ES2709480T3 - Análogos de cortistatina y síntesis y usos de los mismos - Google Patents
Análogos de cortistatina y síntesis y usos de los mismos Download PDFInfo
- Publication number
- ES2709480T3 ES2709480T3 ES14827687T ES14827687T ES2709480T3 ES 2709480 T3 ES2709480 T3 ES 2709480T3 ES 14827687 T ES14827687 T ES 14827687T ES 14827687 T ES14827687 T ES 14827687T ES 2709480 T3 ES2709480 T3 ES 2709480T3
- Authority
- ES
- Spain
- Prior art keywords
- optionally substituted
- compound
- pharmaceutically acceptable
- formula
- certain embodiments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *C1C2C(CC[C@]3(*)C(*)(*)CC[C@@]33)[C@@]3(CC3)O[C@]3(C3)[C@]2C1CC(*)[C@@]3N(*)* Chemical compound *C1C2C(CC[C@]3(*)C(*)(*)CC[C@@]33)[C@@]3(CC3)O[C@]3(C3)[C@]2C1CC(*)[C@@]3N(*)* 0.000 description 25
- MQTJIRVJLIFLLF-QKQMAUGASA-N CC1([C@@H](CC2)[C@]3(CC4)O[C@]4(C[C@@H](CC4)O)C4=CC3=CC1)C2c1cc2cnccc2cc1 Chemical compound CC1([C@@H](CC2)[C@]3(CC4)O[C@]4(C[C@@H](CC4)O)C4=CC3=CC1)C2c1cc2cnccc2cc1 MQTJIRVJLIFLLF-QKQMAUGASA-N 0.000 description 2
- BSRKTIDKRHSAKD-RYZAJTCCSA-N CC1(C(CC2)[C@]3(CC4)O[C@]4(C[C@H](CC4)OC)C4=CC3=CC1)C2c1ccc(/C=C\C=C)c(C=C)c1 Chemical compound CC1(C(CC2)[C@]3(CC4)O[C@]4(C[C@H](CC4)OC)C4=CC3=CC1)C2c1ccc(/C=C\C=C)c(C=C)c1 BSRKTIDKRHSAKD-RYZAJTCCSA-N 0.000 description 1
- UKSPHELQSJVRQO-ISMSCQHXSA-N CC1([C@@H](CC2)[C@]3(CC4)O[C@]4(CC(CC4)OCCOC)C4=CC3=CC1)C2c(cc1)cc2c1ccnc2 Chemical compound CC1([C@@H](CC2)[C@]3(CC4)O[C@]4(CC(CC4)OCCOC)C4=CC3=CC1)C2c(cc1)cc2c1ccnc2 UKSPHELQSJVRQO-ISMSCQHXSA-N 0.000 description 1
- NZASQASVSGSYSP-KBSVMDKASA-N CNC(COC(CCC1=C2)C[C@@]1(CC1)O[C@@]1(C1CCC3c4ccc(/C=C\C=C)c(C=C)c4)C2=CCC13N)=O Chemical compound CNC(COC(CCC1=C2)C[C@@]1(CC1)O[C@@]1(C1CCC3c4ccc(/C=C\C=C)c(C=C)c4)C2=CCC13N)=O NZASQASVSGSYSP-KBSVMDKASA-N 0.000 description 1
- OZPIFVADUQVJEA-RXMQYKEDSA-N C[C@@](CC1)(C=[IH])N1N Chemical compound C[C@@](CC1)(C=[IH])N1N OZPIFVADUQVJEA-RXMQYKEDSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361920674P | 2013-12-24 | 2013-12-24 | |
| US201461935240P | 2014-02-03 | 2014-02-03 | |
| US201461993329P | 2014-05-15 | 2014-05-15 | |
| PCT/US2014/072365 WO2015100420A1 (en) | 2013-12-24 | 2014-12-24 | Cortistatin analogues and syntheses and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2709480T3 true ES2709480T3 (es) | 2019-04-16 |
Family
ID=52350382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14827687T Active ES2709480T3 (es) | 2013-12-24 | 2014-12-24 | Análogos de cortistatina y síntesis y usos de los mismos |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US9994582B2 (OSRAM) |
| EP (2) | EP3505521A1 (OSRAM) |
| JP (2) | JP6494631B2 (OSRAM) |
| KR (1) | KR20160101162A (OSRAM) |
| CN (2) | CN106103452B (OSRAM) |
| AP (1) | AP2016009324A0 (OSRAM) |
| AU (2) | AU2014369834B2 (OSRAM) |
| BR (1) | BR112016014760A2 (OSRAM) |
| CA (1) | CA2934819A1 (OSRAM) |
| CL (1) | CL2016001631A1 (OSRAM) |
| CR (1) | CR20160291A (OSRAM) |
| DO (1) | DOP2016000158A (OSRAM) |
| EA (2) | EA030907B1 (OSRAM) |
| EC (1) | ECSP16062174A (OSRAM) |
| ES (1) | ES2709480T3 (OSRAM) |
| GT (1) | GT201600135A (OSRAM) |
| IL (1) | IL246390A0 (OSRAM) |
| MD (1) | MD20160089A2 (OSRAM) |
| MX (1) | MX361652B (OSRAM) |
| MY (1) | MY180383A (OSRAM) |
| NI (1) | NI201600089A (OSRAM) |
| PE (1) | PE20161405A1 (OSRAM) |
| PH (1) | PH12016501258A1 (OSRAM) |
| RU (1) | RU2016126503A (OSRAM) |
| SA (1) | SA516371410B1 (OSRAM) |
| SG (2) | SG11201605178WA (OSRAM) |
