JP2017503053A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017503053A5 JP2017503053A5 JP2016541363A JP2016541363A JP2017503053A5 JP 2017503053 A5 JP2017503053 A5 JP 2017503053A5 JP 2016541363 A JP2016541363 A JP 2016541363A JP 2016541363 A JP2016541363 A JP 2016541363A JP 2017503053 A5 JP2017503053 A5 JP 2017503053A5
- Authority
- JP
- Japan
- Prior art keywords
- desaturase
- fatty acid
- lipid
- acid
- plant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002632 lipids Chemical class 0.000 claims description 426
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 387
- 229930195729 fatty acid Natural products 0.000 claims description 387
- 239000000194 fatty acid Substances 0.000 claims description 387
- 150000004665 fatty acids Chemical class 0.000 claims description 384
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 380
- 241000196324 Embryophyta Species 0.000 claims description 334
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 210
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 190
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims description 185
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims description 185
- 239000003921 oil Substances 0.000 claims description 174
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 123
- 102100034544 Acyl-CoA 6-desaturase Human genes 0.000 claims description 103
- 108010037138 Linoleoyl-CoA Desaturase Proteins 0.000 claims description 103
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 103
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 103
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 103
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 103
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims description 103
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 102
- 235000020778 linoleic acid Nutrition 0.000 claims description 102
- 108010033653 omega-3 fatty acid desaturase Proteins 0.000 claims description 90
- 102100034542 Acyl-CoA (8-3)-desaturase Human genes 0.000 claims description 89
- 108010073542 Delta-5 Fatty Acid Desaturase Proteins 0.000 claims description 89
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 88
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 87
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims description 82
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 79
- 239000000758 substrate Substances 0.000 claims description 73
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 claims description 72
- 230000000694 effects Effects 0.000 claims description 72
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 claims description 72
- 101000912235 Rebecca salina Acyl-lipid (7-3)-desaturase Proteins 0.000 claims description 69
- 101000877236 Siganus canaliculatus Acyl-CoA Delta-4 desaturase Proteins 0.000 claims description 69
- 238000006243 chemical reaction Methods 0.000 claims description 68
- 229960004488 linolenic acid Drugs 0.000 claims description 67
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims description 63
- 229940012843 omega-3 fatty acid Drugs 0.000 claims description 63
- 102000040430 polynucleotide Human genes 0.000 claims description 62
- 108091033319 polynucleotide Proteins 0.000 claims description 62
- 239000002157 polynucleotide Substances 0.000 claims description 62
- 238000000034 method Methods 0.000 claims description 61
- 239000000203 mixture Substances 0.000 claims description 61
- 108010011713 delta-15 desaturase Proteins 0.000 claims description 57
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims description 56
- 229940033080 omega-6 fatty acid Drugs 0.000 claims description 56
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 52
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 52
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 52
- 239000005642 Oleic acid Substances 0.000 claims description 52
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 52
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 52
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 52
- 235000021313 oleic acid Nutrition 0.000 claims description 52
- 108010022240 delta-8 fatty acid desaturase Proteins 0.000 claims description 46
- 235000021314 Palmitic acid Nutrition 0.000 claims description 44
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 44
- 239000006014 omega-3 oil Substances 0.000 claims description 40
- 235000020664 gamma-linolenic acid Nutrition 0.000 claims description 36
- 238000004519 manufacturing process Methods 0.000 claims description 34
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 32
- 238000000605 extraction Methods 0.000 claims description 27
- 230000014509 gene expression Effects 0.000 claims description 27
- 102000004190 Enzymes Human genes 0.000 claims description 26
- 108090000790 Enzymes Proteins 0.000 claims description 26
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 claims description 26
- 244000197813 Camelina sativa Species 0.000 claims description 24
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims description 23
- 125000003203 triacylglycerol group Chemical group 0.000 claims description 23
- 240000002791 Brassica napus Species 0.000 claims description 22
- -1 optionally Chemical compound 0.000 claims description 21
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims description 20
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims description 20
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims description 20
- 235000021360 Myristic acid Nutrition 0.000 claims description 20
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 20
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims description 20
- 244000178993 Brassica juncea Species 0.000 claims description 19
- AHANXAKGNAKFSK-PDBXOOCHSA-N all-cis-icosa-11,14,17-trienoic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCCC(O)=O AHANXAKGNAKFSK-PDBXOOCHSA-N 0.000 claims description 19
- PRHHYVQTPBEDFE-UHFFFAOYSA-N eicosatrienoic acid Natural products CCCCCC=CCC=CCCCCC=CCCCC(O)=O PRHHYVQTPBEDFE-UHFFFAOYSA-N 0.000 claims description 19
- 241000219198 Brassica Species 0.000 claims description 17
- 235000014595 Camelina sativa Nutrition 0.000 claims description 17
- 235000011293 Brassica napus Nutrition 0.000 claims description 15
- 235000012054 meals Nutrition 0.000 claims description 15
- 230000001939 inductive effect Effects 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 12
- 235000021281 monounsaturated fatty acids Nutrition 0.000 claims description 11
- 230000003796 beauty Effects 0.000 claims description 10
- 150000003904 phospholipids Chemical class 0.000 claims description 10
- 235000003351 Brassica cretica Nutrition 0.000 claims description 9
- 235000003343 Brassica rupestris Nutrition 0.000 claims description 9
- 241000592344 Spermatophyta Species 0.000 claims description 9
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 claims description 9
- 150000001982 diacylglycerols Chemical class 0.000 claims description 9
- 235000010460 mustard Nutrition 0.000 claims description 9
- 150000004671 saturated fatty acids Chemical class 0.000 claims description 9
- 235000006008 Brassica napus var napus Nutrition 0.000 claims description 7
- 238000011282 treatment Methods 0.000 claims description 7
- 241000894007 species Species 0.000 claims description 6
- 235000011332 Brassica juncea Nutrition 0.000 claims description 4
- 235000014700 Brassica juncea var napiformis Nutrition 0.000 claims description 4
- 230000008901 benefit Effects 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000004821 distillation Methods 0.000 claims description 3
- 230000001965 increasing effect Effects 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 101100084165 Caenorhabditis elegans prdx-2 gene Proteins 0.000 claims description 2
- 150000002148 esters Chemical group 0.000 claims description 2
- 235000012041 food component Nutrition 0.000 claims description 2
- 239000005417 food ingredient Substances 0.000 claims description 2
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 claims description 2
- 229960002733 gamolenic acid Drugs 0.000 claims description 2
- 244000144972 livestock Species 0.000 claims 2
- 241000270666 Testudines Species 0.000 claims 1
- 238000004508 fractional distillation Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 235000019198 oils Nutrition 0.000 description 163
- 210000004027 cell Anatomy 0.000 description 146
- 230000000813 microbial effect Effects 0.000 description 40
- 244000068988 Glycine max Species 0.000 description 38
- 235000010469 Glycine max Nutrition 0.000 description 35
- 108090000623 proteins and genes Proteins 0.000 description 35
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 description 31
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 28
- 235000011331 Brassica Nutrition 0.000 description 25
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 24
- 235000015112 vegetable and seed oil Nutrition 0.000 description 23
- 230000002538 fungal effect Effects 0.000 description 20
- 102000057234 Acyl transferases Human genes 0.000 description 19
- 108700016155 Acyl transferases Proteins 0.000 description 19
- 102000004169 proteins and genes Human genes 0.000 description 18
- 241000220243 Brassica sp. Species 0.000 description 17
- 125000003275 alpha amino acid group Chemical group 0.000 description 17
- SRBFZHDQGSBBOR-HWQSCIPKSA-N L-arabinopyranose Chemical compound O[C@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-HWQSCIPKSA-N 0.000 description 15
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 15
- 229930182558 Sterol Natural products 0.000 description 13
- 150000001413 amino acids Chemical class 0.000 description 13
- 125000004432 carbon atom Chemical group C* 0.000 description 13
- 230000000875 corresponding effect Effects 0.000 description 13
- 239000012634 fragment Substances 0.000 description 13
- 150000003432 sterols Chemical class 0.000 description 13
- 235000003702 sterols Nutrition 0.000 description 13
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 12
- 240000006240 Linum usitatissimum Species 0.000 description 12
- 235000004431 Linum usitatissimum Nutrition 0.000 description 12
- 125000004494 ethyl ester group Chemical group 0.000 description 11
- 244000025254 Cannabis sativa Species 0.000 description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 10
- 108700026244 Open Reading Frames Proteins 0.000 description 10
