JP2017508763A5

JP2017508763A5 -

Download PDF

Info

Publication number: JP2017508763A5
Authority: JP; Japan
Prior art keywords: pyridin; carboxamide; indazole; ylmethyl; piperidin
Prior art date: 2015-03-20
Legal status : Granted

Application number

JP2016558073A

Other languages

English (en)

Japanese (ja)

Other versions

JP6586104B2 (ja

JP2017508763A (ja

Filing date

2015-03-20

Publication date

2018-05-10

2015-03-20 Application filed filed Critical

2015-03-20 Priority claimed from PCT/US2015/021847 external-priority patent/WO2015143380A1/en

2017-03-30 Publication of JP2017508763A publication Critical patent/JP2017508763A/ja

2018-05-10 Publication of JP2017508763A5 publication Critical patent/JP2017508763A5/ja

2019-10-02 Application granted granted Critical

2019-10-02 Publication of JP6586104B2 publication Critical patent/JP6586104B2/ja

Status Active legal-status Critical Current

2035-03-20 Anticipated expiration legal-status Critical

Links

125000000217 alkyl group Chemical group 0.000 claims description 367
-1 40 Chemical compound 0.000 claims description 166
125000001424 substituent group Chemical group 0.000 claims description 158
150000004820 halides Chemical class 0.000 claims description 146
125000000623 heterocyclic group Chemical group 0.000 claims description 142
125000003118 aryl group Chemical group 0.000 claims description 94
150000001875 compounds Chemical class 0.000 claims description 67
MUJCJYXCJZCTGK-YLJYHZDGSA-N O=C(N[C@@H]1C[C@@H]1C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(N[C@@H]1C[C@@H]1C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 MUJCJYXCJZCTGK-YLJYHZDGSA-N 0.000 claims description 53
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 43
229910052757 nitrogen Inorganic materials 0.000 claims description 42
BZOFNZCOJLNGRM-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2(CC2)C2=CC=CC=C2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2(CC2)C2=CC=CC=C2)C=C1 BZOFNZCOJLNGRM-UHFFFAOYSA-N 0.000 claims description 40
URLNZXIOSFZUTM-UHFFFAOYSA-N FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=NC=C1 Chemical compound FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=NC=C1 URLNZXIOSFZUTM-UHFFFAOYSA-N 0.000 claims description 40
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 32
125000004452 carbocyclyl group Chemical group 0.000 claims description 32
150000003839 salts Chemical class 0.000 claims description 29
KDILLWUWCNHGSF-UHFFFAOYSA-N FC1=CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CC(CN3CCCCC3)=C2)=CC(F)=C1 Chemical compound FC1=CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CC(CN3CCCCC3)=C2)=CC(F)=C1 KDILLWUWCNHGSF-UHFFFAOYSA-N 0.000 claims description 28
ZGKMMVQSJWEOIZ-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3(CC3)C3=CC=CC=C3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3(CC3)C3=CC=CC=C3)C=C2)C1 ZGKMMVQSJWEOIZ-UHFFFAOYSA-N 0.000 claims description 26
125000001072 heteroaryl group Chemical group 0.000 claims description 26
125000004433 nitrogen atom Chemical group N* 0.000 claims description 26
GUZUCDBAKLABBD-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 GUZUCDBAKLABBD-UHFFFAOYSA-N 0.000 claims description 25
125000001188 haloalkyl group Chemical group 0.000 claims description 23
201000010099 disease Diseases 0.000 claims description 22
208000035475 disorder Diseases 0.000 claims description 21
JPDZJTQRSPOKQM-UHFFFAOYSA-N FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=C1 Chemical compound FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=C1 JPDZJTQRSPOKQM-UHFFFAOYSA-N 0.000 claims description 20
NCWBNLBKELXOEL-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 NCWBNLBKELXOEL-UHFFFAOYSA-N 0.000 claims description 18
LWORCKLPWZUFBJ-UHFFFAOYSA-N FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=N1 Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=N1 LWORCKLPWZUFBJ-UHFFFAOYSA-N 0.000 claims description 18
RYEMGJTVUIUMJV-UHFFFAOYSA-N FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=NC=C1 Chemical compound FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=NC=C1 RYEMGJTVUIUMJV-UHFFFAOYSA-N 0.000 claims description 16
QBICVULYPZHONS-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 QBICVULYPZHONS-UHFFFAOYSA-N 0.000 claims description 16
NCGCGIIOFAPBDI-UHFFFAOYSA-N O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 NCGCGIIOFAPBDI-UHFFFAOYSA-N 0.000 claims description 16
OUIZONDSSAUAJU-UHFFFAOYSA-N O=C(NC1CC2=CC=CC=C2C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1CC2=CC=CC=C2C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 OUIZONDSSAUAJU-UHFFFAOYSA-N 0.000 claims description 15
VKCGOSIANKZDIT-UHFFFAOYSA-N O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 VKCGOSIANKZDIT-UHFFFAOYSA-N 0.000 claims description 13
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
125000004076 pyridyl group Chemical group 0.000 claims description 13
LIXXQBRPVXEVJX-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 LIXXQBRPVXEVJX-UHFFFAOYSA-N 0.000 claims description 12
SRHQFOACTVSFJA-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 SRHQFOACTVSFJA-UHFFFAOYSA-N 0.000 claims description 12
125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 12
USOXYAQJCZZVAQ-UHFFFAOYSA-N O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 USOXYAQJCZZVAQ-UHFFFAOYSA-N 0.000 claims description 11
RLDCHLUXJJZGRL-UHFFFAOYSA-N O=C(NCC1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NCC1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 RLDCHLUXJJZGRL-UHFFFAOYSA-N 0.000 claims description 11
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 10
BLBHPRNNBWUXDY-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 BLBHPRNNBWUXDY-UHFFFAOYSA-N 0.000 claims description 10
KNUGXANPSAQNIA-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1)C1=CC2=C(NN=C2C(=O)NCC2=CC=CC=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1)C1=CC2=C(NN=C2C(=O)NCC2=CC=CC=C2)C=C1 KNUGXANPSAQNIA-UHFFFAOYSA-N 0.000 claims description 10
150000003857 carboxamides Chemical class 0.000 claims description 10
HVEOEVJLUUUHNZ-UHFFFAOYSA-N n-(6-methylpyridin-3-yl)-5-[5-(piperidin-1-ylmethyl)pyridin-3-yl]-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCCCC4)C=NC=3)C=C12 HVEOEVJLUUUHNZ-UHFFFAOYSA-N 0.000 claims description 10
208000011580 syndromic disease Diseases 0.000 claims description 10
UCJFPXRSZDIJPE-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 UCJFPXRSZDIJPE-UHFFFAOYSA-N 0.000 claims description 9
VNXYNYHNKWUMLG-UHFFFAOYSA-N FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 VNXYNYHNKWUMLG-UHFFFAOYSA-N 0.000 claims description 9
SDOXZUGKXVSGGJ-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 SDOXZUGKXVSGGJ-UHFFFAOYSA-N 0.000 claims description 8
MYDOXARYEAYOHH-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 MYDOXARYEAYOHH-UHFFFAOYSA-N 0.000 claims description 8
OEWXJJCRHMIMJU-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CC(C)OC(C)C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CC(C)OC(C)C3)C=C2)CC1 OEWXJJCRHMIMJU-UHFFFAOYSA-N 0.000 claims description 8
KAVIAEXRPPAATG-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CC(F)(F)C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CC(F)(F)C3)C=C2)CC1 KAVIAEXRPPAATG-UHFFFAOYSA-N 0.000 claims description 8
OLUJPDZZXTUOGS-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=CN=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=CN=C3)C=C2)CC1 OLUJPDZZXTUOGS-UHFFFAOYSA-N 0.000 claims description 8
CWXRJUVPRBIFKN-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=CC=N3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=CC=N3)C=C2)CC1 CWXRJUVPRBIFKN-UHFFFAOYSA-N 0.000 claims description 8
QUUXGLIVUHKJLP-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 QUUXGLIVUHKJLP-UHFFFAOYSA-N 0.000 claims description 8
JXGZVZLFUYPZAR-UHFFFAOYSA-N CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN(C)C)=CN=C1 Chemical compound CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN(C)C)=CN=C1 JXGZVZLFUYPZAR-UHFFFAOYSA-N 0.000 claims description 8
YZXXLFSAAVOZRA-UHFFFAOYSA-N CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 YZXXLFSAAVOZRA-UHFFFAOYSA-N 0.000 claims description 8
BHBJWRCDQKJPSL-UHFFFAOYSA-N CN(C)C1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CN(C)C1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 BHBJWRCDQKJPSL-UHFFFAOYSA-N 0.000 claims description 8
WIMYCASGDIOWFC-UHFFFAOYSA-N FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 WIMYCASGDIOWFC-UHFFFAOYSA-N 0.000 claims description 8
RSHDABJMFJXBBK-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CC(F)(F)C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CC(F)(F)C2)C=C1 RSHDABJMFJXBBK-UHFFFAOYSA-N 0.000 claims description 8
UNYXBLHNCQHRPP-UHFFFAOYSA-N FC1=CC=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1 Chemical compound FC1=CC=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1 UNYXBLHNCQHRPP-UHFFFAOYSA-N 0.000 claims description 8
KCLPWUAAAPKILZ-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCCN2CCOCC2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCCN2CCOCC2)C=C1 KCLPWUAAAPKILZ-UHFFFAOYSA-N 0.000 claims description 8
MWVGTXVDLVARER-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CC(F)(F)C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CC(F)(F)C3)C=C2)=C1F MWVGTXVDLVARER-UHFFFAOYSA-N 0.000 claims description 8
LAUKXIWSXLILRE-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=CN=C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=CN=C3)C=C2)=C1F LAUKXIWSXLILRE-UHFFFAOYSA-N 0.000 claims description 8
UGPDYOKDWDHLBN-UHFFFAOYSA-N FC1=CC=CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 Chemical compound FC1=CC=CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 UGPDYOKDWDHLBN-UHFFFAOYSA-N 0.000 claims description 8
ZWEIACXFHVQQEQ-UHFFFAOYSA-N NC1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound NC1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 ZWEIACXFHVQQEQ-UHFFFAOYSA-N 0.000 claims description 8
YSEQNIKAORZDRI-UHFFFAOYSA-N O=C(NC1(CC1)C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1(CC1)C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 YSEQNIKAORZDRI-UHFFFAOYSA-N 0.000 claims description 8
OVZFXVFQUYUBJI-UHFFFAOYSA-N O=C(NC1(CC1)C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1(CC1)C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 OVZFXVFQUYUBJI-UHFFFAOYSA-N 0.000 claims description 8
OMTXRDHFYZTTEY-UHFFFAOYSA-N O=C(NC1=CC=CN=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=CN=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 OMTXRDHFYZTTEY-UHFFFAOYSA-N 0.000 claims description 8
KMUJDVMSVNQUBP-UHFFFAOYSA-N O=C(NC1=CN=CC=N1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CN=CC=N1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 KMUJDVMSVNQUBP-UHFFFAOYSA-N 0.000 claims description 8
ARFXMLYKZKPYTI-UHFFFAOYSA-N O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 ARFXMLYKZKPYTI-UHFFFAOYSA-N 0.000 claims description 8
OKUXQHPECQJHNG-UHFFFAOYSA-N O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 OKUXQHPECQJHNG-UHFFFAOYSA-N 0.000 claims description 8
IRPXEKYAMSRCMG-ZEQKJWHPSA-N O=C(N[C@@H]1C[C@@H]1C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(N[C@@H]1C[C@@H]1C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 IRPXEKYAMSRCMG-ZEQKJWHPSA-N 0.000 claims description 8
RPSADMWPPVLGTD-UHFFFAOYSA-N 5-[5-(piperidin-1-ylmethyl)pyridin-3-yl]-n-pyridin-2-yl-1h-indazole-3-carboxamide Chemical compound N=1NC2=CC=C(C=3C=C(CN4CCCCC4)C=NC=3)C=C2C=1C(=O)NC1=CC=CC=N1 RPSADMWPPVLGTD-UHFFFAOYSA-N 0.000 claims description 7
NEERNGSOLFEXCN-UHFFFAOYSA-N 5-[5-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-n-(6-pyrrolidin-1-ylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound N=1NC2=CC=C(C=3C=C(CN4CCCC4)C=NC=3)C=C2C=1C(=O)NC(C=N1)=CC=C1N1CCCC1 NEERNGSOLFEXCN-UHFFFAOYSA-N 0.000 claims description 7
TUETZCWXDFRNEY-UHFFFAOYSA-N 5-[5-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-n-[6-(trifluoromethyl)pyridin-3-yl]-1h-indazole-3-carboxamide Chemical compound C1=NC(C(F)(F)F)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCCC4)C=NC=3)C=C12 TUETZCWXDFRNEY-UHFFFAOYSA-N 0.000 claims description 7
VEGYHVAUPWTKCC-UHFFFAOYSA-N 5-[5-[(3,3-difluoropyrrolidin-1-yl)methyl]pyridin-3-yl]-n-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1h-indazole-3-carboxamide Chemical compound C1CN(C)CCN1C(N=C1)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CC(F)(F)CC4)C=NC=3)C=C12 VEGYHVAUPWTKCC-UHFFFAOYSA-N 0.000 claims description 7
ARMUIKYDTPTDAW-UHFFFAOYSA-N FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 ARMUIKYDTPTDAW-UHFFFAOYSA-N 0.000 claims description 7
GZXWMRTVNRDJNF-UHFFFAOYSA-N FC1=CC=CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CC(CN3CCCCC3)=C2)=C1 Chemical compound FC1=CC=CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CC(CN3CCCCC3)=C2)=C1 GZXWMRTVNRDJNF-UHFFFAOYSA-N 0.000 claims description 7
NRFVLCTZCXBNIG-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C(F)=C1 NRFVLCTZCXBNIG-UHFFFAOYSA-N 0.000 claims description 7
OTWBLUXIJVJQNC-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C(F)=C1 OTWBLUXIJVJQNC-UHFFFAOYSA-N 0.000 claims description 7
DODFSQJMFJLPEW-UHFFFAOYSA-N O=C(NC1(CC1)C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound O=C(NC1(CC1)C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 DODFSQJMFJLPEW-UHFFFAOYSA-N 0.000 claims description 7
PMSDXFRJIMIWMZ-UHFFFAOYSA-N n-(6-methoxypyridin-3-yl)-5-[5-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-1h-indazole-3-carboxamide Chemical compound C1=NC(OC)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCCC4)C=NC=3)C=C12 PMSDXFRJIMIWMZ-UHFFFAOYSA-N 0.000 claims description 7
VORWFNXWMLLHEI-UHFFFAOYSA-N CC1=CC2=C(C=C1C1=CC=CN=C1)C(=NN2)C(=O)NC1=CC=CN=C1 Chemical compound CC1=CC2=C(C=C1C1=CC=CN=C1)C(=NN2)C(=O)NC1=CC=CN=C1 VORWFNXWMLLHEI-UHFFFAOYSA-N 0.000 claims description 6
GMMPRLWTNPBBCY-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC3=CC=CC=C3C2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC3=CC=CC=C3C2)C=C1 GMMPRLWTNPBBCY-UHFFFAOYSA-N 0.000 claims description 6
SMLKVNCBVUABFV-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=C(F)C=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=C(F)C=C1 SMLKVNCBVUABFV-UHFFFAOYSA-N 0.000 claims description 6
DWYKMSUUGHQKPQ-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CC=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CC=C1 DWYKMSUUGHQKPQ-UHFFFAOYSA-N 0.000 claims description 6
SLDVLHLDCYVDTB-UHFFFAOYSA-N FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 Chemical compound FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 SLDVLHLDCYVDTB-UHFFFAOYSA-N 0.000 claims description 6
YGXACIDLZGUBTN-UHFFFAOYSA-N FC1=CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=CC(F)=C1 Chemical compound FC1=CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=CC(F)=C1 YGXACIDLZGUBTN-UHFFFAOYSA-N 0.000 claims description 6
HZBCRDUGGADSGG-UHFFFAOYSA-N FC1=CC=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 Chemical compound FC1=CC=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 HZBCRDUGGADSGG-UHFFFAOYSA-N 0.000 claims description 6
NPNHUDVOPJLEFM-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=C1 NPNHUDVOPJLEFM-UHFFFAOYSA-N 0.000 claims description 6
XHMCMYNTRDDSMY-UHFFFAOYSA-N 5-[5-[(3,3-difluoropyrrolidin-1-yl)methyl]pyridin-3-yl]-n-(6-methoxypyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(OC)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CC(F)(F)CC4)C=NC=3)C=C12 XHMCMYNTRDDSMY-UHFFFAOYSA-N 0.000 claims description 5
QWXGMMPJHDIFKI-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 QWXGMMPJHDIFKI-UHFFFAOYSA-N 0.000 claims description 5
NQAZQSDSVHBMKZ-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C=C(F)C=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C=C(F)C=C1 NQAZQSDSVHBMKZ-UHFFFAOYSA-N 0.000 claims description 5
LWYFNNRUOAVPFZ-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C=CC=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C=CC=C1 LWYFNNRUOAVPFZ-UHFFFAOYSA-N 0.000 claims description 5
PUQSXBFMOGIPMY-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=C(F)C=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=C(F)C=C1 PUQSXBFMOGIPMY-UHFFFAOYSA-N 0.000 claims description 5
SGVLEUQXBQPXAA-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CC=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CC=C1 SGVLEUQXBQPXAA-UHFFFAOYSA-N 0.000 claims description 5
NIVZAXJUDFOQJX-UHFFFAOYSA-N FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=N1 Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=N1 NIVZAXJUDFOQJX-UHFFFAOYSA-N 0.000 claims description 5
206010028980 Neoplasm Diseases 0.000 claims description 5
CCYLLLQTWUAUOU-UHFFFAOYSA-N O=C(NC1=C2N=CC=CC2=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1=C2N=CC=CC2=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 CCYLLLQTWUAUOU-UHFFFAOYSA-N 0.000 claims description 5
FEWVDWKWQZYMEX-UHFFFAOYSA-N O=C(NC1CC2=CC=CC=C2C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1CC2=CC=CC=C2C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 FEWVDWKWQZYMEX-UHFFFAOYSA-N 0.000 claims description 5
201000011510 cancer Diseases 0.000 claims description 5
208000005069 pulmonary fibrosis Diseases 0.000 claims description 5
UWUHPYCTLHCZEH-UHFFFAOYSA-N 1-(oxan-4-yl)indazole-3-carboxamide Chemical compound O1CCC(CC1)N1N=C(C2=CC=CC=C12)C(=O)N UWUHPYCTLHCZEH-UHFFFAOYSA-N 0.000 claims description 4
OWSOXLZFQAXWLF-UHFFFAOYSA-N 5-(5-aminopyridin-3-yl)-n-(2-methylpyrimidin-5-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(N)C=NC=3)C=C12 OWSOXLZFQAXWLF-UHFFFAOYSA-N 0.000 claims description 4
XRNFQTGLTIXHIQ-UHFFFAOYSA-N 5-(5-aminopyridin-3-yl)-n-(6-methylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(N)C=NC=3)C=C12 XRNFQTGLTIXHIQ-UHFFFAOYSA-N 0.000 claims description 4
GNFBTHXUVNUULM-UHFFFAOYSA-N 5-(5-aminopyridin-3-yl)-n-pyridin-2-yl-1h-indazole-3-carboxamide Chemical compound NC1=CN=CC(C=2C=C3C(C(=O)NC=4N=CC=CC=4)=NNC3=CC=2)=C1 GNFBTHXUVNUULM-UHFFFAOYSA-N 0.000 claims description 4
DWMXJDPAXCQIRJ-UHFFFAOYSA-N 5-(5-morpholin-4-ylpyridin-3-yl)-n-pyridin-2-yl-1h-indazole-3-carboxamide Chemical compound N=1NC2=CC=C(C=3C=C(C=NC=3)N3CCOCC3)C=C2C=1C(=O)NC1=CC=CC=N1 DWMXJDPAXCQIRJ-UHFFFAOYSA-N 0.000 claims description 4
HXLYMJAGYUSYFL-UHFFFAOYSA-N 5-(5-phenoxypyridin-3-yl)-n-pyridin-2-yl-1h-indazole-3-carboxamide Chemical compound N=1NC2=CC=C(C=3C=C(OC=4C=CC=CC=4)C=NC=3)C=C2C=1C(=O)NC1=CC=CC=N1 HXLYMJAGYUSYFL-UHFFFAOYSA-N 0.000 claims description 4
BAXVMXYMKQSHPM-UHFFFAOYSA-N 5-(5-piperidin-1-ylpyridin-3-yl)-n-pyridin-2-yl-1h-indazole-3-carboxamide Chemical compound N=1NC2=CC=C(C=3C=C(C=NC=3)N3CCCCC3)C=C2C=1C(=O)NC1=CC=CC=N1 BAXVMXYMKQSHPM-UHFFFAOYSA-N 0.000 claims description 4
AYAAZBXKVNQTME-UHFFFAOYSA-N 5-[5-(azetidin-1-ylmethyl)pyridin-3-yl]-n-(2-methylpyrimidin-5-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCC4)C=NC=3)C=C12 AYAAZBXKVNQTME-UHFFFAOYSA-N 0.000 claims description 4
PXMPTLNQZWQQHN-UHFFFAOYSA-N 5-[5-(azetidin-1-ylmethyl)pyridin-3-yl]-n-(6-methylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCC4)C=NC=3)C=C12 PXMPTLNQZWQQHN-UHFFFAOYSA-N 0.000 claims description 4
DJVMQFOBIYJRKD-UHFFFAOYSA-N 5-[5-(azetidin-1-ylmethyl)pyridin-3-yl]-n-pyridin-2-yl-1h-indazole-3-carboxamide Chemical compound N=1NC2=CC=C(C=3C=C(CN4CCC4)C=NC=3)C=C2C=1C(=O)NC1=CC=CC=N1 DJVMQFOBIYJRKD-UHFFFAOYSA-N 0.000 claims description 4
LAFITLUBADHXHM-UHFFFAOYSA-N 5-[5-(cyclopropanecarbonylamino)pyridin-3-yl]-n-(2-methylpyrimidin-5-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(NC(=O)C4CC4)C=NC=3)C=C12 LAFITLUBADHXHM-UHFFFAOYSA-N 0.000 claims description 4
LAVKVYQMTOLPMM-UHFFFAOYSA-N 5-[5-(cyclopropanecarbonylamino)pyridin-3-yl]-n-(6-methylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(NC(=O)C4CC4)C=NC=3)C=C12 LAVKVYQMTOLPMM-UHFFFAOYSA-N 0.000 claims description 4
RDQCQZIEYWKSOP-UHFFFAOYSA-N 5-[5-(cyclopropanecarbonylamino)pyridin-3-yl]-n-[6-(trifluoromethyl)pyridin-3-yl]-1h-indazole-3-carboxamide Chemical compound C1=NC(C(F)(F)F)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(NC(=O)C4CC4)C=NC=3)C=C12 RDQCQZIEYWKSOP-UHFFFAOYSA-N 0.000 claims description 4
JPPUGRNZEJVXQS-UHFFFAOYSA-N 5-[5-(cyclopropanecarbonylamino)pyridin-3-yl]-n-pyridin-2-yl-1h-indazole-3-carboxamide Chemical compound C1CC1C(=O)NC(C=1)=CN=CC=1C(C=C12)=CC=C1NN=C2C(=O)NC1=CC=CC=N1 JPPUGRNZEJVXQS-UHFFFAOYSA-N 0.000 claims description 4
VAILTCDUBGYSLS-UHFFFAOYSA-N 5-[5-(dimethylcarbamoylamino)pyridin-3-yl]-n-(2-methylpyrimidin-5-yl)-1h-indazole-3-carboxamide Chemical compound CN(C)C(=O)NC1=CN=CC(C=2C=C3C(C(=O)NC=4C=NC(C)=NC=4)=NNC3=CC=2)=C1 VAILTCDUBGYSLS-UHFFFAOYSA-N 0.000 claims description 4
OPUIVBXHWWEXKD-UHFFFAOYSA-N 5-[5-(dimethylcarbamoylamino)pyridin-3-yl]-n-(6-methylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound CN(C)C(=O)NC1=CN=CC(C=2C=C3C(C(=O)NC=4C=NC(C)=CC=4)=NNC3=CC=2)=C1 OPUIVBXHWWEXKD-UHFFFAOYSA-N 0.000 claims description 4
ZSVHAINLGJUTAH-UHFFFAOYSA-N 5-[5-(morpholin-4-ylmethyl)pyridin-3-yl]-n-pyridin-2-yl-1h-indazole-3-carboxamide Chemical compound N=1NC2=CC=C(C=3C=C(CN4CCOCC4)C=NC=3)C=C2C=1C(=O)NC1=CC=CC=N1 ZSVHAINLGJUTAH-UHFFFAOYSA-N 0.000 claims description 4
ITTMPPCRQVMYHI-UHFFFAOYSA-N 5-[5-[(3,3-difluoropyrrolidin-1-yl)methyl]pyridin-3-yl]-n-(2-methylpyrimidin-5-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CC(F)(F)CC4)C=NC=3)C=C12 ITTMPPCRQVMYHI-UHFFFAOYSA-N 0.000 claims description 4
KGDFIUFWGGCFBB-UHFFFAOYSA-N 5-[5-[(3,3-difluoropyrrolidin-1-yl)methyl]pyridin-3-yl]-n-(6-methylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CC(F)(F)CC4)C=NC=3)C=C12 KGDFIUFWGGCFBB-UHFFFAOYSA-N 0.000 claims description 4
DQBAZKSUCMSPMA-UHFFFAOYSA-N 5-[5-[(3,3-difluoropyrrolidin-1-yl)methyl]pyridin-3-yl]-n-pyridin-2-yl-1h-indazole-3-carboxamide Chemical compound C1C(F)(F)CCN1CC1=CN=CC(C=2C=C3C(C(=O)NC=4N=CC=CC=4)=NNC3=CC=2)=C1 DQBAZKSUCMSPMA-UHFFFAOYSA-N 0.000 claims description 4
PHYAYDPTOYJLDY-UHFFFAOYSA-N 5-[5-[(4,4-difluoropiperidin-1-yl)methyl]pyridin-3-yl]-n-(2-methylpyrimidin-5-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCC(F)(F)CC4)C=NC=3)C=C12 PHYAYDPTOYJLDY-UHFFFAOYSA-N 0.000 claims description 4
YXMQIIRQPPCTNZ-UHFFFAOYSA-N 5-[5-[(4,4-difluoropiperidin-1-yl)methyl]pyridin-3-yl]-n-(6-methylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCC(F)(F)CC4)C=NC=3)C=C12 YXMQIIRQPPCTNZ-UHFFFAOYSA-N 0.000 claims description 4
HLBJSIOTVOWKSO-UHFFFAOYSA-N 5-[5-[(4,4-difluoropiperidin-1-yl)methyl]pyridin-3-yl]-n-pyridin-2-yl-1h-indazole-3-carboxamide Chemical compound C1CC(F)(F)CCN1CC1=CN=CC(C=2C=C3C(C(=O)NC=4N=CC=CC=4)=NNC3=CC=2)=C1 HLBJSIOTVOWKSO-UHFFFAOYSA-N 0.000 claims description 4
SSNAIPSBYKYXJI-UHFFFAOYSA-N 5-[5-[(4-hydroxypiperidin-1-yl)methyl]pyridin-3-yl]-n-(2-methylpyrimidin-5-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCC(O)CC4)C=NC=3)C=C12 SSNAIPSBYKYXJI-UHFFFAOYSA-N 0.000 claims description 4
DVHDDZJLZBVXLU-UHFFFAOYSA-N 5-[5-[(4-hydroxypiperidin-1-yl)methyl]pyridin-3-yl]-n-(6-methylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCC(O)CC4)C=NC=3)C=C12 DVHDDZJLZBVXLU-UHFFFAOYSA-N 0.000 claims description 4
PYCZOPLWZSTCQW-UHFFFAOYSA-N 5-[5-[(4-hydroxypiperidin-1-yl)methyl]pyridin-3-yl]-n-pyridin-2-yl-1h-indazole-3-carboxamide Chemical compound C1CC(O)CCN1CC1=CN=CC(C=2C=C3C(C(=O)NC=4N=CC=CC=4)=NNC3=CC=2)=C1 PYCZOPLWZSTCQW-UHFFFAOYSA-N 0.000 claims description 4
QRGUOSLWSWHNRC-UHFFFAOYSA-N 5-[5-[(dimethylamino)methyl]pyridin-3-yl]-n-(2-methylpyrimidin-5-yl)-1h-indazole-3-carboxamide Chemical compound CN(C)CC1=CN=CC(C=2C=C3C(C(=O)NC=4C=NC(C)=NC=4)=NNC3=CC=2)=C1 QRGUOSLWSWHNRC-UHFFFAOYSA-N 0.000 claims description 4
DIRYEPHKEZGHPA-UHFFFAOYSA-N 5-[5-[(dimethylamino)methyl]pyridin-3-yl]-n-(5-methylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound CN(C)CC1=CN=CC(C=2C=C3C(C(=O)NC=4C=C(C)C=NC=4)=NNC3=CC=2)=C1 DIRYEPHKEZGHPA-UHFFFAOYSA-N 0.000 claims description 4
USZSJQDQULHUNG-UHFFFAOYSA-N 5-[5-[(dimethylamino)methyl]pyridin-3-yl]-n-(6-methylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound CN(C)CC1=CN=CC(C=2C=C3C(C(=O)NC=4C=NC(C)=CC=4)=NNC3=CC=2)=C1 USZSJQDQULHUNG-UHFFFAOYSA-N 0.000 claims description 4
JECWYTVKFCQFHV-UHFFFAOYSA-N 5-[5-[(dimethylamino)methyl]pyridin-3-yl]-n-pyridin-2-yl-1h-indazole-3-carboxamide Chemical compound CN(C)CC1=CN=CC(C=2C=C3C(C(=O)NC=4N=CC=CC=4)=NNC3=CC=2)=C1 JECWYTVKFCQFHV-UHFFFAOYSA-N 0.000 claims description 4
WCYCBJIZCBZEQD-UHFFFAOYSA-N 5-pyridin-3-yl-n-[4-(pyrrolidin-1-ylmethyl)phenyl]-1h-indazole-3-carboxamide Chemical compound N=1NC2=CC=C(C=3C=NC=CC=3)C=C2C=1C(=O)NC(C=C1)=CC=C1CN1CCCC1 WCYCBJIZCBZEQD-UHFFFAOYSA-N 0.000 claims description 4
OLMDVYFVQFYWFE-UHFFFAOYSA-N C12CN(CC(O1)C2)CC=2C=C(C=NC2)C=2C=C1C(=NNC1=CC2)C(=O)NC=2C=NC(=CC2)OC(C)C Chemical compound C12CN(CC(O1)C2)CC=2C=C(C=NC2)C=2C=C1C(=NNC1=CC2)C(=O)NC=2C=NC(=CC2)OC(C)C OLMDVYFVQFYWFE-UHFFFAOYSA-N 0.000 claims description 4
SZBCOWYOKDHMCB-UHFFFAOYSA-N C12CN(CC(O1)C2)CC=2C=C(C=NC2)C=2C=C1C(=NNC1=CC2)C(=O)NC=2C=NC=CC2 Chemical compound C12CN(CC(O1)C2)CC=2C=C(C=NC2)C=2C=C1C(=NNC1=CC2)C(=O)NC=2C=NC=CC2 SZBCOWYOKDHMCB-UHFFFAOYSA-N 0.000 claims description 4
WKZJRKLOHBAPEB-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 WKZJRKLOHBAPEB-UHFFFAOYSA-N 0.000 claims description 4
HBAFPWSGBGSQQB-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 HBAFPWSGBGSQQB-UHFFFAOYSA-N 0.000 claims description 4
CBLMLBIQEITWFU-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 CBLMLBIQEITWFU-UHFFFAOYSA-N 0.000 claims description 4
QUWHRHPZJKFLKS-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(C)CC2)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(C)CC2)=CN=C1 QUWHRHPZJKFLKS-UHFFFAOYSA-N 0.000 claims description 4
XHJMZSMMZDWEHN-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 XHJMZSMMZDWEHN-UHFFFAOYSA-N 0.000 claims description 4
ZRLPBAMXGGHKMV-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 ZRLPBAMXGGHKMV-UHFFFAOYSA-N 0.000 claims description 4
QPAMOYKMVDWVJA-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 QPAMOYKMVDWVJA-UHFFFAOYSA-N 0.000 claims description 4
BETQRCGBNKLSJQ-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 BETQRCGBNKLSJQ-UHFFFAOYSA-N 0.000 claims description 4
QKURDZWSVAXWKQ-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 QKURDZWSVAXWKQ-UHFFFAOYSA-N 0.000 claims description 4
ZRHVZZJOFODMRU-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 ZRHVZZJOFODMRU-UHFFFAOYSA-N 0.000 claims description 4
HSURFFDDNKMOLS-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)N(C)C)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)N(C)C)=CN=C1 HSURFFDDNKMOLS-UHFFFAOYSA-N 0.000 claims description 4
BVLMXFHDJXIMSJ-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 BVLMXFHDJXIMSJ-UHFFFAOYSA-N 0.000 claims description 4
ZHNFDSFMAHLHLU-UHFFFAOYSA-N CC(=O)N1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CC(=O)N1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 ZHNFDSFMAHLHLU-UHFFFAOYSA-N 0.000 claims description 4
SAHAWXIZDZWZFT-UHFFFAOYSA-N CC(=O)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CC(=O)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 SAHAWXIZDZWZFT-UHFFFAOYSA-N 0.000 claims description 4
NJIXDCQZJYMJGB-UHFFFAOYSA-N CC(C)(C)C(=O)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CC(C)(C)C(=O)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 NJIXDCQZJYMJGB-UHFFFAOYSA-N 0.000 claims description 4
ODRMQYQPPFLLRU-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC=CN=C1 ODRMQYQPPFLLRU-UHFFFAOYSA-N 0.000 claims description 4
TXAQSFHIFGHGAJ-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 TXAQSFHIFGHGAJ-UHFFFAOYSA-N 0.000 claims description 4
NHVPPHXSKQJPFV-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 NHVPPHXSKQJPFV-UHFFFAOYSA-N 0.000 claims description 4
FSJVTZIXFKXKDA-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 FSJVTZIXFKXKDA-UHFFFAOYSA-N 0.000 claims description 4
MVXLQCUGYBWFGH-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 MVXLQCUGYBWFGH-UHFFFAOYSA-N 0.000 claims description 4
KTOLUAQAKLZLGP-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 KTOLUAQAKLZLGP-UHFFFAOYSA-N 0.000 claims description 4
MCPPGTULWVUVPD-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 MCPPGTULWVUVPD-UHFFFAOYSA-N 0.000 claims description 4
ROTJULNLBCEZMM-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 ROTJULNLBCEZMM-UHFFFAOYSA-N 0.000 claims description 4
GBUDUNJYGNNKIX-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 GBUDUNJYGNNKIX-UHFFFAOYSA-N 0.000 claims description 4
YPDNNZRHURJCOQ-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 YPDNNZRHURJCOQ-UHFFFAOYSA-N 0.000 claims description 4
NMEVBJIXVCIVPV-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 NMEVBJIXVCIVPV-UHFFFAOYSA-N 0.000 claims description 4
DKUXFWQRZHFUQF-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 DKUXFWQRZHFUQF-UHFFFAOYSA-N 0.000 claims description 4
IMDSNXVQPTWDMM-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 IMDSNXVQPTWDMM-UHFFFAOYSA-N 0.000 claims description 4
BQABOEZZLWAGSL-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 BQABOEZZLWAGSL-UHFFFAOYSA-N 0.000 claims description 4
VFANXNUNQJUOCB-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 VFANXNUNQJUOCB-UHFFFAOYSA-N 0.000 claims description 4
AYGASLMVYUTBED-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 AYGASLMVYUTBED-UHFFFAOYSA-N 0.000 claims description 4
DBWCPOHRGAIXOA-UHFFFAOYSA-N CC(C)(C)N1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC(C)(C)N1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 DBWCPOHRGAIXOA-UHFFFAOYSA-N 0.000 claims description 4
QLBDUPIFOJJAEA-UHFFFAOYSA-N CC(C)(C)N1CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 Chemical compound CC(C)(C)N1CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 QLBDUPIFOJJAEA-UHFFFAOYSA-N 0.000 claims description 4
OYWYWLFNRSQGNH-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC=CN=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC=CN=C1 OYWYWLFNRSQGNH-UHFFFAOYSA-N 0.000 claims description 4
JKQMANNQASUSNW-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 JKQMANNQASUSNW-UHFFFAOYSA-N 0.000 claims description 4
CLJHCSDQKWRYNU-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 CLJHCSDQKWRYNU-UHFFFAOYSA-N 0.000 claims description 4
OPJKNQBMNGEHSM-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 OPJKNQBMNGEHSM-UHFFFAOYSA-N 0.000 claims description 4
UJBNTVICOLWBOT-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 UJBNTVICOLWBOT-UHFFFAOYSA-N 0.000 claims description 4
NINFMZGJKNELSD-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 NINFMZGJKNELSD-UHFFFAOYSA-N 0.000 claims description 4
DYEDTEKNDDTOST-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 DYEDTEKNDDTOST-UHFFFAOYSA-N 0.000 claims description 4
CJYONPQUVJTMSW-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 CJYONPQUVJTMSW-UHFFFAOYSA-N 0.000 claims description 4
RUWFAHOLUWZAJG-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 RUWFAHOLUWZAJG-UHFFFAOYSA-N 0.000 claims description 4
FROCSKYKDCOVPO-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 FROCSKYKDCOVPO-UHFFFAOYSA-N 0.000 claims description 4
SENGVMZFMXHWBL-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 SENGVMZFMXHWBL-UHFFFAOYSA-N 0.000 claims description 4
NTXDCIXMPXQGHT-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 NTXDCIXMPXQGHT-UHFFFAOYSA-N 0.000 claims description 4
VAHYTRPVFLAMLP-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 VAHYTRPVFLAMLP-UHFFFAOYSA-N 0.000 claims description 4
LIHRNGBCRRQLAM-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 LIHRNGBCRRQLAM-UHFFFAOYSA-N 0.000 claims description 4
PQCCNPBIXNEECS-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 PQCCNPBIXNEECS-UHFFFAOYSA-N 0.000 claims description 4
XMWMAWMGHWFUAM-UHFFFAOYSA-N CC(C)(C)N1CCC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)CC1 Chemical compound CC(C)(C)N1CCC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)CC1 XMWMAWMGHWFUAM-UHFFFAOYSA-N 0.000 claims description 4
XTLZAJCBJTVFTQ-UHFFFAOYSA-N CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(=C1)N1CCOCC1 Chemical compound CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(=C1)N1CCOCC1 XTLZAJCBJTVFTQ-UHFFFAOYSA-N 0.000 claims description 4
XVVMLOUNPYBMAX-UHFFFAOYSA-N CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCC2)=C1 Chemical compound CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCC2)=C1 XVVMLOUNPYBMAX-UHFFFAOYSA-N 0.000 claims description 4
YHLDCSWORNPZOA-UHFFFAOYSA-N CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 YHLDCSWORNPZOA-UHFFFAOYSA-N 0.000 claims description 4
CPWPQGQEDRUYLJ-UHFFFAOYSA-N CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CC(F)(F)C2)=CN=C1 Chemical compound CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CC(F)(F)C2)=CN=C1 CPWPQGQEDRUYLJ-UHFFFAOYSA-N 0.000 claims description 4
MMVZLAWKZPDLKK-UHFFFAOYSA-N CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 Chemical compound CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 MMVZLAWKZPDLKK-UHFFFAOYSA-N 0.000 claims description 4
UGLANNGTMQRUNV-UHFFFAOYSA-N CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 UGLANNGTMQRUNV-UHFFFAOYSA-N 0.000 claims description 4
JUHYUPVYGRLAQR-UHFFFAOYSA-N CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 JUHYUPVYGRLAQR-UHFFFAOYSA-N 0.000 claims description 4
PTWVLFIRGVIDKG-UHFFFAOYSA-N CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 PTWVLFIRGVIDKG-UHFFFAOYSA-N 0.000 claims description 4
ASSRYFKQYOVIGD-UHFFFAOYSA-N CC(C)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 Chemical compound CC(C)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 ASSRYFKQYOVIGD-UHFFFAOYSA-N 0.000 claims description 4
BJQZEUSPQBIVTC-UHFFFAOYSA-N CC(C)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 Chemical compound CC(C)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 BJQZEUSPQBIVTC-UHFFFAOYSA-N 0.000 claims description 4
QJZYPMQAQAJFJP-UHFFFAOYSA-N CC(C)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=C(F)N=C1 Chemical compound CC(C)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=C(F)N=C1 QJZYPMQAQAJFJP-UHFFFAOYSA-N 0.000 claims description 4