| SV (1) | SV2016005234A (OSRAM) |
| TN (1) | TN2016000240A1 (OSRAM) |
| WO (1) | WO2015100420A1 (OSRAM) |
| ZA (1) | ZA201603894B (OSRAM) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160101162A (ko) | 2013-12-24 | 2016-08-24 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 코르티스타틴 유사체 및 그의 합성 및 용도 |
| WO2015116904A1 (en) | 2014-02-03 | 2015-08-06 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ror-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| MX2017014338A (es) * | 2015-05-08 | 2018-04-11 | Harvard College | Seleccion dirigida de pacientes para el tratamiento con derivados de cortistatina. |
| EP3294298A4 (en) * | 2015-05-08 | 2018-10-17 | President and Fellows of Harvard College | Cortistatin analogues, syntheses, and uses thereof |
| EP3316889A4 (en) * | 2015-07-01 | 2018-11-14 | President and Fellows of Harvard College | Cortistatin analogues and syntheses and uses thereof |
| WO2017024018A1 (en) | 2015-08-05 | 2017-02-09 | Vitae Pharmaceuticals, Inc. | Modulators of ror-gamma |
| US11008340B2 (en) | 2015-11-20 | 2021-05-18 | Vitae Pharmaceuticals, Llc | Modulators of ROR-gamma |
| WO2017112823A1 (en) * | 2015-12-23 | 2017-06-29 | President And Fellows Of Harvard College | Targeted selection of patients for treatment with specific cortistatin derivatives |
| MX2018007804A (es) * | 2015-12-23 | 2019-07-04 | Harvard College | Analogos de cortistatina y usos de los mismos. |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| CA3014581A1 (en) * | 2016-02-19 | 2017-08-24 | President And Fellows Of Harvard College | Cortistatin analogs |
| US11285144B2 (en) | 2016-08-03 | 2022-03-29 | The Broad Institute, Inc. | Use of CDK8 inhibitors to treat diseases of inflammation and autoimmunity |
| ES3004107T3 (en) | 2017-01-30 | 2025-03-11 | Univ Kyoto | Novel compound, and method for producing regulatory t cells |
| CN107028956A (zh) * | 2017-03-06 | 2017-08-11 | 刘杰 | 一种治疗经期抑郁症的药物组合物 |
| BR112020001246A2 (pt) | 2017-07-24 | 2020-07-21 | Vitae Pharmaceuticals, Llc | inibidores de rory |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| US11261184B2 (en) | 2017-10-02 | 2022-03-01 | Boehringer Ingelheim International Gmbh | [1,6]naphthyridine compounds and derivatives as CDK8/CDK19 inhibitors |
| EP3917523B1 (en) * | 2019-02-01 | 2024-09-11 | University of South Carolina | Bicyclic pyridine compounds for use in treating cancer |
| US12410194B2 (en) | 2019-11-26 | 2025-09-09 | Dana-Farber Cancer Institute, Inc. | Potent and selective azaindole inhibitors of CDK8 and CDK19 |
| US20240400993A1 (en) | 2021-09-27 | 2024-12-05 | Kyoto University | Method for producing t cell |
| JP7572755B2 (ja) | 2021-11-24 | 2024-10-24 | レグセル株式会社 | ヒト誘導性制御性ｔ細胞およびその作製方法 |
| TW202334397A (zh) | 2021-11-24 | 2023-09-01 | 日商雷格細胞股份有限公司 | 用於治療或預防t細胞相關疾病之醫藥組合物 |
| CN119256076A (zh) | 2022-03-23 | 2025-01-03 | 国立大学法人京都大学 | 用于产生调节性t细胞的方法 |
| WO2024071039A1 (ja) | 2022-09-26 | 2024-04-04 | レグセル株式会社 | キメラ抗原受容体（ｃａｒ）を含む誘導性制御性ｔ細胞 |
| AU2023353929A1 (en) | 2022-09-26 | 2025-05-01 | Kyoto University | T cell production method |
| EP4663195A1 (en) | 2023-02-08 | 2025-12-17 | Regcell Co., Ltd. | Pharmaceutical composition for treating or preventing pemphigus |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2886589A (en) | 1957-08-05 | 1959-05-12 | Merck & Co Inc | 8-methyl-5-oxyphenyl hexahydroindan compounds |
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4863457A (en) | 1986-11-24 | 1989-09-05 | Lee David A | Drug delivery device |