- 241000825199 Rebecca salina Species 0.000 description 10
- 150000003626 triacylglycerols Chemical class 0.000 description 10
- 240000006394 Sorghum bicolor Species 0.000 description 9
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 9
- 240000008042 Zea mays Species 0.000 description 9
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 9
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 9
- 241000219195 Arabidopsis thaliana Species 0.000 description 8
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 8
- 244000020518 Carthamus tinctorius Species 0.000 description 8
- 241001555186 Pyramimonas cordata Species 0.000 description 8
- 235000019519 canola oil Nutrition 0.000 description 8
- 239000000828 canola oil Substances 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 241000208125 Nicotiana Species 0.000 description 7
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 7
- 235000012000 cholesterol Nutrition 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 235000004426 flaxseed Nutrition 0.000 description 7
- OSELKOCHBMDKEJ-UHFFFAOYSA-N (10R)-3c-Hydroxy-10r.13c-dimethyl-17c-((R)-1-methyl-4-isopropyl-hexen-(4c)-yl)-(8cH.9tH.14tH)-Delta5-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(=CC)C(C)C)C1(C)CC2 OSELKOCHBMDKEJ-UHFFFAOYSA-N 0.000 description 6
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 description 6
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 6
- 108010052187 1-Acylglycerophosphocholine O-Acyltransferase Proteins 0.000 description 6
- 241000219194 Arabidopsis Species 0.000 description 6
- 244000075850 Avena orientalis Species 0.000 description 6
- 235000007319 Avena orientalis Nutrition 0.000 description 6
- 239000004471 Glycine Substances 0.000 description 6
- 244000299507 Gossypium hirsutum Species 0.000 description 6
- 235000009432 Gossypium hirsutum Nutrition 0.000 description 6
- 240000005979 Hordeum vulgare Species 0.000 description 6
- 235000007340 Hordeum vulgare Nutrition 0.000 description 6
- 102100038805 Lysophospholipid acyltransferase 2 Human genes 0.000 description 6
- 241000907999 Mortierella alpina Species 0.000 description 6
- 240000008346 Oryza glaberrima Species 0.000 description 6
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 6
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 6
- 241000172147 Saprolegnia diclina Species 0.000 description 6
- 235000007244 Zea mays Nutrition 0.000 description 6
- 125000002252 acyl group Chemical group 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 description 6
- 229960002449 glycine Drugs 0.000 description 6
- 229920001184 polypeptide Polymers 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- 230000009261 transgenic effect Effects 0.000 description 6
- 229920000742 Cotton Polymers 0.000 description 5
- 235000011309 Crambe hispanica subsp abyssinica Nutrition 0.000 description 5
- 241000220247 Crambe hispanica subsp. abyssinica Species 0.000 description 5
- 235000001950 Elaeis guineensis Nutrition 0.000 description 5
- 244000127993 Elaeis melanococca Species 0.000 description 5
- 102000009114 Fatty acid desaturases Human genes 0.000 description 5
- 108010087894 Fatty acid desaturases Proteins 0.000 description 5
- 241000219146 Gossypium Species 0.000 description 5
- 240000007594 Oryza sativa Species 0.000 description 5
- 235000007164 Oryza sativa Nutrition 0.000 description 5
- 241001466077 Salina Species 0.000 description 5
- ZOJBYZNEUISWFT-UHFFFAOYSA-N allyl isothiocyanate Chemical compound C=CCN=C=S ZOJBYZNEUISWFT-UHFFFAOYSA-N 0.000 description 5
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 235000021588 free fatty acids Nutrition 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 108020004414 DNA Proteins 0.000 description 4
- 102000013444 Diacylglycerol Cholinephosphotransferase Human genes 0.000 description 4
- 108010001348 Diacylglycerol O-acyltransferase Proteins 0.000 description 4
- 102000002148 Diacylglycerol O-acyltransferase Human genes 0.000 description 4
- 108010051225 Diacylglycerol cholinephosphotransferase Proteins 0.000 description 4
- BTEISVKTSQLKST-UHFFFAOYSA-N Haliclonasterol Natural products CC(C=CC(C)C(C)(C)C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C BTEISVKTSQLKST-UHFFFAOYSA-N 0.000 description 4
- 241000490472 Helianthus sp. Species 0.000 description 4
- 241000282414 Homo sapiens Species 0.000 description 4
- OSELKOCHBMDKEJ-VRUYXKNBSA-N Isofucosterol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@@H]2[C@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C)C(C)C OSELKOCHBMDKEJ-VRUYXKNBSA-N 0.000 description 4
- 241000235058 Komagataella pastoris Species 0.000 description 4
- 241001536507 Micromonas pusilla Species 0.000 description 4
- 241001074116 Miscanthus x giganteus Species 0.000 description 4
- 241000207746 Nicotiana benthamiana Species 0.000 description 4
- 241001467333 Thraustochytriaceae Species 0.000 description 4
- 241000219793 Trifolium Species 0.000 description 4
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical group CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 4
- 235000021323 fish oil Nutrition 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 238000003306 harvesting Methods 0.000 description 4
- OSELKOCHBMDKEJ-WGMIZEQOSA-N isofucosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC/C(=C/C)C(C)C)[C@@]1(C)CC2 OSELKOCHBMDKEJ-WGMIZEQOSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000008164 mustard oil Substances 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 230000037361 pathway Effects 0.000 description 4
- 239000010773 plant oil Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000008158 vegetable oil Substances 0.000 description 4
- MENFZXMQSYYVRK-CRCGJGBYSA-N (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MENFZXMQSYYVRK-CRCGJGBYSA-N 0.000 description 3
- 108010092861 2-acylglycerol O-acyltransferase Proteins 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 3
- 235000007558 Avena sp Nutrition 0.000 description 3
- 235000008697 Cannabis sativa Nutrition 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 241000235087 Lachancea kluyveri Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 102100026918 Phospholipase A2 Human genes 0.000 description 3
- 108010058864 Phospholipases A2 Proteins 0.000 description 3
- 241000195887 Physcomitrella patens Species 0.000 description 3
- 102000014384 Type C Phospholipases Human genes 0.000 description 3
- 108010079194 Type C Phospholipases Proteins 0.000 description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 3
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 235000005822 corn Nutrition 0.000 description 3
- 235000005687 corn oil Nutrition 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 150000002185 fatty acyl-CoAs Chemical class 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 235000019688 fish Nutrition 0.000 description 3
- 229910052738 indium Inorganic materials 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 239000000543 intermediate Substances 0.000 description 3
- 210000001161 mammalian embryo Anatomy 0.000 description 3
- 230000036961 partial effect Effects 0.000 description 3
- 230000008488 polyadenylation Effects 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 235000005713 safflower oil Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- MCWVPSBQQXUCTB-UHFFFAOYSA-N (24Z)-5alpha-Stigmasta-7,24(28)-dien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(=CC)C(C)C)CCC33)C)C3=CCC21 MCWVPSBQQXUCTB-UHFFFAOYSA-N 0.000 description 2
- SGNBVLSWZMBQTH-QGOUJLTDSA-N (3s,8s,9s,10r,13r,14s,17r)-17-[(2r)-5,6-dimethylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCC(C)C(C)C)[C@@]1(C)CC2 SGNBVLSWZMBQTH-QGOUJLTDSA-N 0.000 description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 2
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 2
- CPQUIAPJXYFMHN-UHFFFAOYSA-N 24-methylcholesterol Natural products C1CC2=CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(C)C(C)C)C1(C)CC2 CPQUIAPJXYFMHN-UHFFFAOYSA-N 0.000 description 2
- ZCJRGONXXDDVLB-UHFFFAOYSA-N 28-Isofucosterolacetat Natural products CC=C(CCC(C)C1CCC2C3CCC4CC(CCC4(C)C3CCC12C)OC(=O)C)/C(C)C ZCJRGONXXDDVLB-UHFFFAOYSA-N 0.000 description 2
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 2
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 2
- 101100126948 Arabidopsis thaliana FAE1 gene Proteins 0.000 description 2
- 241000351920 Aspergillus nidulans Species 0.000 description 2
- 241000244203 Caenorhabditis elegans Species 0.000 description 2
- SGNBVLSWZMBQTH-FGAXOLDCSA-N Campesterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 SGNBVLSWZMBQTH-FGAXOLDCSA-N 0.000 description 2
- 241000252212 Danio rerio Species 0.000 description 2
- ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 description 2
- MCWVPSBQQXUCTB-AMOSEXRZSA-N Delta7-Avenasterol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C MCWVPSBQQXUCTB-AMOSEXRZSA-N 0.000 description 2
- 241000200105 Emiliania huxleyi Species 0.000 description 2
- 241000195619 Euglena gracilis Species 0.000 description 2
- 101150115493 FAD3 gene Proteins 0.000 description 2
- GBBBJSKVBYJMBG-QTWVXCTBSA-N Fucosterol Natural products CC=C(CC[C@@H](C)[C@@H]1CC[C@@H]2[C@H]3C=C[C@@H]4C[C@H](O)CC[C@@]4(C)[C@@H]3CC[C@@]12C)C(C)C GBBBJSKVBYJMBG-QTWVXCTBSA-N 0.000 description 2
- 241000223218 Fusarium Species 0.000 description 2
- 101710091951 Glycerol-3-phosphate acyltransferase Proteins 0.000 description 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 2
- 241000208818 Helianthus Species 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 108090001090 Lectins Proteins 0.000 description 2
- 102000004856 Lectins Human genes 0.000 description 2
- 240000001931 Ludwigia octovalvis Species 0.000 description 2
- 241000219745 Lupinus Species 0.000 description 2
- 241000218922 Magnoliophyta Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241000878006 Miscanthus sinensis Species 0.000 description 2
- 108091005461 Nucleic proteins Proteins 0.000 description 2
- 102000011420 Phospholipase D Human genes 0.000 description 2
- 108090000553 Phospholipase D Proteins 0.000 description 2
- 102000015439 Phospholipases Human genes 0.000 description 2
- 108010064785 Phospholipases Proteins 0.000 description 2
- 241000233622 Phytophthora infestans Species 0.000 description 2
- 241000235648 Pichia Species 0.000 description 2
