JP2021516674A5 - - Google Patents
Info
- Publication number
- JP2021516674A5 JP2021516674A5 JP2020544501A JP2020544501A JP2021516674A5 JP 2021516674 A5 JP2021516674 A5 JP 2021516674A5 JP 2020544501 A JP2020544501 A JP 2020544501A JP 2020544501 A JP2020544501 A JP 2020544501A JP 2021516674 A5 JP2021516674 A5 JP 2021516674A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- group
- substituted
- cancer
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862634656P | 2018-02-23 | 2018-02-23 | |
| US62/634,656 | 2018-02-23 | ||
| PCT/US2019/019129 WO2019165192A1 (en) | 2018-02-23 | 2019-02-22 | 5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021516674A JP2021516674A (ja) | 2021-07-08 |
| JP2021516674A5 true JP2021516674A5 (enExample) | 2022-02-24 |
| JP7369132B2 JP7369132B2 (ja) | 2023-10-25 |
Family
ID=65812386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020544501A Active JP7369132B2 (ja) | 2018-02-23 | 2019-02-22 | ５－ヘテロアリール置換イミダゾール－３－カルボキサミドならびにその調製および使用の方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10934297B2 (enExample) |
| EP (1) | EP3755696B1 (enExample) |
| JP (1) | JP7369132B2 (enExample) |
| KR (1) | KR102861944B1 (enExample) |
| CN (1) | CN112020501A (enExample) |
| AU (1) | AU2019224075A1 (enExample) |
| BR (1) | BR112020017087A2 (enExample) |
| CA (1) | CA3091913A1 (enExample) |
| CL (1) | CL2020002177A1 (enExample) |
| EA (1) | EA202092002A1 (enExample) |
| ES (1) | ES2945558T3 (enExample) |
| IL (1) | IL276814A (enExample) |
| MA (1) | MA51908A (enExample) |
| MX (1) | MX2020008852A (enExample) |
| PE (1) | PE20211447A1 (enExample) |
| PH (1) | PH12020551300A1 (enExample) |
| SG (1) | SG11202008029UA (enExample) |
| WO (1) | WO2019165192A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3755696B1 (en) | 2018-02-23 | 2023-04-05 | BioSplice Therapeutics, Inc. | 5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof |
| ES2913975T3 (es) * | 2018-05-07 | 2022-06-07 | Acraf | Compuestos de 1H-indazol-3-carboxamida como inhibidores de la glucógeno sintasa cinasa-3 beta |
| JP7444458B2 (ja) * | 2018-09-21 | 2024-03-06 | 学校法人福岡大学 | プリオン病治療薬 |
| EP4079732A4 (en) * | 2019-12-16 | 2023-10-18 | Korea Research Institute of Chemical Technology | NEW INDAZOLE DERIVATIVE AND ITS USE |
| WO2021120890A1 (en) * | 2019-12-20 | 2021-06-24 | Novartis Ag | Pyrazolyl derivatives useful as anti-cancer agents |
| WO2024259121A1 (en) * | 2023-06-14 | 2024-12-19 | Prothena Biosciences Limited | Bicyclic heteroaromatic compounds for treating neurological disorders |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4164559A (en) | 1977-09-21 | 1979-08-14 | Cornell Research Foundation, Inc. | Collagen drug delivery device |
| US4474752A (en) | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| US6440102B1 (en) | 1998-07-23 | 2002-08-27 | Durect Corporation | Fluid transfer and diagnostic system for treating the inner ear |
| DE19853299C2 (de) | 1998-11-19 | 2003-04-03 | Thomas Lenarz | Katheter zur Applikation von Medikamenten in Flüssigkeitsräumen des menschlichen Innenohrs |
| US6120484A (en) | 1999-02-17 | 2000-09-19 | Silverstein; Herbert | Otological implant for delivery of medicament and method of using same |
| US6967023B1 (en) | 2000-01-10 | 2005-11-22 | Foamix, Ltd. | Pharmaceutical and cosmetic carrier or composition for topical application |
| YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| US6648873B2 (en) | 2001-09-21 | 2003-11-18 | Durect Corp. | Aural catheter system including anchor balloon and balloon inflation device |
| GB0218625D0 (en) * | 2002-08-10 | 2002-09-18 | Astex Technology Ltd | Pharmaceutical compounds |
| MXPA05003317A (es) | 2002-09-25 | 2005-07-05 | Memory Pharm Corp | Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos. |
| FR2845382A1 (fr) * | 2002-10-02 | 2004-04-09 | Sanofi Synthelabo | Derives d'indazolecarboxamides, leur preparation et leur utilisation en therapeutique |
| US7008953B2 (en) | 2003-07-30 | 2006-03-07 | Agouron Pharmaceuticals, Inc. | 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