| CA1283827C (en) | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4853224A (en) | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
| US4997652A (en) | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5098443A (en) | 1989-03-23 | 1992-03-24 | University Of Miami | Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5185152A (en) | 1990-01-10 | 1993-02-09 | Peyman Gholam A | Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5410016A (en) | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| IL105050A0 (en) | 1992-03-27 | 1993-07-08 | Lilly Co Eli | Steroid derivatives |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| SE9401108D0 (sv) | 1994-03-31 | 1994-03-31 | Leiras Oy | Ophthalmic composition I |
| US5725493A (en) | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5847172A (en) | 1995-06-07 | 1998-12-08 | Magainin Pharmaceuticals Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
| US5554187A (en) | 1995-08-18 | 1996-09-10 | Rizzo, Iii; Joseph | Medication dispensing intra-ocular lens system |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| US6074872A (en) | 1996-05-15 | 2000-06-13 | The Scripps Research Institute | Cortistatin: nucleic acids that encode these neuropeptides |
| ZA978537B (en) | 1996-09-23 | 1998-05-12 | Focal Inc | Polymerizable biodegradable polymers including carbonate or dioxanone linkages. |
| AU5902398A (en) | 1996-12-31 | 1998-07-31 | Human Genome Sciences, Inc. | Cortistatin polypeptides |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| US6632457B1 (en) | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
| US6667299B1 (en) | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
| US20030060425A1 (en) | 1998-11-24 | 2003-03-27 | Ahlem Clarence N. | Immune modulation method using steroid compounds |
| US6291516B1 (en) | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
| BR0010197A (pt) | 1999-04-30 | 2002-07-16 | Arch Dev Corp | Derivados de esteróides |
| WO2001023405A2 (en) | 1999-09-30 | 2001-04-05 | Hollis-Eden Pharmaceuticals, Inc. | Therapeutic treatment of androgen receptor driven conditions |
| EP1235851B1 (en) | 1999-10-13 | 2006-05-31 | Johns Hopkins University School of Medicine | Regulators of the hedgehog pathway, compositions and uses related thereto |
| WO2001030802A2 (en) | 1999-10-25 | 2001-05-03 | Hollis-Eden Pharmaceuticals, Inc. | Therapeutic treatments comprising administration of certain steroids for blood cell deficiencies |
| CN1827621A (zh) * | 2000-03-31 | 2006-09-06 | 萨诺化学药物股份公司 | 雪花胺的新衍生物和类似物 |
| EP1392262A1 (en) | 2001-05-24 | 2004-03-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| ITMI20011445A1 (it) | 2001-07-06 | 2003-01-06 | Europ Geie | Analoghi della cortistantina capaci di legarsi selettivamente ai recettori dei secretagoghi dell'ormone della crescita |
| US20030187076A1 (en) | 2002-01-30 | 2003-10-02 | Agoston Gregory E. | Non-steroidal analogs of 2-methoxyestradiol |
| DE60327946D1 (de) | 2002-12-24 | 2009-07-23 | Univ British Columbia | Angiogen-wirkende trisulfat steroide und deren verwendung |
| BRPI0408703A (pt) | 2003-03-24 | 2006-03-07 | Sterix Ltd | derivados de estrogênio como inibidores da esteróide sulfatase |
| JP2006526025A (ja) | 2003-05-28 | 2006-11-16 | エントレメッド インコーポレイテッド | 抗血管新生剤 |
| JP4538455B2 (ja) * | 2003-07-24 | 2010-09-08 | メルク・シャープ・エンド・ドーム・コーポレイション | 抗生物質化合物 |