- 241000235070 Saccharomyces Species 0.000 description 2
- YSKVBPGQYRAUQO-UZSYLJJSSA-N Schottenol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@H](C)CC[C@@H](CC)C(C)C)CC[C@H]33)C)C3=CC[C@H]21 YSKVBPGQYRAUQO-UZSYLJJSSA-N 0.000 description 2
- YSKVBPGQYRAUQO-UHFFFAOYSA-N Schottenol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CCC21 YSKVBPGQYRAUQO-UHFFFAOYSA-N 0.000 description 2
- 235000007230 Sorghum bicolor Nutrition 0.000 description 2
- 244000062793 Sorghum vulgare Species 0.000 description 2
- 241000233675 Thraustochytrium Species 0.000 description 2
- 241001298230 Thraustochytrium sp. Species 0.000 description 2
- 241000223259 Trichoderma Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 description 2
- 125000002009 alkene group Chemical group 0.000 description 2
- 150000001336 alkenes Chemical group 0.000 description 2
- 125000005907 alkyl ester group Chemical group 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 235000021342 arachidonic acid Nutrition 0.000 description 2
- 229940114079 arachidonic acid Drugs 0.000 description 2
- MCWVPSBQQXUCTB-OQTIOYDCSA-N avenasterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@H](C)CC/C(=C/C)C(C)C)CC[C@H]33)C)C3=CC[C@H]21 MCWVPSBQQXUCTB-OQTIOYDCSA-N 0.000 description 2
- 229940076810 beta sitosterol Drugs 0.000 description 2
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 2
- 230000001588 bifunctional effect Effects 0.000 description 2
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 2
- 235000000431 campesterol Nutrition 0.000 description 2
- SGNBVLSWZMBQTH-PODYLUTMSA-N campesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]1(C)CC2 SGNBVLSWZMBQTH-PODYLUTMSA-N 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- OQMZNAMGEHIHNN-CIFIHVIMSA-N delta7-stigmasterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)CC[C@H]33)C)C3=CC=C21 OQMZNAMGEHIHNN-CIFIHVIMSA-N 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- FRKBLBQTSTUKOV-UHFFFAOYSA-N diphosphatidyl glycerol Natural products OP(O)(=O)OCC(OP(O)(O)=O)COP(O)(O)=O FRKBLBQTSTUKOV-UHFFFAOYSA-N 0.000 description 2
- VCSQUSNNIFZJAP-AAQCHOMXSA-N ethyl (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate Chemical compound CCOC(=O)CCCCC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC VCSQUSNNIFZJAP-AAQCHOMXSA-N 0.000 description 2
- 235000019387 fatty acid methyl ester Nutrition 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 230000035558 fertility Effects 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 238000005984 hydrogenation reaction Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000002523 lectin Substances 0.000 description 2
- 235000020667 long-chain omega-3 fatty acid Nutrition 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- XDUHQPOXLUAVEE-BPMMELMSSA-N oleoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCCCC\C=C/CCCCCCCC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 XDUHQPOXLUAVEE-BPMMELMSSA-N 0.000 description 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 2
- 150000003905 phosphatidylinositols Chemical class 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 2
- 229950005143 sitosterol Drugs 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 2
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 description 2
- 238000005809 transesterification reaction Methods 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 230000035899 viability Effects 0.000 description 2
- LGHXTTIAZFVCCU-SSVNFBSYSA-N (2E,4E,6E,8E)-octadeca-2,4,6,8-tetraenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O LGHXTTIAZFVCCU-SSVNFBSYSA-N 0.000 description 1
- MJYQFWSXKFLTAY-OVEQLNGDSA-N (2r,3r)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butane-1,4-diol;(2r,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O.C1=C(O)C(OC)=CC(C[C@@H](CO)[C@H](CO)CC=2C=C(OC)C(O)=CC=2)=C1 MJYQFWSXKFLTAY-OVEQLNGDSA-N 0.000 description 1
- OOFBFGLGGSUMCH-XSKXTFDZSA-N (3S,8S,9S,10R,13R,14S,17R)-4-ethyl-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol Chemical compound C(C)C1C2=CC[C@H]3[C@@H]4CC[C@H]([C@@H](CCCC(C)C)C)[C@]4(CC[C@@H]3[C@]2(CC[C@@H]1O)C)C OOFBFGLGGSUMCH-XSKXTFDZSA-N 0.000 description 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 102100024643 ATP-binding cassette sub-family D member 1 Human genes 0.000 description 1
- 241000224423 Acanthamoeba castellanii Species 0.000 description 1
- 108700037654 Acyl carrier protein (ACP) Proteins 0.000 description 1
- 102000048456 Acyl carrier protein (ACP) Human genes 0.000 description 1
- 201000011452 Adrenoleukodystrophy Diseases 0.000 description 1
- 241000589155 Agrobacterium tumefaciens Species 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 235000011437 Amygdalus communis Nutrition 0.000 description 1
- 241000024188 Andala Species 0.000 description 1
- 244000105975 Antidesma platyphyllum Species 0.000 description 1
- 241000288953 Apina Species 0.000 description 1
- 101100119780 Arabidopsis thaliana FATB gene Proteins 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 description 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 description 1
- KZJWDPNRJALLNS-OAIXMFQVSA-N B-sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCC(CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-OAIXMFQVSA-N 0.000 description 1
- 241001465180 Botrytis Species 0.000 description 1
- 229910001369 Brass Inorganic materials 0.000 description 1
- 235000014698 Brassica juncea var multisecta Nutrition 0.000 description 1
- 240000000385 Brassica napus var. napus Species 0.000 description 1
- 240000008100 Brassica rapa Species 0.000 description 1
- 235000011292 Brassica rapa Nutrition 0.000 description 1
- 235000006618 Brassica rapa subsp oleifera Nutrition 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- RZZPDXZPRHQOCG-OJAKKHQRSA-M CDP-choline(1-) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-M 0.000 description 1
- 240000001432 Calendula officinalis Species 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- WLYGSPLCNKYESI-RSUQVHIMSA-N Carthamin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@@]1(O)C(O)=C(C(=O)\C=C\C=2C=CC(O)=CC=2)C(=O)C(\C=C\2C([C@](O)([C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(O)=C(C(=O)\C=C\C=3C=CC(O)=CC=3)C/2=O)=O)=C1O WLYGSPLCNKYESI-RSUQVHIMSA-N 0.000 description 1
- 241000208809 Carthamus Species 0.000 description 1
- 235000019492 Cashew oil Nutrition 0.000 description 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 244000251987 Coprinus macrorhizus Species 0.000 description 1
- 235000001673 Coprinus macrorhizus Nutrition 0.000 description 1
- 241001362614 Crassa Species 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 102000007605 Cytochromes b5 Human genes 0.000 description 1
- 108010007167 Cytochromes b5 Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 239000003155 DNA primer Substances 0.000 description 1
- 101100096502 Danio rerio spring gene Proteins 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 201000009273 Endometriosis Diseases 0.000 description 1
- 241000160765 Erebia ligea Species 0.000 description 1
- 102100027282 Fanconi anemia group E protein Human genes 0.000 description 1
- 206010016845 Foetal alcohol syndrome Diseases 0.000 description 1
- 241000223195 Fusarium graminearum Species 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 241000223247 Gloeocercospora Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 101000783851 Homo sapiens Protein AAR2 homolog Proteins 0.000 description 1
- 206010020400 Hostility Diseases 0.000 description 1
- 102000004867 Hydro-Lyases Human genes 0.000 description 1
- 108090001042 Hydro-Lyases Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001501873 Isochrysis galbana Species 0.000 description 1
- 238000008214 LDL Cholesterol Methods 0.000 description 1
- 101150083900 LPAT2 gene Proteins 0.000 description 1
- 241001149420 Laccaria bicolor Species 0.000 description 1
- 241000208204 Linum Species 0.000 description 1
- 241001149698 Lipomyces Species 0.000 description 1
- 241001317416 Lius Species 0.000 description 1
- 241000290463 Lottia gigantea Species 0.000 description 1
- 235000010653 Lupinus angustifolius Nutrition 0.000 description 1
- 240000005776 Lupinus angustifolius Species 0.000 description 1
- 241000208467 Macadamia Species 0.000 description 1
- 235000019493 Macadamia oil Nutrition 0.000 description 1
- 241001344131 Magnaporthe grisea Species 0.000 description 1
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 108010049137 Member 1 Subfamily D ATP Binding Cassette Transporter Proteins 0.000 description 1
- 241000179980 Microcoleus Species 0.000 description 1
- 241001609148 Monosiga brevicollis Species 0.000 description 1
- 101100096504 Mus musculus Spring1 gene Proteins 0.000 description 1
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 241000224436 Naegleria Species 0.000 description 1
- 101710202365 Napin Proteins 0.000 description 1
- 241000191342 Nematostella vectensis Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241001267869 Netria Species 0.000 description 1
- 241000221961 Neurospora crassa Species 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 235000002725 Olea europaea Nutrition 0.000 description 1
- 101710089395 Oleosin Proteins 0.000 description 1
- 241001327682 Oncorhynchus mykiss irideus Species 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 241001221669 Ostreococcus Species 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 241000206765 Pavlova lutheri Species 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 241001442530 Perkinsus marinus Species 0.000 description 1
- 244000025272 Persea americana Species 0.000 description 1
- 235000008673 Persea americana Nutrition 0.000 description 1
- 201000011252 Phenylketonuria Diseases 0.000 description 1
- 241000235400 Phycomyces Species 0.000 description 1
- 241000370518 Phytophthora ramorum Species 0.000 description 1
- 241000948155 Phytophthora sojae Species 0.000 description 1
- 206010057244 Post viral fatigue syndrome Diseases 0.000 description 1
- 241001492489 Postia placenta Species 0.000 description 1
- 206010036618 Premenstrual syndrome Diseases 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 102100020958 Protein AAR2 homolog Human genes 0.000 description 1
- 241000087479 Pseudocercospora fijiensis Species 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 241000233639 Pythium Species 0.000 description 1
- 241001505297 Pythium irregulare Species 0.000 description 1
