JP2017508763A5 - - Google Patents
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- Publication number
- JP2017508763A5 JP2017508763A5 JP2016558073A JP2016558073A JP2017508763A5 JP 2017508763 A5 JP2017508763 A5 JP 2017508763A5 JP 2016558073 A JP2016558073 A JP 2016558073A JP 2016558073 A JP2016558073 A JP 2016558073A JP 2017508763 A5 JP2017508763 A5 JP 2017508763A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- carboxamide
- indazole
- ylmethyl
- piperidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *c(cc1c(C(N*)=O)n[n]c1c1)c1I Chemical compound *c(cc1c(C(N*)=O)n[n]c1c1)c1I 0.000 description 7
- DYVUNUQDYHPXSU-UHFFFAOYSA-N CN(C)C1CC1 Chemical compound CN(C)C1CC1 DYVUNUQDYHPXSU-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461968350P | 2014-03-20 | 2014-03-20 | |
| US61/968,350 | 2014-03-20 | ||
| PCT/US2015/021847 WO2015143380A1 (en) | 2014-03-20 | 2015-03-20 | 5-substituted indazole-3-carboxamides and preparation and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017508763A JP2017508763A (ja) | 2017-03-30 |
| JP2017508763A5 true JP2017508763A5 (enExample) | 2018-05-10 |
| JP6586104B2 JP6586104B2 (ja) | 2019-10-02 |
Family
ID=54141450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016558073A Expired - Fee Related JP6586104B2 (ja) | 2014-03-20 | 2015-03-20 | ５−置換インダゾール−３−カルボキサミドならびにその調製および使用の方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9745271B2 (enExample) |
| EP (1) | EP3119393A4 (enExample) |
| JP (1) | JP6586104B2 (enExample) |
| KR (1) | KR20160135283A (enExample) |
| CN (1) | CN106535890A (enExample) |
| BR (1) | BR112016021626A2 (enExample) |
| CA (1) | CA2942687A1 (enExample) |
| CL (1) | CL2016002364A1 (enExample) |
| IL (1) | IL247713A0 (enExample) |
| MA (1) | MA39763A (enExample) |
| MX (1) | MX2016012208A (enExample) |
| PE (1) | PE20170127A1 (enExample) |
| PH (1) | PH12016501835A1 (enExample) |
| RU (1) | RU2016141088A (enExample) |
| SG (2) | SG10201914111XA (enExample) |
| WO (1) | WO2015143380A1 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE041576T2 (hu) | 2011-09-14 | 2019-05-28 | Samumed Llc | Indazol-3-karboxamid-származékok és alkalmazásuk Wnt/b-katenin szignalizáló útvonal inhibitorokként |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| US9908867B2 (en) | 2013-01-08 | 2018-03-06 | Samumed, Llc | 3-(benzoimidazol-2-yl)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof |
| BR112016021626A2 (pt) | 2014-03-20 | 2018-05-15 | Samumed, Llc | indazol-3-carboxamidas 5-substituídas e preparação e uso das mesmas |
| WO2016040193A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| WO2016040190A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| WO2016040185A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
| WO2016040184A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040180A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| US10195185B2 (en) | 2015-08-03 | 2019-02-05 | Samumed, Llc | 3-(1H-imidazo[4,5-C]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10350199B2 (en) | 2015-08-03 | 2019-07-16 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
