EA200870521A1 - Замещенные спироциклические антагонисты cgrp-рецепторов - Google Patents

Замещенные спироциклические антагонисты cgrp-рецепторов

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Publication number
EA200870521A1
EA200870521A1 EA200870521A EA200870521A EA200870521A1 EA 200870521 A1 EA200870521 A1 EA 200870521A1 EA 200870521 A EA200870521 A EA 200870521A EA 200870521 A EA200870521 A EA 200870521A EA 200870521 A1 EA200870521 A1 EA 200870521A1
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EA
Eurasian Patent Office
Prior art keywords
antagonists
cgrp receptors
cgrp
substituted spirocyclic
compounds
Prior art date
Application number
EA200870521A
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English (en)
Inventor
Майкл Р. Вуд
Ян М. Белл
Стивен Н. Галликкио
Харольд Дж. Селник
Крейг А. Стамп
С. Блэйр Зартман
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA200870521A1 publication Critical patent/EA200870521A1/ru

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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

Соединения формулы Iв которой переменные А, А, А, А, М, N, J, Q, R, E, E, E, R, R, R, R, Rи Y принимают значения, описанные в настоящей работе, которые являются антагонистами CGRP-рецепторов и которые применимы в лечении или профилактике заболеваний, таких как мигрень, в которые включен CGRP. Изобретение также относится к фармацевтическим композициям, содержащим данные соединения, и к применению данных соединений и композиций в профилактике или лечении таких заболеваний, в которые включен CGRP.
EA200870521A 2006-05-09 2007-05-04 Замещенные спироциклические антагонисты cgrp-рецепторов EA200870521A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79907106P 2006-05-09 2006-05-09
PCT/US2007/010952 WO2007133491A1 (en) 2006-05-09 2007-05-04 Substituted spirocyclic cgrp receptor antagonists

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EA200870521A1 true EA200870521A1 (ru) 2009-04-28

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US (3) US7629338B2 (ru)
EP (2) EP2024358B1 (ru)
JP (2) JP4435288B2 (ru)
KR (1) KR20090018107A (ru)
CN (1) CN101443323A (ru)
AR (1) AR060872A1 (ru)
AU (1) AU2007284994B2 (ru)
BR (1) BRPI0711352A2 (ru)
CA (1) CA2650932C (ru)
CR (1) CR10415A (ru)
DO (1) DOP2007000093A (ru)
EA (1) EA200870521A1 (ru)
EC (1) ECSP088872A (ru)
GE (1) GEP20115140B (ru)
HN (1) HN2008001667A (ru)
IL (1) IL195110A0 (ru)
MA (1) MA30558B1 (ru)
MX (1) MX2008014353A (ru)
NO (1) NO20085110L (ru)
PE (1) PE20080253A1 (ru)
TW (1) TW200813008A (ru)
WO (2) WO2007133491A1 (ru)
ZA (1) ZA200809275B (ru)

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KR20090018107A (ko) 2009-02-19
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