PT3096756T - Antagonistas do recetor crf1 para o tratamento da hiperplasia adrenal congénita - Google Patents
Antagonistas do recetor crf1 para o tratamento da hiperplasia adrenal congénitaInfo
- Publication number
- PT3096756T PT3096756T PT157029174T PT15702917T PT3096756T PT 3096756 T PT3096756 T PT 3096756T PT 157029174 T PT157029174 T PT 157029174T PT 15702917 T PT15702917 T PT 15702917T PT 3096756 T PT3096756 T PT 3096756T
- Authority
- PT
- Portugal
- Prior art keywords
- treatment
- receptor antagonists
- adrenal hyperplasia
- congenital adrenal
- crf1 receptor
- Prior art date
Links
- 208000005676 Adrenogenital syndrome Diseases 0.000 title 1
- 108091005471 CRHR1 Proteins 0.000 title 1
- 208000008448 Congenital adrenal hyperplasia Diseases 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461929941P | 2014-01-21 | 2014-01-21 | |
| US201461981033P | 2014-04-17 | 2014-04-17 | |
| US201462069155P | 2014-10-27 | 2014-10-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3096756T true PT3096756T (pt) | 2024-08-26 |
Family
ID=52450623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT157029174T PT3096756T (pt) | 2014-01-21 | 2015-01-21 | Antagonistas do recetor crf1 para o tratamento da hiperplasia adrenal congénita |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US20170020877A1 (https=) |
| EP (2) | EP4450070A1 (https=) |
| JP (5) | JP6585625B2 (https=) |
| KR (2) | KR102258522B1 (https=) |
| CN (2) | CN106102740A (https=) |
| AU (4) | AU2015209452C1 (https=) |
| BR (1) | BR112016016975B1 (https=) |
| CA (2) | CA2936974A1 (https=) |
| DK (1) | DK3096756T3 (https=) |
| ES (1) | ES2984706T3 (https=) |
| FI (1) | FI3096756T3 (https=) |
| HR (1) | HRP20241046T1 (https=) |
| HU (1) | HUE068315T2 (https=) |
| IL (5) | IL296683B2 (https=) |
| LT (1) | LT3096756T (https=) |
| MX (3) | MX389004B (https=) |
| NZ (1) | NZ722122A (https=) |
| PL (1) | PL3096756T3 (https=) |
| PT (1) | PT3096756T (https=) |
| RS (1) | RS65839B1 (https=) |
| RU (1) | RU2718918C2 (https=) |
| SI (1) | SI3096756T1 (https=) |
| SM (1) | SMT202400361T1 (https=) |
| WO (1) | WO2015112642A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015112642A1 (en) | 2014-01-21 | 2015-07-30 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia |
| CA2940242C (en) | 2014-02-20 | 2026-01-13 | H. Lundbeck A/S | Anti-acth antibodies and use thereof |
| EP3510029B1 (en) | 2016-09-07 | 2025-11-05 | The Regents of The University of California | Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition |
| CN118845788A (zh) | 2017-08-14 | 2024-10-29 | 云杉生物科学公司 | 促肾上腺皮质激素释放因子受体拮抗剂 |
| EP4438124A3 (en) | 2018-04-27 | 2024-12-18 | Spruce Biosciences, Inc. | Methods for treating testicular and ovarian adrenal rest tumors |
| JP7532328B2 (ja) * | 2018-12-07 | 2024-08-13 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト、その医薬製剤および固体形態 |
| CA3121920A1 (en) * | 2018-12-07 | 2020-06-11 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia |
| TW202116324A (zh) * | 2019-07-19 | 2021-05-01 | 美商雲杉生物科技股份有限公司 | 治療先天性腎上腺增生之方法 |
| JP7623365B2 (ja) * | 2019-09-27 | 2025-01-28 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | Ｃｒｆ受容体アンタゴニストおよび使用方法 |
| IL298901A (en) * | 2020-06-10 | 2023-02-01 | Neurocrine Biosciences Inc | A CRF1 receptor antagonist for the treatment of congenital adrenal hyperplasia |
