JP2017503030A5 - - Google Patents
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- JP2017503030A5 JP2017503030A5 JP2016565135A JP2016565135A JP2017503030A5 JP 2017503030 A5 JP2017503030 A5 JP 2017503030A5 JP 2016565135 A JP2016565135 A JP 2016565135A JP 2016565135 A JP2016565135 A JP 2016565135A JP 2017503030 A5 JP2017503030 A5 JP 2017503030A5
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- JP
- Japan
- Prior art keywords
- composition
- receptor antagonist
- crf1 receptor
- nbi
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002464 receptor antagonist Substances 0.000 claims description 36
- 229940044551 receptor antagonist Drugs 0.000 claims description 36
- 108091005471 CRHR1 Proteins 0.000 claims description 35
- 239000000203 mixture Substances 0.000 claims description 21
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 claims description 12
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 claims description 12
- 229960000258 corticotropin Drugs 0.000 claims description 12
- 230000027288 circadian rhythm Effects 0.000 claims description 10
- 238000010494 dissociation reaction Methods 0.000 claims description 9
- 230000005593 dissociations Effects 0.000 claims description 9
- VKHVAUKFLBBZFJ-SFHVURJKSA-N 3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-n-[(1s)-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]pyrazolo[1,5-a]pyrimidin-7-amine Chemical compound N([C@@H](CC)C=1ON=C(C)N=1)C(N1N=C2C)=CC(C)=NC1=C2C1=CC=C(OC)C=C1C VKHVAUKFLBBZFJ-SFHVURJKSA-N 0.000 claims description 8
- -1 3-methyl-1 , 2,4-oxadiazol-5-yl Chemical group 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- AKLMUGFDGONMAA-UHFFFAOYSA-N 268545-87-5 Chemical compound C=12C3=NC(C)=CC=1N(C(CCC)CCC)CCN2N=C3C1=CC=C(Cl)C=C1Cl AKLMUGFDGONMAA-UHFFFAOYSA-N 0.000 claims description 5
- QBBJSFUFEUXTNU-UHFFFAOYSA-N 3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-n-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-amine Chemical compound CC1=NN2C(NC(CC)CC)=CC(C)=NC2=C1C1=CC=C(OC)C=C1C QBBJSFUFEUXTNU-UHFFFAOYSA-N 0.000 claims description 5
- ANNRUWYFVIGKHA-UHFFFAOYSA-N 3-[6-(dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethyl-n,n-dipropylpyrazolo[1,5-a]pyrimidin-7-amine Chemical compound CC1=NN2C(N(CCC)CCC)=CC(C)=NC2=C1C1=CN=C(N(C)C)C=C1C ANNRUWYFVIGKHA-UHFFFAOYSA-N 0.000 claims description 5
- IEAKXXNRGSLYTQ-DEOSSOPVSA-N SSR 125543 Chemical compound C1=C(C)C(OC)=CC(Cl)=C1C1=C(C)SC(N(CC#C)[C@@H](CC2CC2)C=2C=C(F)C(C)=CC=2)=N1 IEAKXXNRGSLYTQ-DEOSSOPVSA-N 0.000 claims description 5
- 206010010356 Congenital anomaly Diseases 0.000 claims description 4
- 230000001780 adrenocortical effect Effects 0.000 claims description 4
- 206010020718 hyperplasia Diseases 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- JAVQQLIFVFPAQG-UHFFFAOYSA-N 2-phenyl-7h-pyrrolo[2,3-d]pyrimidin-4-amine Chemical compound N=1C=2NC=CC=2C(N)=NC=1C1=CC=CC=C1 JAVQQLIFVFPAQG-UHFFFAOYSA-N 0.000 claims description 3
- DBPWSSGDRRHUNT-CEGNMAFCSA-N 17α-hydroxyprogesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DBPWSSGDRRHUNT-CEGNMAFCSA-N 0.000 claims description 2
- PEHVGBZKEYRQSX-UHFFFAOYSA-N 7-deaza-adenine Chemical compound NC1=NC=NC2=C1C=CN2 PEHVGBZKEYRQSX-UHFFFAOYSA-N 0.000 claims description 2
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 208000005676 Adrenogenital syndrome Diseases 0.000 claims 1
- 208000008448 Congenital adrenal hyperplasia Diseases 0.000 claims 1
- WPFZGADUIUVTCF-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidin-7-amine Chemical compound NC1=CC=NC2=CC=NN12 WPFZGADUIUVTCF-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 13
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019043466A JP6936825B2 (ja) | 2014-01-21 | 2019-03-11 | 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461929941P | 2014-01-21 | 2014-01-21 | |
| US61/929,941 | 2014-01-21 | ||
| US201461981033P | 2014-04-17 | 2014-04-17 | |
| US61/981,033 | 2014-04-17 | ||
| US201462069155P | 2014-10-27 | 2014-10-27 | |
| US62/069,155 | 2014-10-27 | ||
| PCT/US2015/012315 WO2015112642A1 (en) | 2014-01-21 | 2015-01-21 | Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019043466A Division JP6936825B2 (ja) | 2014-01-21 | 2019-03-11 | 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503030A JP2017503030A (ja) | 2017-01-26 |
