JP2017510624A - 肥満細胞安定剤による全身性障害の治療 - Google Patents

肥満細胞安定剤による全身性障害の治療 Download PDF

Info

Publication number
JP2017510624A
JP2017510624A JP2016568473A JP2016568473A JP2017510624A JP 2017510624 A JP2017510624 A JP 2017510624A JP 2016568473 A JP2016568473 A JP 2016568473A JP 2016568473 A JP2016568473 A JP 2016568473A JP 2017510624 A JP2017510624 A JP 2017510624A
Authority
JP
Japan
Prior art keywords
mast cell
composition
cromolyn sodium
cell stabilizer
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2016568473A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017510624A5 (cg-RX-API-DMAC7.html
Inventor
ウィリアム ゲアハルト
ウィリアム ゲアハルト
マンフレート ケラー
マンフレート ケラー
アフメット チュチュンキュー
アフメット チュチュンキュー
プラビン ソーニ
プラビン ソーニ
Original Assignee
パタラ ファーマ リミテッド ライアビリティ カンパニー
パタラ ファーマ リミテッド ライアビリティ カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by パタラ ファーマ リミテッド ライアビリティ カンパニー, パタラ ファーマ リミテッド ライアビリティ カンパニー filed Critical パタラ ファーマ リミテッド ライアビリティ カンパニー
Publication of JP2017510624A publication Critical patent/JP2017510624A/ja
Publication of JP2017510624A5 publication Critical patent/JP2017510624A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016568473A 2014-02-10 2015-02-09 肥満細胞安定剤による全身性障害の治療 Withdrawn JP2017510624A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201461937928P 2014-02-10 2014-02-10
US61/937,928 2014-02-10
US201461971709P 2014-03-28 2014-03-28
US61/971,709 2014-03-28
US201461978711P 2014-04-11 2014-04-11
US61/978,711 2014-04-11
US201562105423P 2015-01-20 2015-01-20
US62/105,423 2015-01-20
PCT/US2015/015029 WO2015120389A1 (en) 2014-02-10 2015-02-09 Mast cell stabilizers treatment for systemic disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019067318A Division JP2019116503A (ja) 2014-02-10 2019-03-29 肥満細胞安定剤による全身性障害の治療

Publications (2)

Publication Number Publication Date
JP2017510624A true JP2017510624A (ja) 2017-04-13
JP2017510624A5 JP2017510624A5 (cg-RX-API-DMAC7.html) 2017-07-06

Family

ID=53773987

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016568473A Withdrawn JP2017510624A (ja) 2014-02-10 2015-02-09 肥満細胞安定剤による全身性障害の治療
JP2019067318A Pending JP2019116503A (ja) 2014-02-10 2019-03-29 肥満細胞安定剤による全身性障害の治療

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019067318A Pending JP2019116503A (ja) 2014-02-10 2019-03-29 肥満細胞安定剤による全身性障害の治療

Country Status (13)

Country Link
US (10) US9962363B2 (cg-RX-API-DMAC7.html)
EP (2) EP3104853B1 (cg-RX-API-DMAC7.html)
JP (2) JP2017510624A (cg-RX-API-DMAC7.html)
CN (1) CN106456595A (cg-RX-API-DMAC7.html)
AU (3) AU2015213678C1 (cg-RX-API-DMAC7.html)
CA (1) CA2938994A1 (cg-RX-API-DMAC7.html)
DK (1) DK3104853T3 (cg-RX-API-DMAC7.html)
ES (1) ES2762806T3 (cg-RX-API-DMAC7.html)
HU (1) HUE047319T2 (cg-RX-API-DMAC7.html)
PL (1) PL3104853T3 (cg-RX-API-DMAC7.html)
PT (1) PT3104853T (cg-RX-API-DMAC7.html)
SI (1) SI3104853T1 (cg-RX-API-DMAC7.html)
WO (1) WO2015120389A1 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023543965A (ja) * 2020-08-14 2023-10-19 イスタンブル ウニヴェルシテシ レクトールルグ 吸入経路を介するソフトミスト吸入器又は振動メッシュ式ネブライザーによるウイルス性肺疾患、急性及び／又は慢性の肺疾患治療におけるヘパリン組成物の使用
JP2023544685A (ja) * 2020-09-14 2023-10-25 イスタンブル ウニヴェルシテシ レクトールルグ 吸入ルートを介するソフトミスト吸入器又は振動型メッシュ式噴霧器を用いた新型コロナウイルス感染症を含むウイルス性肺疾患の治療における抗ウイルス性、抗マラリア性及び／又は粘液溶解性を備える活性物質の使用

