JP2017516459A5 - - Google Patents
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- Publication number
- JP2017516459A5 JP2017516459A5 JP2016558605A JP2016558605A JP2017516459A5 JP 2017516459 A5 JP2017516459 A5 JP 2017516459A5 JP 2016558605 A JP2016558605 A JP 2016558605A JP 2016558605 A JP2016558605 A JP 2016558605A JP 2017516459 A5 JP2017516459 A5 JP 2017516459A5
- Authority
- JP
- Japan
- Prior art keywords
- poloxamer
- heated
- minutes
- cell culture
- culture medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 29
- 229920001983 poloxamer Polymers 0.000 claims 28
- 229960000502 poloxamer Drugs 0.000 claims 28
- 238000000034 method Methods 0.000 claims 17
- 239000006143 cell culture medium Substances 0.000 claims 6
- 230000003833 cell viability Effects 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 238000001816 cooling Methods 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000003801 milling Methods 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 229920001993 poloxamer 188 Polymers 0.000 claims 1
- 229940044519 poloxamer 188 Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461970281P | 2014-03-25 | 2014-03-25 | |
| US61/970,281 | 2014-03-25 | ||
| PCT/US2015/022592 WO2015148736A1 (en) | 2014-03-25 | 2015-03-25 | Methods of preparing a poloxamer for use in cell culture medium |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020017136A Division JP2020103290A (ja) | 2014-03-25 | 2020-02-04 | 細胞培養培地における使用のためのポロキサマーを調製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017516459A JP2017516459A (ja) | 2017-06-22 |
| JP2017516459A5 true JP2017516459A5 (enExample) | 2018-05-10 |
| JP6655548B2 JP6655548B2 (ja) | 2020-02-26 |
Family
ID=52824596
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016558605A Active JP6655548B2 (ja) | 2014-03-25 | 2015-03-25 | 細胞培養培地における使用のためのポロキサマーを調製する方法 |
| JP2020017136A Withdrawn JP2020103290A (ja) | 2014-03-25 | 2020-02-04 | 細胞培養培地における使用のためのポロキサマーを調製する方法 |
| JP2022157928A Active JP7472222B2 (ja) | 2014-03-25 | 2022-09-30 | 細胞培養培地における使用のためのポロキサマーを調製する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020017136A Withdrawn JP2020103290A (ja) | 2014-03-25 | 2020-02-04 | 細胞培養培地における使用のためのポロキサマーを調製する方法 |
| JP2022157928A Active JP7472222B2 (ja) | 2014-03-25 | 2022-09-30 | 細胞培養培地における使用のためのポロキサマーを調製する方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US11034793B2 (enExample) |
| EP (2) | EP3122799B8 (enExample) |
| JP (3) | JP6655548B2 (enExample) |
| KR (1) | KR102352250B1 (enExample) |
| CN (2) | CN111808276A (enExample) |
| AU (1) | AU2015236008B2 (enExample) |
| BR (1) | BR112016021739B1 (enExample) |
| CA (1) | CA2943357C (enExample) |
| ES (1) | ES2778680T3 (enExample) |
| HR (1) | HRP20200372T1 (enExample) |
| IL (2) | IL247902B (enExample) |
| MX (2) | MX2016012288A (enExample) |
| MY (1) | MY178060A (enExample) |
| PL (1) | PL3122799T3 (enExample) |
| RU (1) | RU2710551C2 (enExample) |
| SG (1) | SG11201607929PA (enExample) |
| SI (1) | SI3122799T1 (enExample) |
| WO (1) | WO2015148736A1 (enExample) |
| ZA (1) | ZA201606711B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2710551C2 (ru) | 2014-03-25 | 2019-12-27 | Дженентек, Инк. | Способы приготовления полоксамера для применения в клеточной культуральной среде |
| US11180610B2 (en) | 2016-03-17 | 2021-11-23 | Merck Patent Gmbh | Method for purifying poloxamers |
| KR102662905B1 (ko) * | 2017-12-21 | 2024-05-03 | 시그마-알드리치 컴퍼니., 엘엘씨 | 폴록사머 조성물 및 이의 제조 및 사용 방법 |
| US11383870B2 (en) * | 2018-07-12 | 2022-07-12 | Elena Valentinovna ARSHINTSEVA | Thermal method for sterilizing poloxamer comprising liquid drugs |
| JPWO2020022511A1 (ja) * | 2018-07-27 | 2021-08-02 | 味の素株式会社 | 動物細胞の浮遊培養用の添加物、浮遊培養用培地および浮遊培養方法 |
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| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| WO1990003430A1 (en) | 1988-09-23 | 1990-04-05 | Cetus Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| ATE182278T1 (de) * | 1991-10-04 | 1999-08-15 | Gs Dev Ab | Teilchen, methode zur herstellung der teilchen und deren verwendung |
| JPH09508359A (ja) * | 1994-01-14 | 1997-08-26 | ゾーマ コーポレイション | 抗グラム陽性細菌学的方法および物質 |
| US5912228A (en) * | 1995-01-13 | 1999-06-15 | Xoma Corporation | Therapeutic compositions comprising bactericidal/permeability-increasing (BPI) protein products |
