CL2016001631A1 - Análogos de cortistatina y síntesis y usos de los mismos - Google Patents
Análogos de cortistatina y síntesis y usos de los mismosInfo
- Publication number
- CL2016001631A1 CL2016001631A1 CL2016001631A CL2016001631A CL2016001631A1 CL 2016001631 A1 CL2016001631 A1 CL 2016001631A1 CL 2016001631 A CL2016001631 A CL 2016001631A CL 2016001631 A CL2016001631 A CL 2016001631A CL 2016001631 A1 CL2016001631 A1 CL 2016001631A1
- Authority
- CL
- Chile
- Prior art keywords
- synthesis
- affection
- cortistatin analogues
- cortistatin
- analogues
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
Abstract
<p>COMPUESTOS ANALOGOS DE CORTISTATINA; COMPOSICION FARMACEUTICA; Y METODO DE TRATAMIENTO DE UNA AFECCION DIABETICA, AFECCION INFLAMATORIA, DEGENERACION MACULAR, OBESIDAD, ATEROSCLEROSIS, ANGIOGENESIS, TRANSTORNO PROLIFERATIVO Y CANCER SELCECIONADO DE MIELOMA MULTIPLE, LINFOMA Y LEUCEMIA MIELOCITICA AGUDA, ENTRE OTROS.</p>
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361920674P | 2013-12-24 | 2013-12-24 | |
US201461935240P | 2014-02-03 | 2014-02-03 | |
US201461993329P | 2014-05-15 | 2014-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2016001631A1 true CL2016001631A1 (es) | 2017-02-24 |
Family
ID=52350382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2016001631A CL2016001631A1 (es) | 2013-12-24 | 2016-06-23 | Análogos de cortistatina y síntesis y usos de los mismos |
Country Status (30)
Country | Link |
---|---|
US (3) | US9994582B2 (es) |
EP (2) | EP3505521A1 (es) |
JP (2) | JP6494631B2 (es) |
KR (1) | KR20160101162A (es) |
CN (2) | CN110183461A (es) |
AP (1) | AP2016009324A0 (es) |
AU (2) | AU2014369834B2 (es) |
BR (1) | BR112016014760A2 (es) |
CA (1) | CA2934819A1 (es) |
CL (1) | CL2016001631A1 (es) |
CR (1) | CR20160291A (es) |
DO (1) | DOP2016000158A (es) |
EA (2) | EA201891279A1 (es) |
EC (1) | ECSP16062174A (es) |
ES (1) | ES2709480T3 (es) |
GT (1) | GT201600135A (es) |
IL (1) | IL246390A0 (es) |
MD (1) | MD20160089A2 (es) |
MX (1) | MX361652B (es) |
MY (1) | MY180383A (es) |
NI (1) | NI201600089A (es) |
PE (1) | PE20161405A1 (es) |
PH (1) | PH12016501258A1 (es) |
RU (1) | RU2016126503A (es) |
SA (1) | SA516371410B1 (es) |
SG (2) | SG10201808151RA (es) |
SV (1) | SV2016005234A (es) |
TN (1) | TN2016000240A1 (es) |
WO (1) | WO2015100420A1 (es) |
ZA (1) | ZA201603894B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TN2016000240A1 (en) | 2013-12-24 | 2017-10-06 | Harvard College | Cortistatin analogues and syntheses and uses thereof. |
WO2015116904A1 (en) | 2014-02-03 | 2015-08-06 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ror-gamma |
US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
KR20180003597A (ko) * | 2015-05-08 | 2018-01-09 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 코르티스타틴 유도체로의 치료를 위한 환자의 표적화된 선택 |
WO2016182932A1 (en) * | 2015-05-08 | 2016-11-17 | President And Fellows Of Harvard College | Cortistatin analogues, syntheses, and uses thereof |
WO2017004411A1 (en) * | 2015-07-01 | 2017-01-05 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses and uses thereof |
EP3331876B1 (en) | 2015-08-05 | 2020-10-07 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
MA53943A (fr) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals Llc | Modulateurs de ror-gamma |
KR20180095051A (ko) * | 2015-12-23 | 2018-08-24 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 코르티스타틴 유사체 및 그의 용도 |
WO2017112823A1 (en) * | 2015-12-23 | 2017-06-29 | President And Fellows Of Harvard College | Targeted selection of patients for treatment with specific cortistatin derivatives |
TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
WO2017142621A1 (en) * | 2016-02-19 | 2017-08-24 | President And Fellows Of Harvard College | Cortistatin analogs |
WO2018027082A1 (en) * | 2016-08-03 | 2018-02-08 | The Broad Institute, Inc. | Use of cdk8 inhibitors to treat diseases of inflammation and autoimmunity |
EP3575297A4 (en) | 2017-01-30 | 2021-07-28 | Kyoto University | NOVEL COMPOUND AND METHOD FOR PRODUCING REGULATORY T-CELLS |
CN107028956A (zh) * | 2017-03-06 | 2017-08-11 | 刘杰 | 一种治疗经期抑郁症的药物组合物 |
CN111225914B (zh) | 2017-07-24 | 2022-10-11 | 生命医药有限责任公司 | RORγ的抑制剂 |
WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
CN111163775B (zh) | 2017-10-02 | 2023-07-11 | 勃林格殷格翰国际有限公司 | 作为cdk8/cdk19抑制剂的新型[1,6]萘啶化合物和衍生物 |
JP2022523742A (ja) | 2019-02-01 | 2022-04-26 | ユニヴァーシティー オブ サウスカロライナ | 二環式ピリジン組成物およびがんの治療にそれを使用する方法 |
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2014
- 2014-12-24 TN TN2016000240A patent/TN2016000240A1/en unknown
- 2014-12-24 EA EA201891279A patent/EA201891279A1/ru unknown
- 2014-12-24 RU RU2016126503A patent/RU2016126503A/ru not_active Application Discontinuation
- 2014-12-24 CR CR20160291A patent/CR20160291A/es unknown
- 2014-12-24 PE PE2016000946A patent/PE20161405A1/es unknown
- 2014-12-24 EA EA201691167A patent/EA030907B1/ru not_active IP Right Cessation
- 2014-12-24 CN CN201910351186.8A patent/CN110183461A/zh active Pending
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