VVNPNMFNLNYMRL-UHFFFAOYSA-N CC(C)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC(C)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 VVNPNMFNLNYMRL-UHFFFAOYSA-N 0.000 claims description 4
GHOCUUAXKRYVIJ-UHFFFAOYSA-N CC(C)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1F Chemical compound CC(C)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1F GHOCUUAXKRYVIJ-UHFFFAOYSA-N 0.000 claims description 4
MZWWOHMFFLRKNX-UHFFFAOYSA-N CC(C)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CN=CC=N1 Chemical compound CC(C)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CN=CC=N1 MZWWOHMFFLRKNX-UHFFFAOYSA-N 0.000 claims description 4
SHTMBOCAWHJYIG-UHFFFAOYSA-N CC(C)(F)CN1CCC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 Chemical compound CC(C)(F)CN1CCC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 SHTMBOCAWHJYIG-UHFFFAOYSA-N 0.000 claims description 4
PEMULNLUXYCJFH-UHFFFAOYSA-N CC(C)(F)CN1CCC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2F)C1 Chemical compound CC(C)(F)CN1CCC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2F)C1 PEMULNLUXYCJFH-UHFFFAOYSA-N 0.000 claims description 4
RCHJWVMCJLSGJB-UHFFFAOYSA-N CC(C)C(=O)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CC(C)C(=O)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 RCHJWVMCJLSGJB-UHFFFAOYSA-N 0.000 claims description 4
QALWCXJXRVPKFL-UHFFFAOYSA-N CC(C)CC(=O)NC1=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=NC=C1 Chemical compound CC(C)CC(=O)NC1=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=NC=C1 QALWCXJXRVPKFL-UHFFFAOYSA-N 0.000 claims description 4
VUFABRZZDRZUHU-UHFFFAOYSA-N CC(C)CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C=N1 Chemical compound CC(C)CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C=N1 VUFABRZZDRZUHU-UHFFFAOYSA-N 0.000 claims description 4
YGPDDXLXRZMFLH-UHFFFAOYSA-N CC(C)CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC(C)CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 YGPDDXLXRZMFLH-UHFFFAOYSA-N 0.000 claims description 4
UIOFGJGRDVBISW-UHFFFAOYSA-N CC(C)CN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)C(F)F Chemical compound CC(C)CN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)C(F)F UIOFGJGRDVBISW-UHFFFAOYSA-N 0.000 claims description 4
LXHODWJEUJZONE-UHFFFAOYSA-N CC(C)CN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 Chemical compound CC(C)CN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 LXHODWJEUJZONE-UHFFFAOYSA-N 0.000 claims description 4
GMUSDGNNRPATTC-UHFFFAOYSA-N CC(C)CN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 Chemical compound CC(C)CN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 GMUSDGNNRPATTC-UHFFFAOYSA-N 0.000 claims description 4
ZYLWKLITEYEDLD-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC=CN=C1 ZYLWKLITEYEDLD-UHFFFAOYSA-N 0.000 claims description 4
YDSIASRBSAHDDO-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 YDSIASRBSAHDDO-UHFFFAOYSA-N 0.000 claims description 4
IPBVMBFTMMTZPK-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 IPBVMBFTMMTZPK-UHFFFAOYSA-N 0.000 claims description 4
MTKYIZTXNJUSJU-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 MTKYIZTXNJUSJU-UHFFFAOYSA-N 0.000 claims description 4
SXMRDYBJAOFEOP-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 SXMRDYBJAOFEOP-UHFFFAOYSA-N 0.000 claims description 4
KWGZZKNGABUCPF-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 KWGZZKNGABUCPF-UHFFFAOYSA-N 0.000 claims description 4
GAWQZOAJJNJXBN-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN(C)C)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN(C)C)=CN=C1 GAWQZOAJJNJXBN-UHFFFAOYSA-N 0.000 claims description 4
UMOXVNLBYVUKOS-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(C)CC2)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(C)CC2)=CN=C1 UMOXVNLBYVUKOS-UHFFFAOYSA-N 0.000 claims description 4
ZWETTZAWFJKQNZ-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 ZWETTZAWFJKQNZ-UHFFFAOYSA-N 0.000 claims description 4
IJCLAMNHQHNOII-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 IJCLAMNHQHNOII-UHFFFAOYSA-N 0.000 claims description 4
WTEVRNAAAYZCLQ-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 WTEVRNAAAYZCLQ-UHFFFAOYSA-N 0.000 claims description 4
LPRSNVGUCNUKRR-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 LPRSNVGUCNUKRR-UHFFFAOYSA-N 0.000 claims description 4
ARWNRPOSMGXFEU-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 ARWNRPOSMGXFEU-UHFFFAOYSA-N 0.000 claims description 4
CYPUSANTPONGLU-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 CYPUSANTPONGLU-UHFFFAOYSA-N 0.000 claims description 4
HWUGUDGFPZELNH-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 HWUGUDGFPZELNH-UHFFFAOYSA-N 0.000 claims description 4
QUWHVIBCTMAHNO-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 QUWHVIBCTMAHNO-UHFFFAOYSA-N 0.000 claims description 4
IBWPRGZSZRPGMY-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 IBWPRGZSZRPGMY-UHFFFAOYSA-N 0.000 claims description 4
RYFRAQSCLJHDPN-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 RYFRAQSCLJHDPN-UHFFFAOYSA-N 0.000 claims description 4
LBTSPLLEZBEEMV-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 LBTSPLLEZBEEMV-UHFFFAOYSA-N 0.000 claims description 4
CKTDWGFHFWLMMD-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 CKTDWGFHFWLMMD-UHFFFAOYSA-N 0.000 claims description 4
HFCPGZOXUTZMAW-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)N(C)C)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)N(C)C)=CN=C1 HFCPGZOXUTZMAW-UHFFFAOYSA-N 0.000 claims description 4
DZJDZLYZECJOFO-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 DZJDZLYZECJOFO-UHFFFAOYSA-N 0.000 claims description 4
WNKNLOWIRTYXCK-UHFFFAOYSA-N CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 WNKNLOWIRTYXCK-UHFFFAOYSA-N 0.000 claims description 4
GEUWHRWKJNTEGY-UHFFFAOYSA-N CC(C)CN1CCC(CC1C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 Chemical compound CC(C)CN1CCC(CC1C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 GEUWHRWKJNTEGY-UHFFFAOYSA-N 0.000 claims description 4
SLZPNBCLFVKLSX-UHFFFAOYSA-N CC(C)CN1CCC(CC1C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC(C)CN1CCC(CC1C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 SLZPNBCLFVKLSX-UHFFFAOYSA-N 0.000 claims description 4
UTDHFGIXDNDGOT-UHFFFAOYSA-N CC(C)CN1CCC(CC1C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1F Chemical compound CC(C)CN1CCC(CC1C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1F UTDHFGIXDNDGOT-UHFFFAOYSA-N 0.000 claims description 4
XFYIJWCPRDIPDE-AZUAARDMSA-N CC(C)CN1CC[C@@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CN=C2)[C@@H](F)C1 Chemical compound CC(C)CN1CC[C@@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CN=C2)[C@@H](F)C1 XFYIJWCPRDIPDE-AZUAARDMSA-N 0.000 claims description 4
XFYIJWCPRDIPDE-UYAOXDASSA-N CC(C)CN1CC[C@@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CN=C2)[C@H](F)C1 Chemical compound CC(C)CN1CC[C@@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CN=C2)[C@H](F)C1 XFYIJWCPRDIPDE-UYAOXDASSA-N 0.000 claims description 4
JZBUIKSBAKGQBW-AZUAARDMSA-N CC(C)CN1CC[C@@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)[C@@H](F)C1 Chemical compound CC(C)CN1CC[C@@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)[C@@H](F)C1 JZBUIKSBAKGQBW-AZUAARDMSA-N 0.000 claims description 4
JZBUIKSBAKGQBW-UYAOXDASSA-N CC(C)CN1CC[C@@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)[C@H](F)C1 Chemical compound CC(C)CN1CC[C@@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)[C@H](F)C1 JZBUIKSBAKGQBW-UYAOXDASSA-N 0.000 claims description 4
ZWKAGECZBCJWIA-PKOBYXMFSA-N CC(C)CN1CC[C@@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2F)[C@@H](F)C1 Chemical compound CC(C)CN1CC[C@@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2F)[C@@H](F)C1 ZWKAGECZBCJWIA-PKOBYXMFSA-N 0.000 claims description 4
ZWKAGECZBCJWIA-IEBWSBKVSA-N CC(C)CN1CC[C@@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2F)[C@H](F)C1 Chemical compound CC(C)CN1CC[C@@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2F)[C@H](F)C1 ZWKAGECZBCJWIA-IEBWSBKVSA-N 0.000 claims description 4
XFYIJWCPRDIPDE-ICSRJNTNSA-N CC(C)CN1CC[C@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CN=C2)[C@@H](F)C1 Chemical compound CC(C)CN1CC[C@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CN=C2)[C@@H](F)C1 XFYIJWCPRDIPDE-ICSRJNTNSA-N 0.000 claims description 4
XFYIJWCPRDIPDE-QUCCMNQESA-N CC(C)CN1CC[C@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CN=C2)[C@H](F)C1 Chemical compound CC(C)CN1CC[C@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CN=C2)[C@H](F)C1 XFYIJWCPRDIPDE-QUCCMNQESA-N 0.000 claims description 4
JZBUIKSBAKGQBW-ICSRJNTNSA-N CC(C)CN1CC[C@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)[C@@H](F)C1 Chemical compound CC(C)CN1CC[C@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)[C@@H](F)C1 JZBUIKSBAKGQBW-ICSRJNTNSA-N 0.000 claims description 4
JZBUIKSBAKGQBW-QUCCMNQESA-N CC(C)CN1CC[C@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)[C@H](F)C1 Chemical compound CC(C)CN1CC[C@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)[C@H](F)C1 JZBUIKSBAKGQBW-QUCCMNQESA-N 0.000 claims description 4
ZWKAGECZBCJWIA-HKUYNNGSSA-N CC(C)CN1CC[C@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2F)[C@@H](F)C1 Chemical compound CC(C)CN1CC[C@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2F)[C@@H](F)C1 ZWKAGECZBCJWIA-HKUYNNGSSA-N 0.000 claims description 4
ZWKAGECZBCJWIA-MJGOQNOKSA-N CC(C)CN1CC[C@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2F)[C@H](F)C1 Chemical compound CC(C)CN1CC[C@H](NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2F)[C@H](F)C1 ZWKAGECZBCJWIA-MJGOQNOKSA-N 0.000 claims description 4
RMDUDYPOAIGICZ-UHFFFAOYSA-N CC(C)CNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 Chemical compound CC(C)CNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 RMDUDYPOAIGICZ-UHFFFAOYSA-N 0.000 claims description 4
VTVGMORZNQKEEC-UHFFFAOYSA-N CC(C)CNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=C(F)N=C1 Chemical compound CC(C)CNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=C(F)N=C1 VTVGMORZNQKEEC-UHFFFAOYSA-N 0.000 claims description 4
SLCWSEKVDZJHGZ-UHFFFAOYSA-N CC(C)CNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC(C)CNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 SLCWSEKVDZJHGZ-UHFFFAOYSA-N 0.000 claims description 4
PPIGGSTUWMNOJO-UHFFFAOYSA-N CC(C)CNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1F Chemical compound CC(C)CNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1F PPIGGSTUWMNOJO-UHFFFAOYSA-N 0.000 claims description 4
JYSDSKZUEBJMBP-UHFFFAOYSA-N CC(C)N1CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 Chemical compound CC(C)N1CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 JYSDSKZUEBJMBP-UHFFFAOYSA-N 0.000 claims description 4
YZLZVTHVCHZATF-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(Cl)=C2)C1=CC=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(Cl)=C2)C1=CC=CN=C1 YZLZVTHVCHZATF-UHFFFAOYSA-N 0.000 claims description 4
NSIKMHHEPYBTTP-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 NSIKMHHEPYBTTP-UHFFFAOYSA-N 0.000 claims description 4
RIYGQNJQXMRIQK-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 RIYGQNJQXMRIQK-UHFFFAOYSA-N 0.000 claims description 4
BZGMJNANKZSZST-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)C(F)F Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)C(F)F BZGMJNANKZSZST-UHFFFAOYSA-N 0.000 claims description 4
DLFKEEUQRYJQCK-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 DLFKEEUQRYJQCK-UHFFFAOYSA-N 0.000 claims description 4
AGSCOMWIAAZWLP-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 AGSCOMWIAAZWLP-UHFFFAOYSA-N 0.000 claims description 4
XKQMRSBTPQZDNI-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 XKQMRSBTPQZDNI-UHFFFAOYSA-N 0.000 claims description 4
JERDKCOOACQYRC-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN(C)C)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN(C)C)=CN=C1 JERDKCOOACQYRC-UHFFFAOYSA-N 0.000 claims description 4
DKTXLTKLAWJBLJ-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(C)CC2)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(C)CC2)=CN=C1 DKTXLTKLAWJBLJ-UHFFFAOYSA-N 0.000 claims description 4
ZOUYFPXZYKHUGV-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 ZOUYFPXZYKHUGV-UHFFFAOYSA-N 0.000 claims description 4
IFHAYMZKRSKWHU-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 IFHAYMZKRSKWHU-UHFFFAOYSA-N 0.000 claims description 4
ISDJLZPWIPQNOF-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 ISDJLZPWIPQNOF-UHFFFAOYSA-N 0.000 claims description 4
WNQXYGDNMPWNSV-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 WNQXYGDNMPWNSV-UHFFFAOYSA-N 0.000 claims description 4
SOLQYAQLTDLLOF-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 SOLQYAQLTDLLOF-UHFFFAOYSA-N 0.000 claims description 4
RDHTZERYYHWTGI-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 RDHTZERYYHWTGI-UHFFFAOYSA-N 0.000 claims description 4
DTARDHHYRCPQPI-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 DTARDHHYRCPQPI-UHFFFAOYSA-N 0.000 claims description 4
WUNIOBKOULBZPD-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 WUNIOBKOULBZPD-UHFFFAOYSA-N 0.000 claims description 4
NGZNQZIWGMVYPK-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 NGZNQZIWGMVYPK-UHFFFAOYSA-N 0.000 claims description 4
QOXDBIKPSSKZRX-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 QOXDBIKPSSKZRX-UHFFFAOYSA-N 0.000 claims description 4
BRQCCDJJXCNZBH-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)N(C)C)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)N(C)C)=CN=C1 BRQCCDJJXCNZBH-UHFFFAOYSA-N 0.000 claims description 4
RYJKXSMUMFYFHF-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 RYJKXSMUMFYFHF-UHFFFAOYSA-N 0.000 claims description 4
ZRFQUQSHTMRTPA-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 ZRFQUQSHTMRTPA-UHFFFAOYSA-N 0.000 claims description 4
GKHVRJDBTSZREQ-UHFFFAOYSA-N CC(C)N1CCC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)CC1 Chemical compound CC(C)N1CCC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)CC1 GKHVRJDBTSZREQ-UHFFFAOYSA-N 0.000 claims description 4
KYOIIALRPQYMQJ-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC(F)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC(F)=CN=C1 KYOIIALRPQYMQJ-UHFFFAOYSA-N 0.000 claims description 4
HOTQFGOTIXWTSQ-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(=C1)N1CCN(C)CC1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(=C1)N1CCN(C)CC1 HOTQFGOTIXWTSQ-UHFFFAOYSA-N 0.000 claims description 4
QXWCFGNPBYULRW-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCC2)=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCC2)=C1 QXWCFGNPBYULRW-UHFFFAOYSA-N 0.000 claims description 4
GBUWQECRVRRSTI-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCC2)=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCC2)=C1 GBUWQECRVRRSTI-UHFFFAOYSA-N 0.000 claims description 4
MLSCETBDAWKADJ-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 MLSCETBDAWKADJ-UHFFFAOYSA-N 0.000 claims description 4
CSUYYGBIGCCQKK-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 CSUYYGBIGCCQKK-UHFFFAOYSA-N 0.000 claims description 4
ISAHYZLFYSEBHB-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 ISAHYZLFYSEBHB-UHFFFAOYSA-N 0.000 claims description 4
JIKKMIKWJHHPEU-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 JIKKMIKWJHHPEU-UHFFFAOYSA-N 0.000 claims description 4
AYIDYYJVJKISOT-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN(C)C)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN(C)C)=CN=C1 AYIDYYJVJKISOT-UHFFFAOYSA-N 0.000 claims description 4
RHXNVGWNALGGQM-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CC(F)(F)C2)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CC(F)(F)C2)=CN=C1 RHXNVGWNALGGQM-UHFFFAOYSA-N 0.000 claims description 4
LRCJMSRNFIXCAJ-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(C)CC2)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(C)CC2)=CN=C1 LRCJMSRNFIXCAJ-UHFFFAOYSA-N 0.000 claims description 4
JODQDKJZGQCSLI-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 JODQDKJZGQCSLI-UHFFFAOYSA-N 0.000 claims description 4
VWPTZVMBSFOJFR-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 VWPTZVMBSFOJFR-UHFFFAOYSA-N 0.000 claims description 4
CJJGZBPVJJGKPZ-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 CJJGZBPVJJGKPZ-UHFFFAOYSA-N 0.000 claims description 4
GAPUVZQYIXPYGO-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 GAPUVZQYIXPYGO-UHFFFAOYSA-N 0.000 claims description 4
QQSBPJPTYYIUQB-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 QQSBPJPTYYIUQB-UHFFFAOYSA-N 0.000 claims description 4
HPCIUZMWAXPGBS-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 HPCIUZMWAXPGBS-UHFFFAOYSA-N 0.000 claims description 4
RORZIJULNYXNEH-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 RORZIJULNYXNEH-UHFFFAOYSA-N 0.000 claims description 4
KCGWWTMVYSVJRO-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 KCGWWTMVYSVJRO-UHFFFAOYSA-N 0.000 claims description 4
PIAXEFIVDWMMHM-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 PIAXEFIVDWMMHM-UHFFFAOYSA-N 0.000 claims description 4
FKIBZLVDCBCMJG-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 FKIBZLVDCBCMJG-UHFFFAOYSA-N 0.000 claims description 4
HNUCHBHEERAFBH-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 HNUCHBHEERAFBH-UHFFFAOYSA-N 0.000 claims description 4
BJKQXZIIPALBLF-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 BJKQXZIIPALBLF-UHFFFAOYSA-N 0.000 claims description 4
ZXQTYLMYOOFZPG-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)N(C)C)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)N(C)C)=CN=C1 ZXQTYLMYOOFZPG-UHFFFAOYSA-N 0.000 claims description 4
ZTADWDFEENXOJJ-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CN=CC2=CC=CC=C12 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CN=CC2=CC=CC=C12 ZTADWDFEENXOJJ-UHFFFAOYSA-N 0.000 claims description 4
MBNJIYGLOBCYHY-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CN=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CN=CN=C1 MBNJIYGLOBCYHY-UHFFFAOYSA-N 0.000 claims description 4
UNTXEHYEMKPUMB-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 UNTXEHYEMKPUMB-UHFFFAOYSA-N 0.000 claims description 4
DMOZWQZYBRQETK-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=N1 DMOZWQZYBRQETK-UHFFFAOYSA-N 0.000 claims description 4
FMXDRNCKNMMORY-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=N1 FMXDRNCKNMMORY-UHFFFAOYSA-N 0.000 claims description 4
WZIIWPWOKDOYMQ-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN(C)C)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN(C)C)=CN=C2)C=N1 WZIIWPWOKDOYMQ-UHFFFAOYSA-N 0.000 claims description 4
HCWNYHQYPWVGET-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(C)CC3)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(C)CC3)=CN=C2)C=N1 HCWNYHQYPWVGET-UHFFFAOYSA-N 0.000 claims description 4
JDVHPKOVVWDNTN-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(O)CC3)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(O)CC3)=CN=C2)C=N1 JDVHPKOVVWDNTN-UHFFFAOYSA-N 0.000 claims description 4
DRVVDZXURFYLJT-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=N1 DRVVDZXURFYLJT-UHFFFAOYSA-N 0.000 claims description 4
CYKZIFRWAVLTDD-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=N1 CYKZIFRWAVLTDD-UHFFFAOYSA-N 0.000 claims description 4
MIJFBJPGYRCFQW-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 MIJFBJPGYRCFQW-UHFFFAOYSA-N 0.000 claims description 4
AKPIUFHPHXGNHL-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=N1 AKPIUFHPHXGNHL-UHFFFAOYSA-N 0.000 claims description 4
TZAVBAOGHRLNAB-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=N1 TZAVBAOGHRLNAB-UHFFFAOYSA-N 0.000 claims description 4
WSVLSNLSTICXGP-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)N(C)C)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)N(C)C)=CN=C2)C=N1 WSVLSNLSTICXGP-UHFFFAOYSA-N 0.000 claims description 4
GDGBMWKSRHVIJZ-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=N1 GDGBMWKSRHVIJZ-UHFFFAOYSA-N 0.000 claims description 4
GNXGFLKNQPKVAB-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=N1 GNXGFLKNQPKVAB-UHFFFAOYSA-N 0.000 claims description 4
GNQZCXGELAYYTI-UHFFFAOYSA-N CC(C)OCCCNC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CC(C)OCCCNC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 GNQZCXGELAYYTI-UHFFFAOYSA-N 0.000 claims description 4
MWXXXICPLVMJME-UHFFFAOYSA-N CC(C)OCCCNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 Chemical compound CC(C)OCCCNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 MWXXXICPLVMJME-UHFFFAOYSA-N 0.000 claims description 4
WWNZIYCRAMBPER-UHFFFAOYSA-N CC(C)OCCCNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=C(C)N=C1 Chemical compound CC(C)OCCCNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=C(C)N=C1 WWNZIYCRAMBPER-UHFFFAOYSA-N 0.000 claims description 4
LALDSUXUZYVCSO-UHFFFAOYSA-N CC(C)OCCCNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC(C)OCCCNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 LALDSUXUZYVCSO-UHFFFAOYSA-N 0.000 claims description 4
UBUYDRBBBCNTAK-UHFFFAOYSA-N CC(C)S(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound CC(C)S(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 UBUYDRBBBCNTAK-UHFFFAOYSA-N 0.000 claims description 4
VSOVQCDCLKUEPL-UHFFFAOYSA-N CC(C)S(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound CC(C)S(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 VSOVQCDCLKUEPL-UHFFFAOYSA-N 0.000 claims description 4
HRNPLLOZOLAROH-UHFFFAOYSA-N CC(C)S(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound CC(C)S(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 HRNPLLOZOLAROH-UHFFFAOYSA-N 0.000 claims description 4
QXYZBWOLVUOZCO-UHFFFAOYSA-N CC(F)(F)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 Chemical compound CC(F)(F)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 QXYZBWOLVUOZCO-UHFFFAOYSA-N 0.000 claims description 4
DIXPYJYYVDGSTP-UHFFFAOYSA-N CC(F)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 Chemical compound CC(F)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 DIXPYJYYVDGSTP-UHFFFAOYSA-N 0.000 claims description 4
IUYCDRUKDWDELK-UHFFFAOYSA-N CC(F)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 Chemical compound CC(F)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 IUYCDRUKDWDELK-UHFFFAOYSA-N 0.000 claims description 4
GKPZXCJPBGKJKP-UHFFFAOYSA-N CC(F)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC(F)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 GKPZXCJPBGKJKP-UHFFFAOYSA-N 0.000 claims description 4
MWCQHDCZVLWXHK-UHFFFAOYSA-N CC1(CC1)C(=O)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CC1(CC1)C(=O)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 MWCQHDCZVLWXHK-UHFFFAOYSA-N 0.000 claims description 4
FVQJJIZZIAFVMK-UHFFFAOYSA-N CC1=CC2=C(C=C1C1=CC=CN=C1)C(=NN2)C(=O)NC1=CC=C(CN2CCCC2)C=C1 Chemical compound CC1=CC2=C(C=C1C1=CC=CN=C1)C(=NN2)C(=O)NC1=CC=C(CN2CCCC2)C=C1 FVQJJIZZIAFVMK-UHFFFAOYSA-N 0.000 claims description 4
NISBQZVTNISFHB-UHFFFAOYSA-N CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 NISBQZVTNISFHB-UHFFFAOYSA-N 0.000 claims description 4
OOMCBHDMUUGXQV-UHFFFAOYSA-N CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 OOMCBHDMUUGXQV-UHFFFAOYSA-N 0.000 claims description 4
FROXQYANRGGCOT-UHFFFAOYSA-N CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 FROXQYANRGGCOT-UHFFFAOYSA-N 0.000 claims description 4
JNPGQKOWQIOFHS-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)=C1 JNPGQKOWQIOFHS-UHFFFAOYSA-N 0.000 claims description 4
IRGCCIOGFDRULS-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)=C1 IRGCCIOGFDRULS-UHFFFAOYSA-N 0.000 claims description 4
RHOFCNGLIDFLGN-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 RHOFCNGLIDFLGN-UHFFFAOYSA-N 0.000 claims description 4
SBPIFFNRYRDGNB-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 SBPIFFNRYRDGNB-UHFFFAOYSA-N 0.000 claims description 4
LTNUXELQYAGSLP-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 LTNUXELQYAGSLP-UHFFFAOYSA-N 0.000 claims description 4
DNWXIQNXPBOCJE-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=C1 DNWXIQNXPBOCJE-UHFFFAOYSA-N 0.000 claims description 4
MBGWPFQTFNEPSW-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 MBGWPFQTFNEPSW-UHFFFAOYSA-N 0.000 claims description 4
RNVIBIIOYHEDGQ-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(O)CC3)=CN=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(O)CC3)=CN=C2)=C1 RNVIBIIOYHEDGQ-UHFFFAOYSA-N 0.000 claims description 4
QLDLGLZJFHYDSH-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 QLDLGLZJFHYDSH-UHFFFAOYSA-N 0.000 claims description 4
LRMONTDRJDXNCE-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 LRMONTDRJDXNCE-UHFFFAOYSA-N 0.000 claims description 4
OMBYKUGVLZMZJN-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 OMBYKUGVLZMZJN-UHFFFAOYSA-N 0.000 claims description 4
GOZSRXKSZKBYQH-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 GOZSRXKSZKBYQH-UHFFFAOYSA-N 0.000 claims description 4
RNOQZMVSNFYBMI-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(N)=CN=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(N)=CN=C2)=C1 RNOQZMVSNFYBMI-UHFFFAOYSA-N 0.000 claims description 4
VWSWKGHVJYGXBN-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=C1 VWSWKGHVJYGXBN-UHFFFAOYSA-N 0.000 claims description 4
CTWSFMMMVMOEQP-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 CTWSFMMMVMOEQP-UHFFFAOYSA-N 0.000 claims description 4
PBFPKBYEUUXXHK-UHFFFAOYSA-N CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 Chemical compound CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 PBFPKBYEUUXXHK-UHFFFAOYSA-N 0.000 claims description 4
LDRJSTXQBPDNDP-UHFFFAOYSA-N CC1=NC=C(C=N1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC(C)(C)F)CC2)C=C1 Chemical compound CC1=NC=C(C=N1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC(C)(C)F)CC2)C=C1 LDRJSTXQBPDNDP-UHFFFAOYSA-N 0.000 claims description 4
JFLVXZIEAVYBRC-UHFFFAOYSA-N CC1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound CC1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 JFLVXZIEAVYBRC-UHFFFAOYSA-N 0.000 claims description 4
RMGIYEVSHMRXMI-UHFFFAOYSA-N CC1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound CC1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 RMGIYEVSHMRXMI-UHFFFAOYSA-N 0.000 claims description 4
XCDKWJYLVQKOEY-UHFFFAOYSA-N CC1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound CC1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 XCDKWJYLVQKOEY-UHFFFAOYSA-N 0.000 claims description 4
JPUFLYHOHQLENQ-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=C(F)C=CN=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=C(F)C=CN=C3)C=C2)CC1 JPUFLYHOHQLENQ-UHFFFAOYSA-N 0.000 claims description 4
CBFSRFOBVZMJPN-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=C(F)C=NC=C3F)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=C(F)C=NC=C3F)C=C2)CC1 CBFSRFOBVZMJPN-UHFFFAOYSA-N 0.000 claims description 4
YRAJTVAZMTYYNR-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CC(F)(F)C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CC(F)(F)C3)C=C2)CC1 YRAJTVAZMTYYNR-UHFFFAOYSA-N 0.000 claims description 4
PAXGOEZCSHNCDB-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC(F)(F)C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC(F)(F)C3)C=C2)CC1 PAXGOEZCSHNCDB-UHFFFAOYSA-N 0.000 claims description 4
PPTSMKLSSSIPJV-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC3)C=C2)CC1 PPTSMKLSSSIPJV-UHFFFAOYSA-N 0.000 claims description 4
ZJCCYWCEUMMVNA-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCC3)C=C2)CC1 ZJCCYWCEUMMVNA-UHFFFAOYSA-N 0.000 claims description 4
QEWSWUKXOGEISE-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCCC3)C=C2)CC1 QEWSWUKXOGEISE-UHFFFAOYSA-N 0.000 claims description 4
HLUBSOQKGHSRAU-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCN(C)CC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCN(C)CC3)C=C2)CC1 HLUBSOQKGHSRAU-UHFFFAOYSA-N 0.000 claims description 4
GXTSMVJRYURZCR-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(C)=CN=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(C)=CN=C3)C=C2)CC1 GXTSMVJRYURZCR-UHFFFAOYSA-N 0.000 claims description 4
RANRIBRPFNMOBR-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CC4=CC=CC=C4)=CN=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CC4=CC=CC=C4)=CN=C3)C=C2)CC1 RANRIBRPFNMOBR-UHFFFAOYSA-N 0.000 claims description 4
VDZSXOOHAKLJGC-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN(C)C)=CN=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN(C)C)=CN=C3)C=C2)CC1 VDZSXOOHAKLJGC-UHFFFAOYSA-N 0.000 claims description 4
IYBRJYHJDOHPPY-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCC4)=NC=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCC4)=NC=C3)C=C2)CC1 IYBRJYHJDOHPPY-UHFFFAOYSA-N 0.000 claims description 4
SYIFQNJWVLYCLQ-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCC4)=NC=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCC4)=NC=C3)C=C2)CC1 SYIFQNJWVLYCLQ-UHFFFAOYSA-N 0.000 claims description 4
WHDWBFWAQMFYBM-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCCC4)=NC=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCCC4)=NC=C3)C=C2)CC1 WHDWBFWAQMFYBM-UHFFFAOYSA-N 0.000 claims description 4
AJJVCRXWNBQMMP-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCN(C)CC4)=NC=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCN(C)CC4)=NC=C3)C=C2)CC1 AJJVCRXWNBQMMP-UHFFFAOYSA-N 0.000 claims description 4
KECCUHYWQSOTNE-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(F)=CN=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(F)=CN=C3)C=C2)CC1 KECCUHYWQSOTNE-UHFFFAOYSA-N 0.000 claims description 4
SRQDUJKEIWCEJC-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(OC4CCN(C)CC4)=NC=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(OC4CCN(C)CC4)=NC=C3)C=C2)CC1 SRQDUJKEIWCEJC-UHFFFAOYSA-N 0.000 claims description 4
VFMOTHIHVXTWDR-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(C)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(C)N=C3)C=C2)CC1 VFMOTHIHVXTWDR-UHFFFAOYSA-N 0.000 claims description 4
GJRWDSADIJXAIJ-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CC4=CC=CC=C4)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CC4=CC=CC=C4)N=C3)C=C2)CC1 GJRWDSADIJXAIJ-UHFFFAOYSA-N 0.000 claims description 4
JNIZGMCNXJCLMY-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CN(C)C)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CN(C)C)N=C3)C=C2)CC1 JNIZGMCNXJCLMY-UHFFFAOYSA-N 0.000 claims description 4
JBKJPSLQCSGLCR-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CN4CCCC4)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CN4CCCC4)N=C3)C=C2)CC1 JBKJPSLQCSGLCR-UHFFFAOYSA-N 0.000 claims description 4
XSDPGDCWPNAJTA-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CN4CCCCC4)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CN4CCCCC4)N=C3)C=C2)CC1 XSDPGDCWPNAJTA-UHFFFAOYSA-N 0.000 claims description 4
NJZOMSOQOUBWCA-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CN4CCN(C)CC4)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CN4CCN(C)CC4)N=C3)C=C2)CC1 NJZOMSOQOUBWCA-UHFFFAOYSA-N 0.000 claims description 4
NMMKDNGSZNIAQT-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C#N)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C#N)C=C2)CC1 NMMKDNGSZNIAQT-UHFFFAOYSA-N 0.000 claims description 4
JUGRBTWGTMSDQF-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C3=C(F)C=CC=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C3=C(F)C=CC=C3)C=C2)CC1 JUGRBTWGTMSDQF-UHFFFAOYSA-N 0.000 claims description 4
KKFAGEZFWPRQTH-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C3=CC(F)=CC=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C3=CC(F)=CC=C3)C=C2)CC1 KKFAGEZFWPRQTH-UHFFFAOYSA-N 0.000 claims description 4
MAHYLAFJGDHSKU-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C3=CC=C(F)C=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C3=CC=C(F)C=C3)C=C2)CC1 MAHYLAFJGDHSKU-UHFFFAOYSA-N 0.000 claims description 4
HFUPGDTZPRPZKP-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C3=CC=CC=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C3=CC=CC=C3)C=C2)CC1 HFUPGDTZPRPZKP-UHFFFAOYSA-N 0.000 claims description 4
QUGSNKSLMBUOMC-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N(C)CCN(C)C)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N(C)CCN(C)C)C=C2)CC1 QUGSNKSLMBUOMC-UHFFFAOYSA-N 0.000 claims description 4
GZYILQOCZIEWBN-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCC(F)(F)C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCC(F)(F)C3)C=C2)CC1 GZYILQOCZIEWBN-UHFFFAOYSA-N 0.000 claims description 4
RRYTYPFMPSVZAU-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCC(O)CC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCC(O)CC3)C=C2)CC1 RRYTYPFMPSVZAU-UHFFFAOYSA-N 0.000 claims description 4
XJYZOZXACROJOB-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCC3)C=C2)CC1 XJYZOZXACROJOB-UHFFFAOYSA-N 0.000 claims description 4
WYYAYKQAIPAUAA-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCCC3)C=C2)CC1 WYYAYKQAIPAUAA-UHFFFAOYSA-N 0.000 claims description 4
JKRNPTCRGWXCNJ-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCCCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCCCC3)C=C2)CC1 JKRNPTCRGWXCNJ-UHFFFAOYSA-N 0.000 claims description 4
HYMRTNWGDSSNHJ-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCN(C)CC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCN(C)CC3)C=C2)CC1 HYMRTNWGDSSNHJ-UHFFFAOYSA-N 0.000 claims description 4
YALUUVZPEOIQRZ-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCNCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCNCC3)C=C2)CC1 YALUUVZPEOIQRZ-UHFFFAOYSA-N 0.000 claims description 4
QFCCKSPOORWWBH-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCOCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCOCC3)C=C2)CC1 QFCCKSPOORWWBH-UHFFFAOYSA-N 0.000 claims description 4
YMANWHAZNCBJHR-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(O)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(O)N=C3)C=C2)CC1 YMANWHAZNCBJHR-UHFFFAOYSA-N 0.000 claims description 4
QSPRNGWYRRJFEU-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(OC4=C(F)C=CC=C4)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(OC4=C(F)C=CC=C4)N=C3)C=C2)CC1 QSPRNGWYRRJFEU-UHFFFAOYSA-N 0.000 claims description 4
