04-29 Gangadhara Ganapati Nicotinamide riboside derivatives and their uses
US20200108043A1 (en) * 2017-06-21 2020-04-09 Yale University Compounds and compositions for extending lifespan of a subject
JP2020526511A (ja) * 2017-06-30 2020-08-31 エリジウム・ヘルス・インコーポレイテッド ニコチンアミドリボシドの合成方法
KR101982923B1 (ko) * 2017-07-05 2019-05-27 가천대학교 산학협력단 편두통 진단용 바이오마커 및 상기 바이오마커를 이용한 편두통 진단방법
KR101990681B1 (ko) * 2017-07-05 2019-06-18 가천대학교 산학협력단 편두통 진단용 바이오마커 및 상기 바이오마커를 이용한 편두통 진단방법
EP3727400A4 (en) * 2017-12-22 2021-10-20 Elysium Health, Inc. CRYSTALLINE FORMS OF NICOTINAMIDE RIBOSIDE CHLORIDE
WO2019133815A1 (en) * 2017-12-28 2019-07-04 Kansas State University Research Foundation Nicotinamide riboside treatments of domesticated meat animals
US11180521B2 (en) 2018-01-30 2021-11-23 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
CN110283221A (zh) * 2018-03-19 2019-09-27 药源药物化学(上海)有限公司 杂环化合物的制备和纯化方法
WO2019209840A1 (en) * 2018-04-23 2019-10-31 Elysium Health, Inc. Methods and compositions for treating rheumatoid arthritis
CN110452277A (zh) * 2018-05-07 2019-11-15 明特奇点医疗科技(成都)有限公司 一种烟酰胺核糖的制备方法
BR112020023588A2 (pt) * 2018-05-18 2021-02-09 F. Hoffmann-La Roche Ag método para a produção de brometo de b-d-ribofuranosídeo de nicotinamida cristalino de fórmula o-ia, método, para a produção de sais de ¿-d-ribofuranosídeo de (tio)nicotinamida cristalinos, método para a produção de uma composição compreendendo um sal amorfo de ¿-d-ribofuranosídeo de (tio)nicotinamida, brometo de 2,3,5-tri-o-acetil-¿-d-ribofuranosídeo de nicotinamida cristalino de fórmula o-va, brometo de ¿-d-ribofuranosídeo de nicotinamida ou de tionicotinamida cristalino de fórmulas o-ia e s-ia, composição, uso de um composto ¿-d-ribofuranosídeo de (tio)nicotinamida cristalino, composição farmacêutica, método para a produção de brometo de tri-o-acil-¿-d-ribofuranosídeo de fórmula iii, método para remoção de grupos acila de brometo de 2,3,5-tri-o-acil-¿-d-ribofuranosídeo de nicotinamida de fórmula o-va ou de cloreto de 2,3,5-tri-o-acil-¿-d-ribofuranosídeo de nicotinamida de fórmula o-vb
BR112020023132A2 (pt) 2018-06-21 2021-02-09 Société des Produits Nestlé S.A. composições e métodos que usam um precursor de nicotinamida adenina dinucleotídeo (nad+) e pelo menos uma cetona ou um precursor de cetona
CN108774278A (zh) * 2018-09-10 2018-11-09 张洪喜 一种制备尼克酰胺核苷盐的方法
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
EP3897666A2 (en) 2018-12-17 2021-10-27 Mitopower LLC Nicotinyl riboside compounds and their uses
US10618927B1 (en) 2019-03-22 2020-04-14 Metro International Biotech, Llc Compositions and methods for modulation of nicotinamide adenine dinucleotide
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
US20200397807A1 (en) 2019-06-18 2020-12-24 MitoPower, LLC Nicotinyl riboside compounds and their uses
EP3999518A2 (en) 2019-07-19 2022-05-25 Biosynth AG Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof
WO2021084559A1 (en) * 2019-11-01 2021-05-06 Celagenex Research (India) Pvt. Ltd. Synergistic nutritional compositions for treating cerebrovascular diseases
EP4117680A1 (en) * 2020-03-09 2023-01-18 Société des Produits Nestlé S.A. Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of lung diseases and conditions
CN111454311B (zh) * 2020-04-03 2021-10-19 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
CN113518782B (zh) * 2020-06-19 2023-09-08 邦泰生物工程(深圳)有限公司 一种以烟酰胺为原料制备烟酰胺单核苷酸的方法
CN111808156A (zh) * 2020-07-15 2020-10-23 许昌远志生物科技有限公司 一种β-烟酰胺核糖氯化物的晶型1A、晶型1B及其制备方法
US20230263817A1 (en) * 2020-08-28 2023-08-24 University Of Washington High dose nicotinamide adenine dinucleotide (nad) precursor regimens for reduction of inflammation in human patients with preexisting inflammation
