JP2017505329A5 - - Google Patents
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- Publication number
- JP2017505329A5 JP2017505329A5 JP2016550633A JP2016550633A JP2017505329A5 JP 2017505329 A5 JP2017505329 A5 JP 2017505329A5 JP 2016550633 A JP2016550633 A JP 2016550633A JP 2016550633 A JP2016550633 A JP 2016550633A JP 2017505329 A5 JP2017505329 A5 JP 2017505329A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- formula
- salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000003839 salts Chemical class 0.000 claims 13
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 4
- 210000000845 cartilage Anatomy 0.000 claims 4
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000011976 maleic acid Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010010356 Congenital anomaly Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 230000013632 homeostatic process Effects 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 1
- 206010058314 Dysplasia Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 230000036244 malformation Effects 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1402071.3A GB201402071D0 (en) | 2014-02-07 | 2014-02-07 | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| GB1402071.3 | 2014-02-07 | ||
| PCT/EP2015/052242 WO2015117981A1 (en) | 2014-02-07 | 2015-02-04 | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020011555A Division JP2020097595A (ja) | 2014-02-07 | 2020-01-28 | 炎症性障害の治療のための新規な塩及びその医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017505329A JP2017505329A (ja) | 2017-02-16 |
| JP2017505329A5 true JP2017505329A5 (cg-RX-API-DMAC7.html) | 2018-03-15 |
Family
ID=50390572
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016550633A Pending JP2017505329A (ja) | 2014-02-07 | 2015-02-04 | 炎症性障害の治療のための新規な塩及びその医薬組成物 |
| JP2020011555A Pending JP2020097595A (ja) | 2014-02-07 | 2020-01-28 | 炎症性障害の治療のための新規な塩及びその医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020011555A Pending JP2020097595A (ja) | 2014-02-07 | 2020-01-28 | 炎症性障害の治療のための新規な塩及びその医薬組成物 |
Country Status (28)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201402071D0 (en) * | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| GB201402070D0 (en) * | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
| MX386902B (es) * | 2015-04-13 | 2025-03-19 | Alfasigma Spa | Metodos para el tratamiento de trastornos cardiovasculares. |
| BR112017021583A2 (pt) * | 2015-04-13 | 2018-07-03 | Galapagos Nv | métodos para o tratamento de transtornos inflamatórios |
| JP6871919B2 (ja) | 2015-06-16 | 2021-05-19 | ナノファギックス エルエルシー | 薬物送達及びイメージング化学コンジュゲート、製剤及びその使用方法 |
| CN105198876B (zh) * | 2015-09-18 | 2017-09-29 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物h晶型及其制备方法 |
| CN105198880B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物a晶型及其制备方法 |
| CN105198878B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物f晶型及其制备方法 |
| CN105198879B (zh) * | 2015-09-18 | 2017-09-22 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物c晶型及其制备方法 |
| CN105198877B (zh) * | 2015-09-18 | 2017-09-22 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物g晶型及其制备方法 |
| CN105111206B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物e晶型及其制备方法 |
| CN105218539B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物b晶型及其制备方法 |
| CN105111207B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物d晶型及其制备方法 |
| US20170174788A1 (en) | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and an mmp9 binding protein for treating inflammatory disorders |
| US20170173034A1 (en) | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders |
| WO2017106568A1 (en) | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and a bromodomain inhibitor for treating cancer |
| CN105669669A (zh) * | 2016-03-04 | 2016-06-15 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物的a晶型、b晶型、d晶型、g晶型和m晶型及其制备方法 |
| MX2018011422A (es) * | 2016-03-21 | 2019-07-08 | Crystal Pharmatech Co Ltd | Farmaco de sal cristalina de clorhidrato para tratar o prevenir enfermedad asociada con janus cinasas (jak) y su metodo de preparacion. |
| CN109476662A (zh) * | 2016-08-03 | 2019-03-15 | 苏州科睿思制药有限公司 | 一种jak1选择性抑制剂的新晶型及其制备方法和用途 |
| CA3043396A1 (en) | 2016-11-10 | 2018-05-17 | Galapagos Nv | Compounds and pharmaceutical compositions thereof for the treatment of inflammatory diseases |