| JP2017503030A5 true JP2017503030A5 (https=) | 2018-03-01 |
| JP6585625B2 JP6585625B2 (ja) | 2019-10-02 |
Family
ID=52450623
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565135A Active JP6585625B2 (ja) | 2014-01-21 | 2015-01-21 | 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト |
| JP2019043466A Active JP6936825B2 (ja) | 2014-01-21 | 2019-03-11 | 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト |
| JP2020099865A Active JP7104743B2 (ja) | 2014-01-21 | 2020-06-09 | 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト |
| JP2021184620A Withdrawn JP2022010260A (ja) | 2014-01-21 | 2021-11-12 | 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト |
| JP2024079330A Pending JP2024098001A (ja) | 2014-01-21 | 2024-05-15 | 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019043466A Active JP6936825B2 (ja) | 2014-01-21 | 2019-03-11 | 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト |
| JP2020099865A Active JP7104743B2 (ja) | 2014-01-21 | 2020-06-09 | 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト |
| JP2021184620A Withdrawn JP2022010260A (ja) | 2014-01-21 | 2021-11-12 | 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト |
| JP2024079330A Pending JP2024098001A (ja) | 2014-01-21 | 2024-05-15 | 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US20170020877A1 (https=) |
| EP (2) | EP4450070A1 (https=) |
| JP (5) | JP6585625B2 (https=) |
| KR (2) | KR102258522B1 (https=) |
| CN (2) | CN106102740A (https=) |
| AU (4) | AU2015209452C1 (https=) |
| BR (1) | BR112016016975B1 (https=) |
| CA (2) | CA2936974A1 (https=) |
| DK (1) | DK3096756T3 (https=) |
| ES (1) | ES2984706T3 (https=) |
| FI (1) | FI3096756T3 (https=) |
| HR (1) | HRP20241046T1 (https=) |
| HU (1) | HUE068315T2 (https=) |
| IL (5) | IL296683B2 (https=) |
| LT (1) | LT3096756T (https=) |
| MX (3) | MX389004B (https=) |
| NZ (1) | NZ722122A (https=) |
| PL (1) | PL3096756T3 (https=) |
| PT (1) | PT3096756T (https=) |
| RS (1) | RS65839B1 (https=) |
| RU (1) | RU2718918C2 (https=) |
| SI (1) | SI3096756T1 (https=) |
| SM (1) | SMT202400361T1 (https=) |
| WO (1) | WO2015112642A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015112642A1 (en) | 2014-01-21 | 2015-07-30 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia |
| CA2940242C (en) | 2014-02-20 | 2026-01-13 | H. Lundbeck A/S | Anti-acth antibodies and use thereof |
| EP3510029B1 (en) | 2016-09-07 | 2025-11-05 | The Regents of The University of California | Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition |
| CN118845788A (zh) | 2017-08-14 | 2024-10-29 | 云杉生物科学公司 | 促肾上腺皮质激素释放因子受体拮抗剂 |
| EP4438124A3 (en) | 2018-04-27 | 2024-12-18 | Spruce Biosciences, Inc. | Methods for treating testicular and ovarian adrenal rest tumors |
| JP7532328B2 (ja) * | 2018-12-07 | 2024-08-13 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト、その医薬製剤および固体形態 |
| CA3121920A1 (en) * | 2018-12-07 | 2020-06-11 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia |
| TW202116324A (zh) * | 2019-07-19 | 2021-05-01 | 美商雲杉生物科技股份有限公司 | 治療先天性腎上腺增生之方法 |
| JP7623365B2 (ja) * | 2019-09-27 | 2025-01-28 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | Ｃｒｆ受容体アンタゴニストおよび使用方法 |
| IL298901A (en) * | 2020-06-10 | 2023-02-01 | Neurocrine Biosciences Inc | A CRF1 receptor antagonist for the treatment of congenital adrenal hyperplasia |
| BR112023002497A2 (pt) * | 2020-08-12 | 2023-05-02 | Spruce Biosciences Inc | Métodos e composições para tratamento da síndrome dos ovários policísticos |
| MD20210019A2 (ro) | 2021-04-12 | 2022-10-31 | Максим МАСЮТИН | Metodă de tratament a hiperplaziei suprarenale congenitale, cauzate de deficit de 21-hidroxilază cu debut tardiv prin regimul de glucocorticoizi adaptat individual |
| US11708372B2 (en) | 2021-11-19 | 2023-07-25 | Spruce Biosciences, Inc. | Crystalline composition of tildacerfont and methods of use and preparation thereof |
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| EA202090321A1 (ru) | 2017-08-14 | 2020-09-24 | Спрюс Биосайнсес, Инк. | Антагонисты рецептора кортикотропин-рилизинг фактора |
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