BJSOMLBMQOYFRL-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(OC4=CC(F)=CC=C4)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(OC4=CC(F)=CC=C4)N=C3)C=C2)CC1 BJSOMLBMQOYFRL-UHFFFAOYSA-N 0.000 claims description 4
BWYNMAFSCSQDMY-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(OC4=CC=C(F)C=C4)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(OC4=CC=C(F)C=C4)N=C3)C=C2)CC1 BWYNMAFSCSQDMY-UHFFFAOYSA-N 0.000 claims description 4
OZTGQAIXHVWTNB-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(OC4CCN(C)CC4)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(OC4CCN(C)CC4)N=C3)C=C2)CC1 OZTGQAIXHVWTNB-UHFFFAOYSA-N 0.000 claims description 4
BWQUOTYZWWYZRD-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=CC=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=CC=C3)C=C2)CC1 BWQUOTYZWWYZRD-UHFFFAOYSA-N 0.000 claims description 4
WNCBTEOZEIQSSC-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=CN=C3)C=C2F)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=CN=C3)C=C2F)CC1 WNCBTEOZEIQSSC-UHFFFAOYSA-N 0.000 claims description 4
GFDKNWKMOYINOY-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=NC=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=NC=C3)C=C2)CC1 GFDKNWKMOYINOY-UHFFFAOYSA-N 0.000 claims description 4
CHKZTXVBERIBKO-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=C(C)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=C(C)N=C3)C=C2)CC1 CHKZTXVBERIBKO-UHFFFAOYSA-N 0.000 claims description 4
BCTBWGGLZAUENL-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=C(N)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=C(N)N=C3)C=C2)CC1 BCTBWGGLZAUENL-UHFFFAOYSA-N 0.000 claims description 4
NAFGKAPZTGRJBP-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=NC=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=NC=C3)C=C2)CC1 NAFGKAPZTGRJBP-UHFFFAOYSA-N 0.000 claims description 4
HZVWGRSQHQRYGN-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=C(F)C=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=C(F)C=C3)C=C2)CC1 HZVWGRSQHQRYGN-UHFFFAOYSA-N 0.000 claims description 4
IRSYXIYBPPTADL-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=C(F)C=C3F)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=C(F)C=C3F)C=C2)CC1 IRSYXIYBPPTADL-UHFFFAOYSA-N 0.000 claims description 4
YLYZBCOEFQJGCR-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=CC=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=CC=C3)C=C2)CC1 YLYZBCOEFQJGCR-UHFFFAOYSA-N 0.000 claims description 4
GYEWCJVVGWIRFE-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CC3)C=C2)CC1 GYEWCJVVGWIRFE-UHFFFAOYSA-N 0.000 claims description 4
UMFHYKZQKFBSOE-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCC3)C=C2)CC1 UMFHYKZQKFBSOE-UHFFFAOYSA-N 0.000 claims description 4
LMKLZNLBPSMKJU-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCC3)C=C2)CC1 LMKLZNLBPSMKJU-UHFFFAOYSA-N 0.000 claims description 4
RGUNNYXIJJRHBQ-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCCC3)C=C2)CC1 RGUNNYXIJJRHBQ-UHFFFAOYSA-N 0.000 claims description 4
CHGHSIGMUNZUBF-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(C)CC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(C)CC3)C=C2)CC1 CHGHSIGMUNZUBF-UHFFFAOYSA-N 0.000 claims description 4
NVDQIYJHHXQUNG-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(CC#C)CC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(CC#C)CC3)C=C2)CC1 NVDQIYJHHXQUNG-UHFFFAOYSA-N 0.000 claims description 4
LJVWZNPXABHIRR-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(CC(C)(C)C)CC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(CC(C)(C)C)CC3)C=C2)CC1 LJVWZNPXABHIRR-UHFFFAOYSA-N 0.000 claims description 4
NTOLVOIPVDSPIR-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCNCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCNCC3)C=C2)CC1 NTOLVOIPVDSPIR-UHFFFAOYSA-N 0.000 claims description 4
BGROIAYHOLRIBC-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(N)=O)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(N)=O)C=C2)CC1 BGROIAYHOLRIBC-UHFFFAOYSA-N 0.000 claims description 4
ILDOZRUUOSXQHX-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 ILDOZRUUOSXQHX-UHFFFAOYSA-N 0.000 claims description 4
LKHCIOFJBOMWFZ-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 LKHCIOFJBOMWFZ-UHFFFAOYSA-N 0.000 claims description 4
CVTXFDYAVXNJME-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=N1 CVTXFDYAVXNJME-UHFFFAOYSA-N 0.000 claims description 4
GNJNEZWIKPYBPU-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN(C)C)=CN=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN(C)C)=CN=C2)C=N1 GNJNEZWIKPYBPU-UHFFFAOYSA-N 0.000 claims description 4
JMDUSBRDURFSHI-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=N1 JMDUSBRDURFSHI-UHFFFAOYSA-N 0.000 claims description 4
DZCGDWWIAYJXAY-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=N1 DZCGDWWIAYJXAY-UHFFFAOYSA-N 0.000 claims description 4
BUBSTQATCIYHDD-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(O)CC3)=CN=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(O)CC3)=CN=C2)C=N1 BUBSTQATCIYHDD-UHFFFAOYSA-N 0.000 claims description 4
FCZWANPIFJBGHM-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=N1 FCZWANPIFJBGHM-UHFFFAOYSA-N 0.000 claims description 4
WQPVNPJVKUMJAN-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=N1 WQPVNPJVKUMJAN-UHFFFAOYSA-N 0.000 claims description 4
XCWPPSRGCKDVOV-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=N1 XCWPPSRGCKDVOV-UHFFFAOYSA-N 0.000 claims description 4
OBUZDMRXCGPGKZ-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(N)=CN=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(N)=CN=C2)C=N1 OBUZDMRXCGPGKZ-UHFFFAOYSA-N 0.000 claims description 4
FJYOQHKYTWDLHV-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=N1 FJYOQHKYTWDLHV-UHFFFAOYSA-N 0.000 claims description 4
CKHFFNFNCFYODO-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)N(C)C)=CN=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)N(C)C)=CN=C2)C=N1 CKHFFNFNCFYODO-UHFFFAOYSA-N 0.000 claims description 4
SEXSIAICWKPRTL-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=N1 SEXSIAICWKPRTL-UHFFFAOYSA-N 0.000 claims description 4
IENQCPYGRJGHAU-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=N1 IENQCPYGRJGHAU-UHFFFAOYSA-N 0.000 claims description 4
XWVOEODORSESOA-UHFFFAOYSA-N CCC(CC)NC(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound CCC(CC)NC(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 XWVOEODORSESOA-UHFFFAOYSA-N 0.000 claims description 4
ZGWBGCABZFHLCU-UHFFFAOYSA-N CCC(CC)NC(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(C)CC3)=CN=C2)C=N1 Chemical compound CCC(CC)NC(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(C)CC3)=CN=C2)C=N1 ZGWBGCABZFHLCU-UHFFFAOYSA-N 0.000 claims description 4
RPOPYEHLTWNMJN-UHFFFAOYSA-N CCC(CC)NC(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound CCC(CC)NC(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 RPOPYEHLTWNMJN-UHFFFAOYSA-N 0.000 claims description 4
KPAUWKONILURJN-UHFFFAOYSA-N CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 KPAUWKONILURJN-UHFFFAOYSA-N 0.000 claims description 4
TUJVIKDAJDIGBU-UHFFFAOYSA-N CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 Chemical compound CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 TUJVIKDAJDIGBU-UHFFFAOYSA-N 0.000 claims description 4
PUATYRFKOHMKLV-UHFFFAOYSA-N CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 PUATYRFKOHMKLV-UHFFFAOYSA-N 0.000 claims description 4
YNMDXWGDTQLHGU-UHFFFAOYSA-N CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 YNMDXWGDTQLHGU-UHFFFAOYSA-N 0.000 claims description 4
ITUICFZQSZOZAQ-UHFFFAOYSA-N CCN(CC)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC(C)(C)C)C=C1 Chemical compound CCN(CC)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC(C)(C)C)C=C1 ITUICFZQSZOZAQ-UHFFFAOYSA-N 0.000 claims description 4
LYHXKXZYHFFCLF-UHFFFAOYSA-N CCN(CC)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC(C)C)C=C1 Chemical compound CCN(CC)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC(C)C)C=C1 LYHXKXZYHFFCLF-UHFFFAOYSA-N 0.000 claims description 4
ZEWZYUBCVAILBU-UHFFFAOYSA-N CCN(CC)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 Chemical compound CCN(CC)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 ZEWZYUBCVAILBU-UHFFFAOYSA-N 0.000 claims description 4
NEVXHBSJZWFBJT-UHFFFAOYSA-N CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CN=CC2=CC=CC=C12 Chemical compound CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CN=CC2=CC=CC=C12 NEVXHBSJZWFBJT-UHFFFAOYSA-N 0.000 claims description 4
TYXNBPOUKYPQNV-UHFFFAOYSA-N CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(OC)=CC=C1 Chemical compound CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(OC)=CC=C1 TYXNBPOUKYPQNV-UHFFFAOYSA-N 0.000 claims description 4
OSZCNMWOLFQXNL-UHFFFAOYSA-N CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC2=CC(F)=CC=C2N=C1 Chemical compound CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC2=CC(F)=CC=C2N=C1 OSZCNMWOLFQXNL-UHFFFAOYSA-N 0.000 claims description 4
GQPCNEBNKOBBDY-UHFFFAOYSA-N CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC2=CC=CC=C2N=C1 Chemical compound CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC2=CC=CC=C2N=C1 GQPCNEBNKOBBDY-UHFFFAOYSA-N 0.000 claims description 4
TZQJJRKVAHJEQZ-UHFFFAOYSA-N CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CN=CC2=CC=CC=C12 Chemical compound CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CN=CC2=CC=CC=C12 TZQJJRKVAHJEQZ-UHFFFAOYSA-N 0.000 claims description 4
KRXZPTJSNBNRLQ-SNVBAGLBSA-N CC[C@@H](C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 Chemical compound CC[C@@H](C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 KRXZPTJSNBNRLQ-SNVBAGLBSA-N 0.000 claims description 4
HDURSVVEJSZELF-LLVKDONJSA-N CC[C@@H](C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC[C@@H](C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 HDURSVVEJSZELF-LLVKDONJSA-N 0.000 claims description 4
HDURSVVEJSZELF-NSHDSACASA-N CC[C@H](C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC[C@H](C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 HDURSVVEJSZELF-NSHDSACASA-N 0.000 claims description 4
LHAWFZVSPBMRMC-UHFFFAOYSA-N CN(C(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1)C1=CC=CN=C1 Chemical compound CN(C(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1)C1=CC=CN=C1 LHAWFZVSPBMRMC-UHFFFAOYSA-N 0.000 claims description 4
PGSOSNZOKYEQMH-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=C(F)C=NC=C2F)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=C(F)C=NC=C2F)C=C1 PGSOSNZOKYEQMH-UHFFFAOYSA-N 0.000 claims description 4
FFEYOWJMLKMLPA-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=CN=C2)C(F)(F)F)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=CN=C2)C(F)(F)F)C=C1 FFEYOWJMLKMLPA-UHFFFAOYSA-N 0.000 claims description 4
ZEWNPQQHDKZMIU-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)C(F)(F)F)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)C(F)(F)F)C=C1 ZEWNPQQHDKZMIU-UHFFFAOYSA-N 0.000 claims description 4
CPFVAAQWQKWEPQ-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CC(F)(F)C2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CC(F)(F)C2)C=C1 CPFVAAQWQKWEPQ-UHFFFAOYSA-N 0.000 claims description 4
OGKQUYOIOHYSBR-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC(F)(F)C2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC(F)(F)C2)C=C1 OGKQUYOIOHYSBR-UHFFFAOYSA-N 0.000 claims description 4
JTLVRRDGMDABOK-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC2)C=C1 JTLVRRDGMDABOK-UHFFFAOYSA-N 0.000 claims description 4
IJVRZUAKBDFZTM-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCC2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCC2)C=C1 IJVRZUAKBDFZTM-UHFFFAOYSA-N 0.000 claims description 4
HRNIOICGYCKINN-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCCC2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCCC2)C=C1 HRNIOICGYCKINN-UHFFFAOYSA-N 0.000 claims description 4
FKJUEZSZRZCXKL-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCC3)=NC=C2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCC3)=NC=C2)C=C1 FKJUEZSZRZCXKL-UHFFFAOYSA-N 0.000 claims description 4
AQTIXYSDBRIFBR-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCC3)=NC=C2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCC3)=NC=C2)C=C1 AQTIXYSDBRIFBR-UHFFFAOYSA-N 0.000 claims description 4
SCERWPYNWLXKBF-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCCC3)=NC=C2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCCC3)=NC=C2)C=C1 SCERWPYNWLXKBF-UHFFFAOYSA-N 0.000 claims description 4
BBFPGTHWVXRFRY-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCN(C)CC3)=NC=C2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCN(C)CC3)=NC=C2)C=C1 BBFPGTHWVXRFRY-UHFFFAOYSA-N 0.000 claims description 4
RKEWHYQFHWEFSV-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(OC3CCN(C)CC3)=NC=C2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(OC3CCN(C)CC3)=NC=C2)C=C1 RKEWHYQFHWEFSV-UHFFFAOYSA-N 0.000 claims description 4
KCKIVDJJLWQLNR-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CC(F)(F)C2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CC(F)(F)C2)C=C1 KCKIVDJJLWQLNR-UHFFFAOYSA-N 0.000 claims description 4
JHKFRTFZCDDYQG-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(OC3CCN(C)CC3)N=C2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(OC3CCN(C)CC3)N=C2)C=C1 JHKFRTFZCDDYQG-UHFFFAOYSA-N 0.000 claims description 4
DNJVKYJPNLSBKD-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CN=C(C=N2)C(F)(F)F)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CN=C(C=N2)C(F)(F)F)C=C1 DNJVKYJPNLSBKD-UHFFFAOYSA-N 0.000 claims description 4
ZGDKDZXOLOTEAD-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CN=C(N=C2)C(F)(F)F)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CN=C(N=C2)C(F)(F)F)C=C1 ZGDKDZXOLOTEAD-UHFFFAOYSA-N 0.000 claims description 4
JKIYQJVRAJKOCV-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC(=CC=C2)C(F)(F)F)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC(=CC=C2)C(F)(F)F)C=C1 JKIYQJVRAJKOCV-UHFFFAOYSA-N 0.000 claims description 4
MVKNVVIFQQZTMO-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(C=C2)C(F)(F)F)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(C=C2)C(F)(F)F)C=C1 MVKNVVIFQQZTMO-UHFFFAOYSA-N 0.000 claims description 4
XSAUTWIYGUVADU-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(F)C=C2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(F)C=C2)C=C1 XSAUTWIYGUVADU-UHFFFAOYSA-N 0.000 claims description 4
ZBRIJTWJJIZGLA-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(F)C=C2F)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(F)C=C2F)C=C1 ZBRIJTWJJIZGLA-UHFFFAOYSA-N 0.000 claims description 4
HBJJDZOXMMDUPE-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=CC(=C2)C(F)(F)F)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=CC(=C2)C(F)(F)F)C=C1 HBJJDZOXMMDUPE-UHFFFAOYSA-N 0.000 claims description 4
OAYKYHHOGMUNEQ-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=CC=C2C(F)(F)F)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=CC=C2C(F)(F)F)C=C1 OAYKYHHOGMUNEQ-UHFFFAOYSA-N 0.000 claims description 4
WKXOTJKTXQJULC-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 WKXOTJKTXQJULC-UHFFFAOYSA-N 0.000 claims description 4
JFTVDFSWQZXUDN-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCC2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCC2)C=C1 JFTVDFSWQZXUDN-UHFFFAOYSA-N 0.000 claims description 4
XEXLMLRXTPPCKQ-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1 XEXLMLRXTPPCKQ-UHFFFAOYSA-N 0.000 claims description 4
USPGKXWBRZBZPM-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1 USPGKXWBRZBZPM-UHFFFAOYSA-N 0.000 claims description 4
JKBNDDQHEYYYMD-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(C)CC2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(C)CC2)C=C1 JKBNDDQHEYYYMD-UHFFFAOYSA-N 0.000 claims description 4
KIUMKYHDEZXROR-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC(C)(C)C)CC2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC(C)(C)C)CC2)C=C1 KIUMKYHDEZXROR-UHFFFAOYSA-N 0.000 claims description 4
CHYGYEIQWHTGSX-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC2)C(C)(C)C)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC2)C(C)(C)C)C=C1 CHYGYEIQWHTGSX-UHFFFAOYSA-N 0.000 claims description 4
VEKPWSYMCASLHA-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCNCC2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCNCC2)C=C1 VEKPWSYMCASLHA-UHFFFAOYSA-N 0.000 claims description 4
LOSVKEXMBNGQHW-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 LOSVKEXMBNGQHW-UHFFFAOYSA-N 0.000 claims description 4
ZBZAQKBNOUDZCD-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(N)=O)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(N)=O)C=C1 ZBZAQKBNOUDZCD-UHFFFAOYSA-N 0.000 claims description 4
FIUIBYGPUSVIJD-UHFFFAOYSA-N CN(C)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound CN(C)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 FIUIBYGPUSVIJD-UHFFFAOYSA-N 0.000 claims description 4
JVBMIHNIRLNAMR-UHFFFAOYSA-N CN(C)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound CN(C)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 JVBMIHNIRLNAMR-UHFFFAOYSA-N 0.000 claims description 4
AVOLAQQQOXHEQW-UHFFFAOYSA-N CN(C)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound CN(C)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 AVOLAQQQOXHEQW-UHFFFAOYSA-N 0.000 claims description 4
LRUBFGIBSCUYBD-UHFFFAOYSA-N CN(C)CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound CN(C)CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 LRUBFGIBSCUYBD-UHFFFAOYSA-N 0.000 claims description 4
HGIVQOCDDPCPMB-UHFFFAOYSA-N CN(C)CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=C1 Chemical compound CN(C)CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=C1 HGIVQOCDDPCPMB-UHFFFAOYSA-N 0.000 claims description 4
ITVGAJWURPPQFP-UHFFFAOYSA-N CN(C)CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound CN(C)CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 ITVGAJWURPPQFP-UHFFFAOYSA-N 0.000 claims description 4
IMFOLDJAKRSAQQ-UHFFFAOYSA-N CN(C)CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=C1 Chemical compound CN(C)CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=C1 IMFOLDJAKRSAQQ-UHFFFAOYSA-N 0.000 claims description 4
NUPWDVOWNFBDKS-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC(C)(C)C)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC(C)(C)C)C=C1 NUPWDVOWNFBDKS-UHFFFAOYSA-N 0.000 claims description 4
NQUXBXSNHCFKBT-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=C(F)C=NC=C2F)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=C(F)C=NC=C2F)C=C1 NQUXBXSNHCFKBT-UHFFFAOYSA-N 0.000 claims description 4
LMPAGHHFKUTSHT-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=CN=C2)C(F)(F)F)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=CN=C2)C(F)(F)F)C=C1 LMPAGHHFKUTSHT-UHFFFAOYSA-N 0.000 claims description 4
OWZOUAWTQZSHPJ-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)C(F)(F)F)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)C(F)(F)F)C=C1 OWZOUAWTQZSHPJ-UHFFFAOYSA-N 0.000 claims description 4
XNQPWJASDFWQGU-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CC(F)(F)C2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CC(F)(F)C2)C=C1 XNQPWJASDFWQGU-UHFFFAOYSA-N 0.000 claims description 4
IJGLGLPWGGMLOB-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC(F)(F)C2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC(F)(F)C2)C=C1 IJGLGLPWGGMLOB-UHFFFAOYSA-N 0.000 claims description 4
MXLORFPIFVRFSR-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC2)C=C1 MXLORFPIFVRFSR-UHFFFAOYSA-N 0.000 claims description 4
DNSFPKQUPIOCLA-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCC2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCC2)C=C1 DNSFPKQUPIOCLA-UHFFFAOYSA-N 0.000 claims description 4
ZVQRHPGJIIQFGP-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCCC2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCCC2)C=C1 ZVQRHPGJIIQFGP-UHFFFAOYSA-N 0.000 claims description 4
PHDUJQFBGUYCGO-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCC3)=NC=C2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCC3)=NC=C2)C=C1 PHDUJQFBGUYCGO-UHFFFAOYSA-N 0.000 claims description 4
YQQKPZLJUMVOOO-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCC3)=NC=C2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCC3)=NC=C2)C=C1 YQQKPZLJUMVOOO-UHFFFAOYSA-N 0.000 claims description 4
FYWVTKPBFRSLQF-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCCC3)=NC=C2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCCC3)=NC=C2)C=C1 FYWVTKPBFRSLQF-UHFFFAOYSA-N 0.000 claims description 4
JNJDAGMXVKHFHF-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(OC3CCN(C)CC3)=NC=C2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(OC3CCN(C)CC3)=NC=C2)C=C1 JNJDAGMXVKHFHF-UHFFFAOYSA-N 0.000 claims description 4
ZKSKZFGHHJRESM-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CC(F)(F)C2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CC(F)(F)C2)C=C1 ZKSKZFGHHJRESM-UHFFFAOYSA-N 0.000 claims description 4
GRGUJBLKUYLBAM-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(OC3CCN(C)CC3)N=C2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(OC3CCN(C)CC3)N=C2)C=C1 GRGUJBLKUYLBAM-UHFFFAOYSA-N 0.000 claims description 4
QWXRGVIYJQITFU-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CN=C(C=N2)C(F)(F)F)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CN=C(C=N2)C(F)(F)F)C=C1 QWXRGVIYJQITFU-UHFFFAOYSA-N 0.000 claims description 4
UGYXJAYNMFJLEQ-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CN=C(N=C2)C(F)(F)F)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CN=C(N=C2)C(F)(F)F)C=C1 UGYXJAYNMFJLEQ-UHFFFAOYSA-N 0.000 claims description 4
JCXQDYDYWKKBMN-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC(=CC=C2)C(F)(F)F)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC(=CC=C2)C(F)(F)F)C=C1 JCXQDYDYWKKBMN-UHFFFAOYSA-N 0.000 claims description 4
VMZFKCPSNTXPPD-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(C=C2)C(F)(F)F)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(C=C2)C(F)(F)F)C=C1 VMZFKCPSNTXPPD-UHFFFAOYSA-N 0.000 claims description 4
NPRUMZOOFSTMSH-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(F)C=C2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(F)C=C2)C=C1 NPRUMZOOFSTMSH-UHFFFAOYSA-N 0.000 claims description 4
GUVQXTYZSSIIJB-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=CC(=C2)C(F)(F)F)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=CC(=C2)C(F)(F)F)C=C1 GUVQXTYZSSIIJB-UHFFFAOYSA-N 0.000 claims description 4
GAWFITBELTUSPC-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=CC=C2C(F)(F)F)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=CC=C2C(F)(F)F)C=C1 GAWFITBELTUSPC-UHFFFAOYSA-N 0.000 claims description 4
NVUPDFAZWLDEPA-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 NVUPDFAZWLDEPA-UHFFFAOYSA-N 0.000 claims description 4
KBWXORAAYPWNFR-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCC2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCC2)C=C1 KBWXORAAYPWNFR-UHFFFAOYSA-N 0.000 claims description 4
QWUYAANLSVAPID-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1 QWUYAANLSVAPID-UHFFFAOYSA-N 0.000 claims description 4
GLFQDKPAKKHGOZ-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1 GLFQDKPAKKHGOZ-UHFFFAOYSA-N 0.000 claims description 4
UFEKGYLYUKOMHY-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(C)CC2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(C)CC2)C=C1 UFEKGYLYUKOMHY-UHFFFAOYSA-N 0.000 claims description 4
NXVMFLBWWHBDGK-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC(C)(C)C)CC2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC(C)(C)C)CC2)C=C1 NXVMFLBWWHBDGK-UHFFFAOYSA-N 0.000 claims description 4
FBDLLIRIHYFSNZ-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC2)C(C)(C)C)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC2)C(C)(C)C)C=C1 FBDLLIRIHYFSNZ-UHFFFAOYSA-N 0.000 claims description 4
DGGVLNIRLSYDEV-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCNCC2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCNCC2)C=C1 DGGVLNIRLSYDEV-UHFFFAOYSA-N 0.000 claims description 4
LFGWBUINAADATO-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 LFGWBUINAADATO-UHFFFAOYSA-N 0.000 claims description 4
QOGGMWXIBKKLBB-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(N)=O)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(N)=O)C=C1 QOGGMWXIBKKLBB-UHFFFAOYSA-N 0.000 claims description 4
CXRTVQPZGAPOED-UHFFFAOYSA-N CN(C)CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)=C1 Chemical compound CN(C)CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)=C1 CXRTVQPZGAPOED-UHFFFAOYSA-N 0.000 claims description 4
PCPQHADFZCFDGS-UHFFFAOYSA-N CN(C)CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)=C1 Chemical compound CN(C)CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)=C1 PCPQHADFZCFDGS-UHFFFAOYSA-N 0.000 claims description 4
YTEWGOJCFOKGRJ-UHFFFAOYSA-N CN(C)CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 Chemical compound CN(C)CC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 YTEWGOJCFOKGRJ-UHFFFAOYSA-N 0.000 claims description 4
XNIAMEKLYUQHFK-UHFFFAOYSA-N CN(C)CCCNC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CN(C)CCCNC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 XNIAMEKLYUQHFK-UHFFFAOYSA-N 0.000 claims description 4
RCTBCOSICHGYLT-UHFFFAOYSA-N CN(C)CCN(C)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound CN(C)CCN(C)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 RCTBCOSICHGYLT-UHFFFAOYSA-N 0.000 claims description 4
UREMZVBKWSZBRS-UHFFFAOYSA-N CN(C)CCN(C)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound CN(C)CCN(C)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 UREMZVBKWSZBRS-UHFFFAOYSA-N 0.000 claims description 4
IQCOUGKBWRSGAV-UHFFFAOYSA-N CN(C)CCN(C)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound CN(C)CCN(C)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 IQCOUGKBWRSGAV-UHFFFAOYSA-N 0.000 claims description 4
CYPMWQXBYDLBDW-UHFFFAOYSA-N CN(C)CCNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CN(C)CCNC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 CYPMWQXBYDLBDW-UHFFFAOYSA-N 0.000 claims description 4
OGZAOFGQSXAJLP-UHFFFAOYSA-N CN(C)CCNC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound CN(C)CCNC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 OGZAOFGQSXAJLP-UHFFFAOYSA-N 0.000 claims description 4
ROQPGNVOKQWADF-UHFFFAOYSA-N CN(C)CCNC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound CN(C)CCNC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 ROQPGNVOKQWADF-UHFFFAOYSA-N 0.000 claims description 4
AJMNNNLAIZISOG-UHFFFAOYSA-N CN(C)CCNC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound CN(C)CCNC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 AJMNNNLAIZISOG-UHFFFAOYSA-N 0.000 claims description 4
JLFKZEQPTUOOAH-UHFFFAOYSA-N CN(C1CCN(C)CC1)C(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CN(C1CCN(C)CC1)C(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 JLFKZEQPTUOOAH-UHFFFAOYSA-N 0.000 claims description 4
AEVORDJVSYVLAX-UHFFFAOYSA-N CN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 AEVORDJVSYVLAX-UHFFFAOYSA-N 0.000 claims description 4
ATGLNCFOYSXHFN-UHFFFAOYSA-N CN1CC2(C1)CCC(CC2)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 Chemical compound CN1CC2(C1)CCC(CC2)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 ATGLNCFOYSXHFN-UHFFFAOYSA-N 0.000 claims description 4
FNXBPXMCJORGJC-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC(CN2CCCCC2)=CN=C1 FNXBPXMCJORGJC-UHFFFAOYSA-N 0.000 claims description 4
LDMLSMIEAJLEJY-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC=CN=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC=CN=C1 LDMLSMIEAJLEJY-UHFFFAOYSA-N 0.000 claims description 4
UQAVJLBXWYPMHS-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(C=CN=C1)C(F)(F)F Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(C=CN=C1)C(F)(F)F UQAVJLBXWYPMHS-UHFFFAOYSA-N 0.000 claims description 4
GOVTYONHUIUUBT-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 GOVTYONHUIUUBT-UHFFFAOYSA-N 0.000 claims description 4
ZAOVVESPPYLWLG-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 ZAOVVESPPYLWLG-UHFFFAOYSA-N 0.000 claims description 4
UKOWABTVRQNFPF-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 UKOWABTVRQNFPF-UHFFFAOYSA-N 0.000 claims description 4
FFTNTAZROCHQTE-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 FFTNTAZROCHQTE-UHFFFAOYSA-N 0.000 claims description 4
DPMPGUJCHDKTDM-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 DPMPGUJCHDKTDM-UHFFFAOYSA-N 0.000 claims description 4
FQPWVIYIFZUJOP-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 FQPWVIYIFZUJOP-UHFFFAOYSA-N 0.000 claims description 4
RXMRPFGFMVYFGO-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 RXMRPFGFMVYFGO-UHFFFAOYSA-N 0.000 claims description 4
DGIGJZDBLPQFIJ-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 DGIGJZDBLPQFIJ-UHFFFAOYSA-N 0.000 claims description 4
VMJJYSYSRBACOG-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CC(F)=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CC(F)=C1 VMJJYSYSRBACOG-UHFFFAOYSA-N 0.000 claims description 4
YZZOZJJZLSCXLY-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 YZZOZJJZLSCXLY-UHFFFAOYSA-N 0.000 claims description 4
AINCVSALJDWTNH-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 AINCVSALJDWTNH-UHFFFAOYSA-N 0.000 claims description 4
PZFNGOZOVMFNDG-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 PZFNGOZOVMFNDG-UHFFFAOYSA-N 0.000 claims description 4
QICKQSSZCMIYBA-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=C(N=C1)C(F)(F)F Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=C(N=C1)C(F)(F)F QICKQSSZCMIYBA-UHFFFAOYSA-N 0.000 claims description 4
ODRPNTSIMCWTCV-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 ODRPNTSIMCWTCV-UHFFFAOYSA-N 0.000 claims description 4
QYNUOOSSHDFQSK-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=N1 QYNUOOSSHDFQSK-UHFFFAOYSA-N 0.000 claims description 4
VIOBUGZJFIRSPK-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=N1 VIOBUGZJFIRSPK-UHFFFAOYSA-N 0.000 claims description 4
CFNCLMNLWPBVSZ-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=N1 CFNCLMNLWPBVSZ-UHFFFAOYSA-N 0.000 claims description 4
XJCHGCNZMANFRY-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(O)CC3)=CN=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(O)CC3)=CN=C2)C=N1 XJCHGCNZMANFRY-UHFFFAOYSA-N 0.000 claims description 4
ASMSJANYRBPYHB-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=N1 ASMSJANYRBPYHB-UHFFFAOYSA-N 0.000 claims description 4
KDNJHSVFICDGDB-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=N1 KDNJHSVFICDGDB-UHFFFAOYSA-N 0.000 claims description 4
USBIKJYSTVQEBV-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 USBIKJYSTVQEBV-UHFFFAOYSA-N 0.000 claims description 4
XAHDKESDYBFIIX-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 XAHDKESDYBFIIX-UHFFFAOYSA-N 0.000 claims description 4
RVAJTFJSNGHMJT-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(N)=CN=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(N)=CN=C2)C=N1 RVAJTFJSNGHMJT-UHFFFAOYSA-N 0.000 claims description 4
GMNLPXJQEBESKB-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=N1 GMNLPXJQEBESKB-UHFFFAOYSA-N 0.000 claims description 4
FRXJYTDWJQYMDF-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=N1 FRXJYTDWJQYMDF-UHFFFAOYSA-N 0.000 claims description 4
QZEOKGCQCMCKPR-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)=C1 QZEOKGCQCMCKPR-UHFFFAOYSA-N 0.000 claims description 4
ZHXOYILOCAMXQR-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)=C1 ZHXOYILOCAMXQR-UHFFFAOYSA-N 0.000 claims description 4
LNQVLHKTGASNFK-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 LNQVLHKTGASNFK-UHFFFAOYSA-N 0.000 claims description 4
ZCMXDYZIEUQDFC-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 ZCMXDYZIEUQDFC-UHFFFAOYSA-N 0.000 claims description 4
QCGVOHJDHWHUAS-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 QCGVOHJDHWHUAS-UHFFFAOYSA-N 0.000 claims description 4
BGBGAWXWEKXIQU-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=C1 BGBGAWXWEKXIQU-UHFFFAOYSA-N 0.000 claims description 4
UMNCXPAWXOWMOW-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 UMNCXPAWXOWMOW-UHFFFAOYSA-N 0.000 claims description 4
MDTDCMIFCAGJEW-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(O)CC3)=CN=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(O)CC3)=CN=C2)=C1 MDTDCMIFCAGJEW-UHFFFAOYSA-N 0.000 claims description 4
KDBORODEFDGGSF-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 KDBORODEFDGGSF-UHFFFAOYSA-N 0.000 claims description 4
BGPRHNCLAZEQQZ-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 BGPRHNCLAZEQQZ-UHFFFAOYSA-N 0.000 claims description 4
ABDGOVDUNGDTMM-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 ABDGOVDUNGDTMM-UHFFFAOYSA-N 0.000 claims description 4
HXKRGLYGWAWSEX-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(N)=CN=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(N)=CN=C2)=C1 HXKRGLYGWAWSEX-UHFFFAOYSA-N 0.000 claims description 4
SYDJFQXIJXVZID-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 SYDJFQXIJXVZID-UHFFFAOYSA-N 0.000 claims description 4
ONHCFQMPHQGZCD-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 ONHCFQMPHQGZCD-UHFFFAOYSA-N 0.000 claims description 4
YUNYNZYQUOFRPW-UHFFFAOYSA-N CN1CCC(CC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(=CN=C3)N3CCCCC3)C=N2)CC1 Chemical compound CN1CCC(CC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(=CN=C3)N3CCCCC3)C=N2)CC1 YUNYNZYQUOFRPW-UHFFFAOYSA-N 0.000 claims description 4
BEBRYXUPWYCCTJ-UHFFFAOYSA-N CN1CCC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)CC1 Chemical compound CN1CCC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)CC1 BEBRYXUPWYCCTJ-UHFFFAOYSA-N 0.000 claims description 4
OKGPSVZWHNWFMI-UHFFFAOYSA-N CN1CCC2(CC(C2)NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)CC1 Chemical compound CN1CCC2(CC(C2)NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)CC1 OKGPSVZWHNWFMI-UHFFFAOYSA-N 0.000 claims description 4
