JP2017509586A5 - - Google Patents
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- Publication number
- JP2017509586A5 JP2017509586A5 JP2016542733A JP2016542733A JP2017509586A5 JP 2017509586 A5 JP2017509586 A5 JP 2017509586A5 JP 2016542733 A JP2016542733 A JP 2016542733A JP 2016542733 A JP2016542733 A JP 2016542733A JP 2017509586 A5 JP2017509586 A5 JP 2017509586A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- attached
- protecting group
- heterocyclyl
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001072 heteroaryl group Chemical group 0.000 claims 38
- 125000000623 heterocyclic group Chemical group 0.000 claims 38
- 125000004452 carbocyclyl group Chemical group 0.000 claims 28
- 125000000547 substituted alkyl group Chemical group 0.000 claims 28
- 125000003107 substituted aryl group Chemical group 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 26
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 24
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 24
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 22
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 20
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 20
- 229910052736 halogen Inorganic materials 0.000 claims 19
- 150000002367 halogens Chemical class 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 150000002431 hydrogen Chemical class 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 14
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 14
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 239000001301 oxygen Substances 0.000 claims 10
- 229910052717 sulfur Inorganic materials 0.000 claims 10
- 239000011593 sulfur Substances 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- -1 amino, hydroxyl Chemical group 0.000 claims 8
- 150000003573 thiols Chemical class 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 6
- 125000002915 carbonyl group Chemical class [*:2]C([*:1])=O 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 201000005787 hematologic cancer Diseases 0.000 claims 6
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 6
- 230000002062 proliferating effect Effects 0.000 claims 6
- 206010028537 myelofibrosis Diseases 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 208000003476 primary myelofibrosis Diseases 0.000 claims 4
- 125000000475 sulfinyl group Chemical class [*:2]S([*:1])=O 0.000 claims 4
- 125000000472 sulfonyl group Chemical class *S(*)(=O)=O 0.000 claims 4
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 102100033145 Cyclin-dependent kinase 19 Human genes 0.000 claims 2
- 102100024456 Cyclin-dependent kinase 8 Human genes 0.000 claims 2
- 101000944345 Homo sapiens Cyclin-dependent kinase 19 Proteins 0.000 claims 2
- 101000980937 Homo sapiens Cyclin-dependent kinase 8 Proteins 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 2
- 230000007170 pathology Effects 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361920674P | 2013-12-24 | 2013-12-24 | |
| US61/920,674 | 2013-12-24 | ||
| US201461935240P | 2014-02-03 | 2014-02-03 | |
| US61/935,240 | 2014-02-03 | ||
| US201461993329P | 2014-05-15 | 2014-05-15 | |
| US61/993,329 | 2014-05-15 | ||
| PCT/US2014/072365 WO2015100420A1 (en) | 2013-12-24 | 2014-12-24 | Cortistatin analogues and syntheses and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019038398A Division JP2019108367A (ja) | 2013-12-24 | 2019-03-04 | コルチスタチン類縁体並びにその合成及び使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017509586A JP2017509586A (ja) | 2017-04-06 |
| JP2017509586A5 true JP2017509586A5 (OSRAM) | 2018-01-11 |
| JP6494631B2 JP6494631B2 (ja) | 2019-04-03 |
Family
ID=52350382
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016542733A Expired - Fee Related JP6494631B2 (ja) | 2013-12-24 | 2014-12-24 | コルチスタチン類縁体並びにその合成及び使用 |
| JP2019038398A Withdrawn JP2019108367A (ja) | 2013-12-24 | 2019-03-04 | コルチスタチン類縁体並びにその合成及び使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019038398A Withdrawn JP2019108367A (ja) | 2013-12-24 | 2019-03-04 | コルチスタチン類縁体並びにその合成及び使用 |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US9994582B2 (OSRAM) |
| EP (2) | EP3087080B1 (OSRAM) |
| JP (2) | JP6494631B2 (OSRAM) |
| KR (1) | KR20160101162A (OSRAM) |
| CN (2) | CN106103452B (OSRAM) |
| AP (1) | AP2016009324A0 (OSRAM) |
| AU (2) | AU2014369834B2 (OSRAM) |
| BR (1) | BR112016014760A2 (OSRAM) |
| CA (1) | CA2934819A1 (OSRAM) |