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
JP6499077B2 (ja) 2012-10-25 2019-04-10 ザ ジェネラル ホスピタル コーポレイション アルツハイマー病と関連疾患の治療のための併用療法
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
US10188757B2 (en) 2013-10-22 2019-01-29 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
ES2762806T3 (es) 2014-02-10 2020-05-25 Respivant Sciences Gmbh Tratamiento utilizando estabilizadores de mastocitos para trastornos sistémicos
PT3104854T (pt) * 2014-02-10 2020-06-26 Respivant Sciences Gmbh Estabilizadores de mastócitos para tratamento de doença pulmonar
WO2017027402A1 (en) * 2015-08-07 2017-02-16 Patara Pharma, LLC Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
WO2017027387A1 (en) * 2015-08-07 2017-02-16 Patara Pharma, LLC Methods for the treatment of mast cell related disorders with mast cell stabilizers
KR101694753B1 (ko) 2015-08-28 2017-01-11 주식회사 온코크로스 크로몰린 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 간질환 예방 및 치료용 약학적 조성물
EP3368032A1 (en) * 2015-10-28 2018-09-05 AB Science Use of masitinib and other mast cell inhibitors for treatment of parkinson's disease
WO2017087962A1 (en) * 2015-11-19 2017-05-26 Aztherapies,Inc. Methods for treating alzheimer's disease and related disorders
KR20180081812A (ko) * 2015-11-23 2018-07-17 아즈테라피즈 인코포레이티드 허혈성 뇌졸중 치료용 조성물 및 방법
JP2019524865A (ja) 2016-08-31 2019-09-05 ザ ジェネラル ホスピタル コーポレイション 神経変性疾患と関連する神経炎症におけるマクロファージ／ミクログリア
EP3506893A4 (en) 2016-08-31 2020-01-22 Respivant Sciences GmbH CROMOLYN COMPOSITIONS FOR THE TREATMENT OF CHRONIC COUGH DUE TO IDIOPATHIC PULMONAL FIBROSIS
RU2760682C2 (ru) 2016-09-08 2021-11-29 Имерго Терапьютикс, Инк. Стабилизаторы тучных клеток лечения гиперцитокинемии и вирусной инфекции
JP2019531308A (ja) * 2016-10-07 2019-10-31 レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングＲｅｓｐｉｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ 肺線維症の治療のためのクロモリン組成物
CA3040420A1 (en) * 2016-10-18 2018-04-26 Emergo Therapeutics, Inc. Mast cell stabilizers for treatment of chronic inflammatory conditions
CN108619127B (zh) * 2017-03-21 2023-05-26 中国科学院分子细胞科学卓越创新中心 Aldh1a及其激动剂、催化产物和抑制剂的用途
DK3618811T3 (da) 2017-05-04 2020-12-21 Nanologica Ab Fremgangsmåde til fremstilling af porøse siliciumdioxidpartikler ladet med mindst én biologisk aktiv forbindelse, der er tilpasset til pulmonal, nasal, sublingual og/eller pharyngeal tilførsel
JP7202376B2 (ja) 2017-07-20 2023-01-11 エーゼットセラピーズ， インコーポレイテッド クロモリンナトリウムおよびイブプロフェンの粉末製剤
CN108175849B (zh) * 2018-01-15 2021-08-27 吉林省博大伟业制药有限公司 聚普瑞锌口服制剂及在制备溃疡性结肠炎药物中的应用
JP2021529771A (ja) * 2018-07-02 2021-11-04 ザ ジェネラル ホスピタル コーポレイション クロモリンナトリウムおよびα−ラクトースの粉末製剤
MX2021006869A (es) 2018-12-10 2021-07-02 Massachusetts Gen Hospital Esteres de cromolin y usos de los mismos.
EP3972574A1 (en) * 2019-05-22 2022-03-30 AC BioScience SA Composition and use thereof for the treatment of cutaneous mastocytosis
US11278688B2 (en) * 2020-03-12 2022-03-22 Max Azevedo Inhaling device for heavy metal salts and a method of use thereof for medical treatment
EP4132507A4 (en) 2020-04-06 2024-05-15 The General Hospital Corporation METHODS FOR TREATING CORONAVIRUS-INDUCED INFLAMMATORY CONDITIONS
WO2022051671A1 (en) * 2020-09-04 2022-03-10 Lyme Revive Foundation Mineral cation complex compositions, formulations therof, and methods of use therof
CN115678300B (zh) * 2021-07-22 2023-11-28 东莞美哲塑胶制品有限公司 壳塑复合材料、其加工方法与应用
WO2025215658A1 (en) * 2024-04-09 2025-10-16 Prabakaran Desomayanandam Pharmaceutical compositions of ketotifen

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61143318A (ja) * 1984-11-23 1986-07-01 フアイソンズ・ピ−エルシ− 新規な製剤およびその調整方法
JPH0672869A (ja) * 1992-07-07 1994-03-15 Fisons Plc ナトリウムクロモグリケートの水性医薬組成物
WO2007090646A1 (en) * 2006-02-10 2007-08-16 Pari Pharma Gmbh Nebulised antibiotics for inhalation therapy
US20070193577A1 (en) * 2006-02-03 2007-08-23 Manfred Keller Disodium cromoglycate compositions and methods for administering same
WO2009027095A1 (en) * 2007-08-31 2009-03-05 Pari Pharma Gmbh Aerosols for sinunasal drug delivery
JP2012526084A (ja) * 2009-05-08 2012-10-25 パーリ・ファルマ・ゲーエムベーハー 濃縮肥満細胞安定化用薬学的調合物