| GB201702603D0 (en) | 2017-02-17 | 2017-04-05 | Galápagos Nv | Novel compositions and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| JOP20180018A1 (ar) * | 2017-03-14 | 2019-01-30 | Gilead Sciences Inc | تركيبات صيدلية تتضمن مثبط jak |
| GB201808575D0 (en) | 2018-05-24 | 2018-07-11 | Galapagos Nv | Methods for the treatment of psoriatic arthrits |
| US10815227B2 (en) | 2018-08-27 | 2020-10-27 | Cadila Healthcare Limited | Processes for the preparation of filgotinib |
| WO2020092245A1 (en) * | 2018-10-29 | 2020-05-07 | Zorday IP, LLC | Network-enabled electronic cigarette |
| WO2020177705A1 (zh) * | 2019-03-05 | 2020-09-10 | 苏州科睿思制药有限公司 | Filgotinib的马来酸盐晶型CSI及其制备方法和用途 |
| BR112021019087A2 (pt) * | 2019-03-30 | 2021-11-30 | Unichem Lab Ltd | Novo processo para a preparação de filgotinibe e intermediários do mesmo |
| WO2021044327A1 (en) * | 2019-09-03 | 2021-03-11 | Dr. Reddy's Laboratories Limited | Solid forms of filgotinib maleate and processes thereof |
| CN114075188A (zh) * | 2020-08-11 | 2022-02-22 | 南京柯菲平盛辉制药有限公司 | 芳香杂环酰胺类化合物及其制备方法和医药用途 |
| JP2023553956A (ja) * | 2020-12-09 | 2023-12-26 | セルバトゥス リミテッド | 関節の炎症性障害のための併用療法 |
| CN113773322B (zh) * | 2021-11-10 | 2022-02-11 | 奥锐特药业(天津)有限公司 | 一种Filgotinib的制备方法 |
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| JP2549632B2 (ja) * | 1986-08-20 | 1996-10-30 | 三井石油化学工業株式会社 | オレフインの重合方法 |
| WO2000044722A1 (en) | 1999-01-29 | 2000-08-03 | Chugai Seiyaku Kabushiki Kaisha | Chondrongenesis promotors and indolin-2-one derivatives |
| WO2002087620A1 (en) | 2001-04-27 | 2002-11-07 | Chugai Seiyaku Kabushiki Kaisha | Chondrogenesis promoters |
| US6514989B1 (en) | 2001-07-20 | 2003-02-04 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives |
| JPWO2004039816A1 (ja) * | 2002-10-29 | 2006-03-02 | 塩野義製薬株式会社 | セフェム化合物の無機酸塩の結晶 |
| ATE334131T1 (de) | 2003-02-14 | 2006-08-15 | Pfizer Prod Inc | Triazolopyridine als entzündungshemmende verbindungen |
| US20050222171A1 (en) | 2004-01-22 | 2005-10-06 | Guido Bold | Organic compounds |
| JP2008503712A (ja) | 2004-06-21 | 2008-02-07 | ガラパゴス・ナムローゼ・フェンノートシャップ | 骨関節炎治療の方法及び手段 |
| MX2007002050A (es) | 2004-08-18 | 2007-03-29 | Pharmacia & Upjohn Co Llc | Compuestos de triazolopiridina. |
| MX2007004179A (es) | 2004-10-07 | 2007-06-07 | Warner Lambert Co | Derivados de triazolpiridina como agentes antibacterianos. |
| GB0515026D0 (en) | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
| JP5336375B2 (ja) | 2006-08-30 | 2013-11-06 | セルゾーム リミテッド | キナーゼ阻害剤としてのトリアゾール誘導体 |
| TW200904816A (en) | 2007-06-05 | 2009-02-01 | Takeda Pharmaceutical | Fused heterocycle derivatives and use thereof |
| MX2010000716A (es) | 2007-07-18 | 2010-03-26 | Novartis Ag | Compuestos de heteroarilo biciclicos y su uso como inhibidores de cinasa. |
| WO2009017954A1 (en) | 2007-08-01 | 2009-02-05 | Phenomix Corporation | Inhibitors of jak2 kinase |
| MX2010002312A (es) | 2007-08-31 | 2010-03-18 | Merck Serono Sa | Compuestos de triazolopiridina y su uso como inhibidores de cinasa reguladora de señal de apoptosis. |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| JP5595389B2 (ja) | 2008-06-20 | 2014-09-24 | ジェネンテック， インコーポレイテッド | トリアゾロピリジンｊａｋ阻害剤化合物と方法 |
| WO2010010189A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| WO2010010184A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | [1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors |
| WO2010010186A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| WO2010010187A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
| WO2010010188A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
| US20110124692A1 (en) * | 2008-07-31 | 2011-05-26 | Daiichi Sankyo Company, Limited | Crystalline forms of thiazolidinedione compound and its manufacturing method |
| AU2010254806C1 (en) | 2009-06-05 | 2016-07-07 | Cephalon, Inc. | Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives |
| TWI462920B (zh) * | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
| JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
| SG179137A1 (en) | 2009-09-25 | 2012-04-27 | Kyorin Seiyaku Kk | Maleic acid salt and crystal thereof |
| CN102146082A (zh) | 2010-02-04 | 2011-08-10 | 江苏恒瑞医药股份有限公司 | 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 |