| CL (1) | CL2016001631A1 (OSRAM) |
| CR (1) | CR20160291A (OSRAM) |
| DO (1) | DOP2016000158A (OSRAM) |
| EA (2) | EA030907B1 (OSRAM) |
| EC (1) | ECSP16062174A (OSRAM) |
| ES (1) | ES2709480T3 (OSRAM) |
| GT (1) | GT201600135A (OSRAM) |
| IL (1) | IL246390A0 (OSRAM) |
| MD (1) | MD20160089A2 (OSRAM) |
| MX (1) | MX361652B (OSRAM) |
| MY (1) | MY180383A (OSRAM) |
| NI (1) | NI201600089A (OSRAM) |
| PE (1) | PE20161405A1 (OSRAM) |
| PH (1) | PH12016501258A1 (OSRAM) |
| RU (1) | RU2016126503A (OSRAM) |
| SA (1) | SA516371410B1 (OSRAM) |
| SG (2) | SG11201605178WA (OSRAM) |
| SV (1) | SV2016005234A (OSRAM) |
| TN (1) | TN2016000240A1 (OSRAM) |
| WO (1) | WO2015100420A1 (OSRAM) |
| ZA (1) | ZA201603894B (OSRAM) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA030907B1 (ru) | 2013-12-24 | 2018-10-31 | Президент Энд Феллоус Оф Гарвард Колледж | Аналоги кортистатина, их синтез и применения |
| EA031804B1 (ru) | 2014-02-03 | 2019-02-28 | Вайтаи Фармасьютиклз, Инк. | Дигидропирролопиридиновые ингибиторы ror-гамма |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| WO2016182904A1 (en) * | 2015-05-08 | 2016-11-17 | President And Fellows Of Harvard College | Targeted selection of patients for treatment with cortistatin derivatives |
| EP3294298A4 (en) | 2015-05-08 | 2018-10-17 | President and Fellows of Harvard College | Cortistatin analogues, syntheses, and uses thereof |
| WO2017004411A1 (en) | 2015-07-01 | 2017-01-05 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses and uses thereof |
| WO2017024018A1 (en) | 2015-08-05 | 2017-02-09 | Vitae Pharmaceuticals, Inc. | Modulators of ror-gamma |
| CN108463458B (zh) | 2015-11-20 | 2022-02-01 | 生命医药有限责任公司 | ROR-γ的调节剂 |
| WO2017112823A1 (en) * | 2015-12-23 | 2017-06-29 | President And Fellows Of Harvard College | Targeted selection of patients for treatment with specific cortistatin derivatives |
| CN108699085A (zh) * | 2015-12-23 | 2018-10-23 | 哈佛学院院长等 | 皮质抑素类似物及其用途 |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| WO2017142621A1 (en) * | 2016-02-19 | 2017-08-24 | President And Fellows Of Harvard College | Cortistatin analogs |
| US11285144B2 (en) | 2016-08-03 | 2022-03-29 | The Broad Institute, Inc. | Use of CDK8 inhibitors to treat diseases of inflammation and autoimmunity |
| JP7142846B2 (ja) | 2017-01-30 | 2022-09-28 | 国立大学法人京都大学 | 新規化合物及び制御性ｔ細胞の製造方法 |
| CN107028956A (zh) * | 2017-03-06 | 2017-08-11 | 刘杰 | 一种治疗经期抑郁症的药物组合物 |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| WO2019023207A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | Inhibitors of rorϒ |
| US11261184B2 (en) | 2017-10-02 | 2022-03-01 | Boehringer Ingelheim International Gmbh | [1,6]naphthyridine compounds and derivatives as CDK8/CDK19 inhibitors |
| AU2020216498B2 (en) * | 2019-02-01 | 2025-08-28 | Senex Biotechnology, Inc | Bicyclic pyridine compositions and methods of using the same for cancer therapy |
| CA3159284A1 (en) | 2019-11-26 | 2021-06-03 | Dana-Farber Cancer Institute, Inc. | Potent and selective azaindole inhibitors of cdk8 and cdk19 |
| TW202330910A (zh) | 2021-09-27 | 2023-08-01 | 國立大學法人京都大學 | Ｔ細胞的製造方法 |
| CN118591619A (zh) | 2021-11-24 | 2024-09-03 | 雷格细胞股份有限公司 | 人诱导性调节性t细胞及其制作方法 |
| US20250352578A1 (en) | 2021-11-24 | 2025-11-20 | Regcell Co., Ltd. | Pharmaceutical composition for treating or preventing t cell-related disorders |
| CN119256076A (zh) | 2022-03-23 | 2025-01-03 | 国立大学法人京都大学 | 用于产生调节性t细胞的方法 |
| WO2024071010A1 (ja) | 2022-09-26 | 2024-04-04 | 国立大学法人京都大学 | Ｔ細胞の製造方法 |
| EP4596684A1 (en) | 2022-09-26 | 2025-08-06 | Regcell Co., Ltd. | Induced regulatory t cells containing chimeric antigen receptor (car) |
| JPWO2024166969A1 (OSRAM) | 2023-02-08 | 2024-08-15 |
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| EA030907B1 (ru) * | 2013-12-24 | 2018-10-31 | Президент Энд Феллоус Оф Гарвард Колледж | Аналоги кортистатина, их синтез и применения |
-
2014
- 2014-12-24 EA EA201691167A patent/EA030907B1/ru not_active IP Right Cessation
- 2014-12-24 EA EA201891279A patent/EA201891279A1/ru unknown
- 2014-12-24 SG SG11201605178WA patent/SG11201605178WA/en unknown
- 2014-12-24 WO PCT/US2014/072365 patent/WO2015100420A1/en not_active Ceased
- 2014-12-24 EP EP14827687.6A patent/EP3087080B1/en active Active
- 2014-12-24 RU RU2016126503A patent/RU2016126503A/ru not_active Application Discontinuation
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