CHUQIKQEBWRVTC-UHFFFAOYSA-N CN1CCC2(CC(C2)NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(Cl)=CN=C2)CC1 Chemical compound CN1CCC2(CC(C2)NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(Cl)=CN=C2)CC1 CHUQIKQEBWRVTC-UHFFFAOYSA-N 0.000 claims description 4
JITPBDPJZMCLDE-UHFFFAOYSA-N CN1CCC2(CC(C2)NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CN=C2)CC1 Chemical compound CN1CCC2(CC(C2)NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CN=C2)CC1 JITPBDPJZMCLDE-UHFFFAOYSA-N 0.000 claims description 4
YQIFARZCEJWFCW-UHFFFAOYSA-N CN1CCN(CC1)C1=CC(=C(F)C(F)=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 Chemical compound CN1CCN(CC1)C1=CC(=C(F)C(F)=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 YQIFARZCEJWFCW-UHFFFAOYSA-N 0.000 claims description 4
AXYMBIRCCGAUPU-UHFFFAOYSA-N CN1CCN(CC1)C1=CC(=C(F)C(F)=C1)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 Chemical compound CN1CCN(CC1)C1=CC(=C(F)C(F)=C1)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 AXYMBIRCCGAUPU-UHFFFAOYSA-N 0.000 claims description 4
MOCBDMAMAYRLGT-UHFFFAOYSA-N CN1CCN(CC1)C1=CC(=C(F)C(F)=C1)C1=CC2=C(NN=C2C(=O)NC2COC2)C=C1 Chemical compound CN1CCN(CC1)C1=CC(=C(F)C(F)=C1)C1=CC2=C(NN=C2C(=O)NC2COC2)C=C1 MOCBDMAMAYRLGT-UHFFFAOYSA-N 0.000 claims description 4
SUPZTYXGPMBSFX-UHFFFAOYSA-N CN1CCN(CC1)C1=CC(=C(F)C(F)=C1)C1=CC2=C(NN=C2C(=O)NCC2CCO2)C=C1 Chemical compound CN1CCN(CC1)C1=CC(=C(F)C(F)=C1)C1=CC2=C(NN=C2C(=O)NCC2CCO2)C=C1 SUPZTYXGPMBSFX-UHFFFAOYSA-N 0.000 claims description 4
GZCVGTFTDSUPFG-UHFFFAOYSA-N CN1CCN(CC1)C1=CC(=C(F)C(F)=C1)C1=CC2=C(NN=C2C(=O)NCC2COC2)C=C1 Chemical compound CN1CCN(CC1)C1=CC(=C(F)C(F)=C1)C1=CC2=C(NN=C2C(=O)NCC2COC2)C=C1 GZCVGTFTDSUPFG-UHFFFAOYSA-N 0.000 claims description 4
FOAOKIHWSATEGS-UHFFFAOYSA-N CN1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound CN1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 FOAOKIHWSATEGS-UHFFFAOYSA-N 0.000 claims description 4
DHXNIWKHQCCARZ-UHFFFAOYSA-N CN1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound CN1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 DHXNIWKHQCCARZ-UHFFFAOYSA-N 0.000 claims description 4
DRVJYEWYTABMCG-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)=C1 DRVJYEWYTABMCG-UHFFFAOYSA-N 0.000 claims description 4
WXIHDEPCMWHUNC-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)=C1 WXIHDEPCMWHUNC-UHFFFAOYSA-N 0.000 claims description 4
OOPXDHMOWLHCFD-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 OOPXDHMOWLHCFD-UHFFFAOYSA-N 0.000 claims description 4
GEVANLMXFPEQAX-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=C1 GEVANLMXFPEQAX-UHFFFAOYSA-N 0.000 claims description 4
MYBPRUKWELMKEC-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 MYBPRUKWELMKEC-UHFFFAOYSA-N 0.000 claims description 4
SAOZZHPGOAHDBG-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(O)CC3)=CN=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(O)CC3)=CN=C2)=C1 SAOZZHPGOAHDBG-UHFFFAOYSA-N 0.000 claims description 4
KHVXGPNKOFSBIX-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 KHVXGPNKOFSBIX-UHFFFAOYSA-N 0.000 claims description 4
RUFPMMMXTUCJRD-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(N)=CN=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(N)=CN=C2)=C1 RUFPMMMXTUCJRD-UHFFFAOYSA-N 0.000 claims description 4
SEORRNSDVKJCJA-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=C1 SEORRNSDVKJCJA-UHFFFAOYSA-N 0.000 claims description 4
YDAWTTCIYIKJCI-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 YDAWTTCIYIKJCI-UHFFFAOYSA-N 0.000 claims description 4
MHBYWTBOFHHKTG-UHFFFAOYSA-N CN1CCN(CC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC(CN4CCCCC4)=C3)C=N2)CC1 Chemical compound CN1CCN(CC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC(CN4CCCCC4)=C3)C=N2)CC1 MHBYWTBOFHHKTG-UHFFFAOYSA-N 0.000 claims description 4
BQJYEYKDGLBREH-UHFFFAOYSA-N CN1CCN(CC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC=C3)C=N2)CC1 Chemical compound CN1CCN(CC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC=C3)C=N2)CC1 BQJYEYKDGLBREH-UHFFFAOYSA-N 0.000 claims description 4
PWFTYDRHHWTTET-UHFFFAOYSA-N CN1CCN(CC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCCCC4)=CN=C3)C=N2)CC1 Chemical compound CN1CCN(CC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCCCC4)=CN=C3)C=N2)CC1 PWFTYDRHHWTTET-UHFFFAOYSA-N 0.000 claims description 4
HQNWDUYPTSVYHP-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC(CN4CCCCC4)=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC(CN4CCCCC4)=C3)=C2)CC1 HQNWDUYPTSVYHP-UHFFFAOYSA-N 0.000 claims description 4
FVNVUCTWMHJHGY-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC=C3)=C2)CC1 FVNVUCTWMHJHGY-UHFFFAOYSA-N 0.000 claims description 4
LVHNMMPQQPRORK-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(=CN=C3)N3CCCC3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(=CN=C3)N3CCCC3)=C2)CC1 LVHNMMPQQPRORK-UHFFFAOYSA-N 0.000 claims description 4
OQTDHFHHOKMRHL-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(=CN=C3)N3CCCCC3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(=CN=C3)N3CCCCC3)=C2)CC1 OQTDHFHHOKMRHL-UHFFFAOYSA-N 0.000 claims description 4
PAIUPAPZLQAOMS-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(=CN=C3)N3CCOCC3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(=CN=C3)N3CCOCC3)=C2)CC1 PAIUPAPZLQAOMS-UHFFFAOYSA-N 0.000 claims description 4
QVUWTUALEVEXBP-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCC(F)(F)C4)=CN=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCC(F)(F)C4)=CN=C3)=C2)CC1 QVUWTUALEVEXBP-UHFFFAOYSA-N 0.000 claims description 4
WKVWJBWVDYRWCL-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCC(F)(F)CC4)=CN=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCC(F)(F)CC4)=CN=C3)=C2)CC1 WKVWJBWVDYRWCL-UHFFFAOYSA-N 0.000 claims description 4
TUCYAPRHRLYCGW-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCC(O)CC4)=CN=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCC(O)CC4)=CN=C3)=C2)CC1 TUCYAPRHRLYCGW-UHFFFAOYSA-N 0.000 claims description 4
JFWXUWHRWYVZOH-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCC4)=CN=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCC4)=CN=C3)=C2)CC1 JFWXUWHRWYVZOH-UHFFFAOYSA-N 0.000 claims description 4
FJZPZQMHNLXXRG-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCC4)=CN=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCC4)=CN=C3)=C2)CC1 FJZPZQMHNLXXRG-UHFFFAOYSA-N 0.000 claims description 4
SUKFRIGJFWJPPZ-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCCC4)=CN=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCCC4)=CN=C3)=C2)CC1 SUKFRIGJFWJPPZ-UHFFFAOYSA-N 0.000 claims description 4
SMRVNAQJQUHCLL-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCCCC4)=CN=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCCCC4)=CN=C3)=C2)CC1 SMRVNAQJQUHCLL-UHFFFAOYSA-N 0.000 claims description 4
COCLNDCTIVCGQT-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(OC4=CC=CC=C4)=CN=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(OC4=CC=CC=C4)=CN=C3)=C2)CC1 COCLNDCTIVCGQT-UHFFFAOYSA-N 0.000 claims description 4
UQPCUPYQFBQZOM-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC=CN=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC=CN=C3)=C2)CC1 UQPCUPYQFBQZOM-UHFFFAOYSA-N 0.000 claims description 4
JCPPOUQZGFDRAE-UHFFFAOYSA-N CNC(=O)C1=CC=C(C=N1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)C=C2)C=C1 Chemical compound CNC(=O)C1=CC=C(C=N1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)C=C2)C=C1 JCPPOUQZGFDRAE-UHFFFAOYSA-N 0.000 claims description 4
CSFZLZCPZONEKA-UHFFFAOYSA-N CNC(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 Chemical compound CNC(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 CSFZLZCPZONEKA-UHFFFAOYSA-N 0.000 claims description 4
NNXDZVZNOQFUII-UHFFFAOYSA-N COC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound COC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 NNXDZVZNOQFUII-UHFFFAOYSA-N 0.000 claims description 4
KCNBEJFCYZFBSF-UHFFFAOYSA-N COC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound COC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 KCNBEJFCYZFBSF-UHFFFAOYSA-N 0.000 claims description 4
BAERIHSKFXEWQE-UHFFFAOYSA-N COC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(C)CC3)=CN=C2)C=N1 Chemical compound COC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(C)CC3)=CN=C2)C=N1 BAERIHSKFXEWQE-UHFFFAOYSA-N 0.000 claims description 4
JVSQFHDMQIGSQE-UHFFFAOYSA-N COC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound COC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 JVSQFHDMQIGSQE-UHFFFAOYSA-N 0.000 claims description 4
OKDAXNJHNXANQC-UHFFFAOYSA-N COC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CN=CC(=N2)N2CC(N)C2)C=N1 Chemical compound COC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CN=CC(=N2)N2CC(N)C2)C=N1 OKDAXNJHNXANQC-UHFFFAOYSA-N 0.000 claims description 4
ZBEMMHPEAPMOOL-UHFFFAOYSA-N COC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC(C)C)C=C1 Chemical compound COC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC(C)C)C=C1 ZBEMMHPEAPMOOL-UHFFFAOYSA-N 0.000 claims description 4
HRERMENVFOCZBH-UHFFFAOYSA-N COC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 Chemical compound COC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 HRERMENVFOCZBH-UHFFFAOYSA-N 0.000 claims description 4
YFTMPZJPEXVUMN-UHFFFAOYSA-N COCCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound COCCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 YFTMPZJPEXVUMN-UHFFFAOYSA-N 0.000 claims description 4
DIATVYBJWMHAPW-UHFFFAOYSA-N COCCNC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound COCCNC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 DIATVYBJWMHAPW-UHFFFAOYSA-N 0.000 claims description 4
CHYJBSZRSCVORK-UHFFFAOYSA-N CS(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound CS(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 CHYJBSZRSCVORK-UHFFFAOYSA-N 0.000 claims description 4
UGINKRWOSXONNT-UHFFFAOYSA-N CS(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound CS(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 UGINKRWOSXONNT-UHFFFAOYSA-N 0.000 claims description 4
JKUFOSMJLIZLPK-UHFFFAOYSA-N CS(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound CS(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 JKUFOSMJLIZLPK-UHFFFAOYSA-N 0.000 claims description 4
CNTNWKGZRSIPET-UHFFFAOYSA-N ClC1=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=C(CN2CCCC2)C=C1 Chemical compound ClC1=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=C(CN2CCCC2)C=C1 CNTNWKGZRSIPET-UHFFFAOYSA-N 0.000 claims description 4
QNYXGZSOLOQHSB-UHFFFAOYSA-N ClC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)C=C2)C=C1 Chemical compound ClC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)C=C2)C=C1 QNYXGZSOLOQHSB-UHFFFAOYSA-N 0.000 claims description 4
OLGOEQNTMRVDAM-UHFFFAOYSA-N ClC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1 Chemical compound ClC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1 OLGOEQNTMRVDAM-UHFFFAOYSA-N 0.000 claims description 4
WXGVWEMSJYPLMM-UHFFFAOYSA-N ClC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC3CC3)CC2)C=C1 Chemical compound ClC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC3CC3)CC2)C=C1 WXGVWEMSJYPLMM-UHFFFAOYSA-N 0.000 claims description 4
LBIYKFJZMPDQHP-UHFFFAOYSA-N ClC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NCC2CC2)C=C1 Chemical compound ClC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NCC2CC2)C=C1 LBIYKFJZMPDQHP-UHFFFAOYSA-N 0.000 claims description 4
HJECIHSVINHDLV-UHFFFAOYSA-N FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=NC=C1 Chemical compound FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=NC=C1 HJECIHSVINHDLV-UHFFFAOYSA-N 0.000 claims description 4
FHYMQFAEBVKTPX-UHFFFAOYSA-N FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=NC=C1 Chemical compound FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=NC=C1 FHYMQFAEBVKTPX-UHFFFAOYSA-N 0.000 claims description 4
ZYELYHPPVVATGS-UHFFFAOYSA-N FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=NC=C1 Chemical compound FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=NC=C1 ZYELYHPPVVATGS-UHFFFAOYSA-N 0.000 claims description 4
FCOCEKYUIXQYGM-UHFFFAOYSA-N FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=NC=C1 Chemical compound FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=NC=C1 FCOCEKYUIXQYGM-UHFFFAOYSA-N 0.000 claims description 4
BJWUQMUODPOANX-UHFFFAOYSA-N FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=NC=C1 Chemical compound FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=NC=C1 BJWUQMUODPOANX-UHFFFAOYSA-N 0.000 claims description 4
MJTHGRGQZHJZGQ-UHFFFAOYSA-N FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=NC=C1 Chemical compound FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=NC=C1 MJTHGRGQZHJZGQ-UHFFFAOYSA-N 0.000 claims description 4
FIQLPNRTNIRVKZ-UHFFFAOYSA-N FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=NC=C1 Chemical compound FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=NC=C1 FIQLPNRTNIRVKZ-UHFFFAOYSA-N 0.000 claims description 4
MEAUGMRXQQUFCL-UHFFFAOYSA-N FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=NC=C1 Chemical compound FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=NC=C1 MEAUGMRXQQUFCL-UHFFFAOYSA-N 0.000 claims description 4
BYCYXAPJRILLNY-UHFFFAOYSA-N FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=NC=C1 Chemical compound FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=NC=C1 BYCYXAPJRILLNY-UHFFFAOYSA-N 0.000 claims description 4
FVJRRHPBTYEMAR-UHFFFAOYSA-N FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=NC=C1 Chemical compound FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=NC=C1 FVJRRHPBTYEMAR-UHFFFAOYSA-N 0.000 claims description 4
AYJGZZMZCSYUPT-UHFFFAOYSA-N FC(F)(F)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound FC(F)(F)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 AYJGZZMZCSYUPT-UHFFFAOYSA-N 0.000 claims description 4
VIDLWBFNPPYJQD-UHFFFAOYSA-N FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=N1 Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=N1 VIDLWBFNPPYJQD-UHFFFAOYSA-N 0.000 claims description 4
KDSSWTZBHYILOI-UHFFFAOYSA-N FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=N1 Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=N1 KDSSWTZBHYILOI-UHFFFAOYSA-N 0.000 claims description 4
SSIHSWRFSVKTFQ-UHFFFAOYSA-N FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=N1 Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=N1 SSIHSWRFSVKTFQ-UHFFFAOYSA-N 0.000 claims description 4
YWILAAUJSQJLDV-UHFFFAOYSA-N FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=N1 Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=N1 YWILAAUJSQJLDV-UHFFFAOYSA-N 0.000 claims description 4
NMQAYOYDYFEVNU-UHFFFAOYSA-N FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=N1 Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=N1 NMQAYOYDYFEVNU-UHFFFAOYSA-N 0.000 claims description 4
AFAKIRXXQDWVHE-UHFFFAOYSA-N FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=N1 Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=N1 AFAKIRXXQDWVHE-UHFFFAOYSA-N 0.000 claims description 4
DFQOPFVUDKPLFM-UHFFFAOYSA-N FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=N1 Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=N1 DFQOPFVUDKPLFM-UHFFFAOYSA-N 0.000 claims description 4
LEMFPIMQYVBAIB-UHFFFAOYSA-N FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=N1 Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=N1 LEMFPIMQYVBAIB-UHFFFAOYSA-N 0.000 claims description 4
LMKPWJBIWJAIPJ-UHFFFAOYSA-N FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=N1 Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=N1 LMKPWJBIWJAIPJ-UHFFFAOYSA-N 0.000 claims description 4
XNMAQCVKCAEKDO-UHFFFAOYSA-N FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 XNMAQCVKCAEKDO-UHFFFAOYSA-N 0.000 claims description 4
RPIBBZJIUQCNIP-UHFFFAOYSA-N FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 RPIBBZJIUQCNIP-UHFFFAOYSA-N 0.000 claims description 4
QXJZMCIQAGXIQM-UHFFFAOYSA-N FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 QXJZMCIQAGXIQM-UHFFFAOYSA-N 0.000 claims description 4
HMDVWJDPIYMPBL-UHFFFAOYSA-N FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 Chemical compound FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 HMDVWJDPIYMPBL-UHFFFAOYSA-N 0.000 claims description 4
FWTKOKKFRKVXRW-UHFFFAOYSA-N FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 Chemical compound FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 FWTKOKKFRKVXRW-UHFFFAOYSA-N 0.000 claims description 4
VGHMJNQQHFEMCZ-UHFFFAOYSA-N FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 VGHMJNQQHFEMCZ-UHFFFAOYSA-N 0.000 claims description 4
ADGRSEKEPROZFS-UHFFFAOYSA-N FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 ADGRSEKEPROZFS-UHFFFAOYSA-N 0.000 claims description 4
NXYUWNFOCAMYOY-UHFFFAOYSA-N FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 NXYUWNFOCAMYOY-UHFFFAOYSA-N 0.000 claims description 4
YKCKKFDWWJYCAT-UHFFFAOYSA-N FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 YKCKKFDWWJYCAT-UHFFFAOYSA-N 0.000 claims description 4
CIXHJLWFJKHELN-UHFFFAOYSA-N FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 Chemical compound FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 CIXHJLWFJKHELN-UHFFFAOYSA-N 0.000 claims description 4
LUXYMBCFOAHMSZ-UHFFFAOYSA-N FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 LUXYMBCFOAHMSZ-UHFFFAOYSA-N 0.000 claims description 4
QKTBPCXCRRTHGH-UHFFFAOYSA-N FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound FC(F)(F)C1=CC=CN=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 QKTBPCXCRRTHGH-UHFFFAOYSA-N 0.000 claims description 4
FFKSTDWRFNJGFO-UHFFFAOYSA-N FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=C1 Chemical compound FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=C1 FFKSTDWRFNJGFO-UHFFFAOYSA-N 0.000 claims description 4
YCFWEVNFXCYECT-UHFFFAOYSA-N FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C=C1 Chemical compound FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C=C1 YCFWEVNFXCYECT-UHFFFAOYSA-N 0.000 claims description 4
BXFSDTHYVNOGSB-UHFFFAOYSA-N FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=C1 Chemical compound FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=C1 BXFSDTHYVNOGSB-UHFFFAOYSA-N 0.000 claims description 4
DELGADBNZFRMFN-UHFFFAOYSA-N FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=C1 Chemical compound FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=C1 DELGADBNZFRMFN-UHFFFAOYSA-N 0.000 claims description 4
KFVIETQABBKTOF-UHFFFAOYSA-N FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=C1 Chemical compound FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=C1 KFVIETQABBKTOF-UHFFFAOYSA-N 0.000 claims description 4
AHTTWRYIDQHUDF-UHFFFAOYSA-N FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=C1 Chemical compound FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=C1 AHTTWRYIDQHUDF-UHFFFAOYSA-N 0.000 claims description 4
WGSQYUWNMLVTON-UHFFFAOYSA-N FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=C1 Chemical compound FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=C1 WGSQYUWNMLVTON-UHFFFAOYSA-N 0.000 claims description 4
QKSCVZNRWXSATC-UHFFFAOYSA-N FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=C1 Chemical compound FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=C1 QKSCVZNRWXSATC-UHFFFAOYSA-N 0.000 claims description 4
JAWZSWQUXQCPSD-UHFFFAOYSA-N FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=C1 Chemical compound FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=C1 JAWZSWQUXQCPSD-UHFFFAOYSA-N 0.000 claims description 4
KAVWARFLVQCMSL-UHFFFAOYSA-N FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=C1 Chemical compound FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=C1 KAVWARFLVQCMSL-UHFFFAOYSA-N 0.000 claims description 4
BTRQDKZXIATECD-UHFFFAOYSA-N FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=C1 Chemical compound FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=C1 BTRQDKZXIATECD-UHFFFAOYSA-N 0.000 claims description 4
BOLXISHQNUFVRE-UHFFFAOYSA-N FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 Chemical compound FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 BOLXISHQNUFVRE-UHFFFAOYSA-N 0.000 claims description 4
HEXYSULIWRJOPF-UHFFFAOYSA-N FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 Chemical compound FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 HEXYSULIWRJOPF-UHFFFAOYSA-N 0.000 claims description 4
YTLMXAFEMXPWRZ-UHFFFAOYSA-N FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 Chemical compound FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 YTLMXAFEMXPWRZ-UHFFFAOYSA-N 0.000 claims description 4
VFUAVDVWFJKZGQ-UHFFFAOYSA-N FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=C1 VFUAVDVWFJKZGQ-UHFFFAOYSA-N 0.000 claims description 4
GXTBLSGPJGPCGU-UHFFFAOYSA-N FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 GXTBLSGPJGPCGU-UHFFFAOYSA-N 0.000 claims description 4
HDICSFXIHGAWSJ-UHFFFAOYSA-N FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 HDICSFXIHGAWSJ-UHFFFAOYSA-N 0.000 claims description 4
YJKMHEBMHHSNNI-UHFFFAOYSA-N FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 YJKMHEBMHHSNNI-UHFFFAOYSA-N 0.000 claims description 4
FNRXROYPFKWDJV-UHFFFAOYSA-N FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 FNRXROYPFKWDJV-UHFFFAOYSA-N 0.000 claims description 4
MTNXFXXEOUIZPN-UHFFFAOYSA-N FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 MTNXFXXEOUIZPN-UHFFFAOYSA-N 0.000 claims description 4
NNKWLFNCRALJOU-UHFFFAOYSA-N FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=C1 NNKWLFNCRALJOU-UHFFFAOYSA-N 0.000 claims description 4
AAFACGBURFPZHM-UHFFFAOYSA-N FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 AAFACGBURFPZHM-UHFFFAOYSA-N 0.000 claims description 4
JTDGYWMTJBZFRJ-UHFFFAOYSA-N FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 Chemical compound FC(F)(F)C1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 JTDGYWMTJBZFRJ-UHFFFAOYSA-N 0.000 claims description 4
FSSACRRZPILPRC-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=N1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=N1 FSSACRRZPILPRC-UHFFFAOYSA-N 0.000 claims description 4
ZXSGVMBYRQIESK-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)N=C1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)N=C1 ZXSGVMBYRQIESK-UHFFFAOYSA-N 0.000 claims description 4
GMEQHACCUDSNGL-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C=N1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C=N1 GMEQHACCUDSNGL-UHFFFAOYSA-N 0.000 claims description 4
AOISKDALJBXFPF-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)N=C1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)N=C1 AOISKDALJBXFPF-UHFFFAOYSA-N 0.000 claims description 4
IAJDCDXKEVKCAK-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=N1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=N1 IAJDCDXKEVKCAK-UHFFFAOYSA-N 0.000 claims description 4
GHMNNOKLIQDOGQ-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)N=C1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)N=C1 GHMNNOKLIQDOGQ-UHFFFAOYSA-N 0.000 claims description 4
TXRQGHGHCHIBGK-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=N1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=N1 TXRQGHGHCHIBGK-UHFFFAOYSA-N 0.000 claims description 4
NMSHKOARNIMNKC-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)N=C1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)N=C1 NMSHKOARNIMNKC-UHFFFAOYSA-N 0.000 claims description 4
YKSWHEYJBPEOPB-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=N1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=N1 YKSWHEYJBPEOPB-UHFFFAOYSA-N 0.000 claims description 4
CSYXLCRBYYPSPS-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)N=C1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)N=C1 CSYXLCRBYYPSPS-UHFFFAOYSA-N 0.000 claims description 4
AKQRYKWRPKTBEV-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=N1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=N1 AKQRYKWRPKTBEV-UHFFFAOYSA-N 0.000 claims description 4
ZIKCMUWOLXEHCN-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)N=C1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)N=C1 ZIKCMUWOLXEHCN-UHFFFAOYSA-N 0.000 claims description 4
QZYYXNYCOINPBJ-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=N1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=N1 QZYYXNYCOINPBJ-UHFFFAOYSA-N 0.000 claims description 4
SMHAHSNTTUCKDC-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)N=C1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)N=C1 SMHAHSNTTUCKDC-UHFFFAOYSA-N 0.000 claims description 4
PPYYIIKKJSLCLQ-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 PPYYIIKKJSLCLQ-UHFFFAOYSA-N 0.000 claims description 4
MTVDALOHIANALO-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)N=C1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)N=C1 MTVDALOHIANALO-UHFFFAOYSA-N 0.000 claims description 4
QTQBRNKPPDLTRD-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 QTQBRNKPPDLTRD-UHFFFAOYSA-N 0.000 claims description 4
XDAIPMGRKWBEON-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)N=C1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)N=C1 XDAIPMGRKWBEON-UHFFFAOYSA-N 0.000 claims description 4
KEDIYNGMHZMZLY-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=N1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=N1 KEDIYNGMHZMZLY-UHFFFAOYSA-N 0.000 claims description 4
ODYUMUYTKADCHW-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)N=C1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)N=C1 ODYUMUYTKADCHW-UHFFFAOYSA-N 0.000 claims description 4
HQRGIHLYFKAODF-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=N1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=N1 HQRGIHLYFKAODF-UHFFFAOYSA-N 0.000 claims description 4
UHYOSLHKLDESIS-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)N=C1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)N=C1 UHYOSLHKLDESIS-UHFFFAOYSA-N 0.000 claims description 4
IRXBOBAJRVSOSI-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=N1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=N1 IRXBOBAJRVSOSI-UHFFFAOYSA-N 0.000 claims description 4
WMIHWJFSAZGIMR-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)N=C1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)N=C1 WMIHWJFSAZGIMR-UHFFFAOYSA-N 0.000 claims description 4
DDJUGMRJIUKGCI-UHFFFAOYSA-N FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 Chemical compound FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 DDJUGMRJIUKGCI-UHFFFAOYSA-N 0.000 claims description 4
CWTMLAGPTIHFKA-UHFFFAOYSA-N FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 Chemical compound FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 CWTMLAGPTIHFKA-UHFFFAOYSA-N 0.000 claims description 4
GVPNGWDXHFNKFI-UHFFFAOYSA-N FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 Chemical compound FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 GVPNGWDXHFNKFI-UHFFFAOYSA-N 0.000 claims description 4
KODSZPSJHYBFLV-UHFFFAOYSA-N FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=C1 KODSZPSJHYBFLV-UHFFFAOYSA-N 0.000 claims description 4
KRFJEQRRLUJMRO-UHFFFAOYSA-N FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 KRFJEQRRLUJMRO-UHFFFAOYSA-N 0.000 claims description 4
UFCGCLZYGBXDNP-UHFFFAOYSA-N FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 UFCGCLZYGBXDNP-UHFFFAOYSA-N 0.000 claims description 4
OUVHRLXWFODACO-UHFFFAOYSA-N FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 OUVHRLXWFODACO-UHFFFAOYSA-N 0.000 claims description 4
XITJDXHYROGLCJ-UHFFFAOYSA-N FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 XITJDXHYROGLCJ-UHFFFAOYSA-N 0.000 claims description 4
DQZRFECCIMMHTF-UHFFFAOYSA-N FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=C1 DQZRFECCIMMHTF-UHFFFAOYSA-N 0.000 claims description 4
YPPNHZQRXQNWDU-UHFFFAOYSA-N FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 YPPNHZQRXQNWDU-UHFFFAOYSA-N 0.000 claims description 4
HUJCDDAYUNERHL-UHFFFAOYSA-N FC(F)(F)CN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound FC(F)(F)CN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 HUJCDDAYUNERHL-UHFFFAOYSA-N 0.000 claims description 4
WKZPZYIEPUOGFC-UHFFFAOYSA-N FC(F)(F)CN1CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 Chemical compound FC(F)(F)CN1CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 WKZPZYIEPUOGFC-UHFFFAOYSA-N 0.000 claims description 4
UHFGTYVTLRTTOS-UHFFFAOYSA-N FC(F)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound FC(F)(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 UHFGTYVTLRTTOS-UHFFFAOYSA-N 0.000 claims description 4
IBLIANUTIHBYIW-UHFFFAOYSA-N FC(F)CN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound FC(F)CN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 IBLIANUTIHBYIW-UHFFFAOYSA-N 0.000 claims description 4
XEMXZNTZMIOSQY-UHFFFAOYSA-N FC(F)CN1CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 Chemical compound FC(F)CN1CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 XEMXZNTZMIOSQY-UHFFFAOYSA-N 0.000 claims description 4
IKGVSCAZMYAVHV-UHFFFAOYSA-N FC(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound FC(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 IKGVSCAZMYAVHV-UHFFFAOYSA-N 0.000 claims description 4
DBEFVEODUBEVRW-UHFFFAOYSA-N FC(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 Chemical compound FC(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 DBEFVEODUBEVRW-UHFFFAOYSA-N 0.000 claims description 4
GCBGLUWRPUAVCZ-UHFFFAOYSA-N FC(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 Chemical compound FC(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(F)=CN=C1 GCBGLUWRPUAVCZ-UHFFFAOYSA-N 0.000 claims description 4
QECDVQWPRNDQIV-UHFFFAOYSA-N FC(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound FC(F)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 QECDVQWPRNDQIV-UHFFFAOYSA-N 0.000 claims description 4
SKIYCHMAZRWSLY-UHFFFAOYSA-N FC(F)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C(F)=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 Chemical compound FC(F)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C(F)=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 SKIYCHMAZRWSLY-UHFFFAOYSA-N 0.000 claims description 4
CQLWPOAHXROCTL-UHFFFAOYSA-N FC(F)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 Chemical compound FC(F)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 CQLWPOAHXROCTL-UHFFFAOYSA-N 0.000 claims description 4
BWOCWIAUMWREFC-UHFFFAOYSA-N FC1(F)CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound FC1(F)CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 BWOCWIAUMWREFC-UHFFFAOYSA-N 0.000 claims description 4
XMHJOIWTFWSPQY-UHFFFAOYSA-N FC1(F)CCN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound FC1(F)CCN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 XMHJOIWTFWSPQY-UHFFFAOYSA-N 0.000 claims description 4
ZHVRHEYUIKWVKR-UHFFFAOYSA-N FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 Chemical compound FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 ZHVRHEYUIKWVKR-UHFFFAOYSA-N 0.000 claims description 4
VCCFRSGXDFLLBG-UHFFFAOYSA-N FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 Chemical compound FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 VCCFRSGXDFLLBG-UHFFFAOYSA-N 0.000 claims description 4
HGLUETXHHDKYNL-UHFFFAOYSA-N FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 Chemical compound FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 HGLUETXHHDKYNL-UHFFFAOYSA-N 0.000 claims description 4
DMOHBRLXMOOINT-UHFFFAOYSA-N FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 Chemical compound FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 DMOHBRLXMOOINT-UHFFFAOYSA-N 0.000 claims description 4
JDDYJEHPCDSXOK-UHFFFAOYSA-N FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 Chemical compound FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 JDDYJEHPCDSXOK-UHFFFAOYSA-N 0.000 claims description 4
VZYVGHWOEAOASC-UHFFFAOYSA-N FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 Chemical compound FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 VZYVGHWOEAOASC-UHFFFAOYSA-N 0.000 claims description 4
VONFOOXTIJIVGA-UHFFFAOYSA-N FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 Chemical compound FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 VONFOOXTIJIVGA-UHFFFAOYSA-N 0.000 claims description 4
XENRQDBUTFBYGC-UHFFFAOYSA-N FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 Chemical compound FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 XENRQDBUTFBYGC-UHFFFAOYSA-N 0.000 claims description 4
GPMONRIKNJGSHS-UHFFFAOYSA-N FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 Chemical compound FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 GPMONRIKNJGSHS-UHFFFAOYSA-N 0.000 claims description 4
VQFOEGJVSXQUDW-UHFFFAOYSA-N FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 Chemical compound FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 VQFOEGJVSXQUDW-UHFFFAOYSA-N 0.000 claims description 4
WCNITFAJIVPBDU-UHFFFAOYSA-N FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 Chemical compound FC1(F)CCN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 WCNITFAJIVPBDU-UHFFFAOYSA-N 0.000 claims description 4
TVMZHKZWAYAAFW-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC(F)(F)C3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC(F)(F)C3)C=C2)C1 TVMZHKZWAYAAFW-UHFFFAOYSA-N 0.000 claims description 4
DLZXIUVNWQVTJQ-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC3)C=C2)C1 DLZXIUVNWQVTJQ-UHFFFAOYSA-N 0.000 claims description 4
UFFVSPNCNOYWSU-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC3)C=C2)CC1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC3)C=C2)CC1 UFFVSPNCNOYWSU-UHFFFAOYSA-N 0.000 claims description 4
XTEYURNQOJMBEH-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCC3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCC3)C=C2)C1 XTEYURNQOJMBEH-UHFFFAOYSA-N 0.000 claims description 4
AFBCZSDLFFTPPC-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCC3)C=C2)CC1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCC3)C=C2)CC1 AFBCZSDLFFTPPC-UHFFFAOYSA-N 0.000 claims description 4