| WO2017024025A1 (en) | 2015-08-03 | 2017-02-09 | Sunil Kumar Kc | 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| WO2017023987A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| WO2017023989A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10231956B2 (en) | 2015-08-03 | 2019-03-19 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10206909B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10329309B2 (en) | 2015-08-03 | 2019-06-25 | Samumed, Llc | 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10188634B2 (en) | 2015-08-03 | 2019-01-29 | Samumed, Llc | 3-(3H-imidazo[4,5-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10463651B2 (en) | 2015-08-03 | 2019-11-05 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof |
| US10604512B2 (en) | 2015-08-03 | 2020-03-31 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof |
| US10383861B2 (en) | 2015-08-03 | 2019-08-20 | Sammumed, LLC | 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| US10285983B2 (en) | 2015-08-03 | 2019-05-14 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof |
| WO2017023980A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| US10206908B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| WO2017024026A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| WO2017023993A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-indol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| JP6917989B2 (ja) * | 2015-11-06 | 2021-08-11 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 神経学的疾患を処置するためのムスカリン受容体４（ｍ４）アンタゴニストとしての、ｎ−［２−（１−ベンジルピペリジン−４−イル）エチル］−４−（ピラジン−２−イル）−ピペラジン−１−カルボキサミド誘導体および関連化合物 |
| WO2017079759A1 (en) | 2015-11-06 | 2017-05-11 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-c]pyridines and their anti-inflammatory uses thereof |
| EA039638B1 (ru) * | 2016-01-06 | 2022-02-21 | Нейрокрин Байосайенсиз, Инк. | Антагонисты мускаринового рецептора 4 и способы их применения |
| CN109562176A (zh) * | 2016-04-15 | 2019-04-02 | 费利克斯疗法公司 | 使用静止细胞靶向和egfr抑制剂的用于治疗肿瘤的组合 |
| WO2017181087A1 (en) * | 2016-04-15 | 2017-10-19 | Felicitex Therapeutics, Inc. | Combinations for the treatment of neoplasms using quiescent cell targeting and inhibitors of mitosis |
| AR108325A1 (es) | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
| AR108326A1 (es) | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
| MY199242A (en) * | 2016-06-01 | 2023-10-22 | Samumed Llc | Process for preparing n-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide |
| CN113912586B (zh) | 2016-08-31 | 2023-04-07 | 江苏恒瑞医药股份有限公司 | 氧代吡啶酰胺类衍生物、其制备方法及其在医药上的应用 |
| BR112019008061A2 (pt) | 2016-10-21 | 2019-09-17 | Samumed Llc | métodos de uso de indazol-3-carboxamidas e seu uso como inibidores da via de sinalização de wnt/b-catenina |
| MA46696A (fr) | 2016-11-07 | 2019-09-11 | Samumed Llc | Formulations injectables à dose unique prêtes à l'emploi |
| KR102279347B1 (ko) * | 2016-12-15 | 2021-07-21 | 한국생명공학연구원 | 피리딘계 화합물을 유효성분으로 함유하는 dyrk 관련 질환의 예방 또는 치료용 약학적 조성물 |
| KR101924801B1 (ko) * | 2017-08-16 | 2018-12-04 | 한국원자력의학원 | 트리아졸로피리딘계 유도체를 유효성분으로 함유하는 암 예방 또는 치료용 조성물 |
| KR102687118B1 (ko) | 2017-08-16 | 2024-07-19 | 벤더르빌트 유니버시티 | Mglur4 알로스테릭 증강제로서의 인다졸 화합물, 조성물, 및 신경 기능장애 치료 방법 |
| KR102179406B1 (ko) * | 2017-10-17 | 2020-11-16 | 한국화학연구원 | 신규한 인다졸 유도체 및 이의 용도 |
| JP7369132B2 (ja) * | 2018-02-23 | 2023-10-25 | サミュメッド リミテッド ライアビリティ カンパニー | ５－ヘテロアリール置換イミダゾール－３－カルボキサミドならびにその調製および使用の方法 |
| ES2913975T3 (es) * | 2018-05-07 | 2022-06-07 | Acraf | Compuestos de 1H-indazol-3-carboxamida como inhibidores de la glucógeno sintasa cinasa-3 beta |
| KR102906523B1 (ko) | 2018-09-13 | 2025-12-30 | 브리스톨-마이어스 스큅 컴퍼니 | 수용체-상호작용 단백질 키나제 1 (ripk1) 억제제로서의 1h-인다졸 카르복스아미드 |
| EP3911317A2 (en) * | 2019-01-17 | 2021-11-24 | BioSplice Therapeutics, Inc. | Methods of treating cartilage disorders through inhibition of clk and dyrk |