Family Cites Families (264)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3686320A (en) 1965-03-25 1972-08-22 Fisons Pharmaceuticals Ltd Bis-phenoxy compounds
US3777033A (en) 1965-03-25 1973-12-04 Fisons Pharmaceuticals Ltd Bis-chromonyl pharmaceutical composi-tion and methods
GB1144905A (en) 1965-03-25 1969-03-12 Fisons Pharmaceuticals Ltd Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof
US3686412A (en) 1965-03-25 1972-08-22 Colin Fitzmaurice Compositions containing bis-chromonyl compounds for inhibiting antigen-antibody reactions
US3993073A (en) 1969-04-01 1976-11-23 Alza Corporation Novel drug delivery device
US3598122A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3720690A (en) 1970-04-10 1973-03-13 Fisons Pharmaceuticals Ltd Pharmaceutically active bis-carboxychromone compounds
US3683320A (en) 1970-05-08 1972-08-08 Bunker Ramo Coaxial cable connectors
CA958714A (en) 1970-09-03 1974-12-03 Peter B. Johnson Bis-chromone derivatives
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US4069307A (en) 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US3731683A (en) 1971-06-04 1973-05-08 Alza Corp Bandage for the controlled metering of topical drugs to the skin
US3742951A (en) 1971-08-09 1973-07-03 Alza Corp Bandage for controlled release of vasodilators
US3996934A (en) 1971-08-09 1976-12-14 Alza Corporation Medical bandage
BE795384A (fr) 1972-02-14 1973-08-13 Ici Ltd Pansements
US4152448A (en) 1972-02-15 1979-05-01 Fisons Limited Method and composition for the treatment of a condition of the gastro intestinal tract
US3921636A (en) 1973-01-15 1975-11-25 Alza Corp Novel drug delivery device
GB1475503A (en) 1973-12-19 1977-06-01 Fisons Ltd Topical compositions
US3993072A (en) 1974-08-28 1976-11-23 Alza Corporation Microporous drug delivery device
US4151273A (en) 1974-10-31 1979-04-24 The Regents Of The University Of California Increasing the absorption rate of insoluble drugs
US3972995A (en) 1975-04-14 1976-08-03 American Home Products Corporation Dosage form
US4067992A (en) 1975-09-10 1978-01-10 Fisons Limited Method of treating a psychiatric condition
US4077407A (en) 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4031894A (en) 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
US4060084A (en) 1976-09-07 1977-11-29 Alza Corporation Method and therapeutic system for providing chemotherapy transdermally
US4201211A (en) 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
US4189571A (en) 1978-02-07 1980-02-19 Fisons Limited Esters of cromoglycates
JPS5562012A (en) 1978-11-06 1980-05-10 Teijin Ltd Slow-releasing preparation
US4230105A (en) 1978-11-13 1980-10-28 Merck & Co., Inc. Transdermal delivery of drugs
US4229447A (en) 1979-06-04 1980-10-21 American Home Products Corporation Intraoral methods of using benzodiazepines
US4268519A (en) 1979-06-05 1981-05-19 Fisons Limited Method of treating otitis media
CA1146866A (en) 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
US4291015A (en) 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
FR2505798B1 (fr) 1981-05-14 1986-07-25 Pari Symac Perfectionnement aux dispositifs comportant un ressort helicoidal utilise comme organe de transfert, d'extraction, de dosage ou de melange
EP0084898B1 (en) 1982-01-22 1986-09-03 FISONS plc Liposome and sodium cromoglycate compositions, and methods for their preparation
US4476116A (en) 1982-12-10 1984-10-09 Syntex (U.S.A.) Inc. Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
US5116817A (en) 1982-12-10 1992-05-26 Syntex (U.S.A.) Inc. LHRH preparations for intranasal administration
US4996296A (en) 1983-07-27 1991-02-26 Yeda Research & Development Co., Ltd. Cromolyn binding protein in highly purifed form, and methods for the isolation thereof
US4683135A (en) 1983-07-27 1987-07-28 Yeda Research And Development Co., Ltd. DSCG binding protein and process for preparing same
GB8322178D0 (en) 1983-08-17 1983-09-21 Sterwin Ag Preparing aerosol compositions
US4634699A (en) 1983-11-30 1987-01-06 Burroughs Wellcome Co. Branched chain phenothiazine
GB8332450D0 (en) 1983-12-06 1984-01-11 Fisons Plc Method of treatment
US4596795A (en) 1984-04-25 1986-06-24 The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
JPH0662601B2 (ja) 1985-08-16 1994-08-17 京都薬品工業株式会社 クロモグリク酸誘導体および抗アレルギ−剤
GB8520662D0 (en) 1985-08-17 1985-09-25 Wellcome Found Tricyclic aromatic compounds
US4923892A (en) 1985-08-17 1990-05-08 Burroughs Wellcome Co. Tricyclic aromatic compounds
US4755386A (en) 1986-01-22 1988-07-05 Schering Corporation Buccal formulation
US5231170A (en) 1986-08-27 1993-07-27 Paul Averback Antibodies to dense microspheres
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
DE3879811T2 (de) 1987-08-25 1993-10-07 Kuebler Gmbh Dr Pharmazeutische Zusammensetzung und ihre Verwendung.
US4906476A (en) 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
EP0413583A3 (en) 1989-08-18 1991-07-17 Dey Laboratories; Inc. Clear, stable cromolyn formulation
US5739136A (en) 1989-10-17 1998-04-14 Ellinwood, Jr.; Everett H. Intraoral dosing method of administering medicaments
US5280784A (en) 1990-09-19 1994-01-25 Paul Ritzau Pari-Werk Gmbh Device in particular and inhalating device for treating the lung and the respiratory tracts
US5753208A (en) 1990-11-09 1998-05-19 Egis Gyogyszergyar Antiasthmatic aerosol preparation of sodium cromoglycate
US5633009A (en) 1990-11-28 1997-05-27 Sano Corporation Transdermal administration of azapirones
DE69127756T2 (de) 1990-12-05 1998-02-05 The General Hospital Corp., Charlestown, Mass. Verwendung von no zur behandlung oder prävention der bronchokonstriktion
EP0504459B1 (de) 1991-03-21 1996-06-05 PAUL RITZAU PARI-WERK GmbH Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie
CA2108575C (en) 1991-04-16 2002-10-22 Kouichi Nakamichi Method of manufacturing solid dispersion
US6123924A (en) 1991-09-25 2000-09-26 Fisons Plc Pressurized aerosol inhalation compositions
ATE155695T1 (de) 1991-11-07 1997-08-15 Ritzau Pari Werk Gmbh Paul Vernebler insbesondere zur anwendung in geräten für die inhalationstherapie
DE59105399D1 (de) 1991-11-07 1995-06-08 Ritzau Pari Werk Gmbh Paul Flüssigkeitszerstäubervorrichtung.
US5618842A (en) 1991-12-31 1997-04-08 Lifegroup S.P.A. N-acyl derivatives of aminoalcohols with polycarboxylic acids able to modulate mast cells in inflammatory processes having neuroimmunogenic origin
US5340591A (en) 1992-01-24 1994-08-23 Fujisawa Pharmaceutical Co., Ltd. Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
US5281420A (en) 1992-05-19 1994-01-25 The Procter & Gamble Company Solid dispersion compositions of tebufelone
AU4198793A (en) 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
DE4225928A1 (de) 1992-08-05 1994-02-10 Ritzau Pari Werk Gmbh Paul Zerstäubervorrichtung mit Heizeinrichtung
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
DE4310575C1 (de) 1993-03-31 1994-09-15 Ritzau Pari Werk Gmbh Paul Vorrichtung zum Erzeugen von Aerosolpulsen
GB9317752D0 (en) 1993-08-26 1993-10-13 Fisons Plc New pharmaceutical use
ES2120471T3 (es) 1993-12-17 1998-11-01 Pari Gmbh Spezialisten Fuer Effektive Inhalation Boquilla de pulverizacion.