NSIUTYNXUDQFRY-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCCC3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCCC3)C=C2)C1 NSIUTYNXUDQFRY-UHFFFAOYSA-N 0.000 claims description 4
SWGXAIAMRSENAS-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCC4)=NC=C3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCC4)=NC=C3)C=C2)C1 SWGXAIAMRSENAS-UHFFFAOYSA-N 0.000 claims description 4
IIXICDPUHVHSIK-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCC4)=NC=C3)C=C2)CC1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCC4)=NC=C3)C=C2)CC1 IIXICDPUHVHSIK-UHFFFAOYSA-N 0.000 claims description 4
UBMJAKMSCCDEGE-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCC4)=NC=C3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCC4)=NC=C3)C=C2)C1 UBMJAKMSCCDEGE-UHFFFAOYSA-N 0.000 claims description 4
FRTJMIIAXXADQX-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCC4)=NC=C3)C=C2)CC1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCC4)=NC=C3)C=C2)CC1 FRTJMIIAXXADQX-UHFFFAOYSA-N 0.000 claims description 4
BDGTVBILYGMNKX-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCCC4)=NC=C3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCCC4)=NC=C3)C=C2)C1 BDGTVBILYGMNKX-UHFFFAOYSA-N 0.000 claims description 4
MEBQKLGSZAZYJO-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCCC4)=NC=C3)C=C2)CC1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCCC4)=NC=C3)C=C2)CC1 MEBQKLGSZAZYJO-UHFFFAOYSA-N 0.000 claims description 4
XAWPKGRWFYZJMA-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CC3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CC3)C=C2)C1 XAWPKGRWFYZJMA-UHFFFAOYSA-N 0.000 claims description 4
VSKBSJDZCSNUCB-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CC3)C=C2)CC1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CC3)C=C2)CC1 VSKBSJDZCSNUCB-UHFFFAOYSA-N 0.000 claims description 4
NULGTXOICGHRLA-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCC3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCC3)C=C2)C1 NULGTXOICGHRLA-UHFFFAOYSA-N 0.000 claims description 4
GFVOJXXKYGVCAC-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCC3)C=C2)CC1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCC3)C=C2)CC1 GFVOJXXKYGVCAC-UHFFFAOYSA-N 0.000 claims description 4
ZOJZIXMJHLIGAR-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCC3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCC3)C=C2)C1 ZOJZIXMJHLIGAR-UHFFFAOYSA-N 0.000 claims description 4
VDISAZPNMCEGGL-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCC3)C=C2)CC1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCC3)C=C2)CC1 VDISAZPNMCEGGL-UHFFFAOYSA-N 0.000 claims description 4
RUPPNHPNCQJVHX-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCCC3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCCC3)C=C2)C1 RUPPNHPNCQJVHX-UHFFFAOYSA-N 0.000 claims description 4
NQXFJGPQJJRKMD-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCCC3)C=C2)CC1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCCC3)C=C2)CC1 NQXFJGPQJJRKMD-UHFFFAOYSA-N 0.000 claims description 4
HFRARYLDOCUYBX-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(CC#C)CC3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(CC#C)CC3)C=C2)C1 HFRARYLDOCUYBX-UHFFFAOYSA-N 0.000 claims description 4
GLAOOVFZIPAOER-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(CC#C)CC3)C=C2)CC1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(CC#C)CC3)C=C2)CC1 GLAOOVFZIPAOER-UHFFFAOYSA-N 0.000 claims description 4
BOXDRTRKEFKUIX-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCNCC3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCNCC3)C=C2)C1 BOXDRTRKEFKUIX-UHFFFAOYSA-N 0.000 claims description 4
MIXCMZKHASPJHF-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCNCC3)C=C2)CC1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCNCC3)C=C2)CC1 MIXCMZKHASPJHF-UHFFFAOYSA-N 0.000 claims description 4
QXORXDKQGGHTIN-UHFFFAOYSA-N FC1(F)CCN(CCNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 Chemical compound FC1(F)CCN(CCNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 QXORXDKQGGHTIN-UHFFFAOYSA-N 0.000 claims description 4
UDIPIKYNOUBZDO-UHFFFAOYSA-N FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=N1 Chemical compound FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=N1 UDIPIKYNOUBZDO-UHFFFAOYSA-N 0.000 claims description 4
ZFXCPUNUZSCRHS-UHFFFAOYSA-N FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C=N1 Chemical compound FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C=N1 ZFXCPUNUZSCRHS-UHFFFAOYSA-N 0.000 claims description 4
HKKDQOPKICODAH-UHFFFAOYSA-N FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=N1 Chemical compound FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=N1 HKKDQOPKICODAH-UHFFFAOYSA-N 0.000 claims description 4
HPWJXJINTWEDAL-UHFFFAOYSA-N FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=N1 Chemical compound FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=N1 HPWJXJINTWEDAL-UHFFFAOYSA-N 0.000 claims description 4
RKEYVWSIKYTNKI-UHFFFAOYSA-N FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=N1 Chemical compound FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=N1 RKEYVWSIKYTNKI-UHFFFAOYSA-N 0.000 claims description 4
MHKVRDSXOKGWFB-UHFFFAOYSA-N FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=N1 Chemical compound FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=N1 MHKVRDSXOKGWFB-UHFFFAOYSA-N 0.000 claims description 4
MARBJXHJBAZDJO-UHFFFAOYSA-N FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=N1 Chemical compound FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=N1 MARBJXHJBAZDJO-UHFFFAOYSA-N 0.000 claims description 4
KGFURJWQBPWTLA-UHFFFAOYSA-N FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 Chemical compound FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 KGFURJWQBPWTLA-UHFFFAOYSA-N 0.000 claims description 4
DAHVKKWTQZRCRA-UHFFFAOYSA-N FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=N1 Chemical compound FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=N1 DAHVKKWTQZRCRA-UHFFFAOYSA-N 0.000 claims description 4
VSIPJGWZHXJNNB-UHFFFAOYSA-N FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=N1 Chemical compound FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=N1 VSIPJGWZHXJNNB-UHFFFAOYSA-N 0.000 claims description 4
FMENCUPXKAKIPO-UHFFFAOYSA-N FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 Chemical compound FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 FMENCUPXKAKIPO-UHFFFAOYSA-N 0.000 claims description 4
OCYCTOVFUNXSHX-UHFFFAOYSA-N FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 Chemical compound FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 OCYCTOVFUNXSHX-UHFFFAOYSA-N 0.000 claims description 4
JWJXFBUGYYHDEY-UHFFFAOYSA-N FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=C1 Chemical compound FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=C1 JWJXFBUGYYHDEY-UHFFFAOYSA-N 0.000 claims description 4
GEJZFOWJIQGSIP-UHFFFAOYSA-N FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 Chemical compound FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 GEJZFOWJIQGSIP-UHFFFAOYSA-N 0.000 claims description 4
KRQGNCIDIDZNSI-UHFFFAOYSA-N FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 Chemical compound FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 KRQGNCIDIDZNSI-UHFFFAOYSA-N 0.000 claims description 4
URUCVBIXYFWRTR-UHFFFAOYSA-N FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 Chemical compound FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 URUCVBIXYFWRTR-UHFFFAOYSA-N 0.000 claims description 4
HYECWLCJKAQPLI-UHFFFAOYSA-N FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 Chemical compound FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 HYECWLCJKAQPLI-UHFFFAOYSA-N 0.000 claims description 4
LNCDIMYGMCCWFV-UHFFFAOYSA-N FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 Chemical compound FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 LNCDIMYGMCCWFV-UHFFFAOYSA-N 0.000 claims description 4
PKHWHIXSTZJWOH-UHFFFAOYSA-N FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 Chemical compound FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 PKHWHIXSTZJWOH-UHFFFAOYSA-N 0.000 claims description 4
POSMLJOKPQHIIZ-UHFFFAOYSA-N FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 Chemical compound FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)=C1 POSMLJOKPQHIIZ-UHFFFAOYSA-N 0.000 claims description 4
WTTTUEFPNFWUFW-UHFFFAOYSA-N FC1(F)CN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CC3)C=C2)C1 Chemical compound FC1(F)CN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CC3)C=C2)C1 WTTTUEFPNFWUFW-UHFFFAOYSA-N 0.000 claims description 4
FBGMHXUFODLJQJ-UHFFFAOYSA-N FC1(F)CN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCC3)C=C2)C1 Chemical compound FC1(F)CN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCC3)C=C2)C1 FBGMHXUFODLJQJ-UHFFFAOYSA-N 0.000 claims description 4
LVPVPGVSTBYTAR-UHFFFAOYSA-N FC1(F)CN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCCC3)C=C2)C1 Chemical compound FC1(F)CN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCCC3)C=C2)C1 LVPVPGVSTBYTAR-UHFFFAOYSA-N 0.000 claims description 4
JBKWUNIPDWHWCL-UHFFFAOYSA-N FC1(F)CN(CCNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 Chemical compound FC1(F)CN(CCNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 JBKWUNIPDWHWCL-UHFFFAOYSA-N 0.000 claims description 4
GOYYXDPUFLRHBM-UHFFFAOYSA-N FC1=C(C=C(C=C1F)CN1CCCCC1)C=1C=C2C(=NNC2=CC1)C(=O)NC1=CC2=C(OCCO2)C=C1 Chemical compound FC1=C(C=C(C=C1F)CN1CCCCC1)C=1C=C2C(=NNC2=CC1)C(=O)NC1=CC2=C(OCCO2)C=C1 GOYYXDPUFLRHBM-UHFFFAOYSA-N 0.000 claims description 4
BTQJBXQNXWBELV-UHFFFAOYSA-N FC1=C(C=CC=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound FC1=C(C=CC=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 BTQJBXQNXWBELV-UHFFFAOYSA-N 0.000 claims description 4
LHGZIDJTIQYPMW-UHFFFAOYSA-N FC1=C(C=CC=C1F)C=1C=C2C(=NNC2=CC1)C(=O)NC1=CC2=C(OCCO2)C=C1 Chemical compound FC1=C(C=CC=C1F)C=1C=C2C(=NNC2=CC1)C(=O)NC1=CC2=C(OCCO2)C=C1 LHGZIDJTIQYPMW-UHFFFAOYSA-N 0.000 claims description 4
YRPLGLJVCMELLJ-UHFFFAOYSA-N FC1=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=CN=C1 Chemical compound FC1=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=CN=C1 YRPLGLJVCMELLJ-UHFFFAOYSA-N 0.000 claims description 4
MSVUOTOQCMTVJI-UHFFFAOYSA-N FC1=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=NC=C1 Chemical compound FC1=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=NC=C1 MSVUOTOQCMTVJI-UHFFFAOYSA-N 0.000 claims description 4
NCACFRVWPXCURS-UHFFFAOYSA-N FC1=C(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCCCC4)=CN=C3)C=N2)C=CC=C1 Chemical compound FC1=C(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCCCC4)=CN=C3)C=N2)C=CC=C1 NCACFRVWPXCURS-UHFFFAOYSA-N 0.000 claims description 4
SWUFLYPXNRZJLP-UHFFFAOYSA-N FC1=CC(=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1)N1CCOCC1 Chemical compound FC1=CC(=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1)N1CCOCC1 SWUFLYPXNRZJLP-UHFFFAOYSA-N 0.000 claims description 4
RXMLXGVVYMHYCR-UHFFFAOYSA-N FC1=CC(=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1)N1CCCC1 Chemical compound FC1=CC(=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1)N1CCCC1 RXMLXGVVYMHYCR-UHFFFAOYSA-N 0.000 claims description 4
QHJOQKKROCWOQS-UHFFFAOYSA-N FC1=CC(=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2COC2)C=C1)N1CCCC1 Chemical compound FC1=CC(=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2COC2)C=C1)N1CCCC1 QHJOQKKROCWOQS-UHFFFAOYSA-N 0.000 claims description 4
ILJABXOJAOVHAN-UHFFFAOYSA-N FC1=CC(=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2COC2)C=C1)N1CCCC1 Chemical compound FC1=CC(=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2COC2)C=C1)N1CCCC1 ILJABXOJAOVHAN-UHFFFAOYSA-N 0.000 claims description 4
XBMHKFJVENNFBZ-UHFFFAOYSA-N FC1=CC(CN2CCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 Chemical compound FC1=CC(CN2CCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 XBMHKFJVENNFBZ-UHFFFAOYSA-N 0.000 claims description 4
WKDLWUNMVVBRDW-UHFFFAOYSA-N FC1=CC(CN2CCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 Chemical compound FC1=CC(CN2CCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 WKDLWUNMVVBRDW-UHFFFAOYSA-N 0.000 claims description 4
JPIKHKNXYFFGLP-UHFFFAOYSA-N FC1=CC(CN2CCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2COC2)C=C1 Chemical compound FC1=CC(CN2CCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2COC2)C=C1 JPIKHKNXYFFGLP-UHFFFAOYSA-N 0.000 claims description 4
DWLORVUIUAQJDP-UHFFFAOYSA-N FC1=CC(CN2CCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2CCO2)C=C1 Chemical compound FC1=CC(CN2CCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2CCO2)C=C1 DWLORVUIUAQJDP-UHFFFAOYSA-N 0.000 claims description 4
CYXOFEIINXGIFB-UHFFFAOYSA-N FC1=CC(CN2CCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2COC2)C=C1 Chemical compound FC1=CC(CN2CCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2COC2)C=C1 CYXOFEIINXGIFB-UHFFFAOYSA-N 0.000 claims description 4
CEVSIRBNEWZTRY-UHFFFAOYSA-N FC1=CC(CN2CCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 Chemical compound FC1=CC(CN2CCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 CEVSIRBNEWZTRY-UHFFFAOYSA-N 0.000 claims description 4
FPUMOANBTJHWSB-UHFFFAOYSA-N FC1=CC(CN2CCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 Chemical compound FC1=CC(CN2CCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 FPUMOANBTJHWSB-UHFFFAOYSA-N 0.000 claims description 4
OMAQYFHSPMHHFM-UHFFFAOYSA-N FC1=CC(CN2CCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2COC2)C=C1 Chemical compound FC1=CC(CN2CCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2COC2)C=C1 OMAQYFHSPMHHFM-UHFFFAOYSA-N 0.000 claims description 4
QSQGYZSZRBNLGZ-UHFFFAOYSA-N FC1=CC(CN2CCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2CCO2)C=C1 Chemical compound FC1=CC(CN2CCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2CCO2)C=C1 QSQGYZSZRBNLGZ-UHFFFAOYSA-N 0.000 claims description 4
IHXVXQULDKOYTF-UHFFFAOYSA-N FC1=CC(CN2CCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2COC2)C=C1 Chemical compound FC1=CC(CN2CCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2COC2)C=C1 IHXVXQULDKOYTF-UHFFFAOYSA-N 0.000 claims description 4
KUFZMAIZQMYVKB-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=C(F)C=CN=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=C(F)C=CN=C2)C=C1 KUFZMAIZQMYVKB-UHFFFAOYSA-N 0.000 claims description 4
OVWVTUHEUVTNLK-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=C(F)C=NC=C2F)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=C(F)C=NC=C2F)C=C1 OVWVTUHEUVTNLK-UHFFFAOYSA-N 0.000 claims description 4
VUBLOYCEHSGVES-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=C(NC(=O)C3CC3)C=CN=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=C(NC(=O)C3CC3)C=CN=C2)C=C1 VUBLOYCEHSGVES-UHFFFAOYSA-N 0.000 claims description 4
CRHLECUHLSFENK-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=CN=C2)C(F)(F)F)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=CN=C2)C(F)(F)F)C=C1 CRHLECUHLSFENK-UHFFFAOYSA-N 0.000 claims description 4
AHUCMSPIWGRHOS-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)C(F)(F)F)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)C(F)(F)F)C=C1 AHUCMSPIWGRHOS-UHFFFAOYSA-N 0.000 claims description 4
QMUZTYPYDJZSBA-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CC(F)(F)C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CC(F)(F)C2)C=C1 QMUZTYPYDJZSBA-UHFFFAOYSA-N 0.000 claims description 4
ODPNFYDPYRLWKT-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC(F)(F)C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC(F)(F)C2)C=C1 ODPNFYDPYRLWKT-UHFFFAOYSA-N 0.000 claims description 4
DYJATALJDPPEHA-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC2)C=C1 DYJATALJDPPEHA-UHFFFAOYSA-N 0.000 claims description 4
DWOAHQBLDITLBZ-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCC2)C=C1 DWOAHQBLDITLBZ-UHFFFAOYSA-N 0.000 claims description 4
OVYUJAZZTNGFFC-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCCC2)C=C1 OVYUJAZZTNGFFC-UHFFFAOYSA-N 0.000 claims description 4
YLGANYLBPYBQQU-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCC3)=NC=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCC3)=NC=C2)C=C1 YLGANYLBPYBQQU-UHFFFAOYSA-N 0.000 claims description 4
DIVUNCMXVTVGSO-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCCC3)=NC=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCCC3)=NC=C2)C=C1 DIVUNCMXVTVGSO-UHFFFAOYSA-N 0.000 claims description 4
YNJWWSDZGFJZEL-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCC3)N=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCC3)N=C2)C=C1 YNJWWSDZGFJZEL-UHFFFAOYSA-N 0.000 claims description 4
QZNLLDYBIXSZTE-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)N=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)N=C2)C=C1 QZNLLDYBIXSZTE-UHFFFAOYSA-N 0.000 claims description 4
QNNYQVXFENPBRK-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCCC3)N=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCCC3)N=C2)C=C1 QNNYQVXFENPBRK-UHFFFAOYSA-N 0.000 claims description 4
QIHRPXBZMLTHSD-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCOCC3)N=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCOCC3)N=C2)C=C1 QIHRPXBZMLTHSD-UHFFFAOYSA-N 0.000 claims description 4
OKZVHDZODGQVBR-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)C#N)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)C#N)C=C1 OKZVHDZODGQVBR-UHFFFAOYSA-N 0.000 claims description 4
KVARHIMAAAYGBW-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)C(=O)N2CCCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)C(=O)N2CCCC2)C=C1 KVARHIMAAAYGBW-UHFFFAOYSA-N 0.000 claims description 4
SVJSDONNTPODLI-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)C(=O)NC2CCCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)C(=O)NC2CCCC2)C=C1 SVJSDONNTPODLI-UHFFFAOYSA-N 0.000 claims description 4
VMZDTDVMWYFNDI-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)C(F)(F)F)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)C(F)(F)F)C=C1 VMZDTDVMWYFNDI-UHFFFAOYSA-N 0.000 claims description 4
LXRSPAFARSBPRP-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)C2=C(F)C=CC=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)C2=C(F)C=CC=C2)C=C1 LXRSPAFARSBPRP-UHFFFAOYSA-N 0.000 claims description 4
AAXSXIJDLAWOPA-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)C2=CC=CC=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)C2=CC=CC=C2)C=C1 AAXSXIJDLAWOPA-UHFFFAOYSA-N 0.000 claims description 4
MVFCKTKDSXHNDC-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCC(F)(F)C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCC(F)(F)C2)C=C1 MVFCKTKDSXHNDC-UHFFFAOYSA-N 0.000 claims description 4
DTGIQSSKEYCVOA-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCC2)C=C1 DTGIQSSKEYCVOA-UHFFFAOYSA-N 0.000 claims description 4
WXPWHTZVOPANGL-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCCC2)C=C1 WXPWHTZVOPANGL-UHFFFAOYSA-N 0.000 claims description 4
UNSOTRACUFVEHG-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCCCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCCCC2)C=C1 UNSOTRACUFVEHG-UHFFFAOYSA-N 0.000 claims description 4
IHNSHAPUMVEYIE-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCNCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCNCC2)C=C1 IHNSHAPUMVEYIE-UHFFFAOYSA-N 0.000 claims description 4
BGRLBBUFJKGYQW-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCOCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCOCC2)C=C1 BGRLBBUFJKGYQW-UHFFFAOYSA-N 0.000 claims description 4
XBDMQRWKJGLLQG-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(OC3=C(F)C=CC=C3)N=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(OC3=C(F)C=CC=C3)N=C2)C=C1 XBDMQRWKJGLLQG-UHFFFAOYSA-N 0.000 claims description 4
VVHPTJROGOCIHS-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=CC=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=CC=C2)C=C1 VVHPTJROGOCIHS-UHFFFAOYSA-N 0.000 claims description 4
AWZBCFSGCHXJOI-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=CN=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=CN=C2)C=C1 AWZBCFSGCHXJOI-UHFFFAOYSA-N 0.000 claims description 4
KRVCHBROFPBVKC-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=NC=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=NC=C2)C=C1 KRVCHBROFPBVKC-UHFFFAOYSA-N 0.000 claims description 4
ADXNYUJXMVJAGH-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CN=C(C=N2)C(F)(F)F)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CN=C(C=N2)C(F)(F)F)C=C1 ADXNYUJXMVJAGH-UHFFFAOYSA-N 0.000 claims description 4
SCDAIALHAFRADH-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CN=C(N=C2)C(F)(F)F)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CN=C(N=C2)C(F)(F)F)C=C1 SCDAIALHAFRADH-UHFFFAOYSA-N 0.000 claims description 4
SMGUNJUJVALRLH-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CN=CC=N2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CN=CC=N2)C=C1 SMGUNJUJVALRLH-UHFFFAOYSA-N 0.000 claims description 4
DRXRUYWBJZTDHM-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CN=NC=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CN=NC=C2)C=C1 DRXRUYWBJZTDHM-UHFFFAOYSA-N 0.000 claims description 4
BSOMIHUDJBLODB-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=NC(=CC=C2)C(F)(F)F)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=NC(=CC=C2)C(F)(F)F)C=C1 BSOMIHUDJBLODB-UHFFFAOYSA-N 0.000 claims description 4
HDTXGLQSEIAVQK-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=NC=C(C=C2)C(F)(F)F)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=NC=C(C=C2)C(F)(F)F)C=C1 HDTXGLQSEIAVQK-UHFFFAOYSA-N 0.000 claims description 4
GVNJTDPKUYBUQG-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=NC=CC(=C2)C(F)(F)F)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=NC=CC(=C2)C(F)(F)F)C=C1 GVNJTDPKUYBUQG-UHFFFAOYSA-N 0.000 claims description 4
WCVHIPNHXOYJGC-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=NC=CC=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=NC=CC=C2)C=C1 WCVHIPNHXOYJGC-UHFFFAOYSA-N 0.000 claims description 4
PTULMTAEADHJBL-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 PTULMTAEADHJBL-UHFFFAOYSA-N 0.000 claims description 4
HITCMKOCKRKRDW-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCC2)C=C1 HITCMKOCKRKRDW-UHFFFAOYSA-N 0.000 claims description 4
KLBFPDLRLANJLM-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1 KLBFPDLRLANJLM-UHFFFAOYSA-N 0.000 claims description 4
HPHDQWNIONKSBF-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1 HPHDQWNIONKSBF-UHFFFAOYSA-N 0.000 claims description 4
UBUDJYOALOHRNB-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCN(CC#C)CC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCN(CC#C)CC2)C=C1 UBUDJYOALOHRNB-UHFFFAOYSA-N 0.000 claims description 4
CJQVPDPROQCBKE-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCNCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCNCC2)C=C1 CJQVPDPROQCBKE-UHFFFAOYSA-N 0.000 claims description 4
WUBBEYLMRKCCBW-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 WUBBEYLMRKCCBW-UHFFFAOYSA-N 0.000 claims description 4
BZCGBDUHDJTLST-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2COC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2COC2)C=C1 BZCGBDUHDJTLST-UHFFFAOYSA-N 0.000 claims description 4
WHHONHFBTBTYQC-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2CCO2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2CCO2)C=C1 WHHONHFBTBTYQC-UHFFFAOYSA-N 0.000 claims description 4
CKHCNNLOQVIDGI-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2COC2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2COC2)C=C1 CKHCNNLOQVIDGI-UHFFFAOYSA-N 0.000 claims description 4
PEEGMHUVHOESOC-UHFFFAOYSA-N FC1=CC2=C(C=C1C1=CC(CN3CCCCC3)=CN=C1)C(=NN2)C(=O)NC1=CC=CN=C1 Chemical compound FC1=CC2=C(C=C1C1=CC(CN3CCCCC3)=CN=C1)C(=NN2)C(=O)NC1=CC=CN=C1 PEEGMHUVHOESOC-UHFFFAOYSA-N 0.000 claims description 4
AQRWIEDTFAJEIU-UHFFFAOYSA-N FC1=CC2=C(C=C1C1=CC(CN3CCCCC3)=CN=C1)C(=NN2)C(=O)NC1=NC=CC=C1 Chemical compound FC1=CC2=C(C=C1C1=CC(CN3CCCCC3)=CN=C1)C(=NN2)C(=O)NC1=NC=CC=C1 AQRWIEDTFAJEIU-UHFFFAOYSA-N 0.000 claims description 4
KSHZYSAKFDQNDZ-UHFFFAOYSA-N FC1=CC2=C(C=C1C1=CC=CN=C1)C(=NN2)C(=O)NC1=CC=C(CN2CCCC2)C=C1 Chemical compound FC1=CC2=C(C=C1C1=CC=CN=C1)C(=NN2)C(=O)NC1=CC=C(CN2CCCC2)C=C1 KSHZYSAKFDQNDZ-UHFFFAOYSA-N 0.000 claims description 4
HNOSYDRBCNGZER-UHFFFAOYSA-N FC1=CC=C(C=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound FC1=CC=C(C=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 HNOSYDRBCNGZER-UHFFFAOYSA-N 0.000 claims description 4
PBAPTZAJBSBJBS-UHFFFAOYSA-N FC1=CC=C(C=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound FC1=CC=C(C=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 PBAPTZAJBSBJBS-UHFFFAOYSA-N 0.000 claims description 4
PJTYPTDYMPPVON-UHFFFAOYSA-N FC1=CC=C(C=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound FC1=CC=C(C=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 PJTYPTDYMPPVON-UHFFFAOYSA-N 0.000 claims description 4
BBHRHWDBYWXJHX-UHFFFAOYSA-N FC1=CC=C(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC(CN4CCCCC4)=C3)C=N2)C=C1 Chemical compound FC1=CC=C(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC(CN4CCCCC4)=C3)C=N2)C=C1 BBHRHWDBYWXJHX-UHFFFAOYSA-N 0.000 claims description 4
UORFIBGGQHZIKN-UHFFFAOYSA-N FC1=CC=C(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC=C3)C=N2)C=C1 Chemical compound FC1=CC=C(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC=C3)C=N2)C=C1 UORFIBGGQHZIKN-UHFFFAOYSA-N 0.000 claims description 4
CVPDKFQXHAYHHC-UHFFFAOYSA-N FC1=CC=C(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCCCC4)=CN=C3)C=N2)C=C1 Chemical compound FC1=CC=C(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCCCC4)=CN=C3)C=N2)C=C1 CVPDKFQXHAYHHC-UHFFFAOYSA-N 0.000 claims description 4
OMHZPRFVDIUBHP-UHFFFAOYSA-N FC1=CC=CC(=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound FC1=CC=CC(=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 OMHZPRFVDIUBHP-UHFFFAOYSA-N 0.000 claims description 4
WLODBLIPXRREKC-UHFFFAOYSA-N FC1=CC=CC(=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound FC1=CC=CC(=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 WLODBLIPXRREKC-UHFFFAOYSA-N 0.000 claims description 4
CLZSESXZBUYVIE-UHFFFAOYSA-N FC1=CC=CC(=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound FC1=CC=CC(=C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 CLZSESXZBUYVIE-UHFFFAOYSA-N 0.000 claims description 4
HMBDPKIMDUHPBE-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCC3)=NC=C2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCC3)=NC=C2)C=C1 HMBDPKIMDUHPBE-UHFFFAOYSA-N 0.000 claims description 4
BIEAKQJTAMLAGU-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCC3)=NC=C2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCC3)=NC=C2)C=C1 BIEAKQJTAMLAGU-UHFFFAOYSA-N 0.000 claims description 4
FWWJZHSIXQNMLC-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCC3)N=C2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCC3)N=C2)C=C1 FWWJZHSIXQNMLC-UHFFFAOYSA-N 0.000 claims description 4
MYIYQBSRAXAYHL-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)C=C2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)C=C2)C=C1 MYIYQBSRAXAYHL-UHFFFAOYSA-N 0.000 claims description 4
IEWBAZRQEGBAED-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)N=C2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)N=C2)C=C1 IEWBAZRQEGBAED-UHFFFAOYSA-N 0.000 claims description 4
JBJOKKBDJZHJOM-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCCC3)N=C2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCCC3)N=C2)C=C1 JBJOKKBDJZHJOM-UHFFFAOYSA-N 0.000 claims description 4
HWQXCTWMBGZODG-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCOCC3)N=C2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCOCC3)N=C2)C=C1 HWQXCTWMBGZODG-UHFFFAOYSA-N 0.000 claims description 4
FHADFYLJERTYFG-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCNCC2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCNCC2)C=C1 FHADFYLJERTYFG-UHFFFAOYSA-N 0.000 claims description 4
YIUBBXKKEADDLG-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=CC=C2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=CC=C2)C=C1 YIUBBXKKEADDLG-UHFFFAOYSA-N 0.000 claims description 4
CJRKULDRYZNONZ-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCN(CC(F)(F)F)CC2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCN(CC(F)(F)F)CC2)C=C1 CJRKULDRYZNONZ-UHFFFAOYSA-N 0.000 claims description 4
KZDQZDXPOMPSGW-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCN(CC2)C(=O)C2CC2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCN(CC2)C(=O)C2CC2)C=C1 KZDQZDXPOMPSGW-UHFFFAOYSA-N 0.000 claims description 4
BZWFEEGUXDEKRV-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCN(CC2)C2COC2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCN(CC2)C2COC2)C=C1 BZWFEEGUXDEKRV-UHFFFAOYSA-N 0.000 claims description 4
JMMNJPHPDZHFLB-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCNCC2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCNCC2)C=C1 JMMNJPHPDZHFLB-UHFFFAOYSA-N 0.000 claims description 4
UZGGCPPNHPWZKF-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 UZGGCPPNHPWZKF-UHFFFAOYSA-N 0.000 claims description 4
AOIMVBZMCZAYQQ-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2COC2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2COC2)C=C1 AOIMVBZMCZAYQQ-UHFFFAOYSA-N 0.000 claims description 4
HETQEXLBALAJGH-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2CCO2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2CCO2)C=C1 HETQEXLBALAJGH-UHFFFAOYSA-N 0.000 claims description 4
LUXJBYFOTRZEKE-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2COC2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2COC2)C=C1 LUXJBYFOTRZEKE-UHFFFAOYSA-N 0.000 claims description 4
YPEHSFQCHPNWHL-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCCN2CC(F)(F)C2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCCN2CC(F)(F)C2)C=C1 YPEHSFQCHPNWHL-UHFFFAOYSA-N 0.000 claims description 4
CYOWVNBPJDIIQM-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCCN2CCC(F)(F)C2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCCN2CCC(F)(F)C2)C=C1 CYOWVNBPJDIIQM-UHFFFAOYSA-N 0.000 claims description 4
AAKSSFOFZOHTAB-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCCN2CCCCC2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCCN2CCCCC2)C=C1 AAKSSFOFZOHTAB-UHFFFAOYSA-N 0.000 claims description 4
QPPRYZNOCHAIBI-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=C(F)C=CN=C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=C(F)C=CN=C3)C=C2)=C1F QPPRYZNOCHAIBI-UHFFFAOYSA-N 0.000 claims description 4
YCKOVVZBQVFJHI-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=C(F)C=NC=C3F)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=C(F)C=NC=C3F)C=C2)=C1F YCKOVVZBQVFJHI-UHFFFAOYSA-N 0.000 claims description 4
WKDZDCBLRKTPNZ-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=C(NC(=O)C4CC4)C=CN=C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=C(NC(=O)C4CC4)C=CN=C3)C=C2)=C1F WKDZDCBLRKTPNZ-UHFFFAOYSA-N 0.000 claims description 4
RGNICMIAMZIUKT-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=CN=C3)C(F)(F)F)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=CN=C3)C(F)(F)F)C=C2)=C1F RGNICMIAMZIUKT-UHFFFAOYSA-N 0.000 claims description 4
FKSKCOYGDCANFA-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)C(F)(F)F)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)C(F)(F)F)C=C2)=C1F FKSKCOYGDCANFA-UHFFFAOYSA-N 0.000 claims description 4
TZYYDNOPRCFPBQ-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CC(F)(F)C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CC(F)(F)C3)C=C2)=C1F TZYYDNOPRCFPBQ-UHFFFAOYSA-N 0.000 claims description 4
DECYPTBDNCIICW-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC(F)(F)C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC(F)(F)C3)C=C2)=C1F DECYPTBDNCIICW-UHFFFAOYSA-N 0.000 claims description 4
CUBLHKZXEBDWLS-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC3)C=C2)=C1F CUBLHKZXEBDWLS-UHFFFAOYSA-N 0.000 claims description 4
MWIPUUDKWALSEB-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCC3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCC3)C=C2)=C1F MWIPUUDKWALSEB-UHFFFAOYSA-N 0.000 claims description 4
XCTPHPHXDSMCHR-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCCC3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCCC3)C=C2)=C1F XCTPHPHXDSMCHR-UHFFFAOYSA-N 0.000 claims description 4
SMTKPVJHZLTHJJ-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(CC4=CC=CC=C4)=CN=C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC(CC4=CC=CC=C4)=CN=C3)C=C2)=C1F SMTKPVJHZLTHJJ-UHFFFAOYSA-N 0.000 claims description 4
PUHYMAKDZILKGE-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(CC4=CC=CC=C4)N=C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(CC4=CC=CC=C4)N=C3)C=C2)=C1F PUHYMAKDZILKGE-UHFFFAOYSA-N 0.000 claims description 4
HUQQOJPKEQWJTC-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C#N)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C#N)C=C2)=C1F HUQQOJPKEQWJTC-UHFFFAOYSA-N 0.000 claims description 4
NTRVNUNLEHHAGR-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C(=O)N3CCCC3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C(=O)N3CCCC3)C=C2)=C1F NTRVNUNLEHHAGR-UHFFFAOYSA-N 0.000 claims description 4
KMYUMOBSXCAPHJ-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C(=O)NC3CCCC3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C(=O)NC3CCCC3)C=C2)=C1F KMYUMOBSXCAPHJ-UHFFFAOYSA-N 0.000 claims description 4
SZIHKUPNYPDOPF-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C(F)(F)F)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C(F)(F)F)C=C2)=C1F SZIHKUPNYPDOPF-UHFFFAOYSA-N 0.000 claims description 4
BNBZXHKFXGRRAA-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C3=C(F)C=CC=C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C3=C(F)C=CC=C3)C=C2)=C1F BNBZXHKFXGRRAA-UHFFFAOYSA-N 0.000 claims description 4
TVDMKWGADGNWOR-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C3=CC=CC=C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C3=CC=CC=C3)C=C2)=C1F TVDMKWGADGNWOR-UHFFFAOYSA-N 0.000 claims description 4
DJNGMAVDTSVJPJ-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCC(F)(F)C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCC(F)(F)C3)C=C2)=C1F DJNGMAVDTSVJPJ-UHFFFAOYSA-N 0.000 claims description 4