| US20070004689A1 (en) | 2004-03-12 | 2007-01-04 | Agoston Gregory E | Antiangiogenic agents |
| GB0421106D0 (en) | 2004-09-22 | 2004-10-27 | Sterix Ltd | Compound |
| PT2206719E (pt) | 2005-03-02 | 2015-02-05 | Univ Maryland | Composição farmacêutica compreendendo 3-beta-hidroxi-17- (1-h-benzimidazol-1-il)androsta-5,16-dieno |
| EP1971618A2 (en) | 2006-01-09 | 2008-09-24 | Btg International Limited | Modulators of hypoxia inducible factor-1 and related uses |
| WO2007082980A1 (es) | 2006-01-23 | 2007-07-26 | Consejo Superior De Investigaciones Científicas | Composiciones y procedimientos para tratar trastornos inflamatorios e inmunitarios con cortistatina |
| WO2007103162A2 (en) | 2006-03-01 | 2007-09-13 | Samaritan Pharmaceuticals, Inc. | Structure based drug design of steroidogenesis inhibitors |
| EA200870521A1 (ru) * | 2006-05-09 | 2009-04-28 | Мерк Энд Ко., Инк. | Замещенные спироциклические антагонисты cgrp-рецепторов |
| EP1870405A1 (en) * | 2006-06-22 | 2007-12-26 | Bioprojet | Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands |
| WO2008064425A1 (en) | 2006-11-30 | 2008-06-05 | Solbec Pharmaceuticals Limited | Glycoalkaloid and chemotherapeutic agent combinations and various uses thereof |
| ATE553105T1 (de) | 2006-12-22 | 2012-04-15 | Ind Res Ltd | Azetidin-analoge ais nucleosidase- und phosphorylase-hemmer |
| US7964590B2 (en) | 2007-03-07 | 2011-06-21 | Infinity Discovery, Inc. | Cyclopamine lactam analogs and methods of use thereof |
| US8604004B2 (en) * | 2007-10-04 | 2013-12-10 | President And Fellows Of Harvard College | Moenomycin analogs, methods of synthesis, and uses thereof |
| EP2283159B1 (en) * | 2008-05-05 | 2013-10-09 | The Scripps Research Institute | Synthesis of (+) cortistatin a and related compounds |
| WO2010024930A2 (en) * | 2008-08-28 | 2010-03-04 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses therof |
| US20120190659A1 (en) | 2009-04-22 | 2012-07-26 | Children's Medical Center Corporation | Angiogenesis inhibitors |
| US8598344B2 (en) | 2009-11-30 | 2013-12-03 | Senex Biotechnology | CDKI pathway inhibitors and uses thereof |
| CN103003281A (zh) | 2010-05-20 | 2013-03-27 | 弗·哈夫曼-拉罗切有限公司 | 作为JAK和SYK抑制剂的吡咯并[2，3-b]吡嗪-7-甲酰胺衍生物和它们的用途 |
| JP5614858B2 (ja) | 2010-09-17 | 2014-10-29 | 国立大学法人大阪大学 | 新規コルチスタチンａ類似体およびその用途 |
| EP2663574A4 (en) | 2011-01-10 | 2014-12-17 | Scripps Research Inst | RETRO VIRUS REPLICATION INHIBITORS |
| KR20150023223A (ko) | 2012-02-02 | 2015-03-05 | 세넥스 바이오테크놀러지 인코포레이티드 | Ｃｄｋ8/ｃｄｋ19 선택성 억제제 및 암에 대한 항-전이 및 화학예방 방법에서 이들의 용도 |
| WO2013122609A1 (en) | 2012-02-17 | 2013-08-22 | Genentech, Inc. | Methods of using cdk8 antagonists |
| WO2014123900A1 (en) | 2013-02-05 | 2014-08-14 | Sirenas Marine Discovery | Anti-cancer and anti-hiv compounds |
| US20160000787A1 (en) | 2013-02-26 | 2016-01-07 | Senex Biotechnology, Inc. | Inhibitors of cdk8/19 for use in treating estrogen receptor positive breast cancer |
| EP3007686A4 (en) | 2013-06-10 | 2017-03-15 | Yeda Research and Development Co., Ltd. | Compositions and methods for treating a hematological malignancy associated with an altered runx1 activity or expression |
| PL3046933T3 (pl) | 2013-09-18 | 2019-08-30 | Bcn Peptides, S.A. | Analogi kortystatyny do leczenia chorób zapalnych i/lub immunologicznych |
| KR20160101162A (ko) | 2013-12-24 | 2016-08-24 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 코르티스타틴 유사체 및 그의 합성 및 용도 |
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