US5508451A (en) 1994-07-07 1996-04-16 Hoechst Celanese Corporation Process for the preparation of dialkali metal cromoglycates
US5665378A (en) 1994-09-30 1997-09-09 Davis; Roosevelt Transdermal therapeutic formulation
US6000394A (en) 1994-10-26 1999-12-14 Paul Rizau Pari-Werk Gmbh Generation of an aerosol of an exact dose
US5576346A (en) 1995-04-03 1996-11-19 Ascent Pharmaceuticals, Inc. Process for treating uremic pruritus
US5552436A (en) 1995-04-03 1996-09-03 Ascent Pharmaceuticals, Inc. Process for treating hemangioma
GB9507768D0 (en) 1995-04-13 1995-05-31 Glaxo Group Ltd Method of apparatus
DE19520622C2 (de) 1995-06-06 2003-05-15 Pari Gmbh Vorrichtung zum Vernebeln von Fluiden
SE9502244D0 (sv) 1995-06-20 1995-06-20 Bioglan Ab A composition and a process for the preparation thereof
GB9513218D0 (en) 1995-06-29 1995-09-06 Fisons Plc Inhalation device and method
CA2241515A1 (en) 1995-12-27 1997-07-10 Junko Shima Aqueous composition comprising cromoglycic acid
DE19602628C2 (de) 1996-01-25 2000-06-29 Pari Gmbh Vernebler
US6929801B2 (en) 1996-02-19 2005-08-16 Acrux Dds Pty Ltd Transdermal delivery of antiparkinson agents
US6923983B2 (en) 1996-02-19 2005-08-02 Acrux Dds Pty Ltd Transdermal delivery of hormones
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
AU2458697A (en) 1996-04-18 1997-11-07 Alcon Laboratories, Inc. Calcium channel blockers as human conjunctival mast cell degranulation inhibitors for treating ocular allergic conditions
PT954282E (pt) 1997-01-16 2005-06-30 Massachusetts Inst Technology Preparacao de particulas para inalacao
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
WO1998056381A1 (en) 1997-06-09 1998-12-17 Bridge Pharma, Inc. Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use
US6391452B1 (en) 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
DE19734022C2 (de) 1997-08-06 2000-06-21 Pari Gmbh Inhalationstherapiegerät mit einem Ventil zur Begrenzung des Inspirationsflusses
US5952353A (en) 1997-09-19 1999-09-14 Auburn University Treating/preventing heart failure via inhibition of mast cell degranulation
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
PL195212B1 (pl) 1997-09-29 2007-08-31 Nektar Therapeutics Preparat bioaktywny w postaci proszku i sposób jego wytwarzania
US6365180B1 (en) 1998-01-20 2002-04-02 Glenn A. Meyer Oral liquid compositions
US5869090A (en) 1998-01-20 1999-02-09 Rosenbaum; Jerry Transdermal delivery of dehydroepiandrosterone
US6323219B1 (en) 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
GB9807232D0 (en) 1998-04-03 1998-06-03 Univ Cardiff Aerosol composition
GB9810949D0 (en) 1998-05-22 1998-07-22 Hewlett Healthcare Limited Formulation
DE19827228C2 (de) 1998-06-18 2000-07-13 Pari Gmbh Flüssigkeitszerstäubervorrichtung
US6946144B1 (en) 1998-07-08 2005-09-20 Oryxe Transdermal delivery system
ES2234266T3 (es) 1998-07-24 2005-06-16 Jago Research Ag Formulaciones medicas para aerosoles.
CN1150890C (zh) 1998-08-04 2004-05-26 杰格研究股份公司 药用气溶胶制剂
AU5471199A (en) 1998-08-07 2000-02-28 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
GB9824604D0 (en) 1998-11-11 1999-01-06 Hewlett Healthcare Limited Treatment of allergic conditions
US6660715B2 (en) 1998-11-19 2003-12-09 Massachusetts Institute Of Technology Nonaqueous solutions and suspensions of macromolecules for pulmonary delivery
US7074388B2 (en) 1998-12-10 2006-07-11 Kos Life Science, Inc. Water stabilized medicinal aerosol formulation
EP2258183A1 (en) 1998-12-22 2010-12-08 The University of North Carolina at Chapel Hill Compounds and uses for the treatment of airway diseases and for the delivery of airway drugs
CN1338924A (zh) 1999-01-08 2002-03-06 艾米斯菲尔技术有限公司 聚合物输送剂和输送剂化合物
DE60039379D1 (de) 1999-02-10 2008-08-21 Pfizer Prod Inc Pharmazeutische feste Dispersionen
WO2000066206A2 (en) 1999-05-03 2000-11-09 Battelle Memorial Institute Compositions for aerosolization and inhalation
US20020061281A1 (en) 1999-07-06 2002-05-23 Osbakken Robert S. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US6586008B1 (en) 1999-08-25 2003-07-01 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles during spray drying
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
WO2001013892A2 (en) 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Large porous particles by spray-drying
US7129274B1 (en) 1999-11-05 2006-10-31 Emisphere Technologies Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents
DE19962110C2 (de) 1999-12-22 2003-06-12 Pari Gmbh Inhalationsvernebler mit einstückigem Ventilelement
US6596261B1 (en) 2000-01-25 2003-07-22 Aeropharm Technology Incorporated Method of administering a medicinal aerosol formulation
US20020009491A1 (en) 2000-02-14 2002-01-24 Rothbard Jonathan B. Compositions and methods for enhancing drug delivery across biological membranes and tissues
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8257744B2 (en) 2000-07-07 2012-09-04 Laboratorios Farmacéuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
UA81743C2 (uk) 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
TWI334439B (en) 2001-08-01 2010-12-11 Centocor Inc Anti-tnf antibodies, compositions, methods and uses
RU2318829C2 (ru) 2001-11-14 2008-03-10 Сентокор, Инк. Антитела против il-6, композиции, способы и применение
JP5196701B2 (ja) * 2001-11-29 2013-05-15 エミスフィアー テクノロジーズ インコーポレイテッド クロモリンナトリウムの経口投与用製剤
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
US6596284B1 (en) 2002-04-30 2003-07-22 Thomas E. Fleming Treating eczema with a combination of isotonic saline ocean® and nasal mast cell stabilizers
WO2003105898A1 (en) 2002-06-14 2003-12-24 Centocor, Inc. Modified "s" antibodies
WO2004003147A2 (en) 2002-06-27 2004-01-08 Centocor, Inc. Cngh0004 polypeptides, antibodies, compositions, methods and uses
CA2490621A1 (en) 2002-06-27 2004-01-08 Centocor, Inc. Cngh0005 polypeptides, antibodies, compositions, methods and uses
AU2003272450A1 (en) 2002-09-13 2004-04-30 C. Steven Smith Novel composition and method for treatment of upper respiratory conditions
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
SE0203687D0 (sv) 2002-12-13 2002-12-13 Ian Harwigsson Med Adagit Fa Pharmaceutical Porous Particles
US20050129695A1 (en) 2003-03-28 2005-06-16 Marc Mercken Anti-amyloid antibodies, compositions, methods and uses
WO2004091519A2 (en) 2003-04-11 2004-10-28 Medimmune, Inc. Methods of preventing or treating respiratory conditions
CA2525184C (en) 2003-05-09 2012-10-30 Centocor, Inc. Il-23p40 specific immunoglobulin derived proteins, compositions, methods and uses
WO2005005604A2 (en) 2003-06-30 2005-01-20 Centocor, Inc. Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses
US20050026880A1 (en) 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a cromone for treatment of asthma or chronic obstructive pulmonary disease
DE10347994A1 (de) * 2003-10-15 2005-06-16 Pari GmbH Spezialisten für effektive Inhalation Wässrige Aerosol-Zubereitung
WO2005037317A2 (en) 2003-10-17 2005-04-28 Cornell Research Foundation, Inc. Mast cell-derived renin
WO2005044200A2 (en) 2003-11-05 2005-05-19 Centocor, Inc. Methods and compositions for treating mcp-1 related pathologies