PWTVDIRCNMKAMC-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCC3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCC3)C=C2)=C1F PWTVDIRCNMKAMC-UHFFFAOYSA-N 0.000 claims description 4
DQDAKBFOIMENMV-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCCC3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCCC3)C=C2)=C1F DQDAKBFOIMENMV-UHFFFAOYSA-N 0.000 claims description 4
IHDBGQLZUOSYCO-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCCCC3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CCCCC3)C=C2)=C1F IHDBGQLZUOSYCO-UHFFFAOYSA-N 0.000 claims description 4
JYTKJZIBJRSKJZ-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(OC4=C(F)C=CC=C4)N=C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CC=C(OC4=C(F)C=CC=C4)N=C3)C=C2)=C1F JYTKJZIBJRSKJZ-UHFFFAOYSA-N 0.000 claims description 4
ISZBCGPOBPDYSF-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CN=C(C=N3)C(F)(F)F)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CN=C(C=N3)C(F)(F)F)C=C2)=C1F ISZBCGPOBPDYSF-UHFFFAOYSA-N 0.000 claims description 4
WAIMYCKOTQJVNU-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CN=C(N=C3)C(F)(F)F)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CN=C(N=C3)C(F)(F)F)C=C2)=C1F WAIMYCKOTQJVNU-UHFFFAOYSA-N 0.000 claims description 4
WKFLGRYXTITTGZ-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CN=CC=N3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CN=CC=N3)C=C2)=C1F WKFLGRYXTITTGZ-UHFFFAOYSA-N 0.000 claims description 4
NPJPENFIDASEEP-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CN=NC=C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=CN=NC=C3)C=C2)=C1F NPJPENFIDASEEP-UHFFFAOYSA-N 0.000 claims description 4
NUTOLIATVAVTLC-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=NC(=CC=C3)C(F)(F)F)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=NC(=CC=C3)C(F)(F)F)C=C2)=C1F NUTOLIATVAVTLC-UHFFFAOYSA-N 0.000 claims description 4
OEMKGCLKZFZWTF-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=NC=C(C=C3)C(F)(F)F)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=NC=C(C=C3)C(F)(F)F)C=C2)=C1F OEMKGCLKZFZWTF-UHFFFAOYSA-N 0.000 claims description 4
BGHABYXBOLDJOU-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=NC=CC(=C3)C(F)(F)F)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=NC=CC(=C3)C(F)(F)F)C=C2)=C1F BGHABYXBOLDJOU-UHFFFAOYSA-N 0.000 claims description 4
GOZAKVIRYATEQB-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=NC=CC=C3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=NC=CC=C3)C=C2)=C1F GOZAKVIRYATEQB-UHFFFAOYSA-N 0.000 claims description 4
XTDSIBBTBRACIR-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3CC3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3CC3)C=C2)=C1F XTDSIBBTBRACIR-UHFFFAOYSA-N 0.000 claims description 4
JEKKCSBHFVVYMP-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3CCC3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3CCC3)C=C2)=C1F JEKKCSBHFVVYMP-UHFFFAOYSA-N 0.000 claims description 4
ZJINIVUHMRQFGF-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3CCCC3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3CCCC3)C=C2)=C1F ZJINIVUHMRQFGF-UHFFFAOYSA-N 0.000 claims description 4
SDCWQONRBCNCGC-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3CCCCC3)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3CCCCC3)C=C2)=C1F SDCWQONRBCNCGC-UHFFFAOYSA-N 0.000 claims description 4
HHQMCJUQGRRDED-UHFFFAOYSA-N FC1=CC=CC(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC(CN4CCCCC4)=C3)C=N2)=C1 Chemical compound FC1=CC=CC(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC(CN4CCCCC4)=C3)C=N2)=C1 HHQMCJUQGRRDED-UHFFFAOYSA-N 0.000 claims description 4
ZVTQYAVKBCPWEV-UHFFFAOYSA-N FC1=CC=CC(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC=C3)C=N2)=C1 Chemical compound FC1=CC=CC(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC=C3)C=N2)=C1 ZVTQYAVKBCPWEV-UHFFFAOYSA-N 0.000 claims description 4
XHZJIWAJVYKKTH-UHFFFAOYSA-N FC1=CC=CC(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCCCC4)=CN=C3)C=N2)=C1 Chemical compound FC1=CC=CC(OC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCCCCC4)=CN=C3)C=N2)=C1 XHZJIWAJVYKKTH-UHFFFAOYSA-N 0.000 claims description 4
KNDXXQBOALWAIN-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C(F)=C1 KNDXXQBOALWAIN-UHFFFAOYSA-N 0.000 claims description 4
ZVFHHBPXWHLZKU-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=C1 ZVFHHBPXWHLZKU-UHFFFAOYSA-N 0.000 claims description 4
ZBLYRZCYAWJASQ-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C(F)=C1 ZBLYRZCYAWJASQ-UHFFFAOYSA-N 0.000 claims description 4
RHBSAZCJBKOPJE-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=C1 RHBSAZCJBKOPJE-UHFFFAOYSA-N 0.000 claims description 4
RQLLXNXYJMLIQS-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C(F)=C1 RQLLXNXYJMLIQS-UHFFFAOYSA-N 0.000 claims description 4
FAOQVHRXMYZQND-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)C=C1 FAOQVHRXMYZQND-UHFFFAOYSA-N 0.000 claims description 4
JHJZWKBJWORBGS-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C(F)=C1 JHJZWKBJWORBGS-UHFFFAOYSA-N 0.000 claims description 4
OSOQXMYSGASZCV-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C=C1 OSOQXMYSGASZCV-UHFFFAOYSA-N 0.000 claims description 4
WVCFANRIWQUAHC-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C(F)=C1 WVCFANRIWQUAHC-UHFFFAOYSA-N 0.000 claims description 4
KYASIHUOIZKHIH-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=C1 KYASIHUOIZKHIH-UHFFFAOYSA-N 0.000 claims description 4
DTQNNNJHNQVIAY-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=C1 DTQNNNJHNQVIAY-UHFFFAOYSA-N 0.000 claims description 4
XGNDVXHOCDJRST-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=C1 XGNDVXHOCDJRST-UHFFFAOYSA-N 0.000 claims description 4
APKURPDGRRNSKX-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C(F)=C1 APKURPDGRRNSKX-UHFFFAOYSA-N 0.000 claims description 4
WFMNWCCVTUTHBG-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)C=C1 WFMNWCCVTUTHBG-UHFFFAOYSA-N 0.000 claims description 4
QRNRRGXJRHEFSA-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C(F)=C1 QRNRRGXJRHEFSA-UHFFFAOYSA-N 0.000 claims description 4
FZCVCNIOXPTJEE-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)C=C1 FZCVCNIOXPTJEE-UHFFFAOYSA-N 0.000 claims description 4
CVXZJAUJRHBZNJ-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C(F)=C1 CVXZJAUJRHBZNJ-UHFFFAOYSA-N 0.000 claims description 4
UWZMNVUKSXILBA-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=C1 UWZMNVUKSXILBA-UHFFFAOYSA-N 0.000 claims description 4
JJUAHTJWIATXMQ-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C(F)=C1 JJUAHTJWIATXMQ-UHFFFAOYSA-N 0.000 claims description 4
ZZXDEAYEFOBVCS-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=C1 ZZXDEAYEFOBVCS-UHFFFAOYSA-N 0.000 claims description 4
RTUNHCLGXIYRRW-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C(F)=C1 RTUNHCLGXIYRRW-UHFFFAOYSA-N 0.000 claims description 4
XFNCSJOZPSNSJB-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=C1 XFNCSJOZPSNSJB-UHFFFAOYSA-N 0.000 claims description 4
ZWRBOYIKKDZKIA-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C(F)=C1 ZWRBOYIKKDZKIA-UHFFFAOYSA-N 0.000 claims description 4
AJOFHGHFRAVTCF-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)C=C1 AJOFHGHFRAVTCF-UHFFFAOYSA-N 0.000 claims description 4
APLMNBLNJPMMRM-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=C1 APLMNBLNJPMMRM-UHFFFAOYSA-N 0.000 claims description 4
QWIUKWNOEZUXKC-UHFFFAOYSA-N FC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)C=C2)C=C1 Chemical compound FC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)C=C2)C=C1 QWIUKWNOEZUXKC-UHFFFAOYSA-N 0.000 claims description 4
TWOOKKCUEPLVJK-UHFFFAOYSA-N FC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCC(F)(F)CC2)C=C1 Chemical compound FC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCC(F)(F)CC2)C=C1 TWOOKKCUEPLVJK-UHFFFAOYSA-N 0.000 claims description 4
NPMZREBIFOSTFI-UHFFFAOYSA-N FC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1 Chemical compound FC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1 NPMZREBIFOSTFI-UHFFFAOYSA-N 0.000 claims description 4
SAPCYUIVVXQCCM-UHFFFAOYSA-N FC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1 Chemical compound FC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1 SAPCYUIVVXQCCM-UHFFFAOYSA-N 0.000 claims description 4
JTKXCCCJICSQIR-UHFFFAOYSA-N FC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC3CC3)CC2)C=C1 Chemical compound FC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC3CC3)CC2)C=C1 JTKXCCCJICSQIR-UHFFFAOYSA-N 0.000 claims description 4
ASNIPLDQPZAXAE-UHFFFAOYSA-N FC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NCC2CCOC2)C=C1 Chemical compound FC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NCC2CCOC2)C=C1 ASNIPLDQPZAXAE-UHFFFAOYSA-N 0.000 claims description 4
CCJYQQUOULRBPW-UHFFFAOYSA-N FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 CCJYQQUOULRBPW-UHFFFAOYSA-N 0.000 claims description 4
KDNIIRYCTGXKNE-UHFFFAOYSA-N FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 KDNIIRYCTGXKNE-UHFFFAOYSA-N 0.000 claims description 4
GCTORZWZYBHCTH-UHFFFAOYSA-N FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 GCTORZWZYBHCTH-UHFFFAOYSA-N 0.000 claims description 4
CUAAUSJBQSTHET-UHFFFAOYSA-N FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 CUAAUSJBQSTHET-UHFFFAOYSA-N 0.000 claims description 4
SYEVYOBEJCJRAP-UHFFFAOYSA-N FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 SYEVYOBEJCJRAP-UHFFFAOYSA-N 0.000 claims description 4
BXCUTGOQWAVLGT-UHFFFAOYSA-N FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 BXCUTGOQWAVLGT-UHFFFAOYSA-N 0.000 claims description 4
CKERTOSKZAGLIB-UHFFFAOYSA-N FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 CKERTOSKZAGLIB-UHFFFAOYSA-N 0.000 claims description 4
GTHZRVQVHAPVMY-UHFFFAOYSA-N FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 GTHZRVQVHAPVMY-UHFFFAOYSA-N 0.000 claims description 4
AYBBXZCKGBVCGM-UHFFFAOYSA-N FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 Chemical compound FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(NC(=O)C2CC2)=CN=C1 AYBBXZCKGBVCGM-UHFFFAOYSA-N 0.000 claims description 4
ICVKSWDYIMUNOP-UHFFFAOYSA-N FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 ICVKSWDYIMUNOP-UHFFFAOYSA-N 0.000 claims description 4
JEZQWPWVCISJDB-UHFFFAOYSA-N FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 JEZQWPWVCISJDB-UHFFFAOYSA-N 0.000 claims description 4
SEZXKDIOJZMNMD-UHFFFAOYSA-N FC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)=C1 Chemical compound FC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)=C1 SEZXKDIOJZMNMD-UHFFFAOYSA-N 0.000 claims description 4
JSUKVQXCKVVFND-UHFFFAOYSA-N FC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)=C1 Chemical compound FC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)=C1 JSUKVQXCKVVFND-UHFFFAOYSA-N 0.000 claims description 4
DKPZLHVASALMCH-UHFFFAOYSA-N FC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 Chemical compound FC1=CN=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 DKPZLHVASALMCH-UHFFFAOYSA-N 0.000 claims description 4
SHDGQJDLUBSUKQ-UHFFFAOYSA-N FC1=NC=CC=C1C1=CC2=C(NN=C2C(=O)NCC2CCCO2)C=C1 Chemical compound FC1=NC=CC=C1C1=CC2=C(NN=C2C(=O)NCC2CCCO2)C=C1 SHDGQJDLUBSUKQ-UHFFFAOYSA-N 0.000 claims description 4
GRRZUDOVDPAICN-UHFFFAOYSA-N FC1=NC=CC=C1C1=CC2=C(NN=C2C(=O)NCC2CCOC2)C=C1 Chemical compound FC1=NC=CC=C1C1=CC2=C(NN=C2C(=O)NCC2CCOC2)C=C1 GRRZUDOVDPAICN-UHFFFAOYSA-N 0.000 claims description 4
OSCOLZFFASLTEQ-UHFFFAOYSA-N FCCN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound FCCN1CC(C1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 OSCOLZFFASLTEQ-UHFFFAOYSA-N 0.000 claims description 4
SFEKKPYAVBHKKC-UHFFFAOYSA-N FCCN1CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 Chemical compound FCCN1CC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C1 SFEKKPYAVBHKKC-UHFFFAOYSA-N 0.000 claims description 4
UJVWWVMWLTUVPQ-UHFFFAOYSA-N FCCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound FCCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 UJVWWVMWLTUVPQ-UHFFFAOYSA-N 0.000 claims description 4
KMAZCBWHEKNTTG-UHFFFAOYSA-N FCCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 Chemical compound FCCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 KMAZCBWHEKNTTG-UHFFFAOYSA-N 0.000 claims description 4
NIMQDSTWUSNCDG-UHFFFAOYSA-N FCCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound FCCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 NIMQDSTWUSNCDG-UHFFFAOYSA-N 0.000 claims description 4
GUGHZLAJQJKGHH-UHFFFAOYSA-N N-[6-(2,6-dimethylmorpholin-4-yl)pyridin-3-yl]-5-[5-(piperidin-1-ylmethyl)pyridin-3-yl]-1H-indazole-3-carboxamide Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 GUGHZLAJQJKGHH-UHFFFAOYSA-N 0.000 claims description 4
RBJLCHMGIPCUNS-UHFFFAOYSA-N N1(CCCCCC1)CC=1C=C(C=NC1)C=1C=C2C(=NNC2=CC1)C(=O)NC1=CC2=C(OCCO2)C=C1 Chemical compound N1(CCCCCC1)CC=1C=C(C=NC1)C=1C=C2C(=NNC2=CC1)C(=O)NC1=CC2=C(OCCO2)C=C1 RBJLCHMGIPCUNS-UHFFFAOYSA-N 0.000 claims description 4
JKLMYXQWHFZNHW-UHFFFAOYSA-N N1(CCCCCC1)CC=1C=C(C=NC1)C=1C=C2C(=NNC2=CC1)C(=O)NC1=CC2=C(OCO2)C=C1 Chemical compound N1(CCCCCC1)CC=1C=C(C=NC1)C=1C=C2C(=NNC2=CC1)C(=O)NC1=CC2=C(OCO2)C=C1 JKLMYXQWHFZNHW-UHFFFAOYSA-N 0.000 claims description 4
SGDOEKNOERUZLE-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(CN2CCCCC2)=C1 SGDOEKNOERUZLE-UHFFFAOYSA-N 0.000 claims description 4
JQRIKWMIGZDXHB-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 JQRIKWMIGZDXHB-UHFFFAOYSA-N 0.000 claims description 4
FXAHGBYUFHTPIA-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 FXAHGBYUFHTPIA-UHFFFAOYSA-N 0.000 claims description 4
NWNYTWLPMUIPKD-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 NWNYTWLPMUIPKD-UHFFFAOYSA-N 0.000 claims description 4
YXJPBKXYLOUDRF-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 YXJPBKXYLOUDRF-UHFFFAOYSA-N 0.000 claims description 4
SKNVORHEOGRAKT-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 SKNVORHEOGRAKT-UHFFFAOYSA-N 0.000 claims description 4
ATFRGSKWPHJDLA-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 ATFRGSKWPHJDLA-UHFFFAOYSA-N 0.000 claims description 4
HPFBIRQBOQZNEB-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 HPFBIRQBOQZNEB-UHFFFAOYSA-N 0.000 claims description 4
XGVJTSMQYAALFA-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 XGVJTSMQYAALFA-UHFFFAOYSA-N 0.000 claims description 4
NAPPTSLSJGXXTQ-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 NAPPTSLSJGXXTQ-UHFFFAOYSA-N 0.000 claims description 4
DTCMONXKIUJLND-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 DTCMONXKIUJLND-UHFFFAOYSA-N 0.000 claims description 4
CSICESTYTUUWDC-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 CSICESTYTUUWDC-UHFFFAOYSA-N 0.000 claims description 4
DKTJRCAVSCHWOP-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 DKTJRCAVSCHWOP-UHFFFAOYSA-N 0.000 claims description 4
YQAJOTVQHQZLRJ-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(N)=CN=C1 YQAJOTVQHQZLRJ-UHFFFAOYSA-N 0.000 claims description 4
BVPLDTVHTXSNQK-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 BVPLDTVHTXSNQK-UHFFFAOYSA-N 0.000 claims description 4
UDMAFGONMMRLEL-UHFFFAOYSA-N NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 UDMAFGONMMRLEL-UHFFFAOYSA-N 0.000 claims description 4
WVVUQLYDKDKRCA-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=C(F)C=NC=C2F)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=C(F)C=NC=C2F)C=C1 WVVUQLYDKDKRCA-UHFFFAOYSA-N 0.000 claims description 4
DASUNLYAUSIJOO-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=CN=C2)C(F)(F)F)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=CN=C2)C(F)(F)F)C=C1 DASUNLYAUSIJOO-UHFFFAOYSA-N 0.000 claims description 4
MGHJSTJXYSPERT-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)C(F)(F)F)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)C(F)(F)F)C=C1 MGHJSTJXYSPERT-UHFFFAOYSA-N 0.000 claims description 4
KBPCBAUJPVSVEQ-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC(F)(F)C2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC(F)(F)C2)C=C1 KBPCBAUJPVSVEQ-UHFFFAOYSA-N 0.000 claims description 4
MTYXISCYLWRRNS-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC2)C=C1 MTYXISCYLWRRNS-UHFFFAOYSA-N 0.000 claims description 4
DSUQKNARLYWRHN-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCC2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCC2)C=C1 DSUQKNARLYWRHN-UHFFFAOYSA-N 0.000 claims description 4
SGBUMTJOYHYHBG-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCCC2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCCC2)C=C1 SGBUMTJOYHYHBG-UHFFFAOYSA-N 0.000 claims description 4
FBJLVVHRGLSAAN-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCC3)=NC=C2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCC3)=NC=C2)C=C1 FBJLVVHRGLSAAN-UHFFFAOYSA-N 0.000 claims description 4
VMXZWSWAQHUMNH-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCC3)=NC=C2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCC3)=NC=C2)C=C1 VMXZWSWAQHUMNH-UHFFFAOYSA-N 0.000 claims description 4
RSJCSXVWWPCOLX-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCCC3)=NC=C2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCCC3)=NC=C2)C=C1 RSJCSXVWWPCOLX-UHFFFAOYSA-N 0.000 claims description 4
QNBBPBHNLBSSKG-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CC(F)(F)C2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CC(F)(F)C2)C=C1 QNBBPBHNLBSSKG-UHFFFAOYSA-N 0.000 claims description 4
XXICDBKAMQWYMN-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CN=C(C=N2)C(F)(F)F)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CN=C(C=N2)C(F)(F)F)C=C1 XXICDBKAMQWYMN-UHFFFAOYSA-N 0.000 claims description 4
WBQPTHJTCVMTCT-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CN=C(N=C2)C(F)(F)F)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CN=C(N=C2)C(F)(F)F)C=C1 WBQPTHJTCVMTCT-UHFFFAOYSA-N 0.000 claims description 4
IIAXSNDVAAYVQH-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC(=CC=C2)C(F)(F)F)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC(=CC=C2)C(F)(F)F)C=C1 IIAXSNDVAAYVQH-UHFFFAOYSA-N 0.000 claims description 4
GZAXFBARFVUSAU-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(C=C2)C(F)(F)F)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(C=C2)C(F)(F)F)C=C1 GZAXFBARFVUSAU-UHFFFAOYSA-N 0.000 claims description 4
WFWRRFBSJMSHTL-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(F)C=C2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(F)C=C2)C=C1 WFWRRFBSJMSHTL-UHFFFAOYSA-N 0.000 claims description 4
BKVLGKGGQDTPKS-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(F)C=C2F)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(F)C=C2F)C=C1 BKVLGKGGQDTPKS-UHFFFAOYSA-N 0.000 claims description 4
HACHGGHKQKWNKV-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=CC(=C2)C(F)(F)F)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=CC(=C2)C(F)(F)F)C=C1 HACHGGHKQKWNKV-UHFFFAOYSA-N 0.000 claims description 4
CLCCOFVINLHMGJ-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=CC=C2C(F)(F)F)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=CC=C2C(F)(F)F)C=C1 CLCCOFVINLHMGJ-UHFFFAOYSA-N 0.000 claims description 4
TZEASBBMSJKZON-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1 TZEASBBMSJKZON-UHFFFAOYSA-N 0.000 claims description 4
XBSOSJDHZYYYNY-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCC2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCC2)C=C1 XBSOSJDHZYYYNY-UHFFFAOYSA-N 0.000 claims description 4
KZLHEIZIEWVSFI-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1 KZLHEIZIEWVSFI-UHFFFAOYSA-N 0.000 claims description 4
NFFQVQNXEIEQGQ-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1 NFFQVQNXEIEQGQ-UHFFFAOYSA-N 0.000 claims description 4
NORQIZQBGYWUOB-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCNCC2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCNCC2)C=C1 NORQIZQBGYWUOB-UHFFFAOYSA-N 0.000 claims description 4
AYZVNAKVVPFUBC-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1 AYZVNAKVVPFUBC-UHFFFAOYSA-N 0.000 claims description 4
LCOVUBJUNVBKJF-UHFFFAOYSA-N NC1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound NC1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 LCOVUBJUNVBKJF-UHFFFAOYSA-N 0.000 claims description 4
OYOKMCDTCRJJIH-UHFFFAOYSA-N NC1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound NC1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 OYOKMCDTCRJJIH-UHFFFAOYSA-N 0.000 claims description 4
WTGUDCXMHFHUHU-UHFFFAOYSA-N NC1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound NC1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 WTGUDCXMHFHUHU-UHFFFAOYSA-N 0.000 claims description 4
CHYCEKWHQWSNOW-UHFFFAOYSA-N NC1CN(C1)C1=NC(=CN=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(F)=CC=C2)C=C1 Chemical compound NC1CN(C1)C1=NC(=CN=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(F)=CC=C2)C=C1 CHYCEKWHQWSNOW-UHFFFAOYSA-N 0.000 claims description 4
NIFMVOYEMULIAK-UHFFFAOYSA-N NC1CN(C1)C1=NC(=CN=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=CN=C2)C=C1 Chemical compound NC1CN(C1)C1=NC(=CN=C1)C1=CC2=C(NN=C2C(=O)NC2=CC=CN=C2)C=C1 NIFMVOYEMULIAK-UHFFFAOYSA-N 0.000 claims description 4
208000012902 Nervous system disease Diseases 0.000 claims description 4
QLOIXKYVLVLPBX-UHFFFAOYSA-N O1C2=C(OCC1)C=C(C=C2)NC(=O)C2=NNC1=CC=C(C=C21)C=2C=NC=C(C2)CN2CCC(CC2)C Chemical compound O1C2=C(OCC1)C=C(C=C2)NC(=O)C2=NNC1=CC=C(C=C21)C=2C=NC=C(C2)CN2CCC(CC2)C QLOIXKYVLVLPBX-UHFFFAOYSA-N 0.000 claims description 4
OSKKUTNWQZXDJU-UHFFFAOYSA-N O1COC2=C1C=CC(=C2)NC(=O)C2=NNC1=CC=C(C=C21)C2=C(C(=CC(=C2)CN2CCCCC2)F)F Chemical compound O1COC2=C1C=CC(=C2)NC(=O)C2=NNC1=CC=C(C=C21)C2=C(C(=CC(=C2)CN2CCCCC2)F)F OSKKUTNWQZXDJU-UHFFFAOYSA-N 0.000 claims description 4
QQQOIGGRWCPMQB-UHFFFAOYSA-N O1COC2=C1C=CC(=C2)NC(=O)C2=NNC1=CC=C(C=C21)C2=C(C(=CC=C2)F)F Chemical compound O1COC2=C1C=CC(=C2)NC(=O)C2=NNC1=CC=C(C=C21)C2=C(C(=CC=C2)F)F QQQOIGGRWCPMQB-UHFFFAOYSA-N 0.000 claims description 4
NJZUHYVYFZRKMG-UHFFFAOYSA-N O1COC2=C1C=CC(=C2)NC(=O)C2=NNC1=CC=C(C=C21)C=2C=NC=C(C2)CN2CCC(CC2)C Chemical compound O1COC2=C1C=CC(=C2)NC(=O)C2=NNC1=CC=C(C=C21)C=2C=NC=C(C2)CN2CCC(CC2)C NJZUHYVYFZRKMG-UHFFFAOYSA-N 0.000 claims description 4
FHKMJHIXIBAJIA-UHFFFAOYSA-N O=C(NC1=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=NC=C1)C1CC1 Chemical compound O=C(NC1=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=NC=C1)C1CC1 FHKMJHIXIBAJIA-UHFFFAOYSA-N 0.000 claims description 4
RSEXKBUQSQAARN-UHFFFAOYSA-N O=C(NC1=C2N=CC=CC2=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NC1=C2N=CC=CC2=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 RSEXKBUQSQAARN-UHFFFAOYSA-N 0.000 claims description 4
YSOOMEQNNYHRHN-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 YSOOMEQNNYHRHN-UHFFFAOYSA-N 0.000 claims description 4
TXSWNGOZHCLUCE-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 TXSWNGOZHCLUCE-UHFFFAOYSA-N 0.000 claims description 4
GGHIRDMYKDMOJA-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 GGHIRDMYKDMOJA-UHFFFAOYSA-N 0.000 claims description 4
CYTAHJCDXZFYBQ-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 CYTAHJCDXZFYBQ-UHFFFAOYSA-N 0.000 claims description 4
HVXVNSNKICMJOC-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 HVXVNSNKICMJOC-UHFFFAOYSA-N 0.000 claims description 4
IEAUDKGMLSUPHT-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 IEAUDKGMLSUPHT-UHFFFAOYSA-N 0.000 claims description 4
FQFALXOXCKHRRQ-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 FQFALXOXCKHRRQ-UHFFFAOYSA-N 0.000 claims description 4
WFCHFZIVUYXSQR-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 WFCHFZIVUYXSQR-UHFFFAOYSA-N 0.000 claims description 4
DXMUUMYVHLOHDT-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 DXMUUMYVHLOHDT-UHFFFAOYSA-N 0.000 claims description 4
NQVRKHWJEOCOQS-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 NQVRKHWJEOCOQS-UHFFFAOYSA-N 0.000 claims description 4
JBSWOLFSDAQJLE-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 JBSWOLFSDAQJLE-UHFFFAOYSA-N 0.000 claims description 4
ROIZLBJIGOUCGX-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 ROIZLBJIGOUCGX-UHFFFAOYSA-N 0.000 claims description 4
GLCOAMXPMGEOOI-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 GLCOAMXPMGEOOI-UHFFFAOYSA-N 0.000 claims description 4
MNWPZAPYQASKSH-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 MNWPZAPYQASKSH-UHFFFAOYSA-N 0.000 claims description 4
TWJFKFFBNNDDHQ-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 TWJFKFFBNNDDHQ-UHFFFAOYSA-N 0.000 claims description 4
WQIHPPMDBLMFBN-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 WQIHPPMDBLMFBN-UHFFFAOYSA-N 0.000 claims description 4
LMHWNXBYLHXKMZ-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 LMHWNXBYLHXKMZ-UHFFFAOYSA-N 0.000 claims description 4
UFMWZFDNGPVSOL-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 UFMWZFDNGPVSOL-UHFFFAOYSA-N 0.000 claims description 4
ZURZPUPEZLVRBX-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 ZURZPUPEZLVRBX-UHFFFAOYSA-N 0.000 claims description 4
GRSOSPVSYSBXGB-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 GRSOSPVSYSBXGB-UHFFFAOYSA-N 0.000 claims description 4
GHIYMTAUOFERTE-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 GHIYMTAUOFERTE-UHFFFAOYSA-N 0.000 claims description 4
HEYDIURGORQXEN-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 HEYDIURGORQXEN-UHFFFAOYSA-N 0.000 claims description 4
BGVPQRAPIKYVIX-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 BGVPQRAPIKYVIX-UHFFFAOYSA-N 0.000 claims description 4
YYNPROWRQIRZDQ-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 YYNPROWRQIRZDQ-UHFFFAOYSA-N 0.000 claims description 4
QOJNAKGJXSEUKR-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 QOJNAKGJXSEUKR-UHFFFAOYSA-N 0.000 claims description 4
XNZMKGOYOUJMLF-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 XNZMKGOYOUJMLF-UHFFFAOYSA-N 0.000 claims description 4
NDJKPKCOLSTNDX-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 NDJKPKCOLSTNDX-UHFFFAOYSA-N 0.000 claims description 4
YPBJRYDQDIVRCA-UHFFFAOYSA-N O=C(NC1=CC(CC2=CC=CC=C2)=CN=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC(CC2=CC=CC=C2)=CN=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 YPBJRYDQDIVRCA-UHFFFAOYSA-N 0.000 claims description 4
WNQOHHCKDRLRIW-UHFFFAOYSA-N O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 WNQOHHCKDRLRIW-UHFFFAOYSA-N 0.000 claims description 4
KHZNGPCSMGZKFJ-UHFFFAOYSA-N O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 KHZNGPCSMGZKFJ-UHFFFAOYSA-N 0.000 claims description 4
ZEHITLBECRHTLT-UHFFFAOYSA-N O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 ZEHITLBECRHTLT-UHFFFAOYSA-N 0.000 claims description 4
VCPGBHNTXNJQSL-UHFFFAOYSA-N O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 VCPGBHNTXNJQSL-UHFFFAOYSA-N 0.000 claims description 4
OQVFCGCBKIGYDZ-UHFFFAOYSA-N O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 OQVFCGCBKIGYDZ-UHFFFAOYSA-N 0.000 claims description 4
WUOFIWAATBWWNC-UHFFFAOYSA-N O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 WUOFIWAATBWWNC-UHFFFAOYSA-N 0.000 claims description 4
JNCSDGWJVVKSRK-UHFFFAOYSA-N O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 JNCSDGWJVVKSRK-UHFFFAOYSA-N 0.000 claims description 4
SLWGFQCTXQGWOS-UHFFFAOYSA-N O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 SLWGFQCTXQGWOS-UHFFFAOYSA-N 0.000 claims description 4
XGENYXQKNDLWQY-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 XGENYXQKNDLWQY-UHFFFAOYSA-N 0.000 claims description 4
AHUGOKFODRWFPK-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 AHUGOKFODRWFPK-UHFFFAOYSA-N 0.000 claims description 4
WTPAVDQWYAHXDZ-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 WTPAVDQWYAHXDZ-UHFFFAOYSA-N 0.000 claims description 4
PWXZZYXEJBLQHP-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 PWXZZYXEJBLQHP-UHFFFAOYSA-N 0.000 claims description 4
JQQVISKXLUMSJH-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 JQQVISKXLUMSJH-UHFFFAOYSA-N 0.000 claims description 4
ZMFQPOZWTYSJOD-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 ZMFQPOZWTYSJOD-UHFFFAOYSA-N 0.000 claims description 4
FDEUNJDGJWDUSL-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 FDEUNJDGJWDUSL-UHFFFAOYSA-N 0.000 claims description 4
XADDDJZUOYXLSB-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 XADDDJZUOYXLSB-UHFFFAOYSA-N 0.000 claims description 4
NPBGMTSIOBUVKA-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 NPBGMTSIOBUVKA-UHFFFAOYSA-N 0.000 claims description 4
JCFGAYWQMXGVMM-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 JCFGAYWQMXGVMM-UHFFFAOYSA-N 0.000 claims description 4
NDPGBIUWPQVYOW-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 NDPGBIUWPQVYOW-UHFFFAOYSA-N 0.000 claims description 4
OZVLCJDJOATPEK-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 OZVLCJDJOATPEK-UHFFFAOYSA-N 0.000 claims description 4
GEVIUIXASMBMRL-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 GEVIUIXASMBMRL-UHFFFAOYSA-N 0.000 claims description 4
MYPVNRHSKYMXDK-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 MYPVNRHSKYMXDK-UHFFFAOYSA-N 0.000 claims description 4
ADQKHNGURGDRQY-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 ADQKHNGURGDRQY-UHFFFAOYSA-N 0.000 claims description 4
ZIVTYLVKGDROHC-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 ZIVTYLVKGDROHC-UHFFFAOYSA-N 0.000 claims description 4
WXRQLHJHQCIEPR-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 WXRQLHJHQCIEPR-UHFFFAOYSA-N 0.000 claims description 4
WCTWEXIQNVUGRX-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 WCTWEXIQNVUGRX-UHFFFAOYSA-N 0.000 claims description 4
CCXSYCQWRUEPDJ-UHFFFAOYSA-N O=C(NC1=CC=C(CC2=CC=CC=C2)N=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(CC2=CC=CC=C2)N=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 CCXSYCQWRUEPDJ-UHFFFAOYSA-N 0.000 claims description 4
WTYVMDRKQACILT-UHFFFAOYSA-N O=C(NC1=CC=C(CN2CCC2)N=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(CN2CCC2)N=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 WTYVMDRKQACILT-UHFFFAOYSA-N 0.000 claims description 4
FKCUUMKUMMGHNR-UHFFFAOYSA-N O=C(NC1=CC=C(CN2CCCC2)C=C1)C1=NNC2=C1C=C(C=C2)C1=CN=CN=C1 Chemical compound O=C(NC1=CC=C(CN2CCCC2)C=C1)C1=NNC2=C1C=C(C=C2)C1=CN=CN=C1 FKCUUMKUMMGHNR-UHFFFAOYSA-N 0.000 claims description 4
MLKPXIUKBDBZHU-UHFFFAOYSA-N O=C(NC1=CC=C(CN2CCCC2)N=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(CN2CCCC2)N=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 MLKPXIUKBDBZHU-UHFFFAOYSA-N 0.000 claims description 4
DPHBKXUJVVUYMY-UHFFFAOYSA-N O=C(NC1=CC=C(CN2CCCCC2)N=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(CN2CCCCC2)N=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 DPHBKXUJVVUYMY-UHFFFAOYSA-N 0.000 claims description 4
HOARIKDEFWIWPC-UHFFFAOYSA-N O=C(NC1=CC=C(CN2CCOCC2)N=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(CN2CCOCC2)N=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 HOARIKDEFWIWPC-UHFFFAOYSA-N 0.000 claims description 4
DVTJSWQCIMOKLT-UHFFFAOYSA-N O=C(NC1=CC=C(N=C1)C#N)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(N=C1)C#N)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 DVTJSWQCIMOKLT-UHFFFAOYSA-N 0.000 claims description 4
WRBHGSOPQGTJFM-UHFFFAOYSA-N O=C(NC1=CC=C(N=C1)C(=O)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(N=C1)C(=O)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 WRBHGSOPQGTJFM-UHFFFAOYSA-N 0.000 claims description 4
XFSNFWQFGRREBG-UHFFFAOYSA-N O=C(NC1=CC=C(N=C1)C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(N=C1)C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 XFSNFWQFGRREBG-UHFFFAOYSA-N 0.000 claims description 4
XKGVKNSSZCNSPD-UHFFFAOYSA-N O=C(NC1=CC=C(N=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(N=C1)N1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 XKGVKNSSZCNSPD-UHFFFAOYSA-N 0.000 claims description 4
HRJRNKPDWMNLKF-UHFFFAOYSA-N O=C(NC1=CC=C(N=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(N=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 HRJRNKPDWMNLKF-UHFFFAOYSA-N 0.000 claims description 4
BGNFKBKULGOCQC-UHFFFAOYSA-N O=C(NC1=CC=C(N=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(N=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 BGNFKBKULGOCQC-UHFFFAOYSA-N 0.000 claims description 4
HRFLYMBUXPWMKX-UHFFFAOYSA-N O=C(NC1=CC=C(N=C1)N1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(N=C1)N1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 HRFLYMBUXPWMKX-UHFFFAOYSA-N 0.000 claims description 4
CFWPJKLBPOHRAC-UHFFFAOYSA-N O=C(NC1=CC=C(N=C1)N1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(N=C1)N1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 CFWPJKLBPOHRAC-UHFFFAOYSA-N 0.000 claims description 4
ZPXQBEIDXCDUJM-UHFFFAOYSA-N O=C(NC1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 ZPXQBEIDXCDUJM-UHFFFAOYSA-N 0.000 claims description 4
HKRMPMHWWDATOF-UHFFFAOYSA-N O=C(NC1=CC=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 HKRMPMHWWDATOF-UHFFFAOYSA-N 0.000 claims description 4
VLKSIOZQBZPJHW-UHFFFAOYSA-N O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC2)C=C1)C1CC1 Chemical compound O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCC2)C=C1)C1CC1 VLKSIOZQBZPJHW-UHFFFAOYSA-N 0.000 claims description 4
VQQCAYCXEONHBJ-UHFFFAOYSA-N O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCCC2)C=C1)C1CC1 Chemical compound O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCCC2)C=C1)C1CC1 VQQCAYCXEONHBJ-UHFFFAOYSA-N 0.000 claims description 4
PEKMKSVCJRTPLF-UHFFFAOYSA-N O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCC3)=NC=C2)C=C1)C1CC1 Chemical compound O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCC3)=NC=C2)C=C1)C1CC1 PEKMKSVCJRTPLF-UHFFFAOYSA-N 0.000 claims description 4
ASFPVWXUMJFNDV-UHFFFAOYSA-N O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCC3)=NC=C2)C=C1)C1CC1 Chemical compound O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCC3)=NC=C2)C=C1)C1CC1 ASFPVWXUMJFNDV-UHFFFAOYSA-N 0.000 claims description 4
RTLMFKAMZREYPH-UHFFFAOYSA-N O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCCC3)=NC=C2)C=C1)C1CC1 Chemical compound O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCCC3)=NC=C2)C=C1)C1CC1 RTLMFKAMZREYPH-UHFFFAOYSA-N 0.000 claims description 4