| WO2020150545A1 (en) * | 2019-01-17 | 2020-07-23 | Samumed, Llc | Pyrazole derivatives as modulators of the wnt/b-catenin signaling pathway |
| US12486250B2 (en) | 2019-12-06 | 2025-12-02 | Neurocrine Biosciences, Inc. | Muscarinic receptor 4 antagonists and methods of use |
| US20250243181A2 (en) * | 2019-12-16 | 2025-07-31 | Korea Research Institute Of Chemical Technology | Novel indazole derivative and use thereof |
| US12605368B2 (en) | 2020-04-01 | 2026-04-21 | Kyoto University | Suppression of neuroinflammation and composition and method therefor |
| CN114230565B (zh) * | 2020-09-09 | 2023-10-27 | 成都奥睿药业有限公司 | 5-取代吲哚3-酰胺衍生物及其制备方法和用途 |
| CN116322663A (zh) * | 2020-09-30 | 2023-06-23 | 比奥维拉迪维治疗股份有限公司 | Ampk激活剂及其使用方法 |
| CN115353512B (zh) * | 2021-07-30 | 2025-07-08 | 上海翊石医药科技有限公司 | 一种杂环脲类化合物及其制备方法和用途 |
| CN113735798B (zh) * | 2021-09-27 | 2022-07-12 | 安徽美致诚药业有限公司 | 一种盐酸罗沙替丁醋酸酯的制备方法 |
| WO2023098699A1 (en) * | 2021-12-01 | 2023-06-08 | Nanjing Immunophage Biotech Co., Ltd | Compounds and their uses as cd38 inhibitors |
| US20240132464A1 (en) * | 2022-09-28 | 2024-04-25 | Accutar Biotechnology Inc. | Heterocyclic compounds as e3 ligase inhibitors |
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| US4164559A (en) | 1977-09-21 | 1979-08-14 | Cornell Research Foundation, Inc. | Collagen drug delivery device |
| US4474752A (en) | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| GB9414139D0 (en) | 1994-07-13 | 1994-08-31 | Smithkline Beecham Plc | Novel compounds |
| US6440102B1 (en) | 1998-07-23 | 2002-08-27 | Durect Corporation | Fluid transfer and diagnostic system for treating the inner ear |
| DE19853299C2 (de) | 1998-11-19 | 2003-04-03 | Thomas Lenarz | Katheter zur Applikation von Medikamenten in Flüssigkeitsräumen des menschlichen Innenohrs |
| US6120484A (en) | 1999-02-17 | 2000-09-19 | Silverstein; Herbert | Otological implant for delivery of medicament and method of using same |
| US6967023B1 (en) | 2000-01-10 | 2005-11-22 | Foamix, Ltd. | Pharmaceutical and cosmetic carrier or composition for topical application |
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| CN1656079A (zh) | 2002-05-31 | 2005-08-17 | 卫材株式会社 | 吡唑化合物和含有该化合物的药物组合物 |
| GB0218625D0 (en) | 2002-08-10 | 2002-09-18 | Astex Technology Ltd | Pharmaceutical compounds |
| CA2499128C (en) | 2002-09-25 | 2012-07-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| FR2845382A1 (fr) * | 2002-10-02 | 2004-04-09 | Sanofi Synthelabo | Derives d'indazolecarboxamides, leur preparation et leur utilisation en therapeutique |
| US20040197264A1 (en) | 2003-04-04 | 2004-10-07 | Alexander Schwarz | Microspheres comprising therapeutic and diagnostic radioactive isotopes |
| WO2005014554A1 (en) | 2003-08-08 | 2005-02-17 | Astex Therapeutics Limited | 1h-indazole-3-carboxamide compounds as mapkap kinase modulators |
| EP1532980A1 (en) | 2003-11-24 | 2005-05-25 | Novo Nordisk A/S | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes |
| FR2867778B1 (fr) | 2004-03-16 | 2006-06-09 | Sanofi Synthelabo | Utilisation de derives d'indazolecarboxamides pour la preparation d'un medicament destine au traitement et a la prevention du paludisme |
| WO2005092890A2 (en) | 2004-03-25 | 2005-10-06 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| JP2008520730A (ja) | 2004-11-23 | 2008-06-19 | セルジーン・コーポレーション | 中枢神経系傷害の治療用ｊｎｋ阻害剤 |