- 101100426090 Rattus norvegicus Trim9 gene Proteins 0.000 description 1
- 241000235088 Saccharomyces sp. Species 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 241000233667 Saprolegnia Species 0.000 description 1
- 108010016634 Seed Storage Proteins Proteins 0.000 description 1
- 241000015737 Selaginella moellendorffii Species 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- 241000192581 Synechocystis sp. Species 0.000 description 1
- 241001491687 Thalassiosira pseudonana Species 0.000 description 1
- 102000005488 Thioesterase Human genes 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 101100119784 Umbellularia californica FATB1 gene Proteins 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 101100096505 Xenopus laevis spring1 gene Proteins 0.000 description 1
- 241000235015 Yarrowia lipolytica Species 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 239000010951 brass Substances 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 239000010467 cashew oil Substances 0.000 description 1
- 229940059459 cashew oil Drugs 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 201000003104 endogenous depression Diseases 0.000 description 1
- 125000004050 enoyl group Chemical group 0.000 description 1
- 235000004626 essential fatty acids Nutrition 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 230000004136 fatty acid synthesis Effects 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 208000026934 fetal alcohol spectrum disease Diseases 0.000 description 1
- 201000007794 fetal alcohol syndrome Diseases 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 229940098330 gamma linoleic acid Drugs 0.000 description 1
- XZQYPTBYQYZGRU-FHDVEODPSA-N gamma-linolenoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCC\C=C/C\C=C/C\C=C/CCCCC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 XZQYPTBYQYZGRU-FHDVEODPSA-N 0.000 description 1
- 208000030304 gastrointestinal bleeding Diseases 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 235000009424 haa Nutrition 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 235000006486 human diet Nutrition 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- YECLLIMZHNYFCK-RRNJGNTNSA-N linoleoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCCCC\C=C/C\C=C/CCCCC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 YECLLIMZHNYFCK-RRNJGNTNSA-N 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 239000010469 macadamia oil Substances 0.000 description 1
- 208000024714 major depressive disease Diseases 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 238000012269 metabolic engineering Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 235000019508 mustard seed Nutrition 0.000 description 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229940068065 phytosterols Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 235000002378 plant sterols Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 201000000484 premenstrual tension Diseases 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 108020002982 thioesterase Proteins 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 235000010692 trans-unsaturated fatty acids Nutrition 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019168194A JP6972074B2 (ja) | 2013-12-18 | 2019-09-17 | 長鎖多価不飽和脂肪酸を含む脂質 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013905033A AU2013905033A0 (en) | 2013-12-18 | Production of increased levels of long chain polyunsaturated fatty acids in plant cells | |
| AU2013905033 | 2013-12-18 | ||
| AU2014902471A AU2014902471A0 (en) | 2014-06-27 | Production of increased levels of long chain polyunsaturated fatty acids in plant cells | |
| AU2014902471 | 2014-06-27 | ||
| PCT/AU2014/050433 WO2015089587A1 (en) | 2013-12-18 | 2014-12-18 | Lipid comprising long chain polyunsaturated fatty acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019168194A Division JP6972074B2 (ja) | 2013-12-18 | 2019-09-17 | 長鎖多価不飽和脂肪酸を含む脂質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503053A JP2017503053A (ja) | 2017-01-26 |
| JP2017503053A5 true JP2017503053A5 (enExample) | 2019-10-31 |
| JP6726619B2 JP6726619B2 (ja) | 2020-07-22 |
Family
ID=53367674
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016541363A Active JP6726619B2 (ja) | 2013-12-18 | 2014-12-18 | 長鎖多価不飽和脂肪酸を含む脂質 |
| JP2016575436A Active JP6855249B2 (ja) | 2013-12-18 | 2015-06-18 | ドコサペンタエン酸を含む脂質 |
| JP2019168194A Active JP6972074B2 (ja) | 2013-12-18 | 2019-09-17 | 長鎖多価不飽和脂肪酸を含む脂質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575436A Active JP6855249B2 (ja) | 2013-12-18 | 2015-06-18 | ドコサペンタエン酸を含む脂質 |
| JP2019168194A Active JP6972074B2 (ja) | 2013-12-18 | 2019-09-17 | 長鎖多価不飽和脂肪酸を含む脂質 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US9725399B2 (enExample) |
| EP (1) | EP3082405A4 (enExample) |
| JP (3) | JP6726619B2 (enExample) |
| KR (2) | KR102386838B1 (enExample) |
| CN (2) | CN104726473B (enExample) |
| AU (1) | AU2014366839B2 (enExample) |
| BR (1) | BR112016014508A2 (enExample) |
| CA (2) | CA3241340A1 (enExample) |
| CL (2) | CL2016001560A1 (enExample) |
| EA (2) | EA037817B1 (enExample) |
| IL (1) | IL246275B (enExample) |
| MX (2) | MX384370B (enExample) |
| NZ (1) | NZ721036A (enExample) |
| PE (2) | PE20170253A1 (enExample) |
| PH (1) | PH12016501194B1 (enExample) |
| SG (1) | SG11201604871VA (enExample) |
| UA (1) | UA122768C2 (enExample) |
| WO (1) | WO2015089587A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1756280T3 (pl) | 2004-04-22 | 2015-04-30 | Commw Scient Ind Res Org | Synteza długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach rekombinowanych |
| ES2529572T3 (es) | 2004-04-22 | 2015-02-23 | Commonwealth Scientific And Industrial Research Organisation | Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes |
| CA3015426C (en) | 2008-11-18 | 2020-01-14 | Commonwealth Scientific And Industrial Research Organisation | Recombinant cells comprising exogenous .delta.5 and .delta.6 desaturases, .delta.5 and .delta.6 elongases, and .delta.4 desaturases |
| HUE033766T2 (en) | 2012-06-15 | 2018-01-29 | Commw Scient Ind Res Org | Production of long chain polyunsaturated fatty acids in plant cells |
| US11718577B2 (en) * | 2013-12-18 | 2023-08-08 | Commonwealth Scientific And Industrial Research Organisation | Lipid compositions comprising triacylglycerol with long-chain polyunsaturated fatty acids |
| EA037817B1 (ru) | 2013-12-18 | 2021-05-25 | Коммонвелт Сайнтифик Энд Индастриэл Рисерч Организэйшн | Экстрагированный растительный липид, содержащий длинноцепочечные полиненасыщенные жирные кислоты |
| CN117305343A (zh) * | 2014-06-27 | 2023-12-29 | 联邦科学技术研究组织 | 包含二十二碳五烯酸的提取的植物脂质 |
| CA2953008C (en) | 2014-06-27 | 2024-03-19 | Nuseed Pty Ltd | Lipid comprising docosapentaenoic acid |
| US11484560B2 (en) | 2014-11-14 | 2022-11-01 | Basf Plant Science Company Gmbh | Stabilising fatty acid compositions |
| CA3026079C (en) | 2016-06-01 | 2024-10-01 | Cargill Inc | FISH FOOD PREPARED FROM OILSEED PLANTS PRODUCING OMEGA-3 FATTY ACIDS |
| KR102420456B1 (ko) | 2016-06-16 | 2022-07-14 | 누시드 뉴트리셔널 오스트레일리아 피티와이 엘티디. | 근친교배 형질전환 카놀라 계통 ns-b50027-4 및 이의 종자 |
| IL296501B2 (en) | 2016-06-16 | 2025-07-01 | Nuseed Nutritional Australia Pty Ltd | Canola NS–B50027–4 |
| AU2017366726B2 (en) | 2016-12-03 | 2021-12-09 | The Uab Research Foundation | Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A |
| CN107048405A (zh) * | 2017-03-03 | 2017-08-18 | 武汉锶博睿医药技术有限公司 | 脂肪酸组件微胶囊及其制备方法 |
| US11913006B2 (en) | 2018-03-16 | 2024-02-27 | Nuseed Global Innovation Ltd. | Plants producing modified levels of medium chain fatty acids |
| CN112040766A (zh) | 2018-04-13 | 2020-12-04 | 嘉吉公司 | 栽培含lc-pufa的转基因芸苔属植物的方法 |
| WO2019206443A1 (en) * | 2018-04-25 | 2019-10-31 | Nuseed Pty Ltd. | Dha enriched polyunsaturated fatty acid compositions |
| EP3560342B1 (en) | 2018-04-25 | 2020-06-03 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586640A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586641A1 (en) * | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586642A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Ala enriched polyunsaturated fatty acid compositions |
| CN108929784A (zh) * | 2018-06-21 | 2018-12-04 | 江南大学 | 一种富含多不饱和脂肪酸的甘二酯油脂及其制备方法 |
| EP3586643A1 (en) * | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| WO2020168277A1 (en) | 2019-02-14 | 2020-08-20 | Cargill, Incorporated | Brassica plants producing elevated levels of polyunsaturated fatty acids |
| EP3938480A4 (en) * | 2019-03-14 | 2022-12-28 | DSM IP Assets B.V. | Methods of obtaining lipids from a microbial cell composition by enzyme and ph shock |
| CN109796328B (zh) * | 2019-03-14 | 2022-03-25 | 浙江工业大学 | 一种高纯度香榧籽油金松酸的分离方法 |
| BR112022003731A2 (pt) * | 2019-08-26 | 2022-08-09 | Nuseed Nutritional Australia Pty Ltd | Brassica juncea linha nubj1207 |
| CN110438175A (zh) * | 2019-09-16 | 2019-11-12 | 东北农业大学 | 一种冷冻分离后的轻相米糠油与共轭亚油酸酯交换制备功能性油脂的方法 |
| PE20230178A1 (es) | 2019-10-25 | 2023-02-01 | Nuseed Nutritional Us Inc | Composiciones enriquecidas de acidos grasos poliinsaturados |
| AU2021373697A1 (en) | 2020-11-04 | 2023-06-08 | Basf Plant Science Company Gmbh | Harvest management |
| EP4263837A1 (en) * | 2020-12-18 | 2023-10-25 | Rothamsted Research Limited | Increasing the accumulation of epa and dha in recombinant camelina |
| WO2022204454A1 (en) | 2021-03-25 | 2022-09-29 | Cargill, Incorporated | Fertilizer management |
| US11186597B1 (en) | 2021-06-24 | 2021-11-30 | King Abdulaziz University | Method of extracting phospholipids from fish roe |
| US20240423241A1 (en) | 2021-11-08 | 2024-12-26 | Can Technologies, Inc. | High plant pufa fish food |
Family Cites Families (291)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| DE3484215D1 (de) | 1983-01-17 | 1991-04-11 | Monsanto Co | Chimaerische gene geeignet zur expression in pflanzenzellen. |
| US5504200A (en) | 1983-04-15 | 1996-04-02 | Mycogen Plant Science, Inc. | Plant gene expression |
| US5420034A (en) | 1986-07-31 | 1995-05-30 | Calgene, Inc. | Seed-specific transcriptional regulation |
| ZA871352B (en) | 1986-02-27 | 1987-08-12 | The General Hospital Corporation | Plant cells resistant to herbicidal glutamine synthetase inhibitors |
| MA20977A1 (fr) | 1986-05-19 | 1987-12-31 | Ciba Geigy Ag | Plantes tolerant les herbicides contenant le gene de gluthathione S-Transferase |
| US5188958A (en) | 1986-05-29 | 1993-02-23 | Calgene, Inc. | Transformation and foreign gene expression in brassica species |