US20060078558A1 (en) 2003-11-12 2006-04-13 Whitsett Jeffrey A Diagnosis, prognosis and treatment of pulmonary diseases
DE10355559A1 (de) 2003-11-21 2005-06-23 Orthogen Ag Transskin
US20050191246A1 (en) 2003-12-13 2005-09-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powders comprising low molecular dextran and methods of producing those powders
US8088935B2 (en) 2003-12-23 2012-01-03 Ironwood Pharmaceuticals, Inc. Compounds and methods for the treatment of asthma
IL160936A0 (en) 2004-02-05 2004-08-31 Scott A Cordray Nasal spray and wash
CA2557724A1 (en) 2004-02-27 2005-10-06 Centocor, Inc. Methods and compositions for treating il-13 related pathologies
JP4995080B2 (ja) 2004-05-14 2012-08-08 エミスフェアー・テクノロジーズ・インク 活性薬剤を送達するためのアリールケトン化合物および組成物
EP1754492A1 (en) 2004-05-26 2007-02-21 Reverse Proteomics Research Institute Co., Ltd Novel drug discovery target and medicine acting on the same
WO2006029182A2 (en) 2004-09-07 2006-03-16 The La Jolla Institute For Molecular Medicine Use of mdl-100,907 for treatment of allergic and eosinophil mediated diseases
US20060246075A1 (en) 2004-09-29 2006-11-02 Marc Mercken Anti-amyloid antibodies, compositions, methods and uses
CN103462894A (zh) 2005-03-16 2013-12-25 霍尼韦尔国际公司 药物递送制剂、装置和方法
WO2006105538A2 (en) 2005-03-31 2006-10-05 Centocor, Inc. Methods and compositions for treating il-21 related pathologies
EP1712220A1 (en) 2005-04-15 2006-10-18 PARI GmbH Spezialisten für effektive Inhalation Pharmaceutical aerosol composition
AU2012238334A1 (en) 2005-06-30 2012-11-01 Abbvie Inc. IL-12/p40 binding proteins
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
GB0520794D0 (en) 2005-10-12 2005-11-23 Innovata Biomed Ltd Inhaler
US7566743B2 (en) 2005-11-18 2009-07-28 Mark Glazman System and method for medical treatment
US8454938B2 (en) 2005-12-21 2013-06-04 Solaeromed Inc. Treatment of respiratory diseases
DK2548577T3 (en) 2005-12-29 2017-03-13 Janssen Biotech Inc HUMAN ANTI-IL-23 ANTIBODIES, COMPOSITIONS, PROCEDURES AND APPLICATIONS
DE102006001113B3 (de) 2006-01-09 2007-06-28 Pari GmbH Spezialisten für effektive Inhalation Aerosoltherapievorrichtung
US20070219223A1 (en) 2006-03-07 2007-09-20 Endacea, Inc. Compositions and methods for treating respiratory disorders
US20080035141A1 (en) 2006-06-16 2008-02-14 Warner W R Aerosolized therapy kit
WO2008002893A2 (en) 2006-06-29 2008-01-03 Centocor, Inc. Anti-amyloid antibodies, compositions, methods and uses
US8445437B2 (en) 2006-07-27 2013-05-21 The Brigham And Women's Hospital, Inc. Treatment and prevention of cardiovascular disease using mast cell stabilizers
CA2662701C (en) 2006-09-08 2015-12-08 Abbott Laboratories Interleukin-13 binding proteins
US20080078382A1 (en) 2006-09-20 2008-04-03 Lemahieu Edward Methods and Systems of Delivering Medication Via Inhalation
GB0621707D0 (en) 2006-10-31 2006-12-13 Univ London Pharmacy Formulations for delivery via pressurised metered dose inhalers
EP2091551B1 (en) 2006-11-03 2020-01-15 Alba Therapeutics Corporation Method of treating asthma
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US20080227704A1 (en) 2006-12-21 2008-09-18 Kamens Joanne S CXCL13 binding proteins
WO2008112368A2 (en) 2007-02-08 2008-09-18 Emisphere Technologies, Inc. Phenylalkylcarboxylic acid delivery agents
US8252807B2 (en) 2007-03-02 2012-08-28 Board Of Regents, The University Of Texas System Methods of inhibiting the interaction between S100 and the receptor for advanced glycation end-products
US20080214491A1 (en) 2007-03-02 2008-09-04 Logsdon Craig D Methods of Inhibiting the Interaction Between S100 and the Receptor for Advanced Glycation End-Products
WO2008116165A2 (en) 2007-03-21 2008-09-25 Next Safety, Inc. Methods and systems of delivering medication via inhalation
WO2008130718A1 (en) 2007-04-23 2008-10-30 Atherogenics, Inc. Sulfonamide containing compounds for treatment of inflammatory disorders
WO2009045291A2 (en) 2007-09-28 2009-04-09 The Brigham And Women's Hospital, Inc. Mast cell stabilizers in the treatment of obesity
US20100074901A1 (en) 2007-10-15 2010-03-25 Marc Hubert Mercken Human anti-amyloid antibodies, compositions, methods and uses
DE102007052380A1 (de) 2007-10-31 2009-05-07 Bitop Ag Osmolythaltige Zubereitungen zur Anwendung bei trockenen Schleimhäuten
AU2008323920B2 (en) * 2007-11-06 2012-12-20 3M Innovative Properties Company Medicinal inhalation devices and components thereof
EP2224983B1 (en) 2007-12-20 2017-05-10 AstraZeneca AB Device and method for deaggregating powder 854
WO2009103067A2 (en) 2008-02-14 2009-08-20 The Children's Hospital Of Philadelphia Compositions and methods to treat asthma
WO2009131695A1 (en) 2008-04-25 2009-10-29 Nektar Therapeutics Oligomer-bis-chromonyl compound conjugates
US20100260668A1 (en) 2008-04-29 2010-10-14 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof
SG190572A1 (en) 2008-04-29 2013-06-28 Abbott Lab Dual variable domain immunoglobulins and uses thereof
SG191639A1 (en) 2008-06-03 2013-07-31 Abbott Lab Dual variable domain immunoglobulins and uses thereof
PE20100054A1 (es) 2008-06-03 2010-03-03 Abbott Lab Inmunoglobulina con dominio variable dual
US10517839B2 (en) 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
US8624002B2 (en) 2008-07-08 2014-01-07 Abbvie, Inc. Prostaglandin E2 binding proteins and uses thereof
MX2010014574A (es) 2008-07-08 2011-04-27 Abbott Lab Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas.
US20100087455A1 (en) 2008-10-06 2010-04-08 Auspex Pharmaceuticals, Inc. Substituted xanthine compounds
US20110195924A1 (en) 2008-10-08 2011-08-11 Logsdon Craig D Methods of Inhibiting the Interaction Between S100P and the Receptor for Advanced Glycation End-Products
WO2010057214A2 (en) 2008-11-17 2010-05-20 Wayne State University Nanoparticles and porous particles and methods of making the same
JP2012510821A (ja) 2008-12-04 2012-05-17 アボット・ラボラトリーズ 二重可変ドメイン免疫グロブリンおよびその使用
ES2733214T3 (es) 2009-01-29 2019-11-28 Massachusetts Gen Hospital Derivados de cromolina y métodos relacionados de formación de imágenes y tratamiento
EP2391652A4 (en) 2009-01-29 2013-01-02 Abbott Lab IL-1 BINDING PROTEINS
US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
RU2015132478A (ru) 2009-03-05 2015-12-10 Эббви Инк. Связывающие il-17 белки
US8470805B2 (en) 2009-04-30 2013-06-25 Kaohsiung Medical University Processes for preparing piperazinium salts of KMUP and use thereof
MX2011011669A (es) 2009-05-01 2011-11-18 Abbott Lab Inmunoglobulinas de dominio variable dual y usos de las misma.
KR20100129156A (ko) * 2009-05-28 2010-12-08 엘지전자 주식회사 세탁장치
TW201109438A (en) 2009-07-29 2011-03-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof
NZ598929A (en) 2009-09-01 2014-05-30 Abbvie Inc Dual variable domain immunoglobulins and uses thereof
EP2488201A4 (en) 2009-10-15 2013-12-25 Abbvie Inc IL-1 BINDING PROTEINS
AR078651A1 (es) 2009-10-15 2011-11-23 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
TR201000733A2 (tr) 2010-02-02 2011-08-22 Bi̇lgi̇ç Mahmut Flutikazon, tiotropyum ve sodyum kromoglikat içeren farmasötik bileşimler.
AU2015200579A1 (en) 2010-04-07 2015-02-26 Abbvie Inc. TNF-alpha binding proteins