| FR2867778B1 (fr) * | 2004-03-16 | 2006-06-09 | Sanofi Synthelabo | Utilisation de derives d'indazolecarboxamides pour la preparation d'un medicament destine au traitement et a la prevention du paludisme |
| EP1735306A2 (en) | 2004-03-25 | 2006-12-27 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| CN101001856A (zh) * | 2004-03-25 | 2007-07-18 | 记忆药物公司 | 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途 |
| WO2011050245A1 (en) * | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
| KR20140047160A (ko) * | 2011-08-12 | 2014-04-21 | 에프. 호프만-라 로슈 아게 | 인다졸 화합물, 조성물 및 사용 방법 |
| IN2014CN02646A (enExample) * | 2011-09-14 | 2015-08-07 | Samumed Llc | |
| AU2013224302B2 (en) | 2012-02-21 | 2017-03-30 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| CN106535890A (zh) | 2014-03-20 | 2017-03-22 | 萨穆梅德有限公司 | 5‑取代的吲唑‑3‑羧酰胺及其制备和应用 |
| WO2016040182A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof |
| MX380092B (es) | 2015-11-06 | 2025-03-11 | Samumed Llc | Tratamiento de la osteoartritis. |
| MX390577B (es) | 2016-06-01 | 2025-03-20 | Samumed Llc | Proceso de preparación de n-(5-(3-(7-(3-fluorofenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida. |
| JP2019535672A (ja) | 2016-10-21 | 2019-12-12 | サミュメッド リミテッド ライアビリティ カンパニー | インダゾール−３−カルボキサミドの使用方法およびｗｎｔ／β−カテニンシグナル伝達経路阻害剤としてのそれらの使用 |
| EP3755696B1 (en) | 2018-02-23 | 2023-04-05 | BioSplice Therapeutics, Inc. | 5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof |
-
2019
- 2019-02-22 EP EP19711736.9A patent/EP3755696B1/en active Active
- 2019-02-22 WO PCT/US2019/019129 patent/WO2019165192A1/en not_active Ceased
- 2019-02-22 KR KR1020207027174A patent/KR102861944B1/ko active Active
- 2019-02-22 AU AU2019224075A patent/AU2019224075A1/en not_active Abandoned
- 2019-02-22 PE PE2020001271A patent/PE20211447A1/es unknown
- 2019-02-22 MX MX2020008852A patent/MX2020008852A/es unknown
- 2019-02-22 ES ES19711736T patent/ES2945558T3/es active Active
- 2019-02-22 US US16/283,366 patent/US10934297B2/en active Active
- 2019-02-22 CA CA3091913A patent/CA3091913A1/en active Pending
- 2019-02-22 CN CN201980027314.1A patent/CN112020501A/zh active Pending
- 2019-02-22 BR BR112020017087-9A patent/BR112020017087A2/pt not_active IP Right Cessation
- 2019-02-22 MA MA051908A patent/MA51908A/fr unknown
- 2019-02-22 JP JP2020544501A patent/JP7369132B2/ja active Active
- 2019-02-22 SG SG11202008029UA patent/SG11202008029UA/en unknown
- 2019-02-22 EA EA202092002A patent/EA202092002A1/ru unknown
-
2020
- 2020-08-19 IL IL276814A patent/IL276814A/en unknown
- 2020-08-20 PH PH12020551300A patent/PH12020551300A1/en unknown
- 2020-08-24 CL CL2020002177A patent/CL2020002177A1/es unknown
- 2020-12-30 US US17/138,098 patent/US11713320B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021516674A5 (enExample) | ||
| JP2019514938A5 (enExample) | ||
| JP2016504387A5 (enExample) | ||
| JP2014526510A5 (enExample) | ||
| JP2017508763A5 (enExample) | ||
| RU2016141088A (ru) | 5-замещённые индазол-3-карбоксамиды и их получение и применение | |
| JP2015512443A5 (enExample) | ||
| JP2015515989A5 (enExample) | ||
| RU2014144309A (ru) | Индазольные ингибиторы сигнального пути wnt и их терапевтические применения | |
| CN106188045B (zh) | 作为wnt信号传导抑制剂的化合物、组合物及其应用 | |
| ES2445526T3 (es) | Acetamidas con sustitución N-(hetero)aril, 2-(hetero)arilo para utilizar como moduladores de señalización de Wnt | |
| CN111032647B (zh) | 溶血磷脂酸受体1(lpar1)抑制剂化合物 | |
| CN104955456B (zh) | 作为分拣蛋白抑制剂的n-取代的-5-取代的邻氨甲酰苯甲酸 | |
| RU2014148773A (ru) | 1н-пиразоло[3,4-b]пиридины и их терапевтические применения | |
| TWI691475B (zh) | Ｕｒａｔ１抑制劑 | |
| JP2010522770A5 (enExample) | ||
| JP2019524702A (ja) | テトラヒドロナフチルリジンペンタンアミドインテグリンアンタゴニスト | |
| JP6853819B2 (ja) | Ｗｎｔシグナル伝達経路阻害剤およびその治療用途 | |
| JPWO2008136378A1 (ja) | 新規なスルホンアミド誘導体またはその塩 | |
| JP2016508152A (ja) | Ｃｒａｃチャネル阻害薬としての、ピラゾリルをベースとするカルボキサミド類ｉ | |
| CN105377837B (zh) | 用作s100‑抑制剂的n‑(杂芳基)磺酰胺衍生物 | |
| RU2018141395A (ru) | Изохинолин-3-иловые карбоксамиды и их получение и применение | |
| JP2026503167A (ja) | Ｇｐｒ３５モジュレーター | |
| JP7025542B2 (ja) | Ｔｇｆ－ベータ阻害剤としてのオキサジアゾール及びチアジアゾール | |
| TH1801006577A (th) | ไอโซควิโนลิน-3-อิล คาร์บอกซาไมด์ และการเตรียม และการใช้สิ่งดังกล่าว |