JP2017517335A - 凍結乾燥 - Google Patents
凍結乾燥 Download PDFInfo
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- JP2017517335A JP2017517335A JP2016572334A JP2016572334A JP2017517335A JP 2017517335 A JP2017517335 A JP 2017517335A JP 2016572334 A JP2016572334 A JP 2016572334A JP 2016572334 A JP2016572334 A JP 2016572334A JP 2017517335 A JP2017517335 A JP 2017517335A
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- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Mechanical Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Thermal Sciences (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Drying Of Solid Materials (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- External Artificial Organs (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Description
Claims (30)
- 血液成分を凍結乾燥し、貯蔵し、輸液するための容器であって、該容器は、
不織布上に設けられた重合体を有する多孔質材料から作製される第1壁と、
前記第1壁に接合されることによって該容器の内部容積を画定する第2壁と、
を備え、
前記第2壁は、可撓性高分子材料を含むことを特徴とする容器。 - 請求項1記載の容器において、前記第1壁は、少なくとも1つのガスに対して透過性であることを特徴とする容器。
- 請求項2記載の容器において、前記第1壁は、水蒸気に対して透過性であることを特徴とする容器。
- 請求項3記載の容器において、前記第1壁は、防水性であることを特徴とする容器。
- 請求項4記載の容器において、前記第1壁は、少なくとも15permの水蒸気透過度を有することを特徴とする容器。
- 請求項5記載の容器において、前記第1壁は、100cmより大きい防水度を有することを特徴とする容器。
- 請求項1記載の容器において、前記容器は、前記第1壁と前記第2壁との間にポートコネクタをさらに備えることを特徴とする容器。
- 請求項1記載の容器において、前記容器は、前記内部容積内に凍結乾燥されたヒト血漿をさらに備えることを特徴とする容器。
- 血液成分を凍結乾燥し、凍結乾燥された血液成分を貯蔵するための容器であって、該容器は、
第1室と、
経路を介して、前記第1室に流体接続可能な第2室と、
前記経路に設けられるシールと、
を備え、
前記第1室は、
可撓性高分子材料から作製され、水蒸気に対して第1透過度を有する第1壁と、
前記第1壁に接合されることによって、前記第1室の内部容積を画定する第2壁と、
を備え、
前記第2壁の少なくとも一部は、水蒸気に対して第2透過度を有する領域を有し、前記第2透過度は前記第1透過度よりも高く、
前記第2室は、
可撓性高分子材料から作製される第3壁と、
前記第3壁に接合されることによって、前記第2室の内部容積を画定する第4壁と、
を備え、
前記シールは、前記第1室と前記第2室とを分離し、前記シールが開放されることによって、前記経路を介した前記第1室から前記第2室への連通が可能となることを特徴とする容器。 - 請求項9記載の容器において、前記シールは、クランプ、溶着部、破断可能部、又はそれらの組み合わせのうちの1つ以上であることを特徴とする容器。
- 請求項10記載の容器において、前記第1室は、血液成分を前記第1室の前記内部容積に付加するための第1ポートをさらに備えることを特徴とする容器。
- 請求項11記載の容器において、前記第2室は、再水和流体を前記第2室の前記内部容積に付加するための第2ポートをさらに備えることを特徴とする容器。
- 請求項12記載の容器において、前記第2室は、再水和された血液成分を前記第1室の前記内部容積から取り出すための第3ポートをさらに備えることを特徴とする容器。
- 請求項13記載の容器において、前記第2壁の前記少なくとも一部は、不織布であることを特徴とする容器。
- 物質を凍結乾燥させる方法であって、該方法は、
容器に物質を保持させるステップと、
前記物質を第1圧力にさらすステップと、
前記物質の液体成分のうちの少なくとも一部を蒸発させるステップと、
前記物質を冷却して、残留液体成分を凍結して固体にするステップと、
前記物質を、前記第1圧力よりも低い第2圧力にさらすステップと、
前記固体の一部を昇華させるステップと、
を有することを特徴とする方法。 - 請求項15記載の方法において、前記蒸発させるステップは、前記物質に熱エネルギーを付加することを含むことを特徴とする方法。
- 請求項16記載の方法において、前記昇華させるステップは、前記物質に熱エネルギーを付加することを含むことを特徴とする方法。