CN112028954B (zh) * 2020-09-14 2022-04-29 浩宇康宁健康科技(湖北)有限公司 烟酰胺核糖的制备方法
WO2022157173A1 (en) 2021-01-19 2022-07-28 Biosynth Ag Method of making nicotinamide ribofuranoside salts by salt metathesis, the crystalline form of its tosylate salt and the co-crystallized form of its chloride:iodide salt
AU2022214447A1 (en) * 2021-01-29 2023-08-10 ChromaDex Inc. Ethyl cellulose based coatings for microencapsulation of nicotinamide riboside and other nicotinyl riboside compounds
WO2022251491A1 (en) 2021-05-27 2022-12-01 Metro International Biotech, Llc Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use
CN113943333B (zh) * 2021-10-09 2023-07-14 广东生命源科技有限公司 一种氢化烟酰胺核糖的制备方法及应用
CN118176006A (zh) * 2021-10-27 2024-06-11 益力舒健康公司 治疗更年期综合征的方法
WO2023147161A2 (en) * 2022-01-31 2023-08-03 New Frontier Bio, Inc. Nicotinate and nicotinamide riboside-based compounds and derivatives thereof
CN114577935B (zh) * 2022-03-03 2024-07-23 中科谱研(北京)科技有限公司 一种胶囊中烟酰胺核糖氯化物的分离检测方法
KR20240161799A (ko) * 2022-03-15 2024-11-12 크로마덱스 아이엔씨. 결정질 베타 니코틴아미드 리보시드 트리아세테이트 클로라이드의 생산 방법
CN114933621A (zh) * 2022-04-13 2022-08-23 深圳市迪克曼生物科技有限公司 烟酰胺核糖的有机酸盐及其结晶形态、制备方法与用途
CN115287278B (zh) * 2022-06-17 2023-11-10 武汉真福医药股份有限公司 一种枯草芽孢杆菌纤溶酶及其制备方法和抗氧化溶血栓组合物
WO2024160239A1 (zh) 2023-02-01 2024-08-08 博迪贺康(北京)生物技术有限公司 一种化合物及其应用
CN116655528B (zh) * 2023-04-28 2025-12-02 宁波百思佳医药科技有限公司 一种氯化1-甲基烟酰铵的制备方法
WO2024259359A2 (en) 2023-06-14 2024-12-19 ChromaDex Inc. Nicotinamide riboside and derivatives thereof in intravenous formulations and methods of use thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288089B1 (en) 1998-12-21 2001-09-11 Michael Zawada Use of kinase inhibitors for treating neurodegenerative diseases
CA2421269A1 (en) 2002-08-09 2004-02-09 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
JP2007530417A (ja) 2003-07-01 2007-11-01 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 細胞及び生物の寿命及びストレス応答を操作するための組成物
EP2805719A1 (en) 2005-03-30 2014-11-26 Glaxosmithkline LLC Nicotinamide riboside and analogues thereof
DK1910384T3 (da) 2005-08-04 2012-12-17 Sirtris Pharmaceuticals Inc Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser
TW200918542A (en) 2007-06-20 2009-05-01 Sirtris Pharmaceuticals Inc Sirtuin modulating compounds
CL2008001822A1 (es) 2007-06-20 2009-03-13 Sirtris Pharmaceuticals Inc Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras.
ES2586459T3 (es) 2008-05-01 2016-10-14 Glaxosmithkline Llc Quinolinas y análogos relacionados como moduladores de sirtuina
CA2729128C (en) 2008-07-03 2016-05-31 Sirtris Pharmaceuticals, Inc. Benzimidazoles and related analogs as sirtuin modulators
MX2011003373A (es) 2008-09-29 2011-06-09 Sirtris Pharmaceuticals Inc Quinazolinona, quinolona y analogos relacionados como moduladores de sirtuina.
BRPI0922435A2 (pt) 2008-12-19 2018-09-11 Sirtris Pharmaceuticals Inc "composto de tiazolopiridina moduladores de sirtuina, composição farmacêutica compreendendo o mesmo e seu uso."
MX2012004995A (es) 2009-10-29 2012-10-03 Sirtris Pharmaceuticals Inc Piridinas biciclicas y analogos como moduladores de sirtuina.
JP2014530870A (ja) 2011-10-20 2014-11-20 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ
JP6073343B2 (ja) 2011-10-20 2017-02-01 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ
RU2014120180A (ru) 2011-10-20 2015-11-27 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Замещенные бициклические аза-гетероциклы и аналоги в качестве модуляторов сиртуина
GB201313465D0 (en) * 2013-07-29 2013-09-11 Queens University Of The Belfast Methods of preparing nicotinamide riboside and derivatives thereof
CA2928656C (en) * 2013-10-30 2020-07-28 ChromaDex Inc. Nicotinamide riboside compositions for topical use in treating skin conditions

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