JP2013523153A (ja) 2010-04-07 2013-06-17 アッヴィ・インコーポレイテッド ＴＮＦ−α結合タンパク質
SG185502A1 (en) 2010-05-14 2012-12-28 Abbvie Inc Il-1 binding proteins
AU2016222339B2 (en) 2010-05-14 2017-11-23 Abbvie Inc. IL-1 binding proteins
US8586044B2 (en) 2010-05-28 2013-11-19 Northwestern University Treatment of chronic pelvic pain syndrome
US9592220B2 (en) 2010-06-17 2017-03-14 Aradigm Corporation Diagnosis and treatment methods for entry of gastrointestinal contents into respiratory tract
ES2535979T3 (es) 2010-07-21 2015-05-19 Astrazeneca Ab Inhalador
CA2809433A1 (en) 2010-08-26 2012-03-01 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
BR112013010857A2 (pt) 2010-11-02 2016-09-13 Abbott Laboratoires imonoglubulinas de duplo domínio variável e usos das mesmas
CA2821976A1 (en) 2010-12-21 2012-09-13 Abbvie Inc. Il-1 -alpha and -beta bispecific dual variable domain immunoglobulins and their use
US20120275996A1 (en) 2010-12-21 2012-11-01 Abbott Laboratories IL-1 Binding Proteins
WO2012088302A2 (en) 2010-12-22 2012-06-28 Abbott Laboratories Half immunoglobulin binding proteins and uses thereof
EP2658538A2 (en) 2010-12-30 2013-11-06 M.D. Ziv Harish Preparations for topical prevention and/or treatment of oral allergic symptoms due to oral contact with fruits and/or vegetables
GB201110058D0 (en) 2011-06-15 2011-07-27 3M Innovative Properties Co Medicinal inhalation devices, valves and components thereof
KR20140069091A (ko) 2011-09-06 2014-06-09 베로나 파마 피엘씨 기침 및 기침으로 인한 발작 치료
BR112014016299A8 (pt) 2011-12-30 2017-07-04 Abbvie Inc imunoglobulinas de domínio variável e usos das mesmas
US20130171059A1 (en) 2011-12-30 2013-07-04 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
KR20240145521A (ko) 2012-01-18 2024-10-07 테크필즈 파마 코., 엘티디. 폐 병태의 치료를 위한 고침투 전구약물 조성물 및 그의 약제학적 조성물
GB2498746A (en) 2012-01-26 2013-07-31 Innovata Biomed Ltd Inhaler which locks when empty
CN104703584B (zh) 2012-02-28 2019-05-31 艾塞尤提卡控股公司 可吸入药物组合物
US20150018396A1 (en) 2012-03-08 2015-01-15 President And Fellows Of Harvard College Prevention and treatment of respiratory infection with peroxisome proliferator activator receptor delta agonist
US9730921B2 (en) 2012-03-27 2017-08-15 Duke University Compositions and methods for the prevention and treatment of mast cell-induced vascular leakage
US10105500B2 (en) 2012-05-09 2018-10-23 Virginia Commonwealth University Dry powder inhaler (DPI) designs for producing aerosols with high fine particle fractions
MX2014013998A (es) 2012-05-25 2015-07-06 Xlear Inc Composiciones antimucosidad a base de xilitol y metodos y composiciones.
US9427534B2 (en) 2012-07-05 2016-08-30 Clement Clarke International Ltd. Drug delivery inhaler devices
TW201402608A (zh) 2012-07-12 2014-01-16 Abbvie Inc Ｉｌ－１結合蛋白質
PT3470432T (pt) 2012-08-21 2021-12-14 Regeneron Pharma Métodos para tratamento ou prevenção da asma por meio de administração de um antagonista de il-4r
JP6499077B2 (ja) 2012-10-25 2019-04-10 ザ ジェネラル ホスピタル コーポレイション アルツハイマー病と関連疾患の治療のための併用療法
US20150290135A1 (en) 2012-11-16 2015-10-15 Merck Sharp & Dohme Corp. Process for making agglomerates using acoustic mixing technology
WO2014115098A1 (en) 2013-01-26 2014-07-31 Mahesh Kandula Compositions and methods for the treatment of neurological diseases and inflammation
RU2015143833A (ru) 2013-03-15 2017-04-21 Эббви Инк. СВЯЗЫВАЮЩИЕ БЕЛКИ С ДВОЙНОЙ СПЕЦИФИЧНОСТЬЮ, НАПРАВЛЕННЫЕ ПРОТИВ TNFα
MX381503B (es) 2013-05-23 2025-03-12 Aztherapies Inc Métodos para la liberación de cromolina.
NZ716977A (en) 2013-08-23 2017-09-29 Afferent Pharmaceuticals Inc Methods of using diaminopyrimidine p2x3 and p2x2/3 receptor modulators for treatment of acute and sub-acute cough, urge to cough and chronic cough, in respiratory diseases
US10188757B2 (en) 2013-10-22 2019-01-29 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
US9492408B2 (en) 2013-10-24 2016-11-15 University of Pittsburgh—of the Commonwealth System of Higher Education Protection from chemical-induced acute lung injury
GB2522727B (en) 2013-11-26 2017-01-25 Purity Health Pharma Ltd Pulmonary delivery devices
EP2883564A1 (en) 2013-12-16 2015-06-17 PARI Pharma GmbH Aerosol delivery device and method of operating the aerosol delivery device
US11485787B2 (en) 2014-02-05 2022-11-01 Dana-Farber Cancer Institute, Inc. Agents that modulate RGMb-neogenin-BMP signaling and methods of use thereof
ES2762806T3 (es) 2014-02-10 2020-05-25 Respivant Sciences Gmbh Tratamiento utilizando estabilizadores de mastocitos para trastornos sistémicos
PT3104854T (pt) 2014-02-10 2020-06-26 Respivant Sciences Gmbh Estabilizadores de mastócitos para tratamento de doença pulmonar
US20150273119A1 (en) 2014-03-26 2015-10-01 Snu R&Db Foundation Formulation comprising anti-scarring agents and biocompatible polymers for medical device coating
US20150306107A1 (en) 2014-04-24 2015-10-29 Jansfat Biotechnology Co., Ltd. SAA Derivative Compound Restores eNOS And Inhibits Oxidative Stress-Induced A Diseases In Hypoxia
WO2015161510A1 (en) 2014-04-25 2015-10-29 Jansfat Biotechnology Co., Ltd. Saa derivative compound restores enos and inhibits oxidative stress-induced diseases in hypoxia
US20150337315A1 (en) 2014-05-20 2015-11-26 Michael M. Grunstein Compositions and methods targeting signaling by the g protein beta-gamma subunit for the treatment of asthma
DE102014009164A1 (de) 2014-06-03 2015-12-03 Herbalist & Doc Gesundheitsgesellschaft Mbh Silikonölhaltige nasal anzuwendende Formulierungen
US10508307B2 (en) 2014-06-05 2019-12-17 Transgenion—International Institute for Regenerative Translational Medicine GmbH Methods of diagnosing chronic obstructive pulmonary disease (COPD) using novel molecular biomarkers
EP3152328A2 (en) 2014-06-05 2017-04-12 Transgenion-International Institute For Regenerative Translational Medicine Gmbh Methods of diagnosing chronic obstructive pulmonary disease (copd) using novel molecular biomarkers
EP3152329A2 (en) 2014-06-05 2017-04-12 Transregion-International Institute For Translational Medicine Gmbh Methods of diagnosing chronic obstructive pulmonary disease (copd) using novel molecular biomarkers
WO2016004389A2 (en) 2014-07-03 2016-01-07 Abbvie Inc. Monovalent binding proteins
WO2016011254A1 (en) 2014-07-16 2016-01-21 Henry J. Legere Md, Pa Combinations of antihistamines and leukotriene antagonists and methods of use thereof
WO2016052953A1 (ko) 2014-09-30 2016-04-07 주식회사 엘지화학 (메트)아크릴레이트 화합물, 이로부터 유도된 반복단위를 포함하는 코폴리머 및 호모폴리머
WO2016064908A1 (en) 2014-10-25 2016-04-28 Sumner Bluffs, Llc. Systems and methods for determining compliance and efficacy of a dosing regimen for a pharmaceutical agent
WO2017011729A1 (en) 2015-07-16 2017-01-19 Patara Pharma, LLC Combination therapies for the treatment of lung diseases
WO2017027402A1 (en) 2015-08-07 2017-02-16 Patara Pharma, LLC Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
WO2017027387A1 (en) 2015-08-07 2017-02-16 Patara Pharma, LLC Methods for the treatment of mast cell related disorders with mast cell stabilizers
WO2017048860A1 (en) 2015-09-14 2017-03-23 Vgsk Technologies, Inc. A sterically stabilized carrier for subcutaneous, sublingual and oral therapeutics, compositions and methods for treating a mammal