| US5177010A (en) | 1986-06-30 | 1993-01-05 | University Of Toledo | Process for transforming corn and the products thereof |
| SE455438B (sv) | 1986-11-24 | 1988-07-11 | Aga Ab | Sett att senka en brennares flamtemperatur samt brennare med munstycken for oxygen resp brensle |
| US5004863B2 (en) | 1986-12-03 | 2000-10-17 | Agracetus | Genetic engineering of cotton plants and lines |
| CN87100603A (zh) | 1987-01-21 | 1988-08-10 | 昂科公司 | 抗黑素瘤疫苗 |
| MC2115A1 (fr) | 1987-12-15 | 1991-07-05 | Gene Shears Pty Ltd | Ribozynes |
| US5416011A (en) | 1988-07-22 | 1995-05-16 | Monsanto Company | Method for soybean transformation and regeneration |
| US5932479A (en) | 1988-09-26 | 1999-08-03 | Auburn University | Genetic engineering of plant chloroplasts |
| ATE160174T1 (de) | 1989-08-09 | 1997-11-15 | Dekalb Genetics Corp | Methoden und zusammensetzungen für die herstellung von stabil transformierten, fruchtbaren mais pflanzen und zellen dafür |
| DK0472712T3 (da) | 1990-03-16 | 2002-01-14 | Calgene Llc | Sekvenser, der præferentielt eksprimeres i tidlig frøudvikling og dertil relaterede fremgangsmåder |
| US5877402A (en) | 1990-05-01 | 1999-03-02 | Rutgers, The State University Of New Jersey | DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein |
| US5451513A (en) | 1990-05-01 | 1995-09-19 | The State University of New Jersey Rutgers | Method for stably transforming plastids of multicellular plants |
| US5861187A (en) | 1990-08-30 | 1999-01-19 | Cargill, Incorporated | Oil from canola seed with altered fatty acid profiles and a method of producing oil |
| US7135614B1 (en) | 1990-08-30 | 2006-11-14 | Cargill, Incorporated | Brassica or helianthus plants having mutant delta-12 or delta-15 sequences |
| US5518908A (en) | 1991-09-23 | 1996-05-21 | Monsanto Company | Method of controlling insects |
| US6683232B1 (en) | 1991-10-10 | 2004-01-27 | Rhone-Poulenc Agrochimie | Production of γ linolenic acid by a Δ6-desaturase |
| US6355861B1 (en) | 1991-10-10 | 2002-03-12 | Rhone-Poulenc Agrochimie | Production of gamma linolenic acid by a Δ6-desaturase |
| US5614393A (en) | 1991-10-10 | 1997-03-25 | Rhone-Poulenc Agrochimie | Production of γ-linolenic acid by a Δ6-desaturase |
| PH31293A (en) | 1991-10-10 | 1998-07-06 | Rhone Poulenc Agrochimie | Production of y-linolenic acid by a delta6-desaturage. |
| CA2124673C (en) | 1991-12-04 | 2008-08-05 | John Browse | Fatty acid desaturase genes from plants |
| US5593874A (en) | 1992-03-19 | 1997-01-14 | Monsanto Company | Enhanced expression in plants |
| US5683898A (en) | 1992-05-15 | 1997-11-04 | Sagami Chemical Research Center | Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid |
| FI940203L (fi) | 1992-05-15 | 1994-03-14 | Sagami Chem Res | Geeni, joka koodaa eikosapeutaanihappoa syntetisoivia entsyymejä, ja menetelmä eikospentaanihapon valmistamiseksi |
| US5798259A (en) | 1992-05-15 | 1998-08-25 | Sagami Chemical Research Center | Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid |
| US6372965B1 (en) | 1992-11-17 | 2002-04-16 | E.I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants |
| US6872872B1 (en) | 1992-11-17 | 2005-03-29 | E. I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants |
| EP0688160B1 (en) | 1993-03-11 | 1998-05-13 | National Research Council Of Canada | Enhanced regeneration system for cereals |
| CA2092588C (en) | 1993-03-26 | 2008-07-08 | Narender S. Nehra | Enhanced regeneration system for cereals |
| SE9302431D0 (sv) | 1993-07-16 | 1993-07-16 | Ab Astra | Use of indenoindole compounds |
| US5362865A (en) | 1993-09-02 | 1994-11-08 | Monsanto Company | Enhanced expression in plants using non-translated leader sequences |
| GB9324707D0 (en) | 1993-12-02 | 1994-01-19 | Olsen Odd Arne | Promoter |
| GB9403512D0 (en) | 1994-02-24 | 1994-04-13 | Olsen Odd Arne | Promoter |
| US5545818A (en) | 1994-03-11 | 1996-08-13 | Calgene Inc. | Expression of Bacillus thuringiensis cry proteins in plant plastids |
| US6310194B1 (en) | 1994-09-26 | 2001-10-30 | Carnegie Institution Of Washington | Plant fatty acid hydroxylases |
| US5834293A (en) | 1994-09-28 | 1998-11-10 | Vanderbilt University | Cytochrome P450 arachidonic acid epoxygenase genetic mutation associated with hypertension |
| DE4435392B4 (de) | 1994-10-04 | 2008-02-07 | Immuno Ag | Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF |
| JPH08163991A (ja) * | 1994-12-15 | 1996-06-25 | Mitsui Petrochem Ind Ltd | タキサン型ジテルペンの製造方法 |
| GB9515941D0 (en) | 1995-08-03 | 1995-10-04 | Zeneca Ltd | DNA constructs |
| US7541519B2 (en) | 1995-12-14 | 2009-06-02 | Cargill, Incorporated | Fatty acid desaturases and mutant sequences thereof |
| US6342658B1 (en) | 1995-12-14 | 2002-01-29 | Cargill, Incorporated | Fatty acid desaturases and mutant sequences thereof |
| EP0880312B1 (en) | 1995-12-14 | 2006-03-08 | Cargill Incorporated | Plants having mutant sequences that confer altered fatty acid profiles |
| SE9601236D0 (sv) | 1996-03-29 | 1996-03-29 | Sten Stymne | Novel plant enzyme and use thereof |
| TR199800294T1 (xx) | 1996-06-21 | 1999-10-21 | Monsanto Company | Sabit transforme edilen verimli bu�day �retim y�ntemleri. |
| US5850026A (en) | 1996-07-03 | 1998-12-15 | Cargill, Incorporated | Canola oil having increased oleic acid and decreased linolenic acid content |
| AU727694B2 (en) | 1996-07-10 | 2000-12-21 | Sagami Chemical Research Center | Process for producing icosapentaenoic acid by genetic recombination |
| US6337266B1 (en) | 1996-07-22 | 2002-01-08 | Micron Technology, Inc. | Small electrode for chalcogenide memories |
| US7109392B1 (en) | 1996-10-09 | 2006-09-19 | Cargill, Incorporated | Methods for increasing oleic acid content in seeds from transgenic plants containing a mutant delta 12 desaturase |
| WO1998018952A1 (en) | 1996-10-30 | 1998-05-07 | Nippon Suisan Kaisha, Ltd. | Process for producing fats containing highly unsaturated fatty acids containing selectively concentrated docosahexaenoic acid |
| US6194167B1 (en) | 1997-02-18 | 2001-02-27 | Washington State University Research Foundation | ω-3 fatty acid desaturase |
| AT406373B (de) | 1997-02-27 | 2000-04-25 | Immuno Ag | Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie |
| DE69840022D1 (de) | 1997-03-04 | 2008-10-30 | Suntory Ltd | Verfahren zur herstellung von hochungesättigten fettsäuren und hochungesättigte fettsäuren enthaltendes lipid |
| US5977436A (en) | 1997-04-09 | 1999-11-02 | Rhone Poulenc Agrochimie | Oleosin 5' regulatory region for the modification of plant seed lipid composition |
| ATE297994T1 (de) | 1997-04-11 | 2005-07-15 | Calgene Llc | Verfahren und zusammensetzungen für die synthese von langkettigen, mehrfach ungesättigten fettsäuren in pflanzen. |
| US6428990B1 (en) | 1997-04-11 | 2002-08-06 | Abbott Laboratories | Human desaturase gene and uses thereof |
| US6075183A (en) | 1997-04-11 | 2000-06-13 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US6051754A (en) | 1997-04-11 | 2000-04-18 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US6432684B1 (en) | 1997-04-11 | 2002-08-13 | Abbott Laboratories | Human desaturase gene and uses thereof |
| US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US5972664A (en) | 1997-04-11 | 1999-10-26 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US7589253B2 (en) | 1997-04-15 | 2009-09-15 | Commonwealth Scientific And Industrial Research Organisation | Fatty acid epoxygenase genes from plants and uses therefor in modifying fatty acid metabolism |
| ATE342361T1 (de) | 1997-04-15 | 2006-11-15 | Commw Scient Ind Res Org | Pflanzengene, die für fettsäurenepoxygenase kodieren und ihre verwendungen |
| US6235529B1 (en) | 1997-04-29 | 2001-05-22 | The Regents Of The University Of California | Compositions and methods for plant transformation and regeneration |
| US6566583B1 (en) | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| IL133272A0 (en) | 1997-06-04 | 2001-04-30 | Calgene Llc | Production of polyunsaturated fatty acid by expression of polyketide-like synthesis genes in plants |
| EP0987936A4 (en) | 1997-06-12 | 2001-03-14 | Cargill Inc | FATTY ACID DESATURASES AND MUTED SEQUENCES THEREOF |
| AU8583798A (en) | 1997-07-23 | 1999-02-16 | Centro De Investigacion Y De Estudios Avanzados Del I.P.N. | Improved plastid transformation of higher plants and production of trans genic plants with herbicide resistance |
| DE69840362D1 (de) | 1997-09-12 | 2009-01-29 | Commw Scient Ind Res Org | Regulation der genexpression in pflanzen |
| AU746032B2 (en) | 1997-09-30 | 2002-04-11 | Regents Of The University Of California, The | Production of proteins in plant seeds |
| GB9724783D0 (en) | 1997-11-24 | 1998-01-21 | Inst Arable Crops Research | Novel polypeptides |
| EP1042485A2 (en) | 1997-12-23 | 2000-10-11 | University Of Bristol | Desaturase |
| US20030152983A1 (en) | 1997-12-23 | 2003-08-14 | University Of Bristol | Desaturase |
| US6100447A (en) | 1998-02-12 | 2000-08-08 | Applied Phytologics, Inc. | Method of barley transformation |
| US6838594B1 (en) | 1998-03-20 | 2005-01-04 | E. I. Du Pont De Nemours And Company | Limnanthes oil genes |
| AU763296B2 (en) | 1998-03-20 | 2003-07-17 | E.I. Du Pont De Nemours And Company | Limanthes oil genes |
| US6492108B1 (en) | 1998-03-26 | 2002-12-10 | Incyte Genomics, Inc. | Delta-6 desaturase homologs |
| EP1080189A4 (en) | 1998-05-29 | 2003-01-08 | Univ Ohio | COMPOSITIONS AND METHODS FOR THE PRODUCTION OF FATTY ACIDS, THEIR DERIVATIVES AND SUBSEQUENT PRODUCTS |
| AU4564399A (en) | 1998-06-12 | 1999-12-30 | Abbott Laboratories | Polyunsaturated fatty acids in plants |
| EP1086236B1 (en) | 1998-06-12 | 2007-09-05 | Calgene LLC | Polyunsaturated fatty acids in plants |
| US7135617B2 (en) | 1998-07-02 | 2006-11-14 | Calgene Llc | Diacylglycerol acyl transferase proteins |
| WO2000011176A2 (en) | 1998-08-20 | 2000-03-02 | E.I. Du Pont De Nemours And Company | Genes for plant fatty acid modifying enzymes associated with conjugated double bond formation |
| WO2000011012A1 (en) | 1998-08-24 | 2000-03-02 | Rutgers, The State University Of New Jersey | Synthetic fatty acid desaturase gene for expression in plants |
| US6403349B1 (en) | 1998-09-02 | 2002-06-11 | Abbott Laboratories | Elongase gene and uses thereof |
| US6677145B2 (en) | 1998-09-02 | 2004-01-13 | Abbott Laboratories | Elongase genes and uses thereof |
