JP2017511148A - ヘルパータンパク質を過剰発現するように改変された組換え宿主細胞 - Google Patents

ヘルパータンパク質を過剰発現するように改変された組換え宿主細胞 Download PDF

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Publication number
JP2017511148A
JP2017511148A JP2016562915A JP2016562915A JP2017511148A JP 2017511148 A JP2017511148 A JP 2017511148A JP 2016562915 A JP2016562915 A JP 2016562915A JP 2016562915 A JP2016562915 A JP 2016562915A JP 2017511148 A JP2017511148 A JP 2017511148A
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protein
host cell
seq
amino acid
functional homologue
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Japanese (ja)
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JP2017511148A5 (enExample
Inventor
ガッセル，ブリジット
マッタノビッチ，ディートハルト
ブーへティクス，マルクス
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Validogen GmbH
Lonza AG
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VTU Technology GmbH
Lonza AG
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Publication of JP2017511148A publication Critical patent/JP2017511148A/ja
Publication of JP2017511148A5 publication Critical patent/JP2017511148A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2016562915A 2014-04-17 2015-04-16 ヘルパータンパク質を過剰発現するように改変された組換え宿主細胞 Pending JP2017511148A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14165186.9 2014-04-17
EP14165186 2014-04-17
PCT/EP2015/058242 WO2015158808A2 (en) 2014-04-17 2015-04-16 Recombinant host cell engineered to overexpress helper proteins

Related Child Applications (1)

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JP2019236345A Division JP7062633B2 (ja) 2014-04-17 2019-12-26 ヘルパータンパク質を過剰発現するように改変された組換え宿主細胞

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JP2017511148A true JP2017511148A (ja) 2017-04-20
JP2017511148A5 JP2017511148A5 (enExample) 2018-05-17

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JP2016562915A Pending JP2017511148A (ja) 2014-04-17 2015-04-16 ヘルパータンパク質を過剰発現するように改変された組換え宿主細胞
JP2019236345A Active JP7062633B2 (ja) 2014-04-17 2019-12-26 ヘルパータンパク質を過剰発現するように改変された組換え宿主細胞

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Country Status (11)

Country Link
US (1) US10865416B2 (enExample)
EP (2) EP3132028B1 (enExample)
JP (2) JP2017511148A (enExample)
KR (1) KR102373954B1 (enExample)
CN (1) CN106661541B (enExample)
AU (1) AU2015248815B2 (enExample)
BR (1) BR112016023304A2 (enExample)
CA (1) CA2948369C (enExample)
IL (1) IL248376B (enExample)
SG (2) SG11201608084TA (enExample)
WO (1) WO2015158808A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017511147A (ja) * 2014-04-17 2017-04-20 ベーリンガー インゲルハイム エルツェーファウ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 目的タンパク質を発現させるための組換え宿主細胞
JP2022508470A (ja) * 2019-01-11 2022-01-19 ロンザ リミテッド 組換え宿主細胞内での炭素源調節タンパク質産生
JP2022515531A (ja) * 2018-12-28 2022-02-18 豊益（上海）生物技術研発中心有限公司 外来遺伝子を発現させるためのピキア・パストリス変異株
JP2023512309A (ja) * 2020-02-04 2023-03-24 クララ フーズ カンパニー 高収量組換え微生物のためのシステムおよび方法ならびにその使用

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HK1244185A1 (zh) 2014-11-11 2018-08-03 Clara Foods Co. 用於生成卵清蛋白的方法和组合物
CA3056920A1 (en) * 2017-03-29 2018-10-04 Karlheinz GRILLITSCH Recombinant host cell with altered membrane lipid composition
CN109722445A (zh) * 2017-10-27 2019-05-07 成都必高生物科技有限公司 提升溶菌酶产量及活性的方法
SG11202004412RA (en) * 2017-11-20 2020-06-29 Axxence Holding B V Production of a flavour compound in a host cell
CN118028130A (zh) 2018-05-17 2024-05-14 保尔特纺织品公司 用于改善重组蛋白分泌的sec经修饰菌株
US20210269811A1 (en) * 2018-06-27 2021-09-02 Boehringer Ingelheim Rcv Gmbh & Co Kg Means and methods for increased protein expression by use of transcription factors
EP3824083A4 (en) * 2018-09-24 2022-01-05 Orta Dogu Teknik Universitesi Design of alcohol dehydrogenase 2 (adh2) promoter variants by promoter engineering
CN109439639B (zh) * 2018-10-09 2021-07-20 天津科技大学 伏马毒素降解酶FumDPS及其基因和应用
CN109439640B (zh) * 2018-10-09 2021-07-20 天津科技大学 伏马毒素降解酶FumDSB及其基因和应用
EP4613765A1 (en) 2019-07-11 2025-09-10 Clara Foods Co. Protein compositions and consumable products thereof
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
CN111349177B (zh) * 2020-03-13 2022-04-22 西北农林科技大学 一种融合抗菌肽cat的制备方法和应用
CN111607575B (zh) * 2020-04-07 2022-10-04 天津科技大学 一种转氨酶phta、制备方法和应用
CN111549007B (zh) * 2020-04-07 2022-10-04 天津科技大学 一种转氨酶tsta、制备方法和应用
CN113088533B (zh) * 2021-04-15 2023-03-24 华中科技大学 一种高效表达藤壶粘胶蛋白的酵母工程菌及其制备方法
CN113801801B (zh) * 2021-10-08 2023-03-07 枣庄市杰诺生物酶有限公司 一株高效生产碱性果胶酶的重组菌及其应用
CN118147180A (zh) * 2024-05-09 2024-06-07 芝诺(苏州)生物科技有限公司 一种代谢工程改造毕赤酵母合成人乳铁蛋白的方法

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Publication number Priority date Publication date Assignee Title
JP2017511147A (ja) * 2014-04-17 2017-04-20 ベーリンガー インゲルハイム エルツェーファウ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 目的タンパク質を発現させるための組換え宿主細胞
JP2022515531A (ja) * 2018-12-28 2022-02-18 豊益（上海）生物技術研発中心有限公司 外来遺伝子を発現させるためのピキア・パストリス変異株
JP7430189B2 (ja) 2018-12-28 2024-02-09 豊益（上海）生物技術研発中心有限公司 外来遺伝子を発現させるためのピキア・パストリス変異株
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JP7061234B2 (ja) 2019-01-11 2022-04-27 ロンザ リミテッド 組換え宿主細胞内での炭素源調節タンパク質産生
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Also Published As

Publication number Publication date
WO2015158808A3 (en) 2016-01-28
IL248376B (en) 2021-04-29
WO2015158808A2 (en) 2015-10-22
EP4311857A2 (en) 2024-01-31
CN106661541B (zh) 2021-09-03
US10865416B2 (en) 2020-12-15
EP4311857A3 (en) 2024-07-31
CN106661541A (zh) 2017-05-10
EP3132028B1 (en) 2023-10-25
BR112016023304A2 (pt) 2017-10-17
CA2948369C (en) 2023-09-26
JP2020072696A (ja) 2020-05-14
AU2015248815B2 (en) 2021-07-08
EP3132028A2 (en) 2017-02-22
KR102373954B1 (ko) 2022-03-14
US20170029827A1 (en) 2017-02-02
JP7062633B2 (ja) 2022-05-06
SG11201608084TA (en) 2016-10-28
AU2015248815A1 (en) 2016-11-03
CA2948369A1 (en) 2015-10-22
SG10201809146QA (en) 2018-11-29
IL248376A0 (en) 2016-11-30
KR20170002453A (ko) 2017-01-06

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