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61143318A (ja) * 1984-11-23 1986-07-01 フアイソンズ・ピ−エルシ− 新規な製剤およびその調整方法
JPH0672869A (ja) * 1992-07-07 1994-03-15 Fisons Plc ナトリウムクロモグリケートの水性医薬組成物
US20070193577A1 (en) * 2006-02-03 2007-08-23 Manfred Keller Disodium cromoglycate compositions and methods for administering same
WO2007090646A1 (en) * 2006-02-10 2007-08-16 Pari Pharma Gmbh Nebulised antibiotics for inhalation therapy
WO2009027095A1 (en) * 2007-08-31 2009-03-05 Pari Pharma Gmbh Aerosols for sinunasal drug delivery
JP2012526084A (ja) * 2009-05-08 2012-10-25 パーリ・ファルマ・ゲーエムベーハー 濃縮肥満細胞安定化用薬学的調合物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023543965A (ja) * 2020-08-14 2023-10-19 イスタンブル ウニヴェルシテシ レクトールルグ 吸入経路を介するソフトミスト吸入器又は振動メッシュ式ネブライザーによるウイルス性肺疾患、急性及び／又は慢性の肺疾患治療におけるヘパリン組成物の使用
JP2023544685A (ja) * 2020-09-14 2023-10-25 イスタンブル ウニヴェルシテシ レクトールルグ 吸入ルートを介するソフトミスト吸入器又は振動型メッシュ式噴霧器を用いた新型コロナウイルス感染症を含むウイルス性肺疾患の治療における抗ウイルス性、抗マラリア性及び／又は粘液溶解性を備える活性物質の使用