| US20030163845A1 (en) | 1998-09-02 | 2003-08-28 | Pradip Mukerji | Elongase genes and uses thereof |
| US6913916B1 (en) | 1998-09-02 | 2005-07-05 | Abbott Laboratories | Elongase genes and uses thereof |
| AU1097900A (en) | 1998-10-05 | 2000-04-26 | Abbott Laboratories | Delta 6 and delta 12 desaturases and modified fatty acid biosynthesis and products produced therefrom |
| WO2000020603A1 (en) | 1998-10-05 | 2000-04-13 | Abbott Laboratories | Altered fatty acid biosynthesis in insect cells using delta five desaturase |
| JP2002527051A (ja) | 1998-10-09 | 2002-08-27 | メルク エンド カムパニー インコーポレーテッド | デルタ６脂肪酸デサチュラーゼ |
| JP4182192B2 (ja) | 1998-11-26 | 2008-11-19 | 独立行政法人産業技術総合研究所 | イコサペンタエン酸及び／又はドコサヘキサエン酸の生合成に関与する酵素群をコードする遺伝子 |
| US6864077B1 (en) | 1998-12-03 | 2005-03-08 | Edgar B. Cahoon | Membrane-bound desaturases |
| JP2001095588A (ja) | 1998-12-04 | 2001-04-10 | Research Institute Of Innovative Technology For The Earth | 緑藻のω３脂肪酸不飽和化酵素遺伝子及びその利用 |
| US6825017B1 (en) | 1998-12-07 | 2004-11-30 | Washington State University Research Foundation | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids |
| US7217856B2 (en) | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7211418B2 (en) | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US20070244192A1 (en) | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
| US7247461B2 (en) | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| US8003772B2 (en) | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| US7271315B2 (en) | 1999-01-14 | 2007-09-18 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US6448473B1 (en) | 1999-03-05 | 2002-09-10 | Monsanto Technology Llc | Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways |
| EP1035207A1 (en) | 1999-03-09 | 2000-09-13 | MultiGene Biotech GmbH | cDNA molecules of the members of gene family encoding human fatty acid desaturases and their use in diagnosis and therapy |
| WO2000055330A1 (en) | 1999-03-18 | 2000-09-21 | The University Of Bristol | Polysaturated fatty acid (pufa) elongase from caenorhabditis elegans |
| IL146782A0 (en) | 1999-06-07 | 2002-07-25 | Basf Plant Science Gmbh | 6-acetylenase and 6-desaturase from ceratodon purpureus |
| EP1190080A1 (de) | 1999-07-06 | 2002-03-27 | BASF Plant Science GmbH | $g(D)6-DESATURASEGENE EXPRIMIERENDE PFLANZEN UND PUFAS ENTHALTENDE ÖLE AUS DIESEN PFLANZEN UND EIN VERFAHREN ZUR HERSTELLUNG UNGESÄTTIGTER FETTSÄUREN |
| AU6091600A (en) | 1999-07-12 | 2001-01-30 | Ohio University | Mammalian cells expressing desaturases and elongases |
| US7070970B2 (en) | 1999-08-23 | 2006-07-04 | Abbott Laboratories | Elongase genes and uses thereof |
| CN1378602A (zh) | 1999-08-26 | 2002-11-06 | 卡尔根尼有限公司 | 含修饰的多不饱和脂肪酸的植物 |
| US7531718B2 (en) | 1999-08-26 | 2009-05-12 | Monsanto Technology, L.L.C. | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
| US7067722B2 (en) | 1999-08-26 | 2006-06-27 | Monsanto Technology Llc | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
| DE10044468A1 (de) | 1999-09-10 | 2001-03-15 | Axiva Gmbh | Neue Nukleinsäure aus Tetrahymena kodierend für eine delta-6Desaturase, ihre Herstellung und ihre Verwendung |
| FR2798391B1 (fr) | 1999-09-15 | 2001-12-14 | Inst Nat Sante Rech Med | Enzyme thyroidienne nadph oxydase, acide nucleique codant pour cette enzyme et leurs applications |
| DE19950589A1 (de) | 1999-10-20 | 2001-05-23 | Gvs Ges Fuer Erwerb Und Verwer | Elongasepromotoren für gewebespezifische Expression von Transgenen in Pflanzen |
| JP4221476B2 (ja) | 1999-11-19 | 2009-02-12 | 独立行政法人産業技術総合研究所 | イコサペンタエン酸生合成遺伝子群をクローニングしたプラスミド及びイコサペンタエン酸を産生するラン藻 |
| WO2001038512A2 (en) | 1999-11-22 | 2001-05-31 | Plant Bioscience Limited | Enhanced transgene expression by co-expression with a suppressor of post-transcriptional gene silencing (ptgs) |
| US6620986B1 (en) | 1999-11-23 | 2003-09-16 | The United States Of America As Represented By The Secretary Of Agriculture | Transformation of Ricinus communis, the castor plant |
| AU1499601A (en) | 1999-11-25 | 2001-06-04 | Basf Plant Science Gmbh | Moss genes from physcomitrella patents encoding proteins involved in the synthesis of polyunsaturated fatty acids and lipids |
| JP2001169780A (ja) | 1999-12-15 | 2001-06-26 | Natl Inst Of Advanced Industrial Science & Technology Meti | ドコサヘキサエン酸生産細菌の遺伝子 |
| GB9929681D0 (en) | 1999-12-15 | 2000-02-09 | Implyx Ltd | Transgenic insect |
| GB9929897D0 (en) | 1999-12-18 | 2000-02-09 | Slabas Antoni R | Improvements in or relating to conjugated fatty acids and related compounds |
| US20030172398A1 (en) | 1999-12-21 | 2003-09-11 | Browse John A. | Novel delta-12 desaturase and methods of using it for synthesis of polyunsaturated fatty acids |
| US6591257B1 (en) | 1999-12-23 | 2003-07-08 | Hewlett-Packard Development Company | Apparatus and method for a compositional decision support reasoning system |
| PL207026B1 (pl) | 2000-02-09 | 2010-10-29 | Basf Ag | Wyizolowany kwas nukleinowy, konstrukt genowy zawierający ten kwas, sekwencja aminokwasowa kodowana przez wyizolowaną sekwencję tego kwasu nukleinowego, wektor zawierający kwas nukleinowy lub konstrukt genowy, roślina transgeniczna lub mikroorganizm transgeniczny zawierający kwas nukleinowy, konstrukt genowy lub wektor, przeciwciało specyficznie wiążące się z polipeptydem kodowanym przez kwas nukleinowy, cząsteczka antysensownego kwasu nukleinowego oraz sposób wytwarzania wielonienasyconych kwasów tłuszczowych (PUFA) |
| US7411054B2 (en) | 2000-03-07 | 2008-08-12 | Millennium Pharmaceuticals, Inc. | 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor |
| US6686185B1 (en) | 2000-03-07 | 2004-02-03 | Millennium Pharmaceuticals, Inc. | 25934, a novel fatty acid desaturase and uses therefor |
| US20020111307A1 (en) | 2000-06-23 | 2002-08-15 | Glucksmann Maria Alexandra | 46508, a novel human peptidyl-tRNA hydrolase family member and uses thereof |
| US20040157221A9 (en) | 2000-03-07 | 2004-08-12 | Millennium Pharmaceuticals, Inc. | Novel 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor |
| US6492577B1 (en) | 2000-03-16 | 2002-12-10 | The Regents Of The University Of California | Leafy cotyledon2 genes and their uses |
| CA2301158A1 (en) | 2000-03-24 | 2001-09-24 | Stephen J. Allen | Screening methods for compounds useful for modulating lipid metabolism in disease |
| WO2001073060A2 (en) | 2000-03-24 | 2001-10-04 | Millennium Pharmaceuticals, Inc. | 18221, dual specificity phosphatase and uses thereof |
| WO2001075069A1 (en) | 2000-03-31 | 2001-10-11 | Idemitsu Petrochemical Co., Ltd. | Process for producing lipids and lipid-secreting microorganisms |
| DE60142734D1 (de) | 2000-04-18 | 2010-09-16 | Commw Scient Ind Res Org | Verfahren zur modifizierung des baumwollölgehaltes |
| WO2001087140A2 (en) | 2000-05-16 | 2001-11-22 | Crosetto Dario B | Method and apparatus for anatomical and functional medical imaging |
| US7091005B2 (en) | 2000-05-16 | 2006-08-15 | Merck & Co., Inc. | Gene responsible for Stargardt-like dominant macular dystrophy |
| EP1404820A2 (en) | 2000-05-19 | 2004-04-07 | Millennium Pharmaceuticals, Inc. | 50365, a hexokinase family member and uses therefor |
| WO2001092489A2 (en) | 2000-05-26 | 2001-12-06 | Washington State University Research Foundation | Palmitate desaturase gene |
| WO2001096363A1 (en) | 2000-06-12 | 2001-12-20 | Boyce Thompson Institute For Plant Research | Fatty acid desaturase gene and protein for modulating activation of defense signaling pathways in plants |
| EP1297155A2 (en) | 2000-06-29 | 2003-04-02 | Millennium Pharmaceuticals, Inc. | 25869, a human carboxylesterase and uses thereof |
| WO2002006302A2 (en) | 2000-07-17 | 2002-01-24 | Millennium Pharmaceuticals, Inc. | 16816 and 16839, novel human phospholipase c molecules and uses therefor |
| GB0316629D0 (en) | 2003-07-16 | 2003-08-20 | Univ York | Transgenic cell |
| EP1339839A2 (en) | 2000-08-21 | 2003-09-03 | Millennium Pharmaceuticals, Inc. | Human transporter family members and uses thereof |
| CA2430987A1 (en) | 2000-09-26 | 2002-04-04 | Xenon Genetics, Inc. | Methods and compositions employing a novel stearoyl-coa desaturase-hscd5 |
| ES2343106T3 (es) | 2000-09-28 | 2010-07-23 | BIORIGINAL FOOD & SCIENCE CORP. | Fad4, fad5, fad5-2 y fad6, miembros de la familia de desaturasas de acidos grasos y usos de los mismos. |
| US7297523B2 (en) | 2000-11-29 | 2007-11-20 | Xenon Pharmaceuticals Inc. | Human elongase genes and uses thereof |
| DE10102337A1 (de) | 2001-01-19 | 2002-07-25 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren, neue Biosynthesegene sowie neue pflanzliche Expressionskonstrukte |
| DE10102338A1 (de) | 2001-01-19 | 2002-07-25 | Basf Plant Science Gmbh | Verfahren zur Expression von Biosynthesegenen in pflanzlichen Samen unter Verwendung von neuen multiplen Expressionskonstrukten |
| EP1392823B1 (en) | 2001-01-25 | 2011-11-30 | Abbott Laboratories | Desaturase genes and uses thereof |
| US6635451B2 (en) | 2001-01-25 | 2003-10-21 | Abbott Laboratories | Desaturase genes and uses thereof |
| DE10106660A1 (de) | 2001-02-12 | 2002-08-29 | Celanese Ventures Gmbh | Verfahren zur Herstellung von gamma-Linolensäure aus einer Ciliaten-Kultur durch Zusatz geeigneter Vorläufermoleküle zu dem Kulturmedium |
| GB0107510D0 (en) | 2001-03-26 | 2001-05-16 | Univ Bristol | New elongase gene and a process for the production of -9-polyunsaturated fatty acids |
| WO2002081702A1 (fr) | 2001-04-05 | 2002-10-17 | Idemitsu Technofine Co., Ltd. | Genes de desaturase en position $g(d)6 d'acide gras, plasmides et transformants contenant ces genes |
| TWI426126B (zh) | 2001-04-16 | 2014-02-11 | Dsm Ip Assets Bv | 多不飽和脂肪酸（ｐｕｆａ）聚乙醯合成酶系統及其用途（二） |
| TWI324181B (en) | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| US7045683B2 (en) | 2001-05-04 | 2006-05-16 | Abbott Laboratories | Δ4-desaturase genes and uses thereof |
| US20030082754A1 (en) | 2001-05-04 | 2003-05-01 | Pradip Mukerji | Delta4 - desaturase genes and uses thereof |
| EP2255668A3 (en) | 2001-05-14 | 2012-04-04 | Martek Biosciences Corporation | Production and Use of a Polar Lipid-Rich Fraction Containing Omega-3 and/or Omega-6 Highly Unsaturated Fatty Acids from Microbes, Genetically Modified Plant Seeds and Marine Organisms |
| WO2002102970A2 (en) | 2001-06-06 | 2002-12-27 | Bioriginal Food & Science Corporation | Flax (linum usitatissimim l.) seed-specific promoters |
| DE10134660A1 (de) | 2001-07-20 | 2003-02-06 | Basf Plant Science Gmbh | Fettsäure-Desaturase-Gene aus Granatapfel und Verfahren zur Herstellung von ungesättigten Fettsäuren |