| JP2013049632A (ja) * | 2011-08-30 | 2013-03-14 | Kowa Co | ベンゾチアジン化合物のモノマレイン酸塩を有効成分とするアレルギー疾患の予防及び／又は治療剤 |
| SA112330992B1 (ar) | 2011-11-10 | 2015-09-13 | كيورين فارماسوتيكال كو.، ليمتد | صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي |
| US20130310340A1 (en) | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
| WO2013189771A1 (en) | 2012-06-22 | 2013-12-27 | Galapagos Nv | Aminotriazolopyridine for use in the treatment of inflammation, and pharmaceutical compositions thereof |
| GB201402071D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| GB201402070D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
| BR112017021583A2 (pt) | 2015-04-13 | 2018-07-03 | Galapagos Nv | métodos para o tratamento de transtornos inflamatórios |
| MX386902B (es) | 2015-04-13 | 2025-03-19 | Alfasigma Spa | Metodos para el tratamiento de trastornos cardiovasculares. |
| US20170173034A1 (en) | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders |
| JOP20180018A1 (ar) | 2017-03-14 | 2019-01-30 | Gilead Sciences Inc | تركيبات صيدلية تتضمن مثبط jak |
| GB201808575D0 (en) | 2018-05-24 | 2018-07-11 | Galapagos Nv | Methods for the treatment of psoriatic arthrits |
-
2014
- 2014-02-07 GB GBGB1402071.3A patent/GB201402071D0/en not_active Ceased
-
2015
- 2015-02-04 PT PT157049743T patent/PT3102575T/pt unknown
- 2015-02-04 IL IL246833A patent/IL246833B/en unknown
- 2015-02-04 MX MX2020003368A patent/MX395415B/es unknown
- 2015-02-04 JP JP2016550633A patent/JP2017505329A/ja active Pending
- 2015-02-04 SI SI201531491T patent/SI3102575T1/sl unknown
- 2015-02-04 EP EP20211405.4A patent/EP3842432A1/en not_active Withdrawn
- 2015-02-04 EA EA201691584A patent/EA032596B1/ru unknown
- 2015-02-04 EP EP15704974.3A patent/EP3102575B1/en active Active
- 2015-02-04 NZ NZ722603A patent/NZ722603A/en unknown
- 2015-02-04 RS RS20210134A patent/RS61450B1/sr unknown
- 2015-02-04 KR KR1020167023807A patent/KR102478614B1/ko active Active
- 2015-02-04 SG SG11201606433PA patent/SG11201606433PA/en unknown
- 2015-02-04 DK DK15704974.3T patent/DK3102575T3/da active
- 2015-02-04 HR HRP20210194TT patent/HRP20210194T1/hr unknown
- 2015-02-04 AU AU2015215045A patent/AU2015215045B2/en active Active
- 2015-02-04 PL PL15704974T patent/PL3102575T3/pl unknown
- 2015-02-04 CN CN202010324636.7A patent/CN111499630A/zh active Pending
- 2015-02-04 CA CA2938219A patent/CA2938219C/en active Active
- 2015-02-04 WO PCT/EP2015/052242 patent/WO2015117981A1/en not_active Ceased
- 2015-02-04 EA EA201990330A patent/EA201990330A1/ru unknown
- 2015-02-04 SM SM20210060T patent/SMT202100060T1/it unknown
- 2015-02-04 LT LTEP15704974.3T patent/LT3102575T/lt unknown
- 2015-02-04 ES ES15704974T patent/ES2853375T3/es active Active
- 2015-02-04 US US14/614,396 patent/US9382247B2/en active Active
- 2015-02-04 MX MX2016010068A patent/MX376000B/es active IP Right Grant
- 2015-02-04 SG SG10202013187PA patent/SG10202013187PA/en unknown
- 2015-02-04 CN CN201580006893.3A patent/CN105960407A/zh active Pending
- 2015-02-04 HU HUE15704974A patent/HUE053309T2/hu unknown
- 2015-02-06 UY UY0001035984A patent/UY35984A/es not_active Application Discontinuation
- 2015-02-06 AR ARP150100351A patent/AR099307A1/es unknown
- 2015-02-06 TW TW104104160A patent/TWI767878B/zh active
- 2015-02-06 TW TW110136599A patent/TWI792593B/zh active
-
2016
- 2016-07-01 US US15/200,228 patent/US20160376269A1/en not_active Abandoned
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2017
- 2017-07-10 US US15/645,308 patent/US10708263B2/en active Active
-
2019
- 2019-04-08 AU AU2019202441A patent/AU2019202441B2/en active Active
- 2019-09-30 US US16/588,207 patent/US10919890B2/en active Active
-
2020
- 2020-01-28 JP JP2020011555A patent/JP2020097595A/ja active Pending
- 2020-10-26 AU AU2020260391A patent/AU2020260391B2/en active Active
-
2021
- 2021-01-08 US US17/144,788 patent/US11667633B2/en active Active
- 2021-02-01 CY CY20211100080T patent/CY1124349T1/el unknown
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2022
- 2022-09-23 AU AU2022235624A patent/AU2022235624B2/en active Active
-
2023
- 2023-04-25 US US18/306,867 patent/US12234235B2/en active Active
-
2025
- 2025-01-22 US US19/033,986 patent/US20250289816A1/en active Pending
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