Also Published As

Publication number Publication date
EP3104853B1 (en) 2019-10-02
AU2015213678C1 (en) 2019-03-21
AU2015213678B2 (en) 2017-10-19
US20160346245A1 (en) 2016-12-01
HUE047319T2 (hu) 2020-04-28
US10238628B2 (en) 2019-03-26
US20190388386A1 (en) 2019-12-26
US20190175546A1 (en) 2019-06-13
US9968586B2 (en) 2018-05-15
JP2019116503A (ja) 2019-07-18
CA2938994A1 (en) 2015-08-13
US20180280341A1 (en) 2018-10-04
CN106456595A (zh) 2017-02-22
EP3104853A1 (en) 2016-12-21
US20160367519A1 (en) 2016-12-22
US9265749B2 (en) 2016-02-23
US20170273941A1 (en) 2017-09-28
US20150224077A1 (en) 2015-08-13
US10398673B2 (en) 2019-09-03
US9962363B2 (en) 2018-05-08
AU2015213678A1 (en) 2016-08-25
US20190307721A1 (en) 2019-10-10
EP3104853A4 (en) 2017-08-16
AU2019236630A1 (en) 2019-10-17
AU2018200429A1 (en) 2018-02-08
SI3104853T1 (sl) 2020-03-31
DK3104853T3 (da) 2019-12-09
EP3653207A1 (en) 2020-05-20
PL3104853T3 (pl) 2020-05-18
ES2762806T3 (es) 2020-05-25
WO2015120389A1 (en) 2015-08-13
AU2018200429B2 (en) 2019-10-10
US9707206B2 (en) 2017-07-18
PT3104853T (pt) 2020-01-14
US20150297557A1 (en) 2015-10-22
US20180271828A1 (en) 2018-09-27

Similar Documents

Publication Publication Date Title
US10398673B2 (en) Mast cell stabilizers treatment for systemic disorders
US10596146B2 (en) Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
US10391078B2 (en) Methods for the treatment of mast cell related disorders with mast cell stabilizers
EP3104854B1 (en) Mast cell stabilizers for lung disease treatment

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161026

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170525

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170525

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20170525

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20170607

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170705

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170803

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170920

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171218

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180213

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180409

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180706

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20181205

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190329

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20190411

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20190517

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20190813