KR102352250B1 - 세포 배양 배지에 사용하기 위한 폴록사머를 제조하는 방법 - Google Patents

세포 배양 배지에 사용하기 위한 폴록사머를 제조하는 방법 Download PDF

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KR102352250B1
KR102352250B1 KR1020167029244A KR20167029244A KR102352250B1 KR 102352250 B1 KR102352250 B1 KR 102352250B1 KR 1020167029244 A KR1020167029244 A KR 1020167029244A KR 20167029244 A KR20167029244 A KR 20167029244A KR 102352250 B1 KR102352250 B1 KR 102352250B1
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poloxamer
minutes
cell culture
cell
culture medium
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KR20160138161A (ko
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가네쉬 프라사드 비스베스바란
로버트 데이빗 키스
스티븐 제이. 마이어
인찬 권
카라 칼훈
케이트 윈체스터
아멜리아 아담스
마리온 글렌
스테판 쾨니크
앨런 디스
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제넨테크, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/50—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing nitrogen, e.g. polyetheramines or Jeffamines(r)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/58—Ethylene oxide or propylene oxide copolymers, e.g. pluronics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/50—Soluble polymers, e.g. polyethyleneglycol [PEG]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
KR1020167029244A 2014-03-25 2015-03-25 세포 배양 배지에 사용하기 위한 폴록사머를 제조하는 방법 Active KR102352250B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461970281P 2014-03-25 2014-03-25
US61/970,281 2014-03-25
PCT/US2015/022592 WO2015148736A1 (en) 2014-03-25 2015-03-25 Methods of preparing a poloxamer for use in cell culture medium

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KR20160138161A KR20160138161A (ko) 2016-12-02
KR102352250B1 true KR102352250B1 (ko) 2022-01-17

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US (2) US11034793B2 (enExample)
EP (2) EP3122799B8 (enExample)
JP (3) JP6655548B2 (enExample)
KR (1) KR102352250B1 (enExample)
CN (2) CN106414552B (enExample)
AU (1) AU2015236008B2 (enExample)
BR (1) BR112016021739B1 (enExample)
CA (1) CA2943357C (enExample)
ES (1) ES2778680T3 (enExample)
HR (1) HRP20200372T1 (enExample)
IL (2) IL247902B (enExample)
MX (2) MX2016012288A (enExample)
MY (1) MY178060A (enExample)
PL (1) PL3122799T3 (enExample)
RU (1) RU2710551C2 (enExample)
SG (1) SG11201607929PA (enExample)
SI (1) SI3122799T1 (enExample)
WO (1) WO2015148736A1 (enExample)
ZA (1) ZA201606711B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6655548B2 (ja) 2014-03-25 2020-02-26 ジェネンテック， インコーポレイテッド 細胞培養培地における使用のためのポロキサマーを調製する方法
CN108779242B (zh) * 2016-03-17 2021-06-11 默克专利股份公司 纯化泊洛沙姆的方法
KR102662905B1 (ko) * 2017-12-21 2024-05-03 시그마-알드리치 컴퍼니., 엘엘씨 폴록사머 조성물 및 이의 제조 및 사용 방법
US11383870B2 (en) * 2018-07-12 2022-07-12 Elena Valentinovna ARSHINTSEVA Thermal method for sterilizing poloxamer comprising liquid drugs
JPWO2020022511A1 (ja) * 2018-07-27 2021-08-02 味の素株式会社 動物細胞の浮遊培養用の添加物、浮遊培養用培地および浮遊培養方法

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PL3122799T3 (pl) 2020-06-29
KR20160138161A (ko) 2016-12-02
AU2015236008B2 (en) 2018-12-20
JP2023011566A (ja) 2023-01-24
MY178060A (en) 2020-09-30
RU2710551C2 (ru) 2019-12-27
ZA201606711B (en) 2019-12-18
BR112016021739B1 (pt) 2021-11-03
IL247902B (en) 2021-01-31
US20170009015A1 (en) 2017-01-12
JP2020103290A (ja) 2020-07-09
CN106414552B (zh) 2020-08-25
WO2015148736A8 (en) 2016-08-18
EP3122799B8 (en) 2020-03-11
US11912823B2 (en) 2024-02-27
MX2021001981A (es) 2021-04-28
BR112016021739A2 (pt) 2017-08-15
JP2017516459A (ja) 2017-06-22
IL279583B (en) 2022-03-01
CA2943357C (en) 2023-06-27
WO2015148736A1 (en) 2015-10-01
CN106414552A (zh) 2017-02-15
AU2015236008A1 (en) 2016-10-27
EP3122799B1 (en) 2020-01-15
HRP20200372T1 (hr) 2020-06-12
CN111808276A (zh) 2020-10-23
EP3122799A1 (en) 2017-02-01
IL279583A (en) 2021-03-01
RU2016141568A (ru) 2018-04-28
SI3122799T1 (sl) 2020-06-30
US20210371587A1 (en) 2021-12-02
ES2778680T3 (es) 2020-08-11
EP3778702A1 (en) 2021-02-17
EP3778702B1 (en) 2023-06-28
CA2943357A1 (en) 2015-10-01
NZ725151A (en) 2021-05-28
RU2016141568A3 (enExample) 2018-09-26
IL247902A0 (en) 2016-11-30
JP7472222B2 (ja) 2024-04-22
SG11201607929PA (en) 2016-10-28
US11034793B2 (en) 2021-06-15
JP6655548B2 (ja) 2020-02-26
MX2016012288A (es) 2017-01-23

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