JANKGYNLWAFQHT-UHFFFAOYSA-N O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1)C1CC1 Chemical compound O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CC2)C=C1)C1CC1 JANKGYNLWAFQHT-UHFFFAOYSA-N 0.000 claims description 4
MKFMCWSCOJLYTI-UHFFFAOYSA-N O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCC2)C=C1)C1CC1 Chemical compound O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCC2)C=C1)C1CC1 MKFMCWSCOJLYTI-UHFFFAOYSA-N 0.000 claims description 4
GPFSZGQTYQQJRJ-UHFFFAOYSA-N O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1)C1CC1 Chemical compound O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCC2)C=C1)C1CC1 GPFSZGQTYQQJRJ-UHFFFAOYSA-N 0.000 claims description 4
QSHFMYYPALJTKV-UHFFFAOYSA-N O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1)C1CC1 Chemical compound O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCCCC2)C=C1)C1CC1 QSHFMYYPALJTKV-UHFFFAOYSA-N 0.000 claims description 4
KGQNOIHPUYYDFG-UHFFFAOYSA-N O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC#C)CC2)C=C1)C1CC1 Chemical compound O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC#C)CC2)C=C1)C1CC1 KGQNOIHPUYYDFG-UHFFFAOYSA-N 0.000 claims description 4
SLLJPULGYWZLIL-UHFFFAOYSA-N O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCNCC2)C=C1)C1CC1 Chemical compound O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCNCC2)C=C1)C1CC1 SLLJPULGYWZLIL-UHFFFAOYSA-N 0.000 claims description 4
IPVNHNMQWBZDKV-UHFFFAOYSA-N O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1)C1CC1 Chemical compound O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCOCC2)C=C1)C1CC1 IPVNHNMQWBZDKV-UHFFFAOYSA-N 0.000 claims description 4
MWUPBXOTUJVLAV-UHFFFAOYSA-N O=C(NC1=CN=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CN=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 MWUPBXOTUJVLAV-UHFFFAOYSA-N 0.000 claims description 4
NVTRIGWAKUAGKN-UHFFFAOYSA-N O=C(NC1=NC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=NC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 NVTRIGWAKUAGKN-UHFFFAOYSA-N 0.000 claims description 4
KHKUWKNLXQAEQZ-UHFFFAOYSA-N O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 KHKUWKNLXQAEQZ-UHFFFAOYSA-N 0.000 claims description 4
AJHUDYMOHSCZPN-UHFFFAOYSA-N O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 AJHUDYMOHSCZPN-UHFFFAOYSA-N 0.000 claims description 4
WBYCLKDXLLJJLY-UHFFFAOYSA-N O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 WBYCLKDXLLJJLY-UHFFFAOYSA-N 0.000 claims description 4
AGVLZICMNKQXTC-UHFFFAOYSA-N O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 AGVLZICMNKQXTC-UHFFFAOYSA-N 0.000 claims description 4
ZHCJQXOKHFPFTF-UHFFFAOYSA-N O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 ZHCJQXOKHFPFTF-UHFFFAOYSA-N 0.000 claims description 4
JJRSPVUHXJBNBC-UHFFFAOYSA-N O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 JJRSPVUHXJBNBC-UHFFFAOYSA-N 0.000 claims description 4
OGWUBIFMULKCEK-UHFFFAOYSA-N O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CN=CN=C1 Chemical compound O=C(NC1CC1)C1=NNC2=C1C=C(C=C2)C1=CN=CN=C1 OGWUBIFMULKCEK-UHFFFAOYSA-N 0.000 claims description 4
YLGPHAWFKIMDOU-UHFFFAOYSA-N O=C(NC1CC2=CC=CC=C2C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NC1CC2=CC=CC=C2C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 YLGPHAWFKIMDOU-UHFFFAOYSA-N 0.000 claims description 4
LJEPTYWIFHVZJA-UHFFFAOYSA-N O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 LJEPTYWIFHVZJA-UHFFFAOYSA-N 0.000 claims description 4
REZNYYBDVHBXEN-UHFFFAOYSA-N O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 REZNYYBDVHBXEN-UHFFFAOYSA-N 0.000 claims description 4
XMFVPLPMEUJCPL-UHFFFAOYSA-N O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 XMFVPLPMEUJCPL-UHFFFAOYSA-N 0.000 claims description 4
LWJCZZLIXBHFHB-UHFFFAOYSA-N O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 LWJCZZLIXBHFHB-UHFFFAOYSA-N 0.000 claims description 4
UWJZYUJUXKICGE-UHFFFAOYSA-N O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 UWJZYUJUXKICGE-UHFFFAOYSA-N 0.000 claims description 4
DJYZSLHRFBLUNU-UHFFFAOYSA-N O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 DJYZSLHRFBLUNU-UHFFFAOYSA-N 0.000 claims description 4
QAWFBZVLSGICRV-UHFFFAOYSA-N O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 QAWFBZVLSGICRV-UHFFFAOYSA-N 0.000 claims description 4
IRURAKFOEHRTGD-UHFFFAOYSA-N O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 IRURAKFOEHRTGD-UHFFFAOYSA-N 0.000 claims description 4
PSKREZZRLDXSSK-UHFFFAOYSA-N O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 PSKREZZRLDXSSK-UHFFFAOYSA-N 0.000 claims description 4
CVQOEJCBNKIMRR-UHFFFAOYSA-N O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1CCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 CVQOEJCBNKIMRR-UHFFFAOYSA-N 0.000 claims description 4
AYRZIPMVUSXZOB-UHFFFAOYSA-N O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 AYRZIPMVUSXZOB-UHFFFAOYSA-N 0.000 claims description 4
QLKPFOSARVJPCQ-UHFFFAOYSA-N O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 QLKPFOSARVJPCQ-UHFFFAOYSA-N 0.000 claims description 4
BBUXCJVYECNWJQ-UHFFFAOYSA-N O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 BBUXCJVYECNWJQ-UHFFFAOYSA-N 0.000 claims description 4
DLQKOZHDXITYLS-UHFFFAOYSA-N O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 DLQKOZHDXITYLS-UHFFFAOYSA-N 0.000 claims description 4
IHVCECIARKMOPU-UHFFFAOYSA-N O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 IHVCECIARKMOPU-UHFFFAOYSA-N 0.000 claims description 4
HHZVRFVQXCZLKV-UHFFFAOYSA-N O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 HHZVRFVQXCZLKV-UHFFFAOYSA-N 0.000 claims description 4
MPRXZVHVIOZVGP-UHFFFAOYSA-N O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 MPRXZVHVIOZVGP-UHFFFAOYSA-N 0.000 claims description 4
UUJUTSLGIBGPLH-UHFFFAOYSA-N O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 UUJUTSLGIBGPLH-UHFFFAOYSA-N 0.000 claims description 4
XEAPQIXQGSPIMN-UHFFFAOYSA-N O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 XEAPQIXQGSPIMN-UHFFFAOYSA-N 0.000 claims description 4
YAKYLIPASJDSNC-UHFFFAOYSA-N O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 YAKYLIPASJDSNC-UHFFFAOYSA-N 0.000 claims description 4
UEZHKJJFOLPGJG-UHFFFAOYSA-N O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 UEZHKJJFOLPGJG-UHFFFAOYSA-N 0.000 claims description 4
KUWGJODVKPOXJV-UHFFFAOYSA-N O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 KUWGJODVKPOXJV-UHFFFAOYSA-N 0.000 claims description 4
YUFYYFFPKWOQMH-UHFFFAOYSA-N O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 YUFYYFFPKWOQMH-UHFFFAOYSA-N 0.000 claims description 4
JPDXZTDHCUFLBR-UHFFFAOYSA-N O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 JPDXZTDHCUFLBR-UHFFFAOYSA-N 0.000 claims description 4
LNRHWZDOKAWJKR-UHFFFAOYSA-N O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 LNRHWZDOKAWJKR-UHFFFAOYSA-N 0.000 claims description 4
CABMRUBWTLQYTR-UHFFFAOYSA-N O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 CABMRUBWTLQYTR-UHFFFAOYSA-N 0.000 claims description 4
XXDKTQRJVJVNSB-UHFFFAOYSA-N O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 XXDKTQRJVJVNSB-UHFFFAOYSA-N 0.000 claims description 4
AEWWVCMCKJTVJM-UHFFFAOYSA-N O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 AEWWVCMCKJTVJM-UHFFFAOYSA-N 0.000 claims description 4
HGJABNOULIJVBM-UHFFFAOYSA-N O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CN=CN=C1 Chemical compound O=C(NC1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CN=CN=C1 HGJABNOULIJVBM-UHFFFAOYSA-N 0.000 claims description 4
QGHQFQVYCWCRDG-UHFFFAOYSA-N O=C(NC1CCN(CC#C)CC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound O=C(NC1CCN(CC#C)CC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 QGHQFQVYCWCRDG-UHFFFAOYSA-N 0.000 claims description 4
PNTNMBKDZSHTQR-UHFFFAOYSA-N O=C(NC1CCN(CC#C)CC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1CCN(CC#C)CC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 PNTNMBKDZSHTQR-UHFFFAOYSA-N 0.000 claims description 4
HKXXMLSRFNAFQX-UHFFFAOYSA-N O=C(NC1CCN(CC2=CC=CC=C2)CC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1CCN(CC2=CC=CC=C2)CC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 HKXXMLSRFNAFQX-UHFFFAOYSA-N 0.000 claims description 4
LKFHRPNESHEOLG-UHFFFAOYSA-N O=C(NC1CCN(CC2CCC2)CC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1CCN(CC2CCC2)CC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 LKFHRPNESHEOLG-UHFFFAOYSA-N 0.000 claims description 4
LWDXPHRNFWTDEN-UHFFFAOYSA-N O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 LWDXPHRNFWTDEN-UHFFFAOYSA-N 0.000 claims description 4
GGCJLPFLHLLTIS-UHFFFAOYSA-N O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 GGCJLPFLHLLTIS-UHFFFAOYSA-N 0.000 claims description 4
ASEHOGWDSXAUGC-UHFFFAOYSA-N O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 ASEHOGWDSXAUGC-UHFFFAOYSA-N 0.000 claims description 4
ODHBUXFPBHSBJE-UHFFFAOYSA-N O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 ODHBUXFPBHSBJE-UHFFFAOYSA-N 0.000 claims description 4
DFGIQXFZSRMVMK-UHFFFAOYSA-N O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 DFGIQXFZSRMVMK-UHFFFAOYSA-N 0.000 claims description 4
QZNMPIFBLCTZNM-UHFFFAOYSA-N O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 QZNMPIFBLCTZNM-UHFFFAOYSA-N 0.000 claims description 4
DGZQIKWIWKVPRI-UHFFFAOYSA-N O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 DGZQIKWIWKVPRI-UHFFFAOYSA-N 0.000 claims description 4
ZQGLIKYYVSIGBZ-UHFFFAOYSA-N O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 ZQGLIKYYVSIGBZ-UHFFFAOYSA-N 0.000 claims description 4
VIWOUJDSWNVOIP-UHFFFAOYSA-N O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 VIWOUJDSWNVOIP-UHFFFAOYSA-N 0.000 claims description 4
RHRVTTNXLMWCTP-UHFFFAOYSA-N O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NC1CCNCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 RHRVTTNXLMWCTP-UHFFFAOYSA-N 0.000 claims description 4
LKOVCAFJBAJFTL-UHFFFAOYSA-N O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 LKOVCAFJBAJFTL-UHFFFAOYSA-N 0.000 claims description 4
ZZUQNZJWDNPVMW-UHFFFAOYSA-N O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 ZZUQNZJWDNPVMW-UHFFFAOYSA-N 0.000 claims description 4
SCLWTYFOAXNWJH-UHFFFAOYSA-N O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 Chemical compound O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCOCC1 SCLWTYFOAXNWJH-UHFFFAOYSA-N 0.000 claims description 4
MHLFNWQFDYZQFR-UHFFFAOYSA-N O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 MHLFNWQFDYZQFR-UHFFFAOYSA-N 0.000 claims description 4
UUDOPCPUFMOGIQ-UHFFFAOYSA-N O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 UUDOPCPUFMOGIQ-UHFFFAOYSA-N 0.000 claims description 4
SPAOTHXTANKZGY-UHFFFAOYSA-N O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 SPAOTHXTANKZGY-UHFFFAOYSA-N 0.000 claims description 4
VYDDGTSGBRGCTR-UHFFFAOYSA-N O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 VYDDGTSGBRGCTR-UHFFFAOYSA-N 0.000 claims description 4
INXVUKPGGDQXDJ-UHFFFAOYSA-N O=C(NCC1CCCO1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NCC1CCCO1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 INXVUKPGGDQXDJ-UHFFFAOYSA-N 0.000 claims description 4
HLMCEFUBHJLHJA-UHFFFAOYSA-N O=C(NCC1CCOC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NCC1CCOC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 HLMCEFUBHJLHJA-UHFFFAOYSA-N 0.000 claims description 4
ZEYJNJADSHIWPZ-UHFFFAOYSA-N O=C(NCCN1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NCCN1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 ZEYJNJADSHIWPZ-UHFFFAOYSA-N 0.000 claims description 4
ZSZWGUUBIXRDSC-UHFFFAOYSA-N O=C(NCCN1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NCCN1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 ZSZWGUUBIXRDSC-UHFFFAOYSA-N 0.000 claims description 4
BZVVVXRNQBZIHM-UHFFFAOYSA-N O=C(NCCN1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound O=C(NCCN1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 BZVVVXRNQBZIHM-UHFFFAOYSA-N 0.000 claims description 4
VBLBBTAYARKVIJ-UHFFFAOYSA-N OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 VBLBBTAYARKVIJ-UHFFFAOYSA-N 0.000 claims description 4
VVZVXAGYZLAMJM-UHFFFAOYSA-N OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 VVZVXAGYZLAMJM-UHFFFAOYSA-N 0.000 claims description 4
RGLPYNJWPLFTOJ-UHFFFAOYSA-N OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 RGLPYNJWPLFTOJ-UHFFFAOYSA-N 0.000 claims description 4
BICVTQBMIVSNTN-UHFFFAOYSA-N OC1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound OC1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 BICVTQBMIVSNTN-UHFFFAOYSA-N 0.000 claims description 4
HLPVGIDHXALRIL-UHFFFAOYSA-N OC1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 Chemical compound OC1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC=C2)C=N1 HLPVGIDHXALRIL-UHFFFAOYSA-N 0.000 claims description 4
WUYHGFVMYUUODD-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=C(F)C=NC=C3F)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=C(F)C=NC=C3F)C=C2)CC1 WUYHGFVMYUUODD-UHFFFAOYSA-N 0.000 claims description 4
UPHFKTOCEGWKGQ-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CC(F)(F)C3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CC(F)(F)C3)C=C2)CC1 UPHFKTOCEGWKGQ-UHFFFAOYSA-N 0.000 claims description 4
GHCQLROCSXOKBD-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC(F)(F)C3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC(F)(F)C3)C=C2)CC1 GHCQLROCSXOKBD-UHFFFAOYSA-N 0.000 claims description 4
JJXGOUGVOGYNTA-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCC3)C=C2)CC1 JJXGOUGVOGYNTA-UHFFFAOYSA-N 0.000 claims description 4
XCCAOULHFCOBAG-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCC3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCC3)C=C2)CC1 XCCAOULHFCOBAG-UHFFFAOYSA-N 0.000 claims description 4
XQZNYZNJVWDZHP-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCCC3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCCC3)C=C2)CC1 XQZNYZNJVWDZHP-UHFFFAOYSA-N 0.000 claims description 4
WQNKEMBRUSIFGV-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCC4)=NC=C3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCC4)=NC=C3)C=C2)CC1 WQNKEMBRUSIFGV-UHFFFAOYSA-N 0.000 claims description 4
WKCHUPNITDBGFH-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCC4)=NC=C3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCC4)=NC=C3)C=C2)CC1 WKCHUPNITDBGFH-UHFFFAOYSA-N 0.000 claims description 4
VNXWMHCAJOUPLA-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCCC4)=NC=C3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(CN4CCCCC4)=NC=C3)C=C2)CC1 VNXWMHCAJOUPLA-UHFFFAOYSA-N 0.000 claims description 4
CBANAVVOJQMNQH-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CC(F)(F)C3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N3CC(F)(F)C3)C=C2)CC1 CBANAVVOJQMNQH-UHFFFAOYSA-N 0.000 claims description 4
IXWQOOGXPLDPCN-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=C(F)C=C3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=C(F)C=C3)C=C2)CC1 IXWQOOGXPLDPCN-UHFFFAOYSA-N 0.000 claims description 4
HDKUYUYJTVGXLB-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=C(F)C=C3F)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=C(F)C=C3F)C=C2)CC1 HDKUYUYJTVGXLB-UHFFFAOYSA-N 0.000 claims description 4
UGEBSHUKWYMZKE-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CC3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CC3)C=C2)CC1 UGEBSHUKWYMZKE-UHFFFAOYSA-N 0.000 claims description 4
AJMRPBQHMARYRD-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCC3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCC3)C=C2)CC1 AJMRPBQHMARYRD-UHFFFAOYSA-N 0.000 claims description 4
PLXUYNVPNGWPGM-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCC3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCC3)C=C2)CC1 PLXUYNVPNGWPGM-UHFFFAOYSA-N 0.000 claims description 4
NRBLEVMGZIZMGE-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCCC3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCCCC3)C=C2)CC1 NRBLEVMGZIZMGE-UHFFFAOYSA-N 0.000 claims description 4
CYMGSISBHDQVAT-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(CC#C)CC3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(CC#C)CC3)C=C2)CC1 CYMGSISBHDQVAT-UHFFFAOYSA-N 0.000 claims description 4
VMUFIETUBGTCNT-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCNCC3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCNCC3)C=C2)CC1 VMUFIETUBGTCNT-UHFFFAOYSA-N 0.000 claims description 4
FHZJFDWAXLUNDG-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCOCC3)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCOCC3)C=C2)CC1 FHZJFDWAXLUNDG-UHFFFAOYSA-N 0.000 claims description 4
JRKXYICQDHOPTH-UHFFFAOYSA-N OCC(CO)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 Chemical compound OCC(CO)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 JRKXYICQDHOPTH-UHFFFAOYSA-N 0.000 claims description 4
VTDUMLRNYRIGDR-UHFFFAOYSA-N OCC1(CO)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 Chemical compound OCC1(CO)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 VTDUMLRNYRIGDR-UHFFFAOYSA-N 0.000 claims description 4
210000000988 bone and bone Anatomy 0.000 claims description 4
230000003176 fibrotic effect Effects 0.000 claims description 4
JQBBKEKEHNCKGZ-UHFFFAOYSA-N n-(2-methylpyrimidin-5-yl)-5-(5-morpholin-4-ylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(C=NC=3)N3CCOCC3)C=C12 JQBBKEKEHNCKGZ-UHFFFAOYSA-N 0.000 claims description 4
FSPBIXJXWILDBP-UHFFFAOYSA-N n-(2-methylpyrimidin-5-yl)-5-(5-phenoxypyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(OC=4C=CC=CC=4)C=NC=3)C=C12 FSPBIXJXWILDBP-UHFFFAOYSA-N 0.000 claims description 4
JRZABGMOMNGYRH-UHFFFAOYSA-N n-(2-methylpyrimidin-5-yl)-5-(5-pyrrolidin-1-ylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(C=NC=3)N3CCCC3)C=C12 JRZABGMOMNGYRH-UHFFFAOYSA-N 0.000 claims description 4
RXSSTZCPYDQIHB-UHFFFAOYSA-N n-(2-methylpyrimidin-5-yl)-5-[5-(morpholin-4-ylmethyl)pyridin-3-yl]-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCOCC4)C=NC=3)C=C12 RXSSTZCPYDQIHB-UHFFFAOYSA-N 0.000 claims description 4
VKNDFKHJWONMCW-UHFFFAOYSA-N n-(2-methylpyrimidin-5-yl)-5-[5-(piperidin-1-ylmethyl)pyridin-3-yl]-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCCCC4)C=NC=3)C=C12 VKNDFKHJWONMCW-UHFFFAOYSA-N 0.000 claims description 4
FJQLBBOHMPVGMM-UHFFFAOYSA-N n-(2-methylpyrimidin-5-yl)-5-pyridin-3-yl-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=NC=CC=3)C=C12 FJQLBBOHMPVGMM-UHFFFAOYSA-N 0.000 claims description 4
FYNHXNXQVYAUHS-UHFFFAOYSA-N n-(6-methylpyridin-3-yl)-5-(5-phenoxypyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(OC=4C=CC=CC=4)C=NC=3)C=C12 FYNHXNXQVYAUHS-UHFFFAOYSA-N 0.000 claims description 4
PXHNBVVFQIEOJV-UHFFFAOYSA-N n-(6-methylpyridin-3-yl)-5-(5-piperidin-1-ylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(C=NC=3)N3CCCCC3)C=C12 PXHNBVVFQIEOJV-UHFFFAOYSA-N 0.000 claims description 4
WVJVPLBYYXPRAX-UHFFFAOYSA-N n-(6-methylpyridin-3-yl)-5-(5-pyrrolidin-1-ylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(C=NC=3)N3CCCC3)C=C12 WVJVPLBYYXPRAX-UHFFFAOYSA-N 0.000 claims description 4
BAEZRGRYMMNLAO-UHFFFAOYSA-N n-(6-methylpyridin-3-yl)-5-[5-(morpholin-4-ylmethyl)pyridin-3-yl]-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCOCC4)C=NC=3)C=C12 BAEZRGRYMMNLAO-UHFFFAOYSA-N 0.000 claims description 4
DFWOASBDUYPTDR-UHFFFAOYSA-N n-(6-methylpyridin-3-yl)-5-[5-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCCC4)C=NC=3)C=C12 DFWOASBDUYPTDR-UHFFFAOYSA-N 0.000 claims description 4
DLBLWFYPWSQYDL-UHFFFAOYSA-N n-[4-(cyclopropanecarbonylamino)pyridin-3-yl]-5-[5-(piperidin-1-ylmethyl)pyridin-3-yl]-1h-indazole-3-carboxamide Chemical compound C1CC1C(=O)NC1=CC=NC=C1NC(=O)C(C1=C2)=NNC1=CC=C2C(C=1)=CN=CC=1CN1CCCCC1 DLBLWFYPWSQYDL-UHFFFAOYSA-N 0.000 claims description 4
JQJPCDHQEJIXCN-UHFFFAOYSA-N n-[6-(2-fluorophenoxy)pyridin-3-yl]-5-[5-(piperidin-1-ylmethyl)pyridin-3-yl]-1h-indazole-3-carboxamide Chemical compound FC1=CC=CC=C1OC(N=C1)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCCCC4)C=NC=3)C=C12 JQJPCDHQEJIXCN-UHFFFAOYSA-N 0.000 claims description 4
QKIMZMOVFWDQGI-UHFFFAOYSA-N n-pyridin-2-yl-5-(5-pyrrolidin-1-ylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound N=1NC2=CC=C(C=3C=C(C=NC=3)N3CCCC3)C=C2C=1C(=O)NC1=CC=CC=N1 QKIMZMOVFWDQGI-UHFFFAOYSA-N 0.000 claims description 4
GGXXEIBVHXKRAU-UHFFFAOYSA-N n-pyridin-2-yl-5-[5-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-1h-indazole-3-carboxamide Chemical compound N=1NC2=CC=C(C=3C=C(CN4CCCC4)C=NC=3)C=C2C=1C(=O)NC1=CC=CC=N1 GGXXEIBVHXKRAU-UHFFFAOYSA-N 0.000 claims description 4
ORGPDJCSGNDYBJ-UHFFFAOYSA-N n-pyridin-2-yl-5-pyridin-3-yl-1h-indazole-3-carboxamide Chemical compound N=1NC2=CC=C(C=3C=NC=CC=3)C=C2C=1C(=O)NC1=CC=CC=N1 ORGPDJCSGNDYBJ-UHFFFAOYSA-N 0.000 claims description 4
239000008194 pharmaceutical composition Substances 0.000 claims description 4
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 4
UPOXRKVFQPEWLU-UHFFFAOYSA-N 1-[5-(piperidin-1-ylmethyl)pyridin-3-yl]indazole-3-carboxamide Chemical compound N1(CCCCC1)CC=1C=C(C=NC=1)N1N=C(C2=CC=CC=C12)C(=O)N UPOXRKVFQPEWLU-UHFFFAOYSA-N 0.000 claims description 3
208000019693 Lung disease Diseases 0.000 claims description 3
201000008482 osteoarthritis Diseases 0.000 claims description 3
208000009575 Angelman syndrome Diseases 0.000 claims description 2
201000000046 Beckwith-Wiedemann syndrome Diseases 0.000 claims description 2
FFJGQMMQEQZTRX-UHFFFAOYSA-N C1(CC1)NC(=O)C1=NNC2=CC=C(C=C12)C=1C=NC=C(C1)CN1CCCC1 Chemical compound C1(CC1)NC(=O)C1=NNC2=CC=C(C=C12)C=1C=NC=C(C1)CN1CCCC1 FFJGQMMQEQZTRX-UHFFFAOYSA-N 0.000 claims description 2
WCYDQONJPNULCK-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 WCYDQONJPNULCK-UHFFFAOYSA-N 0.000 claims description 2
ZYCOJEVOUVKVRX-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 ZYCOJEVOUVKVRX-UHFFFAOYSA-N 0.000 claims description 2
VKIJNNFOLLPCBW-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN(C)C)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN(C)C)=CN=C1 VKIJNNFOLLPCBW-UHFFFAOYSA-N 0.000 claims description 2
HRWPFFWADINLFT-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 HRWPFFWADINLFT-UHFFFAOYSA-N 0.000 claims description 2
WWKSRHVDANWABC-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 WWKSRHVDANWABC-UHFFFAOYSA-N 0.000 claims description 2
VJPKFIHWWCRDSB-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 VJPKFIHWWCRDSB-UHFFFAOYSA-N 0.000 claims description 2
UZRIJLRLRHDCNB-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 UZRIJLRLRHDCNB-UHFFFAOYSA-N 0.000 claims description 2
DNVFUEHVGVQLKS-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 DNVFUEHVGVQLKS-UHFFFAOYSA-N 0.000 claims description 2
ILAHNGHJJIQOMP-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 ILAHNGHJJIQOMP-UHFFFAOYSA-N 0.000 claims description 2
BOJXBGDDIUBWMG-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(O)CC2)=CN=C1 BOJXBGDDIUBWMG-UHFFFAOYSA-N 0.000 claims description 2
UXOZZZPZMUJHOE-UHFFFAOYSA-N CC(C)(F)CN1CCC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CN=C2)C1 Chemical compound CC(C)(F)CN1CCC(CNC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(F)=CN=C2)C1 UXOZZZPZMUJHOE-UHFFFAOYSA-N 0.000 claims description 2
NRQPEYSFPBTNNB-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C=N1 NRQPEYSFPBTNNB-UHFFFAOYSA-N 0.000 claims description 2
HTKABSXZNVIXRU-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=N1 HTKABSXZNVIXRU-UHFFFAOYSA-N 0.000 claims description 2
QXLMNWFAKBGZQE-UHFFFAOYSA-N CC(C)S(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(C)CC3)=CN=C2)C=N1 Chemical compound CC(C)S(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(C)CC3)=CN=C2)C=N1 QXLMNWFAKBGZQE-UHFFFAOYSA-N 0.000 claims description 2
DSFHCYOPWWMISX-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=C(NC(=O)C4CC4)C=CN=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=C(NC(=O)C4CC4)C=CN=C3)C=C2)CC1 DSFHCYOPWWMISX-UHFFFAOYSA-N 0.000 claims description 2
USPMHAUDQVZBMS-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=CN=C3)C(F)(F)F)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=CN=C3)C(F)(F)F)C=C2)CC1 USPMHAUDQVZBMS-UHFFFAOYSA-N 0.000 claims description 2
LJOBYHQMTXLTFF-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)C(F)(F)F)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)C(F)(F)F)C=C2)CC1 LJOBYHQMTXLTFF-UHFFFAOYSA-N 0.000 claims description 2
TVCCPFIJXPTXSQ-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CN4CCOCC4)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CN4CCOCC4)N=C3)C=C2)CC1 TVCCPFIJXPTXSQ-UHFFFAOYSA-N 0.000 claims description 2
BABXVAKLVDPCKE-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C(=O)NC3CCCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C(=O)NC3CCCC3)C=C2)CC1 BABXVAKLVDPCKE-UHFFFAOYSA-N 0.000 claims description 2
OTOOKXXHZNUEOR-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C(F)(F)F)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C(F)(F)F)C=C2)CC1 OTOOKXXHZNUEOR-UHFFFAOYSA-N 0.000 claims description 2
MZQXUDSPAYJGCI-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)S(C)(=O)=O)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)S(C)(=O)=O)C=C2)CC1 MZQXUDSPAYJGCI-UHFFFAOYSA-N 0.000 claims description 2
KXLSJRZLURHBHJ-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=C(C=N3)C(F)(F)F)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=C(C=N3)C(F)(F)F)C=C2)CC1 KXLSJRZLURHBHJ-UHFFFAOYSA-N 0.000 claims description 2
BEKLVSVUKDYGEQ-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=C(N=C3)C(F)(F)F)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=C(N=C3)C(F)(F)F)C=C2)CC1 BEKLVSVUKDYGEQ-UHFFFAOYSA-N 0.000 claims description 2
KEDYLPSJDRCOMI-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC(=CC=C3)C(F)(F)F)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC(=CC=C3)C(F)(F)F)C=C2)CC1 KEDYLPSJDRCOMI-UHFFFAOYSA-N 0.000 claims description 2
JIVHRRBKFFISFF-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=C(C=C3)C(F)(F)F)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=C(C=C3)C(F)(F)F)C=C2)CC1 JIVHRRBKFFISFF-UHFFFAOYSA-N 0.000 claims description 2
JKPIWECVMUTRJM-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=CC(=C3)C(F)(F)F)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=CC(=C3)C(F)(F)F)C=C2)CC1 JKPIWECVMUTRJM-UHFFFAOYSA-N 0.000 claims description 2
HGGDWBHEWCKXGU-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=CC=C3C(F)(F)F)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=CC=C3C(F)(F)F)C=C2)CC1 HGGDWBHEWCKXGU-UHFFFAOYSA-N 0.000 claims description 2
LJCADLAMBXBZLZ-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(CC3)C(C)(C)C)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCN(CC3)C(C)(C)C)C=C2)CC1 LJCADLAMBXBZLZ-UHFFFAOYSA-N 0.000 claims description 2
QRHLHBCKWMPLDC-UHFFFAOYSA-N CCC(CC)NC(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound CCC(CC)NC(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 QRHLHBCKWMPLDC-UHFFFAOYSA-N 0.000 claims description 2
AXKWQOPWAOVZCG-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCN(C)CC2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCN(C)CC2)C=C1 AXKWQOPWAOVZCG-UHFFFAOYSA-N 0.000 claims description 2
HIRHTUZCMXFWIT-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCN(C)CC2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCN(C)CC2)C=C1 HIRHTUZCMXFWIT-UHFFFAOYSA-N 0.000 claims description 2
FLRIRHQYYRGIAK-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC#C)CC2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC#C)CC2)C=C1 FLRIRHQYYRGIAK-UHFFFAOYSA-N 0.000 claims description 2
AZIKYGKPHOSJDX-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=N1 AZIKYGKPHOSJDX-UHFFFAOYSA-N 0.000 claims description 2
FCUIVGSOPKJISX-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=C1 FCUIVGSOPKJISX-UHFFFAOYSA-N 0.000 claims description 2
ATUAQHFGNHTXTM-UHFFFAOYSA-N CN1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound CN1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 ATUAQHFGNHTXTM-UHFFFAOYSA-N 0.000 claims description 2
AVOMXEWODBUKSP-UHFFFAOYSA-N CN1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3=C(F)C=C(F)C=C3)=CN=C2)C=N1 Chemical compound CN1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3=C(F)C=C(F)C=C3)=CN=C2)C=N1 AVOMXEWODBUKSP-UHFFFAOYSA-N 0.000 claims description 2
XCWMMTANKPXNAA-UHFFFAOYSA-N CN1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3=C(F)C=CC(F)=C3)=CN=C2)C=N1 Chemical compound CN1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3=C(F)C=CC(F)=C3)=CN=C2)C=N1 XCWMMTANKPXNAA-UHFFFAOYSA-N 0.000 claims description 2
XTAVRINAOUYGSM-UHFFFAOYSA-N CN1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3=C(F)C=CC=C3F)=CN=C2)C=N1 Chemical compound CN1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3=C(F)C=CC=C3F)=CN=C2)C=N1 XTAVRINAOUYGSM-UHFFFAOYSA-N 0.000 claims description 2
RDWXHIDMJBBRND-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCC2)=C1 RDWXHIDMJBBRND-UHFFFAOYSA-N 0.000 claims description 2
CSQVBPRNPRCVLW-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)=C1 CSQVBPRNPRCVLW-UHFFFAOYSA-N 0.000 claims description 2
LSVPYOYTZJUUPD-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=C1 LSVPYOYTZJUUPD-UHFFFAOYSA-N 0.000 claims description 2
VZLAMHVYNFZKPP-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 VZLAMHVYNFZKPP-UHFFFAOYSA-N 0.000 claims description 2
UABIDHZPVDBHDQ-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 UABIDHZPVDBHDQ-UHFFFAOYSA-N 0.000 claims description 2
QBPMDWZZAWBPKD-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)=C1 QBPMDWZZAWBPKD-UHFFFAOYSA-N 0.000 claims description 2
NJWFQIMHSLWONE-UHFFFAOYSA-N CN1CCN(CC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC=C3)C=C2)CC1 Chemical compound CN1CCN(CC2=CC=C(NC(=O)C3=NNC4=C3C=C(C=C4)C3=C(F)C(F)=CC=C3)C=C2)CC1 NJWFQIMHSLWONE-UHFFFAOYSA-N 0.000 claims description 2
LOTQKJLANFHFJV-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCOCC4)=CN=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(CN4CCOCC4)=CN=C3)=C2)CC1 LOTQKJLANFHFJV-UHFFFAOYSA-N 0.000 claims description 2
DESJTROZWWMYTR-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(NC(=O)C4CC4)=CN=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(NC(=O)C4CC4)=CN=C3)=C2)CC1 DESJTROZWWMYTR-UHFFFAOYSA-N 0.000 claims description 2
YFAQBFJRPVXVTF-UHFFFAOYSA-N CNC(=O)C1=CC=C(C=N1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)C=C2)C=C1F Chemical compound CNC(=O)C1=CC=C(C=N1)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CN3CCCC3)C=C2)C=C1F YFAQBFJRPVXVTF-UHFFFAOYSA-N 0.000 claims description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
LWKJAICZOFCSMM-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCOCC3)C=C2)C1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCOCC3)C=C2)C1 LWKJAICZOFCSMM-UHFFFAOYSA-N 0.000 claims description 2
LGGHHEIZNAQLET-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCOCC3)C=C2)CC1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCOCC3)C=C2)CC1 LGGHHEIZNAQLET-UHFFFAOYSA-N 0.000 claims description 2
LDNXJYFCXWWJSO-UHFFFAOYSA-N FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=N1 Chemical compound FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=N1 LDNXJYFCXWWJSO-UHFFFAOYSA-N 0.000 claims description 2
HSRUQIYRNUEGNR-UHFFFAOYSA-N FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=N1 Chemical compound FC1(F)CN(C1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=N1 HSRUQIYRNUEGNR-UHFFFAOYSA-N 0.000 claims description 2
QWLKXYKXOGDHKR-UHFFFAOYSA-N FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 Chemical compound FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 QWLKXYKXOGDHKR-UHFFFAOYSA-N 0.000 claims description 2
CTTTXIKJAPLWDX-UHFFFAOYSA-N FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=C1 Chemical compound FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)=C1 CTTTXIKJAPLWDX-UHFFFAOYSA-N 0.000 claims description 2
MDMRZIAQTWCOTB-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C(F)=C1 MDMRZIAQTWCOTB-UHFFFAOYSA-N 0.000 claims description 2
DRRFAMBCSVYWGH-UHFFFAOYSA-N FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 Chemical compound FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)C2)=CN=C1 DRRFAMBCSVYWGH-UHFFFAOYSA-N 0.000 claims description 2
FEMAFTXQIRFNLB-UHFFFAOYSA-N FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 Chemical compound FC1=CN=CC(F)=C1NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 FEMAFTXQIRFNLB-UHFFFAOYSA-N 0.000 claims description 2
208000028506 Familial Exudative Vitreoretinopathies Diseases 0.000 claims description 2
208000008875 Fuhrmann syndrome Diseases 0.000 claims description 2
208000033321 ICF syndrome Diseases 0.000 claims description 2
ZLGFIPCEQXZPLV-UHFFFAOYSA-N NC1CN(C1)C1=NC(=CN=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=CN=C2)C2=CC(F)=CC=C2)C=C1 Chemical compound NC1CN(C1)C1=NC(=CN=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=CN=C2)C2=CC(F)=CC=C2)C=C1 ZLGFIPCEQXZPLV-UHFFFAOYSA-N 0.000 claims description 2
PCWDJMXBHRGUOP-UHFFFAOYSA-N O=C(NC1CCN(CC#C)CC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 Chemical compound O=C(NC1CCN(CC#C)CC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCC1 PCWDJMXBHRGUOP-UHFFFAOYSA-N 0.000 claims description 2
DUIQGDMQTOATRP-UHFFFAOYSA-N O=C(NC1CCN(CC#C)CC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound O=C(NC1CCN(CC#C)CC1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 DUIQGDMQTOATRP-UHFFFAOYSA-N 0.000 claims description 2
OGIBCWJQVVCFMB-UHFFFAOYSA-N O=C(NC1CCN(CC#C)CC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1CCN(CC#C)CC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 OGIBCWJQVVCFMB-UHFFFAOYSA-N 0.000 claims description 2
LSHBNTHUSPGZSR-UHFFFAOYSA-N OC1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound OC1CCN(CC1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 LSHBNTHUSPGZSR-UHFFFAOYSA-N 0.000 claims description 2
CEGXOSXKYZPQTG-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=CN=C3)C(F)(F)F)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=CN=C3)C(F)(F)F)C=C2)CC1 CEGXOSXKYZPQTG-UHFFFAOYSA-N 0.000 claims description 2
LEBLSLQVOOFLKB-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)C(F)(F)F)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)C(F)(F)F)C=C2)CC1 LEBLSLQVOOFLKB-UHFFFAOYSA-N 0.000 claims description 2