| US20050089879A1 (en) | 2001-07-31 | 2005-04-28 | Ivo Feussner | Method for producing arachidonic acid in transgenic organisms |
| US6875595B2 (en) | 2001-09-13 | 2005-04-05 | Divergence, Inc. | Nematode fatty acid desaturase-like sequences |
| JP2003116566A (ja) | 2001-10-12 | 2003-04-22 | Osamu Suzuki | ｎ−３系ドコサペンタエン酸の製造方法 |
| US7211656B2 (en) | 2002-01-30 | 2007-05-01 | Abbott Laboratories | Desaturase genes, enzymes encoded thereby, and uses thereof |
| EP1472357B1 (de) | 2002-01-30 | 2009-12-16 | BASF Plant Science GmbH | Verfahren zur herstellung mehrfach ungesättigter fettsäuren mittels eines neuen elongase-gens |
| GB2385852A (en) | 2002-02-27 | 2003-09-03 | Rothamsted Ex Station | Delta 6-desaturases from Primulaceae |
| US7700833B2 (en) | 2002-03-01 | 2010-04-20 | Cornell University | Process for the production of unsaturated fatty acids |
| EP2302060B1 (en) | 2002-03-16 | 2012-07-25 | The University of York | Desaturases |
| US7566813B2 (en) | 2002-03-21 | 2009-07-28 | Monsanto Technology, L.L.C. | Nucleic acid constructs and methods for producing altered seed oil compositions |
| DE10219203A1 (de) | 2002-04-29 | 2003-11-13 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in Pflanzen |
| CA2883729C (en) | 2002-05-22 | 2017-03-07 | Virginia M. Ursin | Fatty acid desaturases from fungi |
| CN1735690A (zh) | 2002-06-21 | 2006-02-15 | 孟山都技术有限公司 | 硫酯酶相关核酸序列及方法 |
| WO2004005442A1 (de) | 2002-07-03 | 2004-01-15 | Basf Plant Science Gmbh | Verfahren zur herstellung von konjugierten mehrfach ungesättigten fettsäuren mit mindestens zwei doppelbindungen in pflanzen |
| CA2496016A1 (en) | 2002-08-12 | 2004-05-13 | Monsanto Technology Llc | Methods for increasing total oil levels in plants |
| DE10246125A1 (de) | 2002-10-01 | 2004-04-15 | Aventis Behring Gmbh | Konzentrat eines Faktor VIII:C-haltigen von-Willebrand-Faktors und das dazu gehörige Verfahren |
| BR0317304A (pt) | 2002-12-19 | 2005-11-08 | Univ Bristol | Processo para a produção de compostos, sequência de ácido nucleico isolada, sequência de aminoácidos, construção gênica, vetor, e, organismo |
| US8084074B2 (en) | 2003-02-12 | 2011-12-27 | E. I. Du Pont De Nemours And Company | Production of very long chain polyunsaturated fatty acids in oil seed plants |
| US20040172682A1 (en) | 2003-02-12 | 2004-09-02 | Kinney Anthony J. | Production of very long chain polyunsaturated fatty acids in oilseed plants |
| ATE517984T1 (de) | 2003-02-27 | 2011-08-15 | Basf Plant Science Gmbh | Verfahren zur herstellung mehrfach ungesättigter fettsäuren |
| JP3840459B2 (ja) * | 2003-03-20 | 2006-11-01 | 裕司 島田 | グリセリドおよびその製造方法 |
| EP3121269A1 (de) * | 2003-03-31 | 2017-01-25 | University Of Bristol | Neue pflanzliche acyltransferase spezifisch für langkettige mehrfach ungesättigte fettsäuren |
| DE10315026A1 (de) | 2003-04-02 | 2004-10-14 | Bioplanta Arzneimittel Gmbh | Zusammensetzungen enthaltend omega-3-fettsäurehaltige Öle und Pflanzenextrakte |
| JP4732333B2 (ja) | 2003-04-08 | 2011-07-27 | ビーエーエスエフ プラント サイエンス ゲーエムベーハー | ミドリムシ（Ｅｕｇｌｅｎａｇｒａｃｉｌｉｓ）由来のΔ−４−デサチュラーゼを発現する植物およびＰＵＦＡ含有油 |
| ATE394483T1 (de) | 2003-04-16 | 2008-05-15 | Basf Plant Science Gmbh | Verwendung von genen zur erhöhung des ölgehaltes in pflanzen |
| US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US8313911B2 (en) | 2003-05-07 | 2012-11-20 | E I Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| US20110059496A1 (en) | 2003-06-25 | 2011-03-10 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
| US7267976B2 (en) | 2003-07-02 | 2007-09-11 | E.I. Du Pont De Nemours And Company | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts |
| CA2530123C (en) * | 2003-07-09 | 2012-05-01 | The Nisshin Oillio Group, Ltd. | Method for producing symmetric triglycerides |
| PT2172536T (pt) | 2003-08-01 | 2016-08-17 | Basf Plant Science Gmbh | Processo para a produção de ácidos gordos poli-insaturados em organismos transgénicos |
| AU2004268196B2 (en) | 2003-08-21 | 2010-03-04 | Monsanto Technology Llc | Fatty acid desaturases from primula |
| US20050132441A1 (en) | 2003-11-12 | 2005-06-16 | Damude Howard G. | Delta15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast |
| US7504259B2 (en) | 2003-11-12 | 2009-03-17 | E. I. Du Pont De Nemours And Company | Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast |
| MY140210A (en) | 2003-12-22 | 2009-11-30 | Suntory Holdings Ltd | Marchantiales-derived unsaturated fatty acid synthetase genes and use of the same |
| WO2005080578A2 (en) | 2004-02-17 | 2005-09-01 | The University Of York | Desaturase enzymes |
| EP4219670A3 (de) | 2004-02-27 | 2023-08-09 | BASF Plant Science GmbH | Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen pflanzen |
| CA2558726C (en) | 2004-02-27 | 2017-11-07 | Basf Plant Science Gmbh | Method for producing unsaturated .omega.-3-fatty acids in transgenic organisms |
| CN1930277B (zh) | 2004-02-27 | 2011-02-02 | 巴斯福植物科学有限公司 | 在转基因植物中产生多不饱和脂肪酸的方法 |
| DE102004017370A1 (de) | 2004-04-08 | 2005-10-27 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | PUFA-PKS Gene aus Ulkenia |
| DE102004017369A1 (de) | 2004-04-08 | 2005-11-03 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Screeningverfahren zur Identifizierung von PUFA-PKS in Proben |
| JP2007533310A (ja) | 2004-04-16 | 2007-11-22 | モンサント テクノロジー エルエルシー | トウモロコシにおける脂肪酸デサチュラーゼの発現 |
| ES2529572T3 (es) | 2004-04-22 | 2015-02-23 | Commonwealth Scientific And Industrial Research Organisation | Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes |
| PL1756280T3 (pl) | 2004-04-22 | 2015-04-30 | Commw Scient Ind Res Org | Synteza długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach rekombinowanych |
| AU2005250074B2 (en) | 2004-06-04 | 2011-04-14 | Fluxome Sciences A/S | Metabolically engineered cells for the production of polyunsaturated fatty acids |
| US7550651B2 (en) | 2004-06-25 | 2009-06-23 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| DE102004060340A1 (de) | 2004-07-16 | 2006-02-09 | Basf Plant Science Gmbh | Verfahren zur Erhöhung des Gehalts an mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen |
| JP4587451B2 (ja) | 2004-08-20 | 2010-11-24 | サントリーホールディングス株式会社 | ω３脂肪酸不飽和化活性を有するポリペプチドおよびそのポリペプチドをコードするポリヌクレオチドならびにそれらの利用 |
| WO2006031699A2 (en) * | 2004-09-10 | 2006-03-23 | Diversa Corporation | Compositions and methods for making and modifying oils |
| DE102004044421B4 (de) | 2004-09-14 | 2010-06-24 | Biotest Ag | Verfahren zur Trennung eines von Willebrand Faktors mit einer spezifischen VWF-Aktivität von wenigstens 50 E/mg VWF-Antigen von einem von Willebrand Faktor mit niedriger Aktivität und Verwendung von Hydroxylapatit dafür |
| GB0421937D0 (en) | 2004-10-02 | 2004-11-03 | Univ York | Acyl CoA synthetases |
| US8685679B2 (en) | 2004-11-04 | 2014-04-01 | E I Du Pont De Nemours And Company | Acyltransferase regulation to increase the percent of polyunsaturated fatty acids in total lipids and oils of oleaginous organisms |
| US7273746B2 (en) | 2004-11-04 | 2007-09-25 | E.I. Dupont De Nemours And Company | Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7198937B2 (en) | 2004-11-04 | 2007-04-03 | E. I. Du Pont De Nemours And Company | Mortierella alpina diacylglycerol acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7192762B2 (en) | 2004-11-04 | 2007-03-20 | E. I. Du Pont De Nemours And Company | Mortierella alpina glycerol-3-phosphate o-acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US20060094102A1 (en) | 2004-11-04 | 2006-05-04 | Zhixiong Xue | Ammonium transporter promoter for gene expression in oleaginous yeast |
| US7879591B2 (en) | 2004-11-04 | 2011-02-01 | E.I. Du Pont De Nemours And Company | High eicosapentaenoic acid producing strains of Yarrowia lipolytica |
| US7189559B2 (en) | 2004-11-04 | 2007-03-13 | E. I. Du Pont De Nemours And Company | Mortierella alpina lysophosphatidic acid acyltransferase homolog for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7550286B2 (en) * | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| US20100120103A1 (en) | 2004-12-14 | 2010-05-13 | Avesthagen Limited | Recombinant Production Docosahexaenoic Acid (DHA) in Yeast |
| DE102004063326A1 (de) | 2004-12-23 | 2006-07-06 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen |
| DE102004062294A1 (de) | 2004-12-23 | 2006-07-06 | Basf Plant Science Gmbh | Verfahren zur Herstellung von mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen |
| DE102005013779A1 (de) | 2005-03-22 | 2006-09-28 | Basf Plant Science Gmbh | Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen |
| WO2006127655A2 (en) | 2005-05-20 | 2006-11-30 | Washington State University | Enhancement of hydroxy fatty acid accumulation in oilseed plants |
| JP5033122B2 (ja) | 2005-05-23 | 2012-09-26 | アルカディア バイオサイエンシズ，インコーポレイテッド | 増量ガンマ−リノレン酸を含むベニバナ |
| WO2006135866A2 (en) | 2005-06-10 | 2006-12-21 | Martek Biosciences Corporation | Pufa polyketide synthase systems and uses thereof |
| WO2007005727A2 (en) | 2005-07-01 | 2007-01-11 | Martek Biosciences Corporation | Microwaveable popcorn and methods of making |
| US20110138495A1 (en) | 2005-07-05 | 2011-06-09 | Arthur Weissinger | Methods and Compositions for Expressing Proteins In Plants |
| DE102005038036A1 (de) | 2005-08-09 | 2007-02-15 | Basf Plant Science Gmbh | Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen |
| GB2431158A (en) | 2005-10-13 | 2007-04-18 | Rothamsted Res Ltd | Process for the production of arachidonic and/or eicosapentaenoic acid |
| DE102005052551A1 (de) | 2005-11-02 | 2007-05-16 | Rothamsted Res Harpenden | Verfahren zur Herstellung von y-Linolensäure und/oder Stearidonsäure in transgenen Brassicaceae und Linaceae |
| WO2007061742A1 (en) | 2005-11-23 | 2007-05-31 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| US9265745B2 (en) * | 2005-12-21 | 2016-02-23 | Brudy Technology S.L. | Use of DHA, EPA or DHA-derived EPA for treating a pathology associated with cellular oxidative damage |
| WO2007092460A2 (en) | 2006-02-03 | 2007-08-16 | The Texas A & M University System | Enhancing expression of value-added genes by transgenic expression of tombusvirus-based p19 gene mutants |
| GB0603160D0 (en) | 2006-02-16 | 2006-03-29 | Rothamsted Res Ltd | Nucleic acid |
| AR059376A1 (es) | 2006-02-21 | 2008-03-26 | Basf Plant Science Gmbh | Procedimiento para la produccion de acidos grasos poliinsaturados |