| JP2008537684A (ja) | 2005-01-24 | 2008-09-25 | ニューロシステック コーポレイション | 内耳およびその他の組織へ治療薬および／またはその他の薬剤を送達するための装置および方法 |
| CN101312968A (zh) | 2005-09-23 | 2008-11-26 | 记忆药物公司 | 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑、吡唑并吡啶、异噻唑并吡啶及其制备和用途 |
| TW200804338A (en) | 2005-11-24 | 2008-01-16 | Astrazeneca Ab | New compounds |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| CN101790526A (zh) | 2007-06-08 | 2010-07-28 | 雅培制药有限公司 | 用作激酶抑制剂的5-杂芳基取代的吲唑化合物 |
| AU2009219800A1 (en) * | 2008-02-29 | 2009-09-03 | Pfizer Inc. | Indazole derivatives |
| ES2835553T3 (es) * | 2009-08-10 | 2021-06-22 | Biosplice Therapeutics Inc | Inhibidores de indazol de la vía de señalización de Wnt y sus usos terapéuticos |
| WO2011050245A1 (en) | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
| SMT201700581T1 (it) * | 2009-12-21 | 2018-01-11 | Samumed Llc | 1h-pirazolo[3,4-b]piridine e loro usi terapeutici |
| AR081626A1 (es) * | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| IT1402028B1 (it) | 2010-10-14 | 2013-08-28 | Gsi Geosyntec Invest B V | Metodo e dispositivo per il drenaggio di acqua infiltrata in strutture idrauliche. |
| HUE041576T2 (hu) * | 2011-09-14 | 2019-05-28 | Samumed Llc | Indazol-3-karboxamid-származékok és alkalmazásuk Wnt/b-katenin szignalizáló útvonal inhibitorokként |
| DE102011087651A1 (de) | 2011-12-02 | 2013-06-06 | Siemens Aktiengesellschaft | Schaltgeräteauslöseeinrichtung |
| EA024939B1 (ru) | 2012-02-21 | 2016-11-30 | Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. | 1h-индазол-3-карбоксамидные соединения в качестве ингибиторов гликогенсинтазы киназы 3-бета |
| PH12017500997A1 (en) * | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| CR20160432A (es) | 2014-03-20 | 2017-07-21 | Bayer Pharma AG | Inhibidores de las vías de señalización de wnt |
| BR112016021626A2 (pt) | 2014-03-20 | 2018-05-15 | Samumed, Llc | indazol-3-carboxamidas 5-substituídas e preparação e uso das mesmas |
| CR20160433A (es) | 2014-03-20 | 2016-12-06 | Bayer Pharma AG | Nuevos compuestos |
| EA201691481A1 (ru) | 2014-03-20 | 2017-02-28 | Инфларкс Гмбх | ИНГИБИТОРЫ C5a ДЛЯ ЛЕЧЕНИЯ ВИРУСНОЙ ПНЕВМОНИИ |
-
2015
- 2015-03-20 BR BR112016021626-1A patent/BR112016021626A2/pt not_active Application Discontinuation
- 2015-03-20 US US14/664,517 patent/US9745271B2/en active Active
- 2015-03-20 WO PCT/US2015/021847 patent/WO2015143380A1/en not_active Ceased
- 2015-03-20 SG SG10201914111XA patent/SG10201914111XA/en unknown
- 2015-03-20 MX MX2016012208A patent/MX2016012208A/es unknown
- 2015-03-20 RU RU2016141088A patent/RU2016141088A/ru not_active Application Discontinuation
- 2015-03-20 MA MA039763A patent/MA39763A/fr unknown
- 2015-03-20 CA CA2942687A patent/CA2942687A1/en not_active Abandoned
- 2015-03-20 PE PE2016001658A patent/PE20170127A1/es unknown
- 2015-03-20 CN CN201580026082.XA patent/CN106535890A/zh active Pending
- 2015-03-20 JP JP2016558073A patent/JP6586104B2/ja not_active Expired - Fee Related
- 2015-03-20 EP EP15765201.7A patent/EP3119393A4/en not_active Ceased
- 2015-03-20 SG SG11201607816UA patent/SG11201607816UA/en unknown
- 2015-03-20 KR KR1020167028641A patent/KR20160135283A/ko not_active Withdrawn
-
2016
- 2016-09-08 IL IL247713A patent/IL247713A0/en unknown
- 2016-09-20 PH PH12016501835A patent/PH12016501835A1/en unknown
- 2016-09-20 CL CL2016002364A patent/CL2016002364A1/es unknown
-
2017
- 2017-07-19 US US15/653,747 patent/US10669240B2/en active Active
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