ZDRHMRAFQFIEON-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=C(C=N3)C(F)(F)F)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=C(C=N3)C(F)(F)F)C=C2)CC1 ZDRHMRAFQFIEON-UHFFFAOYSA-N 0.000 claims description 2
LQDZRZATLXMJRZ-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=C(N=C3)C(F)(F)F)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CN=C(N=C3)C(F)(F)F)C=C2)CC1 LQDZRZATLXMJRZ-UHFFFAOYSA-N 0.000 claims description 2
GXUMNPAEZRGBOC-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC(=CC=C3)C(F)(F)F)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC(=CC=C3)C(F)(F)F)C=C2)CC1 GXUMNPAEZRGBOC-UHFFFAOYSA-N 0.000 claims description 2
URPSFXPHSCFTNO-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=C(C=C3)C(F)(F)F)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=C(C=C3)C(F)(F)F)C=C2)CC1 URPSFXPHSCFTNO-UHFFFAOYSA-N 0.000 claims description 2
SPLQTCGEDOYQJY-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=CC=C3C(F)(F)F)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=CC=C3C(F)(F)F)C=C2)CC1 SPLQTCGEDOYQJY-UHFFFAOYSA-N 0.000 claims description 2
IZRNLJNOSVICSR-UHFFFAOYSA-N OCC1(CO)CN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=CN=C3)C=C2)C1 Chemical compound OCC1(CO)CN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=CN=C3)C=C2)C1 IZRNLJNOSVICSR-UHFFFAOYSA-N 0.000 claims description 2
208000008589 Obesity Diseases 0.000 claims description 2
201000010769 Prader-Willi syndrome Diseases 0.000 claims description 2
206010049422 Precancerous skin lesion Diseases 0.000 claims description 2
208000007135 Retinal Neovascularization Diseases 0.000 claims description 2
208000006289 Rett Syndrome Diseases 0.000 claims description 2
208000022617 SERKAL syndrome Diseases 0.000 claims description 2
206010072610 Skeletal dysplasia Diseases 0.000 claims description 2
206010040869 Skin hypoplasia Diseases 0.000 claims description 2
208000008383 Wilms tumor Diseases 0.000 claims description 2
210000001766 X chromosome Anatomy 0.000 claims description 2
201000006288 alpha thalassemia Diseases 0.000 claims description 2
229910052799 carbon Inorganic materials 0.000 claims description 2
208000029078 coronary artery disease Diseases 0.000 claims description 2
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
AIMMVWOEOZMVMS-UHFFFAOYSA-N cyclopropanecarboxamide Chemical compound NC(=O)C1CC1 AIMMVWOEOZMVMS-UHFFFAOYSA-N 0.000 claims description 2
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
201000006902 exudative vitreoretinopathy Diseases 0.000 claims description 2
230000036244 malformation Effects 0.000 claims description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
208000026721 nail disease Diseases 0.000 claims description 2
201000008026 nephroblastoma Diseases 0.000 claims description 2
201000010193 neural tube defect Diseases 0.000 claims description 2
235000020824 obesity Nutrition 0.000 claims description 2
201000001937 osteoporosis-pseudoglioma syndrome Diseases 0.000 claims description 2
239000000546 pharmaceutical excipient Substances 0.000 claims description 2
208000015768 polyposis Diseases 0.000 claims description 2
208000035581 susceptibility to neural tube defects Diseases 0.000 claims description 2
208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 2
OTHYMKKLOZXVPL-UHFFFAOYSA-N O=C(NC1(CC1)C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NC1(CC1)C1=CC=CC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 OTHYMKKLOZXVPL-UHFFFAOYSA-N 0.000 claims 17
QLMPTBIYWMNZEX-UHFFFAOYSA-N 1-[5-[(4,4-difluoropiperidin-1-yl)methyl]pyridin-3-yl]indazole-3-carboxamide Chemical compound FC1(CCN(CC1)CC=1C=C(C=NC=1)N1N=C(C2=CC=CC=C12)C(=O)N)F QLMPTBIYWMNZEX-UHFFFAOYSA-N 0.000 claims 2
VQDDENHFABKYCO-UHFFFAOYSA-N CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound CC(C)(C)CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 VQDDENHFABKYCO-UHFFFAOYSA-N 0.000 claims 2
QWXGPPCATZWGEL-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 QWXGPPCATZWGEL-UHFFFAOYSA-N 0.000 claims 2
YRKWZEFTXVXMRO-UHFFFAOYSA-N CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound CC(C)(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 YRKWZEFTXVXMRO-UHFFFAOYSA-N 0.000 claims 2
YUZLIWYSQUERDB-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(OC2=CC=CC=C2)=CN=C1 YUZLIWYSQUERDB-UHFFFAOYSA-N 0.000 claims 2
JQTRWJWKPYHJCX-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 JQTRWJWKPYHJCX-UHFFFAOYSA-N 0.000 claims 2
BZUGESHEICTBLN-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCCCC2)C=N1 BZUGESHEICTBLN-UHFFFAOYSA-N 0.000 claims 2
ZSHQNEMPFLTDRE-UHFFFAOYSA-N CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 Chemical compound CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(Cl)=CN=C1 ZSHQNEMPFLTDRE-UHFFFAOYSA-N 0.000 claims 2
FROQFCVBVKLGON-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(C)=CN=C2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(C)=CN=C2)C=C1 FROQFCVBVKLGON-UHFFFAOYSA-N 0.000 claims 2
FAQZFDZBNQNGSH-UHFFFAOYSA-N CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC#C)CC2)C=C1 Chemical compound CN(C)C(=O)NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2CCN(CC#C)CC2)C=C1 FAQZFDZBNQNGSH-UHFFFAOYSA-N 0.000 claims 2
FTIZHGWBDRHXGO-UHFFFAOYSA-N CN(C)CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 Chemical compound CN(C)CC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCCC3)=CN=C2)C=N1 FTIZHGWBDRHXGO-UHFFFAOYSA-N 0.000 claims 2
JIOXPTWXZISQIO-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(F)C=C2F)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=NC=C(F)C=C2F)C=C1 JIOXPTWXZISQIO-UHFFFAOYSA-N 0.000 claims 2
FKZRJRZJHVTAKK-UHFFFAOYSA-N CN(C)CCNC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 Chemical compound CN(C)CCNC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC=C1 FKZRJRZJHVTAKK-UHFFFAOYSA-N 0.000 claims 2
DTUVAINNEHZNJN-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)C(F)(F)F Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)C(F)(F)F DTUVAINNEHZNJN-UHFFFAOYSA-N 0.000 claims 2
ZBLLAVBKPJLEGT-UHFFFAOYSA-N CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 Chemical compound CN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 ZBLLAVBKPJLEGT-UHFFFAOYSA-N 0.000 claims 2
DCVLAUJWZHESQA-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)C=N1 DCVLAUJWZHESQA-UHFFFAOYSA-N 0.000 claims 2
XEGOSZVXMZTLHR-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCCC3)=CN=C2)=C1 XEGOSZVXMZTLHR-UHFFFAOYSA-N 0.000 claims 2
ZIPWVJFBAGIKQK-UHFFFAOYSA-N CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 Chemical compound CN1CCN(CC1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(OC3=CC=CC=C3)=CN=C2)=C1 ZIPWVJFBAGIKQK-UHFFFAOYSA-N 0.000 claims 2
GIZLLBJIJVKMDY-UHFFFAOYSA-N CN1CCN(CC1)CC1=NC=CC(=C1)N1N=C(C2=CC=CC=C12)C(=O)N Chemical compound CN1CCN(CC1)CC1=NC=CC(=C1)N1N=C(C2=CC=CC=C12)C(=O)N GIZLLBJIJVKMDY-UHFFFAOYSA-N 0.000 claims 2
POBLWJSKXFODGB-UHFFFAOYSA-N CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(N)=CN=C3)=C2)CC1 Chemical compound CN1CCN(CC2=NC=CC(NC(=O)C3=NNC4=C3C=C(C=C4)C3=CC(N)=CN=C3)=C2)CC1 POBLWJSKXFODGB-UHFFFAOYSA-N 0.000 claims 2
MYURJWLOMIQACW-UHFFFAOYSA-N FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=NC=C1 Chemical compound FC(F)(F)C1=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)=NC=C1 MYURJWLOMIQACW-UHFFFAOYSA-N 0.000 claims 2
MUIHNHOFIIJZNJ-UHFFFAOYSA-N FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=N1 Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC3)=CN=C2)=N1 MUIHNHOFIIJZNJ-UHFFFAOYSA-N 0.000 claims 2
KJCCDSXAZLMMJZ-UHFFFAOYSA-N FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=N1 Chemical compound FC(F)(F)C1=NC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(NC(=O)C3CC3)=CN=C2)C=N1 KJCCDSXAZLMMJZ-UHFFFAOYSA-N 0.000 claims 2
XEPVYVZWBSIVHA-UHFFFAOYSA-N FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCCC3)=CN=C2)=C1 XEPVYVZWBSIVHA-UHFFFAOYSA-N 0.000 claims 2
CKQAFQDFBHFBAN-UHFFFAOYSA-N FC1=CC(=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2CCO2)C=C1)N1CCCC1 Chemical compound FC1=CC(=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCC2CCO2)C=C1)N1CCCC1 CKQAFQDFBHFBAN-UHFFFAOYSA-N 0.000 claims 2
ZKCISTXMMWELBJ-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CC3=CC=CC=C3)=CN=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CC3=CC=CC=C3)=CN=C2)C=C1 ZKCISTXMMWELBJ-UHFFFAOYSA-N 0.000 claims 2
PQRAVOWMIPATGO-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCC3)=NC=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCC3)=NC=C2)C=C1 PQRAVOWMIPATGO-UHFFFAOYSA-N 0.000 claims 2
PIVSBBYTZWHGGM-UHFFFAOYSA-N FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=NC=CC=C3C(F)(F)F)C=C2)=C1F Chemical compound FC1=CC=CC(C2=CC3=C(NN=C3C(=O)NC3=NC=CC=C3C(F)(F)F)C=C2)=C1F PIVSBBYTZWHGGM-UHFFFAOYSA-N 0.000 claims 2
VZPWDMFKSKZUDO-UHFFFAOYSA-N N1(CCCC1)C1=NC=CC(=C1)N1N=C(C2=CC=CC=C12)C(=O)N Chemical compound N1(CCCC1)C1=NC=CC(=C1)N1N=C(C2=CC=CC=C12)C(=O)N VZPWDMFKSKZUDO-UHFFFAOYSA-N 0.000 claims 2
CJUSGECLSFNYDB-UHFFFAOYSA-N NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CC(F)(F)C2)C=C1 Chemical compound NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CC(F)(F)C2)C=C1 CJUSGECLSFNYDB-UHFFFAOYSA-N 0.000 claims 2
XJDNCDMMLYYGES-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 XJDNCDMMLYYGES-UHFFFAOYSA-N 0.000 claims 2
MATOPIUFMDGDFP-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC2)=CN=C1 MATOPIUFMDGDFP-UHFFFAOYSA-N 0.000 claims 2
AFDIREMVSCLNII-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 AFDIREMVSCLNII-UHFFFAOYSA-N 0.000 claims 2
AJBQSJMHFSPTKU-UHFFFAOYSA-N O=C(NC1=CC=C(N=C1)C(=O)NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 Chemical compound O=C(NC1=CC=C(N=C1)C(=O)NC1CCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCCC2)=CN=C1 AJBQSJMHFSPTKU-UHFFFAOYSA-N 0.000 claims 2
XEYLPNHWRYBWAN-UHFFFAOYSA-N O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 Chemical compound O=C(NC1CCOCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCC2)=CN=C1 XEYLPNHWRYBWAN-UHFFFAOYSA-N 0.000 claims 2
RRHAPEOKCJVQAG-UHFFFAOYSA-N n-(2-methylpyrimidin-5-yl)-5-(5-piperidin-1-ylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(C=NC=3)N3CCCCC3)C=C12 RRHAPEOKCJVQAG-UHFFFAOYSA-N 0.000 claims 2
JFCBFGAKAIMGKB-UHFFFAOYSA-N n-(6-methylpyridin-3-yl)-5-pyridin-3-yl-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=NC=CC=3)C=C12 JFCBFGAKAIMGKB-UHFFFAOYSA-N 0.000 claims 2
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
VOPDPNWWHXDWOB-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N(C)C)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)N(C)C)C=C2)CC1 VOPDPNWWHXDWOB-UHFFFAOYSA-N 0.000 claims 1
IFYGFCFUZQZBIW-UHFFFAOYSA-N CNC(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C(F)=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 Chemical compound CNC(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C(F)=C3)C2=CC(CN3CCCCC3)=CN=C2)C=N1 IFYGFCFUZQZBIW-UHFFFAOYSA-N 0.000 claims 1
206010058314 Dysplasia Diseases 0.000 claims 1
208000025966 Neurological disease Diseases 0.000 claims 1
206010047486 Virilism Diseases 0.000 claims 1
210000000845 cartilage Anatomy 0.000 claims 1
210000001072 colon Anatomy 0.000 claims 1
125000004552 isoquinolin-4-yl group Chemical group C1=NC=C(C2=CC=CC=C12)* 0.000 claims 1
231100000794 masculinization Toxicity 0.000 claims 1
HGSBEJDJFBESFS-UHFFFAOYSA-N FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=C1 Chemical compound FC(F)(F)C1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC=CN=C2)C=C1 HGSBEJDJFBESFS-UHFFFAOYSA-N 0.000 description 26
0 *c(cc1c(C(N*)=O)n[n]c1c1)c1I Chemical compound *c(cc1c(C(N*)=O)n[n]c1c1)c1I 0.000 description 7
206010016654 Fibrosis Diseases 0.000 description 6
230000004761 fibrosis Effects 0.000 description 5
201000011240 Frontotemporal dementia Diseases 0.000 description 4
102000013814 Wnt Human genes 0.000 description 3
108050003627 Wnt Proteins 0.000 description 3
206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
DJLGJXQDNVBTGZ-UHFFFAOYSA-N 1-[2-(dimethylamino)ethyl]indazole-3-carboxamide Chemical compound C1=CC=C2N(CCN(C)C)N=C(C(N)=O)C2=C1 DJLGJXQDNVBTGZ-UHFFFAOYSA-N 0.000 description 2
NLHIOPHGGVFVCJ-UHFFFAOYSA-N 1-[5-[(dimethylamino)methyl]pyridin-3-yl]indazole-3-carboxamide Chemical compound CN(C)CC=1C=C(C=NC=1)N1N=C(C2=CC=CC=C12)C(=O)N NLHIOPHGGVFVCJ-UHFFFAOYSA-N 0.000 description 2
125000004484 1-methylpiperidin-4-yl group Chemical group CN1CCC(CC1)* 0.000 description 2
AUGJHXMSSLXBJN-UHFFFAOYSA-N 5-[5-(dimethylcarbamoylamino)pyridin-3-yl]-n-pyridin-2-yl-1h-indazole-3-carboxamide Chemical compound CN(C)C(=O)NC1=CN=CC(C=2C=C3C(C(=O)NC=4N=CC=CC=4)=NNC3=CC=2)=C1 AUGJHXMSSLXBJN-UHFFFAOYSA-N 0.000 description 2
206010003805 Autism Diseases 0.000 description 2
208000020706 Autistic disease Diseases 0.000 description 2
208000020084 Bone disease Diseases 0.000 description 2
208000003174 Brain Neoplasms Diseases 0.000 description 2
OKPBTVDAKJADFW-UHFFFAOYSA-N CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 Chemical compound CC#CCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC=CN=C1 OKPBTVDAKJADFW-UHFFFAOYSA-N 0.000 description 2
MPVUQNJBXACXQM-UHFFFAOYSA-N CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 Chemical compound CC(C)(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCC(F)(F)CC2)=CN=C1 MPVUQNJBXACXQM-UHFFFAOYSA-N 0.000 description 2
JKCWPMFGUIVNAJ-UHFFFAOYSA-N CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC=CN=C1 Chemical compound CC(C)N1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C(F)=C2)C1=CC=CN=C1 JKCWPMFGUIVNAJ-UHFFFAOYSA-N 0.000 description 2
WKYFWOUULIPQFP-UHFFFAOYSA-N CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(=C1)N1CCOCC1 Chemical compound CC(C)NC(=O)C1=NNC2=C1C=C(C=C2)C1=C(F)C(F)=CC(=C1)N1CCOCC1 WKYFWOUULIPQFP-UHFFFAOYSA-N 0.000 description 2
KJZMRKYDNPHUBY-UHFFFAOYSA-N CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(N)=CN=C2)C=N1 Chemical compound CC(C)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(N)=CN=C2)C=N1 KJZMRKYDNPHUBY-UHFFFAOYSA-N 0.000 description 2
RMCZCTUOAGFUHF-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CN4CCC4)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(CN4CCC4)N=C3)C=C2)CC1 RMCZCTUOAGFUHF-UHFFFAOYSA-N 0.000 description 2
TWQOIARLJVAPBO-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C(=O)N3CCCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(N=C3)C(=O)N3CCCC3)C=C2)CC1 TWQOIARLJVAPBO-UHFFFAOYSA-N 0.000 description 2
LHVGAHZHDHSUOQ-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(NCCN(C)C)N=C3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC=C(NCCN(C)C)N=C3)C=C2)CC1 LHVGAHZHDHSUOQ-UHFFFAOYSA-N 0.000 description 2
ROGHPSVSLDMEEG-UHFFFAOYSA-N CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCOCC3)C=C2)CC1 Chemical compound CC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3CCOCC3)C=C2)CC1 ROGHPSVSLDMEEG-UHFFFAOYSA-N 0.000 description 2
ZSWUWJGYFKVOGD-UHFFFAOYSA-N CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=N1 Chemical compound CC1CN(CC(C)O1)C1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)C=N1 ZSWUWJGYFKVOGD-UHFFFAOYSA-N 0.000 description 2
OSACZMDYLNMABK-UHFFFAOYSA-N CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CC(F)(F)C2)=CN=C1 Chemical compound CCC(CC)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CC(F)(F)C2)=CN=C1 OSACZMDYLNMABK-UHFFFAOYSA-N 0.000 description 2
CSOZRZSXIVGPJX-UHFFFAOYSA-N CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCN(C)CC3)=NC=C2)C=C1 Chemical compound CN(C)CC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCN(C)CC3)=NC=C2)C=C1 CSOZRZSXIVGPJX-UHFFFAOYSA-N 0.000 description 2
YIAWQZOGPPTTRE-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=C(F)C(F)=CC(CN3CCCCC3)=C2)C=N1 YIAWQZOGPPTTRE-UHFFFAOYSA-N 0.000 description 2
206010009944 Colon cancer Diseases 0.000 description 2
WQNHAJXOQLHSDI-UHFFFAOYSA-N FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=N1 Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=N1 WQNHAJXOQLHSDI-UHFFFAOYSA-N 0.000 description 2
QQGWEECDGXTTEA-UHFFFAOYSA-N FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 Chemical compound FC(F)(F)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)CC3)=CN=C2)=C1 QQGWEECDGXTTEA-UHFFFAOYSA-N 0.000 description 2
PDGMRHYNXPIHHX-UHFFFAOYSA-N FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCCC3)C=C2)CC1 Chemical compound FC1(F)CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=CC(=NC=C3)N3CCCCC3)C=C2)CC1 PDGMRHYNXPIHHX-UHFFFAOYSA-N 0.000 description 2
SWYLLTSGHXQYMC-UHFFFAOYSA-N FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 Chemical compound FC1(F)CN(C1)C1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(=CN=C2)N2CCOCC2)=C1 SWYLLTSGHXQYMC-UHFFFAOYSA-N 0.000 description 2
BSJFVQIKZGZIDB-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CC3=CC=CC=C3)N=C2)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(CC3=CC=CC=C3)N=C2)C=C1 BSJFVQIKZGZIDB-UHFFFAOYSA-N 0.000 description 2
VWIRNGPVJGYQBL-UHFFFAOYSA-N FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=NC=CC=C2C(F)(F)F)C=C1 Chemical compound FC1=CC(CN2CCCCC2)=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=NC=CC=C2C(F)(F)F)C=C1 VWIRNGPVJGYQBL-UHFFFAOYSA-N 0.000 description 2
AEZTXPJXGUKRJN-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCCC3)=NC=C2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC(CN3CCCCC3)=NC=C2)C=C1 AEZTXPJXGUKRJN-UHFFFAOYSA-N 0.000 description 2
CNGFGRYPVBTGCR-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCOCC2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NC2=CC=C(N=C2)N2CCOCC2)C=C1 CNGFGRYPVBTGCR-UHFFFAOYSA-N 0.000 description 2
JMCQNZMEZQNEPP-UHFFFAOYSA-N FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCCN2CCCC2)C=C1 Chemical compound FC1=CC=CC(=C1F)C1=CC2=C(NN=C2C(=O)NCCN2CCCC2)C=C1 JMCQNZMEZQNEPP-UHFFFAOYSA-N 0.000 description 2
ZYZZARZAWUXKOF-UHFFFAOYSA-N FCCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CN=CC2=CC=CC=C12 Chemical compound FCCN1CCC(CC1)NC(=O)C1=NNC2=C1C=C(C=C2)C1=CN=CC2=CC=CC=C12 ZYZZARZAWUXKOF-UHFFFAOYSA-N 0.000 description 2
101000781981 Homo sapiens Protein Wnt-11 Proteins 0.000 description 2
208000023105 Huntington disease Diseases 0.000 description 2
201000002832 Lewy body dementia Diseases 0.000 description 2
206010058467 Lung neoplasm malignant Diseases 0.000 description 2
206010025323 Lymphomas Diseases 0.000 description 2
208000001089 Multiple system atrophy Diseases 0.000 description 2
JYMHZUIPAFNUDR-UHFFFAOYSA-N O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 Chemical compound O=C(NC1=CC(=NC=C1)N1CCCCC1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCCCC2)=CN=C1 JYMHZUIPAFNUDR-UHFFFAOYSA-N 0.000 description 2
SYSVEIOZHJJNIK-UHFFFAOYSA-N O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 Chemical compound O=C(NC1=CC(CN2CCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(=CN=C1)N1CCCCC1 SYSVEIOZHJJNIK-UHFFFAOYSA-N 0.000 description 2
JDQREPRFDROSSJ-UHFFFAOYSA-N O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 Chemical compound O=C(NC1=CC(CN2CCCC2)=NC=C1)C1=NNC2=C1C=C(C=C2)C1=CC(CN2CCOCC2)=CN=C1 JDQREPRFDROSSJ-UHFFFAOYSA-N 0.000 description 2
IEAHTEHKZVDBMQ-UHFFFAOYSA-N O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCC2)C=C1)C1CC1 Chemical compound O=C(NC1=CN=CC(=C1)C1=CC2=C(NN=C2C(=O)NC2=CC(=NC=C2)N2CCCC2)C=C1)C1CC1 IEAHTEHKZVDBMQ-UHFFFAOYSA-N 0.000 description 2
208000018737 Parkinson disease Diseases 0.000 description 2
208000002158 Proliferative Vitreoretinopathy Diseases 0.000 description 2
102100036567 Protein Wnt-11 Human genes 0.000 description 2
206010038934 Retinopathy proliferative Diseases 0.000 description 2
208000000453 Skin Neoplasms Diseases 0.000 description 2
208000015100 cartilage disease Diseases 0.000 description 2
208000019425 cirrhosis of liver Diseases 0.000 description 2
201000005202 lung cancer Diseases 0.000 description 2
208000020816 lung neoplasm Diseases 0.000 description 2
201000001441 melanoma Diseases 0.000 description 2
201000006417 multiple sclerosis Diseases 0.000 description 2
YYMBMKIYDALVAC-UHFFFAOYSA-N n-(2-methylpyrimidin-5-yl)-5-[5-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=NC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(CN4CCCC4)C=NC=3)C=C12 YYMBMKIYDALVAC-UHFFFAOYSA-N 0.000 description 2
NDRHJKNLNNRUQC-UHFFFAOYSA-N n-(6-methylpyridin-3-yl)-5-(5-morpholin-4-ylpyridin-3-yl)-1h-indazole-3-carboxamide Chemical compound C1=NC(C)=CC=C1NC(=O)C1=NNC2=CC=C(C=3C=C(C=NC=3)N3CCOCC3)C=C12 NDRHJKNLNNRUQC-UHFFFAOYSA-N 0.000 description 2
208000021971 neovascular inflammatory vitreoretinopathy Diseases 0.000 description 2
201000001119 neuropathy Diseases 0.000 description 2
230000007823 neuropathy Effects 0.000 description 2
230000006785 proliferative vitreoretinopathy Effects 0.000 description 2
201000000849 skin cancer Diseases 0.000 description 2
HTVIGXKKKOEVOV-UHFFFAOYSA-N 1-[5-[(4-methylpiperidin-1-yl)methyl]pyridin-3-yl]indazole-3-carboxamide Chemical compound CC1CCN(CC1)CC=1C=C(C=NC=1)N1N=C(C2=CC=CC=C12)C(=O)N HTVIGXKKKOEVOV-UHFFFAOYSA-N 0.000 description 1
208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
208000006468 Adrenal Cortex Neoplasms Diseases 0.000 description 1
208000024827 Alzheimer disease Diseases 0.000 description 1
206010061424 Anal cancer Diseases 0.000 description 1
208000007860 Anus Neoplasms Diseases 0.000 description 1
206010002961 Aplasia Diseases 0.000 description 1
208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
206010004593 Bile duct cancer Diseases 0.000 description 1
206010005003 Bladder cancer Diseases 0.000 description 1
206010005949 Bone cancer Diseases 0.000 description 1
208000018084 Bone neoplasm Diseases 0.000 description 1
206010006187 Breast cancer Diseases 0.000 description 1
208000026310 Breast neoplasm Diseases 0.000 description 1
DYVUNUQDYHPXSU-UHFFFAOYSA-N CN(C)C1CC1 Chemical compound CN(C)C1CC1 DYVUNUQDYHPXSU-UHFFFAOYSA-N 0.000 description 1
RAYLUCFWHWEBQF-UHFFFAOYSA-N CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=N1 Chemical compound CN1CCC(CC1)OC1=CC=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)C=N1 RAYLUCFWHWEBQF-UHFFFAOYSA-N 0.000 description 1
OFFGOLPZOOFIQB-UHFFFAOYSA-N CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 Chemical compound CN1CCC(CC1)OC1=NC=CC(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCOCC3)=CN=C2)=C1 OFFGOLPZOOFIQB-UHFFFAOYSA-N 0.000 description 1
206010007279 Carcinoid tumour of the gastrointestinal tract Diseases 0.000 description 1
206010008342 Cervix carcinoma Diseases 0.000 description 1
208000010693 Charcot-Marie-Tooth Disease Diseases 0.000 description 1
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 description 1
208000001333 Colorectal Neoplasms Diseases 0.000 description 1
101100317380 Danio rerio wnt4a gene Proteins 0.000 description 1
206010012289 Dementia Diseases 0.000 description 1
206010067889 Dementia with Lewy bodies Diseases 0.000 description 1
201000010374 Down Syndrome Diseases 0.000 description 1
102100028554 Dual specificity tyrosine-phosphorylation-regulated kinase 1A Human genes 0.000 description 1
206010014733 Endometrial cancer Diseases 0.000 description 1
206010014759 Endometrial neoplasm Diseases 0.000 description 1
201000009273 Endometriosis Diseases 0.000 description 1
208000000461 Esophageal Neoplasms Diseases 0.000 description 1
208000006168 Ewing Sarcoma Diseases 0.000 description 1
FUKWQCKGVXFWRT-UHFFFAOYSA-N FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C(F)=C1 Chemical compound FC1=CN=C(NC(=O)C2=NNC3=C2C=C(C=C3)C2=CC(CN3CCC(F)(F)C3)=CN=C2)C(F)=C1 FUKWQCKGVXFWRT-UHFFFAOYSA-N 0.000 description 1
208000022072 Gallbladder Neoplasms Diseases 0.000 description 1
206010051066 Gastrointestinal stromal tumour Diseases 0.000 description 1
206010018364 Glomerulonephritis Diseases 0.000 description 1
208000017604 Hodgkin disease Diseases 0.000 description 1
208000021519 Hodgkin lymphoma Diseases 0.000 description 1
208000010747 Hodgkins lymphoma Diseases 0.000 description 1
101000838016 Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1A Proteins 0.000 description 1
101000814371 Homo sapiens Protein Wnt-10a Proteins 0.000 description 1
101000770799 Homo sapiens Protein Wnt-10b Proteins 0.000 description 1
101000804728 Homo sapiens Protein Wnt-2b Proteins 0.000 description 1
101000804792 Homo sapiens Protein Wnt-5a Proteins 0.000 description 1
101000804804 Homo sapiens Protein Wnt-5b Proteins 0.000 description 1
101000855002 Homo sapiens Protein Wnt-6 Proteins 0.000 description 1
101000855004 Homo sapiens Protein Wnt-7a Proteins 0.000 description 1
101000814380 Homo sapiens Protein Wnt-7b Proteins 0.000 description 1
101000814350 Homo sapiens Protein Wnt-8a Proteins 0.000 description 1
101000650149 Homo sapiens Protein Wnt-8b Proteins 0.000 description 1
101000650117 Homo sapiens Protein Wnt-9a Proteins 0.000 description 1
101000650119 Homo sapiens Protein Wnt-9b Proteins 0.000 description 1
101000781955 Homo sapiens Proto-oncogene Wnt-1 Proteins 0.000 description 1
101000954762 Homo sapiens Proto-oncogene Wnt-3 Proteins 0.000 description 1
206010021042 Hypopharyngeal cancer Diseases 0.000 description 1
206010056305 Hypopharyngeal neoplasm Diseases 0.000 description 1
208000029523 Interstitial Lung disease Diseases 0.000 description 1
208000007766 Kaposi sarcoma Diseases 0.000 description 1
208000008839 Kidney Neoplasms Diseases 0.000 description 1
206010023421 Kidney fibrosis Diseases 0.000 description 1
206010023825 Laryngeal cancer Diseases 0.000 description 1
208000009829 Lewy Body Disease Diseases 0.000 description 1
208000032271 Malignant tumor of penis Diseases 0.000 description 1
206010027476 Metastases Diseases 0.000 description 1
208000034578 Multiple myelomas Diseases 0.000 description 1
208000021642 Muscular disease Diseases 0.000 description 1
208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
208000033833 Myelomonocytic Chronic Leukemia Diseases 0.000 description 1
201000009623 Myopathy Diseases 0.000 description 1
208000001894 Nasopharyngeal Neoplasms Diseases 0.000 description 1
206010061306 Nasopharyngeal cancer Diseases 0.000 description 1
206010029260 Neuroblastoma Diseases 0.000 description 1
ZISQKWOCTUPEDW-UHFFFAOYSA-N OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=CC(=C3)C(F)(F)F)C=C2)CC1 Chemical compound OC1CCN(CC2=CN=CC(=C2)C2=CC3=C(NN=C3C(=O)NC3=NC=CC(=C3)C(F)(F)F)C=C2)CC1 ZISQKWOCTUPEDW-UHFFFAOYSA-N 0.000 description 1
206010030155 Oesophageal carcinoma Diseases 0.000 description 1
206010031127 Orthostatic hypotension Diseases 0.000 description 1
206010033128 Ovarian cancer Diseases 0.000 description 1
206010061535 Ovarian neoplasm Diseases 0.000 description 1
206010061902 Pancreatic neoplasm Diseases 0.000 description 1
208000027089 Parkinsonian disease Diseases 0.000 description 1
206010034010 Parkinsonism Diseases 0.000 description 1
208000002471 Penile Neoplasms Diseases 0.000 description 1
206010034299 Penile cancer Diseases 0.000 description 1
108091000080 Phosphotransferase Proteins 0.000 description 1
208000000609 Pick Disease of the Brain Diseases 0.000 description 1
208000024571 Pick disease Diseases 0.000 description 1
208000007913 Pituitary Neoplasms Diseases 0.000 description 1
206010035226 Plasma cell myeloma Diseases 0.000 description 1
208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
208000024777 Prion disease Diseases 0.000 description 1
206010060862 Prostate cancer Diseases 0.000 description 1
208000000236 Prostatic Neoplasms Diseases 0.000 description 1
102100039461 Protein Wnt-10a Human genes 0.000 description 1
102100029062 Protein Wnt-10b Human genes 0.000 description 1
102100035289 Protein Wnt-2b Human genes 0.000 description 1
102100035331 Protein Wnt-5b Human genes 0.000 description 1
102100020732 Protein Wnt-6 Human genes 0.000 description 1
102100020729 Protein Wnt-7a Human genes 0.000 description 1
102100039470 Protein Wnt-7b Human genes 0.000 description 1
102100039453 Protein Wnt-8a Human genes 0.000 description 1
102100027542 Protein Wnt-8b Human genes 0.000 description 1
102100027503 Protein Wnt-9a Human genes 0.000 description 1
102100027502 Protein Wnt-9b Human genes 0.000 description 1
208000032056 Radiation Fibrosis Syndrome Diseases 0.000 description 1
206010067953 Radiation fibrosis Diseases 0.000 description 1
206010038389 Renal cancer Diseases 0.000 description 1
201000000582 Retinoblastoma Diseases 0.000 description 1
208000004337 Salivary Gland Neoplasms Diseases 0.000 description 1
206010061934 Salivary gland cancer Diseases 0.000 description 1
206010039491 Sarcoma Diseases 0.000 description 1
206010039710 Scleroderma Diseases 0.000 description 1
208000005718 Stomach Neoplasms Diseases 0.000 description 1
208000006011 Stroke Diseases 0.000 description 1
208000032859 Synucleinopathies Diseases 0.000 description 1
208000024313 Testicular Neoplasms Diseases 0.000 description 1
206010057644 Testis cancer Diseases 0.000 description 1
208000000728 Thymus Neoplasms Diseases 0.000 description 1
208000024770 Thyroid neoplasm Diseases 0.000 description 1
208000030886 Traumatic Brain injury Diseases 0.000 description 1
208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
206010067269 Uterine fibrosis Diseases 0.000 description 1
206010047741 Vulval cancer Diseases 0.000 description 1
208000004354 Vulvar Neoplasms Diseases 0.000 description 1
101150010310 WNT-4 gene Proteins 0.000 description 1
101150019524 WNT2 gene Proteins 0.000 description 1
102000052547 Wnt-1 Human genes 0.000 description 1
102000052556 Wnt-2 Human genes 0.000 description 1
108700020986 Wnt-2 Proteins 0.000 description 1
102000052549 Wnt-3 Human genes 0.000 description 1
102000052548 Wnt-4 Human genes 0.000 description 1
108700020984 Wnt-4 Proteins 0.000 description 1
102000043366 Wnt-5a Human genes 0.000 description 1
102000044880 Wnt3A Human genes 0.000 description 1
108700013515 Wnt3A Proteins 0.000 description 1
101100485099 Xenopus laevis wnt2b-b gene Proteins 0.000 description 1
230000033115 angiogenesis Effects 0.000 description 1
201000011165 anus cancer Diseases 0.000 description 1
210000004227 basal ganglia Anatomy 0.000 description 1
208000026900 bile duct neoplasm Diseases 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
210000003169 central nervous system Anatomy 0.000 description 1
201000010881 cervical cancer Diseases 0.000 description 1
208000006990 cholangiocarcinoma Diseases 0.000 description 1
210000000349 chromosome Anatomy 0.000 description 1
201000010902 chronic myelomonocytic leukemia Diseases 0.000 description 1
230000007882 cirrhosis Effects 0.000 description 1
230000000112 colonic effect Effects 0.000 description 1
208000029742 colonic neoplasm Diseases 0.000 description 1
230000007850 degeneration Effects 0.000 description 1
230000003412 degenerative effect Effects 0.000 description 1
208000017004 dementia pugilistica Diseases 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000002124 endocrine Effects 0.000 description 1
206010015037 epilepsy Diseases 0.000 description 1
201000004101 esophageal cancer Diseases 0.000 description 1
208000024519 eye neoplasm Diseases 0.000 description 1
201000010175 gallbladder cancer Diseases 0.000 description 1
206010017758 gastric cancer Diseases 0.000 description 1
201000011243 gastrointestinal stromal tumor Diseases 0.000 description 1
208000003884 gestational trophoblastic disease Diseases 0.000 description 1
206010061989 glomerulosclerosis Diseases 0.000 description 1
206010073071 hepatocellular carcinoma Diseases 0.000 description 1
231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
230000001969 hypertrophic effect Effects 0.000 description 1
201000006866 hypopharynx cancer Diseases 0.000 description 1
201000008319 inclusion body myositis Diseases 0.000 description 1
208000023589 ischemic disease Diseases 0.000 description 1
201000010982 kidney cancer Diseases 0.000 description 1
206010023841 laryngeal neoplasm Diseases 0.000 description 1
208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
230000009401 metastasis Effects 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
230000004770 neurodegeneration Effects 0.000 description 1
230000000926 neurological effect Effects 0.000 description 1
201000008106 ocular cancer Diseases 0.000 description 1
201000008968 osteosarcoma Diseases 0.000 description 1
201000002528 pancreatic cancer Diseases 0.000 description 1
208000008443 pancreatic carcinoma Diseases 0.000 description 1
230000037361 pathway Effects 0.000 description 1
208000033808 peripheral neuropathy Diseases 0.000 description 1
102000020233 phosphotransferase Human genes 0.000 description 1
208000010916 pituitary tumor Diseases 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
201000002212 progressive supranuclear palsy Diseases 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
201000002793 renal fibrosis Diseases 0.000 description 1
208000037803 restenosis Diseases 0.000 description 1
201000009410 rhabdomyosarcoma Diseases 0.000 description 1
230000036573 scar formation Effects 0.000 description 1
230000037390 scarring Effects 0.000 description 1
230000011664 signaling Effects 0.000 description 1
201000002314 small intestine cancer Diseases 0.000 description 1
206010062261 spinal cord neoplasm Diseases 0.000 description 1
201000011549 stomach cancer Diseases 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
102000013498 tau Proteins Human genes 0.000 description 1
108010026424 tau Proteins Proteins 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
201000003120 testicular cancer Diseases 0.000 description 1
201000002510 thyroid cancer Diseases 0.000 description 1
230000009529 traumatic brain injury Effects 0.000 description 1
201000005112 urinary bladder cancer Diseases 0.000 description 1
208000037965 uterine sarcoma Diseases 0.000 description 1
206010046885 vaginal cancer Diseases 0.000 description 1
208000013139 vaginal neoplasm Diseases 0.000 description 1
201000005102 vulva cancer Diseases 0.000 description 1
101150068520 wnt3a gene Proteins 0.000 description 1

JP2016558073A 2014-03-20 2015-03-20 ５−置換インダゾール−３−カルボキサミドならびにその調製および使用の方法 Active JP6586104B2 (ja)