| MX340759B (es) | 2006-03-15 | 2015-03-11 | Dsm Ip Assets B V * | Aceites de semillas vegetales que contienen ácidos grasos poli-insaturados. |
| US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| WO2007133425A2 (en) | 2006-05-01 | 2007-11-22 | E.I. Du Pont De Nemours And Company | Fungal delta12 desaturase and delta15 desaturase motifs |
| EP2029751B1 (en) | 2006-05-29 | 2012-02-22 | Icon Genetics GmbH | Plant virus-based inducible expression system |
| DE102006034313A1 (de) | 2006-07-21 | 2008-01-24 | Basf Plant Science Gmbh | Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure |
| CA2659993C (en) | 2006-08-24 | 2016-01-05 | Basf Plant Science Gmbh | Isolation and characterization of a novel pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains |
| BRPI0716075A2 (pt) | 2006-08-29 | 2013-08-06 | Commw Scient Ind Res Org | sÍntese de Ácidos graxos |
| WO2008040787A2 (de) | 2006-10-06 | 2008-04-10 | Basf Plant Science Gmbh | Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen |
| US8916361B2 (en) | 2006-11-17 | 2014-12-23 | Abbott Laboratories | Elongase gene and uses thereof |
| US7709239B2 (en) | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| WO2008104559A1 (de) | 2007-02-27 | 2008-09-04 | Norddeutsche Pflanzenzucht | Verfahren zur herstellung von mehrfach ungesättigten fettsäuren in transgenen organismen |
| DK2129777T3 (en) | 2007-04-03 | 2016-01-25 | Du Pont | MULTIZYMER AND USE THEREOF FOR THE PRODUCTION OF polyunsaturated fatty acids |
| US8119860B2 (en) | 2007-04-16 | 2012-02-21 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| US7943365B2 (en) | 2007-05-03 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Δ-5 desaturases and their use in making polyunsaturated fatty acids |
| EP2154947A2 (en) | 2007-05-31 | 2010-02-24 | Monsanto Technology, LLC | Compositions for production of soybean with elevated oil content |
| CA2694661C (en) | 2007-07-31 | 2017-10-03 | Basf Plant Science Gmbh | Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms |
| WO2009016208A2 (de) | 2007-07-31 | 2009-02-05 | Basf Plant Science Gmbh | Elongasen und verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen |
| CA2700008A1 (en) | 2007-08-01 | 2009-02-05 | Bioglow Inc. | Bioluminescent plants comprising bacterial lux operon and methods of making same |
| US8119784B2 (en) | 2008-04-02 | 2012-02-21 | E. I. Du Pont De Nemours And Company | Delta-4 desaturase and its use in making polyunsaturated fatty acids |
| FR2929514B1 (fr) * | 2008-04-08 | 2011-01-14 | Lr Beva | Compositions comprenant de l'acide myristique, des acides gras comprenant un diene conjugue n-5cis, n-7trans ou un triene conjugue n-5cis, n-7trans, n-9cis et leurs applications |
| CA2721879A1 (en) | 2008-04-25 | 2009-10-29 | Basf Plant Science Gmbh | Plant seed oil |
| US20110218348A1 (en) | 2008-04-25 | 2011-09-08 | Commonwealth Scientific Industrial Research Organisation | Polypeptides and methods for producing triacylglycerols comprising modified fatty acids |
| US8785727B2 (en) | 2008-04-30 | 2014-07-22 | Rothamsted Research Ltd. | Desaturase and method for the production of polyunsaturated fatty acids in transgenic organisms |
| JP5047872B2 (ja) | 2008-04-30 | 2012-10-10 | 篠田プラズマ株式会社 | ガス放電管および表示装置 |
| US7807899B2 (en) | 2008-05-08 | 2010-10-05 | Monsanto Technology Llc | Plants and seeds of hybrid corn variety CH720554 |
| CA2726489A1 (en) | 2008-06-03 | 2009-12-10 | Basf Plant Science Gmbh | Fatiy acid dehydratases and uses thereof |
| US8874418B2 (en) | 2008-06-16 | 2014-10-28 | Engineering Services Networks, Inc. | Systems and methods for automated simulation of a propulsion system and testing of propulsion control systems |
| US8168858B2 (en) | 2008-06-20 | 2012-05-01 | E. I. Du Pont De Nemours And Company | Delta-9 fatty acid elongase genes and their use in making polyunsaturated fatty acids |
| WO2010000708A2 (en) | 2008-07-01 | 2010-01-07 | Basf Plant Science Gmbh | Promoters from brassica napus for seed specific gene expression |
| CA2768737A1 (en) | 2008-07-21 | 2010-01-28 | Commonwealth Scientific And Industrial Research Organisation | Improved vegetable oils and uses therefor |
| ES2603530T3 (es) | 2008-07-21 | 2017-02-28 | Commonwealth Scientific And Industrial Research Organisation | Aceite de semilla de algodón mejorado y usos |
| EP2331695B1 (en) | 2008-08-26 | 2014-07-23 | BASF Plant Science GmbH | Nucleic acids encoding desaturases and modified plant oil |
| EP2337791B1 (en) | 2008-10-14 | 2013-07-24 | Monsanto Technology LLC | Utilization of fatty acid desaturases from hemiselmis spp |
| CA3015426C (en) | 2008-11-18 | 2020-01-14 | Commonwealth Scientific And Industrial Research Organisation | Recombinant cells comprising exogenous .delta.5 and .delta.6 desaturases, .delta.5 and .delta.6 elongases, and .delta.4 desaturases |
| DE112009003708T5 (de) | 2008-12-12 | 2012-09-13 | Basf Plant Science Gmbh | Desaturasen und Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenenOrganismen |
| CA2760326A1 (en) | 2009-05-13 | 2010-11-18 | Basf Plant Science Company Gmbh | Acyltransferases and uses thereof in fatty acid production |
| BRPI1009690A2 (pt) * | 2009-06-16 | 2015-08-25 | Du Pont | "célula hospedeira microbiana oleaginosa, óleo, método de elaboração de um óleo, método de aumento da eficiência de conversão de alongamento de c18 para c20 em uma célula hospedeira recombinante microbiana oleaginosa e método de aumento da eficiência de conversão de dessaturação (delta) 4 em uma célula hospedeira recombinante microbiana oleaginosa produtora de ácidos graxos póli-insaturados de cadeia longa" |
| US8188335B2 (en) | 2009-07-17 | 2012-05-29 | Abbott Laboratories | Δ9-elongase for production of polyunsaturated fatty acid-enriched oils |
| US9493520B2 (en) | 2009-07-17 | 2016-11-15 | Basf Plant Science Company Gmbh | Fatty acid desaturases and elongases and uses thereof |
| US9428757B2 (en) | 2009-08-31 | 2016-08-30 | Basf Plant Science Company Gmbh | Regulatory nucleic acid molecules for enhancing seed-specific gene expression in plants promoting enhanced polyunsaturated fatty acid synthesis |
| WO2011064181A1 (en) | 2009-11-24 | 2011-06-03 | Basf Plant Science Company Gmbh | Novel fatty acid desaturase and uses thereof |
| EP2504438A1 (en) | 2009-11-24 | 2012-10-03 | BASF Plant Science Company GmbH | Novel fatty acid elongase and uses thereof |
| TW201144442A (en) | 2010-05-17 | 2011-12-16 | Dow Agrosciences Llc | Production of DHA and other LC-PUFAs in plants |
| CA2804025C (en) | 2010-06-28 | 2023-02-21 | Commonwealth Scientific And Industrial Research Organisation | Methods of producing lipids |
| CN106434392A (zh) * | 2010-10-01 | 2017-02-22 | 国立大学法人九州大学 | 原生藻菌的转化方法 |
| AU2011317632B2 (en) | 2010-10-21 | 2016-08-18 | Basf Plant Science Company Gmbh | Novel fatty acid desaturases, elongases, elongation components and uses therof |
| TW201307553A (zh) | 2011-07-26 | 2013-02-16 | Dow Agrosciences Llc | 在植物中生產二十二碳六烯酸（ｄｈａ）及其他長鏈多元不飽和脂肪酸（ｌｃ－ｐｕｆａ）之技術 |
| BR112014025265A2 (pt) | 2012-04-12 | 2017-07-11 | Rothamsted Res Ltd | produção de ácidos graxos poli-insaturados ômega-3 de cadeia longa |
| HUE033766T2 (en) | 2012-06-15 | 2018-01-29 | Commw Scient Ind Res Org | Production of long chain polyunsaturated fatty acids in plant cells |
| AU2013298113A1 (en) | 2012-08-03 | 2015-01-29 | Basf Plant Science Company Gmbh | Novel enzymes, enzyme components and uses thereof |
| GB201217524D0 (en) | 2012-10-01 | 2012-11-14 | Rothamsted Res Ltd | Recombinant organisms |
| EA037817B1 (ru) | 2013-12-18 | 2021-05-25 | Коммонвелт Сайнтифик Энд Индастриэл Рисерч Организэйшн | Экстрагированный растительный липид, содержащий длинноцепочечные полиненасыщенные жирные кислоты |
| CA2953008C (en) | 2014-06-27 | 2024-03-19 | Nuseed Pty Ltd | Lipid comprising docosapentaenoic acid |
-
2014
- 2014-12-18 EA EA201600471A patent/EA037817B1/ru unknown
- 2014-12-18 US US14/575,756 patent/US9725399B2/en active Active
- 2014-12-18 NZ NZ721036A patent/NZ721036A/en unknown
- 2014-12-18 EP EP14870813.4A patent/EP3082405A4/en active Pending
- 2014-12-18 CA CA3241340A patent/CA3241340A1/en active Pending
- 2014-12-18 JP JP2016541363A patent/JP6726619B2/ja active Active
- 2014-12-18 CN CN201410796297.7A patent/CN104726473B/zh active Active
- 2014-12-18 KR KR1020167019100A patent/KR102386838B1/ko active Active
- 2014-12-18 AU AU2014366839A patent/AU2014366839B2/en active Active
- 2014-12-18 KR KR1020227011997A patent/KR102535223B1/ko active Active
- 2014-12-18 UA UAA201607729A patent/UA122768C2/uk unknown
- 2014-12-18 WO PCT/AU2014/050433 patent/WO2015089587A1/en not_active Ceased
- 2014-12-18 CN CN202010034905.6A patent/CN111154724B/zh active Active
- 2014-12-18 CA CA2933909A patent/CA2933909A1/en active Pending
- 2014-12-18 PH PH1/2016/501194A patent/PH12016501194B1/en unknown
- 2014-12-18 SG SG11201604871VA patent/SG11201604871VA/en unknown
- 2014-12-18 PE PE2016000847A patent/PE20170253A1/es unknown
- 2014-12-18 MX MX2016008270A patent/MX384370B/es unknown
- 2014-12-18 BR BR112016014508A patent/BR112016014508A2/pt not_active Application Discontinuation
-
2015
- 2015-06-18 MX MX2016017355A patent/MX394273B/es unknown
- 2015-06-18 EA EA202092987A patent/EA202092987A3/ru unknown
- 2015-06-18 PE PE2016002775A patent/PE20170431A1/es unknown
- 2015-06-18 US US14/743,531 patent/US9718759B2/en active Active
- 2015-06-18 JP JP2016575436A patent/JP6855249B2/ja active Active
-
2016
- 2016-06-16 IL IL246275A patent/IL246275B/en active IP Right Grant
- 2016-06-17 CL CL2016001560A patent/CL2016001560A1/es unknown
-
2017
- 2017-01-13 US US15/406,099 patent/US10190073B2/en active Active
- 2017-06-08 US US15/617,642 patent/US10125084B2/en active Active
-
2018
- 2018-09-28 US US16/146,469 patent/US11623911B2/en active Active
- 2018-12-14 US US16/220,695 patent/US10800729B2/en active Active
-
2019
- 2019-09-17 JP JP2019168194A patent/JP6972074B2/ja active Active
- 2019-10-29 CL CL2019003105A patent/CL2019003105A1/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6972074B2 (ja) | 長鎖多価不飽和脂肪酸を含む脂質 | |
| US12421472B2 (en) | Process for producing extracted lipid comprising docosahexaenoic acid | |
| US10793507B2 (en) | Lipid compositions comprising triacylglycerol with long-chain polyunsaturated fatty acids at the SN-2 position | |
| JP2017503053A5 (enExample) | ||
| JP7668830B2 (ja) | ドコサペンタエン酸を含む脂質 | |
| US20230416186A1 (en) | Lipid compositions comprising triacylglycerol with long-chain polyunsaturated fatty acids |