CA2948369C - Recombinant host cell engineered to overexpress helper proteins - Google Patents
Recombinant host cell engineered to overexpress helper proteins Download PDFInfo
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- CA2948369C CA2948369C CA2948369A CA2948369A CA2948369C CA 2948369 C CA2948369 C CA 2948369C CA 2948369 A CA2948369 A CA 2948369A CA 2948369 A CA2948369 A CA 2948369A CA 2948369 C CA2948369 C CA 2948369C
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C12P21/00—Preparation of peptides or proteins
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP14165186.9 | 2014-04-17 | ||
| EP14165186 | 2014-04-17 | ||
| PCT/EP2015/058242 WO2015158808A2 (en) | 2014-04-17 | 2015-04-16 | Recombinant host cell engineered to overexpress helper proteins |
Publications (2)
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| CA2948369A1 CA2948369A1 (en) | 2015-10-22 |
| CA2948369C true CA2948369C (en) | 2023-09-26 |
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| US (1) | US10865416B2 (enExample) |
| EP (2) | EP3132028B1 (enExample) |
| JP (2) | JP2017511148A (enExample) |
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| CA (1) | CA2948369C (enExample) |
| IL (1) | IL248376B (enExample) |
| SG (2) | SG11201608084TA (enExample) |
| WO (1) | WO2015158808A2 (enExample) |
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| SG10201809152QA (en) | 2014-04-17 | 2018-11-29 | Boehringer Ingelheim Rcv Gmbh | Recombinant host cell for expressing proteins of interest |
| HK1244185A1 (zh) | 2014-11-11 | 2018-08-03 | Clara Foods Co. | 用於生成卵清蛋白的方法和组合物 |
| CA3056920A1 (en) * | 2017-03-29 | 2018-10-04 | Karlheinz GRILLITSCH | Recombinant host cell with altered membrane lipid composition |
| CN109722445A (zh) * | 2017-10-27 | 2019-05-07 | 成都必高生物科技有限公司 | 提升溶菌酶产量及活性的方法 |
| SG11202004412RA (en) * | 2017-11-20 | 2020-06-29 | Axxence Holding B V | Production of a flavour compound in a host cell |
| CN118028130A (zh) | 2018-05-17 | 2024-05-14 | 保尔特纺织品公司 | 用于改善重组蛋白分泌的sec经修饰菌株 |
| US20210269811A1 (en) * | 2018-06-27 | 2021-09-02 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Means and methods for increased protein expression by use of transcription factors |
| EP3824083A4 (en) * | 2018-09-24 | 2022-01-05 | Orta Dogu Teknik Universitesi | Design of alcohol dehydrogenase 2 (adh2) promoter variants by promoter engineering |
| CN109439639B (zh) * | 2018-10-09 | 2021-07-20 | 天津科技大学 | 伏马毒素降解酶FumDPS及其基因和应用 |
| CN109439640B (zh) * | 2018-10-09 | 2021-07-20 | 天津科技大学 | 伏马毒素降解酶FumDSB及其基因和应用 |
| CN111378585B (zh) * | 2018-12-28 | 2023-06-16 | 丰益(上海)生物技术研发中心有限公司 | 用于表达外源基因的毕赤酵母突变株 |
| CN116904331A (zh) * | 2019-01-11 | 2023-10-20 | 龙沙有限公司 | 重组宿主细胞中碳源调节的蛋白的产生 |
| EP4613765A1 (en) | 2019-07-11 | 2025-09-10 | Clara Foods Co. | Protein compositions and consumable products thereof |
| US12096784B2 (en) | 2019-07-11 | 2024-09-24 | Clara Foods Co. | Protein compositions and consumable products thereof |
| US10927360B1 (en) | 2019-08-07 | 2021-02-23 | Clara Foods Co. | Compositions comprising digestive enzymes |
| BR112022015325A2 (pt) * | 2020-02-04 | 2022-09-27 | Clara Foods Co | Sistemas e métodos para alta produção de microganismos recombinantes e uso dos mesmos |
| CN111349177B (zh) * | 2020-03-13 | 2022-04-22 | 西北农林科技大学 | 一种融合抗菌肽cat的制备方法和应用 |
| CN111607575B (zh) * | 2020-04-07 | 2022-10-04 | 天津科技大学 | 一种转氨酶phta、制备方法和应用 |
| CN111549007B (zh) * | 2020-04-07 | 2022-10-04 | 天津科技大学 | 一种转氨酶tsta、制备方法和应用 |
| CN113088533B (zh) * | 2021-04-15 | 2023-03-24 | 华中科技大学 | 一种高效表达藤壶粘胶蛋白的酵母工程菌及其制备方法 |
| CN113801801B (zh) * | 2021-10-08 | 2023-03-07 | 枣庄市杰诺生物酶有限公司 | 一株高效生产碱性果胶酶的重组菌及其应用 |
| CN118147180A (zh) * | 2024-05-09 | 2024-06-07 | 芝诺(苏州)生物科技有限公司 | 一种代谢工程改造毕赤酵母合成人乳铁蛋白的方法 |
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| BR112012020882A2 (pt) * | 2010-02-24 | 2015-11-03 | Merck Sharp & Dohme | métodos para produzir uma glicoproteína heteróloga e para produzir uma composição de glicoproteína, célula hospedeira, composição de glicoproteína, e, uso da pichia pastoris recombinante. |
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| KR101472273B1 (ko) * | 2012-03-29 | 2014-12-24 | 엘에스엠 주식회사 | ＣＧＴａｓｅ의 세포 표면 발현 재조합 벡터 |
| SG10201809152QA (en) * | 2014-04-17 | 2018-11-29 | Boehringer Ingelheim Rcv Gmbh | Recombinant host cell for expressing proteins of interest |
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2019
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| WO2015158808A3 (en) | 2016-01-28 |
| IL248376B (en) | 2021-04-29 |
| WO2015158808A2 (en) | 2015-10-22 |
| EP4311857A2 (en) | 2024-01-31 |
| CN106661541B (zh) | 2021-09-03 |
| US10865416B2 (en) | 2020-12-15 |
| JP2017511148A (ja) | 2017-04-20 |
| EP4311857A3 (en) | 2024-07-31 |
| CN106661541A (zh) | 2017-05-10 |
| EP3132028B1 (en) | 2023-10-25 |
| BR112016023304A2 (pt) | 2017-10-17 |
| JP2020072696A (ja) | 2020-05-14 |
| AU2015248815B2 (en) | 2021-07-08 |
| EP3132028A2 (en) | 2017-02-22 |
| KR102373954B1 (ko) | 2022-03-14 |
| US20170029827A1 (en) | 2017-02-02 |
| JP7062633B2 (ja) | 2022-05-06 |
| SG11201608084TA (en) | 2016-10-28 |
| AU2015248815A1 (en) | 2016-11-03 |
| CA2948369A1 (en) | 2015-10-22 |
| SG10201809146QA (en) | 2018-11-29 |
| IL248376A0 (en) | 2016-11-30 |
| KR20170002453A (ko) | 2017-01-06 |
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