- 請求項17記載の方法において、前記昇華させるステップは、前記物質に赤外線エネルギーを付加することを含むことを特徴とする方法。
- 請求項18記載の方法において、前記方法は、前記物質を冷却している間に、前記物質を押圧するステップをさらに有することを特徴とする方法。
- 物質を凍結乾燥する方法であって、該方法は、
容器に液体をプールして、プールされた液体を生成するステップと、
前記プールされた液体に光増感剤を付加するステップと、
前記光増感剤を含む前記プールされた液体を光源にさらして、病原体が減少された液体を生成するステップと、
前記病原体が減少された液体を凍結乾燥するステップと、
を有し、
前記凍結乾燥するステップは、
前記病原体が減少された液体を冷却して、液体成分を凍結して、固体を生成するステップと、
前記固体を、大気圧より低い第1圧力にさらすステップと、
前記固体の一部を昇華させるステップと、
を有することを特徴とする方法。 - 請求項20記載の方法において、前記光増感剤は、リボフラビンであることを特徴とする方法。
- 請求項21記載の方法において、前記光源は、紫外線領域の波長の光を生成することを特徴とする方法。
- 請求項20記載の方法において、前記液体は、ヒト血漿であることを特徴とする方法。
- 物質を凍結乾燥させる際に使用されるシステムであって、該システムは、
第1面を有する第1プレートと、
前記第1面と対向する第2面を有し、流体を循環させるためのチャネルを備えた第2プレートと、
前記第1面と前記第2面との間の空間を増大及び減少させるように動作するプレート動作システムと、
を備えることを特徴とするシステム。 - 請求項24記載のシステムにおいて、該システムは、前記第1プレートに赤外線放射物質をさらに備え、前記赤外線放射物質は、前記第1面であることを特徴とするシステム。
- 請求項24記載のシステムにおいて、前記第1面は、マクロ構造を付与するための形状を備えることを特徴とするシステム。
- 請求項24記載のシステムにおいて、前記第1プレートと前記第2プレートは、同じ構造であることを特徴とするシステム。
- 凍結乾燥のために血液成分を含む液体を準備する方法であって、該方法は、
血液成分を含む複数の体積の液体をプールして、プールされた1つの体積の液体を生成するステップと、
前記プールされた1つの体積の液体から液体の一部を除去して、体積を減少させた液体を生成するステップと、
前記体積を減少させた液体を複数の容器に充填するステップと、
を有し、
前記複数の容器は、水蒸気に対して透過性を示す壁を有することを特徴とする方法。 - 請求項28記載の方法において、該方法は、前記体積を減少させた液体において病原体を減少させるステップをさらに有することを特徴とする方法。
- 請求項29記載の方法において、前記病原体を減少させるステップは、
前記体積を減少させた液体に光増感剤を付加するステップと、
前記光増感剤と前記体積を減少させた液体を光源にさらすステップと、
を有することを特徴とする方法。
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JP2022119957A (ja) | 2022-08-17 |
CN110822822A (zh) | 2020-02-21 |
US20150354894A1 (en) | 2015-12-10 |
CN106461327A (zh) | 2017-02-22 |
US20200149814A1 (en) | 2020-05-14 |
US10539367B2 (en) | 2020-01-21 |
CN110822822B (zh) | 2021-08-24 |
JP2020054835A (ja) | 2020-04-09 |
US20200141644A1 (en) | 2020-05-07 |
EP3151662A2 (en) | 2017-04-12 |
WO2015191599A3 (en) | 2016-04-07 |
US11067336B2 (en) | 2021-07-20 |
US20200141645A1 (en) | 2020-05-07 |
CN106461327B (zh) | 2019-12-13 |
US10969171B2 (en) | 2021-04-06 |
US9863699B2 (en) | 2018-01-09 |
US10976105B2 (en) | 2021-04-13 |
JP2021164676A (ja) | 2021-10-14 |
EP3769618A1 (en) | 2021-01-27 |
JP7084530B2 (ja) | 2022-06-14 |
US11137206B2 (en) | 2021-10-05 |
US20180128544A1 (en) | 2018-05-10 |
EP3151662B1 (en) | 2020-10-21 |
JP6659591B2 (ja) | 2020-03-04 |
WO2015191599A2 (en) | 2015-12-17 |
US20200141646A1 (en) | 2020-05-07 |
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Free format text: JAPANESE INTERMEDIATE CODE: R250 |