| KR20050085971A (ko) | 1995-04-27 | 2005-08-29 | 아브게닉스, 인크. | 면역화된 제노마우스 유래의 인간 항체 |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| WO1998024893A2 (en) | 1996-12-03 | 1998-06-11 | Abgenix, Inc. | TRANSGENIC MAMMALS HAVING HUMAN IG LOCI INCLUDING PLURAL VH AND Vλ REGIONS AND ANTIBODIES PRODUCED THEREFROM |
| GB9625175D0 (en) * | 1996-12-04 | 1997-01-22 | Medi Cult As | Serum-free cell culture media |
| US5804420A (en) * | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| JP2003512821A (ja) | 1999-10-04 | 2003-04-08 | メディカゴ インコーポレイテッド | 外来性遺伝子の転写調節方法 |
| EP1601326A4 (en) * | 2003-02-12 | 2011-05-11 | Ceremed Inc | RANDOM ALKYLENE OXIDE COPOLYMERS FOR MEDICAL AND SURGICAL USES |
| US8802116B2 (en) * | 2003-02-27 | 2014-08-12 | Novasel Australia Pty. Ltd. | Poloxamer emulsion preparations |
| AU2003900887A0 (en) * | 2003-02-27 | 2003-03-13 | Novasel Australia Pty Ltd | Poloxamer emulsion preparations |
| WO2005014163A1 (en) | 2003-08-04 | 2005-02-17 | Camurus Ab | Method for loading amphiphile particles with active agents |
| WO2005053652A1 (en) | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride |
| EP1809272A4 (en) | 2004-10-18 | 2008-01-02 | Maroon Biotech Corp | METHOD AND COMPOSITIONS FOR TREATING DAMAGES THROUGH FREE RADICALS |
| US9149433B2 (en) * | 2004-11-30 | 2015-10-06 | Basf Corporation | Method for formation of micro-prilled polymers |
| CN1939534B (zh) | 2005-09-27 | 2010-12-01 | 长春金赛药业股份有限公司 | 含有人生长激素或人粒细胞巨噬细胞刺激因子的用于治疗损伤和溃疡的外用制剂 |
| MX2009001636A (es) * | 2006-08-16 | 2009-02-23 | Novartis Ag | Metodo para elaborar dispersiones solidas de compuestos terapeuticos altamente cristalinos. |
| KR100932613B1 (ko) | 2007-04-27 | 2009-12-17 | 한남대학교 산학협력단 | 고분자 용융공정을 이용한 약물전달용 생체적합성 고분자나노 미립구의 제조방법 및 그 나노 미립구 |
| WO2009055312A1 (en) * | 2007-10-22 | 2009-04-30 | Dfb Pharmaceuticals, Inc. | Process for producing a poloxamer gel |
| JP5727790B2 (ja) | 2007-12-27 | 2015-06-03 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 細胞培養プロセス |
| BR112012015596B1 (pt) * | 2009-12-23 | 2021-06-01 | Sanofi Pasteur | Processo de cultura de células aderentes |
| ES2612530T3 (es) * | 2012-03-30 | 2017-05-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Composición de microesferas, método de preparación y aplicaciones de la misma |
| RU2710551C2 (ru) | 2014-03-25 | 2019-12-27 | Дженентек, Инк. | Способы приготовления полоксамера для применения в клеточной культуральной среде |
-
2015
- 2015-03-25 RU RU2016141568A patent/RU2710551C2/ru active
- 2015-03-25 JP JP2016558605A patent/JP6655548B2/ja active Active
- 2015-03-25 BR BR112016021739-0A patent/BR112016021739B1/pt active IP Right Grant
- 2015-03-25 KR KR1020167029244A patent/KR102352250B1/ko active Active
- 2015-03-25 WO PCT/US2015/022592 patent/WO2015148736A1/en not_active Ceased
- 2015-03-25 CA CA2943357A patent/CA2943357C/en active Active
- 2015-03-25 EP EP15715932.8A patent/EP3122799B8/en active Active
- 2015-03-25 AU AU2015236008A patent/AU2015236008B2/en active Active
- 2015-03-25 EP EP20151556.6A patent/EP3778702B1/en active Active
- 2015-03-25 MX MX2016012288A patent/MX2016012288A/es unknown
- 2015-03-25 SI SI201531128T patent/SI3122799T1/sl unknown
- 2015-03-25 MY MYPI2016001715A patent/MY178060A/en unknown
- 2015-03-25 CN CN202010723304.6A patent/CN111808276A/zh active Pending
- 2015-03-25 SG SG11201607929PA patent/SG11201607929PA/en unknown
- 2015-03-25 PL PL15715932T patent/PL3122799T3/pl unknown
- 2015-03-25 ES ES15715932T patent/ES2778680T3/es active Active
- 2015-03-25 CN CN201580026701.5A patent/CN106414552B/zh active Active
- 2015-03-25 HR HRP20200372TT patent/HRP20200372T1/hr unknown
-
2016
- 2016-09-19 IL IL247902A patent/IL247902B/en active IP Right Grant
- 2016-09-22 MX MX2021001981A patent/MX2021001981A/es unknown
- 2016-09-22 US US15/273,155 patent/US11034793B2/en active Active
- 2016-09-28 ZA ZA2016/06711A patent/ZA201606711B/en unknown
-
2020
- 2020-02-04 JP JP2020017136A patent/JP2020103290A/ja not_active Withdrawn
- 2020-12-20 IL IL279583A patent/IL279583B/en unknown
-
2021
- 2021-05-13 US US17/319,886 patent/US11912823B2/en active Active
-
2022
- 2022-09-30 JP JP2022157928A patent/JP7472222B2/ja active Active
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