| BR112023002497A2 (pt) * | 2020-08-12 | 2023-05-02 | Spruce Biosciences Inc | Métodos e composições para tratamento da síndrome dos ovários policísticos |
| MD20210019A2 (ro) | 2021-04-12 | 2022-10-31 | Максим МАСЮТИН | Metodă de tratament a hiperplaziei suprarenale congenitale, cauzate de deficit de 21-hidroxilază cu debut tardiv prin regimul de glucocorticoizi adaptat individual |
| US11708372B2 (en) | 2021-11-19 | 2023-07-25 | Spruce Biosciences, Inc. | Crystalline composition of tildacerfont and methods of use and preparation thereof |
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| EA202090321A1 (ru) | 2017-08-14 | 2020-09-24 | Спрюс Биосайнсес, Инк. | Антагонисты рецептора кортикотропин-рилизинг фактора |
| EP4438124A3 (en) * | 2018-04-27 | 2024-12-18 | Spruce Biosciences, Inc. | Methods for treating testicular and ovarian adrenal rest tumors |
| CA3121920A1 (en) | 2018-12-07 | 2020-06-11 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia |
| TW202116324A (zh) | 2019-07-19 | 2021-05-01 | 美商雲杉生物科技股份有限公司 | 治療先天性腎上腺增生之方法 |
| JP7623365B2 (ja) | 2019-09-27 | 2025-01-28 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | Ｃｒｆ受容体アンタゴニストおよび使用方法 |
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2015
- 2015-01-21 WO PCT/US2015/012315 patent/WO2015112642A1/en not_active Ceased
- 2015-01-21 MX MX2016009499A patent/MX389004B/es unknown
- 2015-01-21 PT PT157029174T patent/PT3096756T/pt unknown
- 2015-01-21 IL IL296683A patent/IL296683B2/en unknown
- 2015-01-21 ES ES15702917T patent/ES2984706T3/es active Active
- 2015-01-21 CA CA2936974A patent/CA2936974A1/en active Pending
- 2015-01-21 AU AU2015209452A patent/AU2015209452C1/en active Active
- 2015-01-21 HU HUE15702917A patent/HUE068315T2/hu unknown
- 2015-01-21 CN CN201580005270.4A patent/CN106102740A/zh active Pending
- 2015-01-21 CA CA3155599A patent/CA3155599A1/en active Pending
- 2015-01-21 US US15/113,362 patent/US20170020877A1/en not_active Abandoned
- 2015-01-21 IL IL317035A patent/IL317035A/en unknown
- 2015-01-21 BR BR112016016975-1A patent/BR112016016975B1/pt active IP Right Grant
- 2015-01-21 PL PL15702917.4T patent/PL3096756T3/pl unknown
- 2015-01-21 JP JP2016565135A patent/JP6585625B2/ja active Active
- 2015-01-21 RU RU2016133972A patent/RU2718918C2/ru active
- 2015-01-21 EP EP24174933.2A patent/EP4450070A1/en active Pending
- 2015-01-21 EP EP15702917.4A patent/EP3096756B1/en active Active
- 2015-01-21 IL IL304134A patent/IL304134B2/en unknown
- 2015-01-21 KR KR1020167022375A patent/KR102258522B1/ko active Active
- 2015-01-21 RS RS20240910A patent/RS65839B1/sr unknown
- 2015-01-21 CN CN202010134003.XA patent/CN111228274A/zh active Pending
- 2015-01-21 KR KR1020217015795A patent/KR20210064407A/ko not_active Ceased
- 2015-01-21 HR HRP20241046TT patent/HRP20241046T1/hr unknown
- 2015-01-21 FI FIEP15702917.4T patent/FI3096756T3/fi active
- 2015-01-21 NZ NZ722122A patent/NZ722122A/en unknown
- 2015-01-21 SM SM20240361T patent/SMT202400361T1/it unknown
- 2015-01-21 SI SI201532025T patent/SI3096756T1/sl unknown
- 2015-01-21 DK DK15702917.4T patent/DK3096756T3/da active
- 2015-01-21 LT LTEPPCT/US2015/012315T patent/LT3096756T/lt unknown
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2016
- 2016-07-14 IL IL246783A patent/IL246783B/en unknown
- 2016-07-21 MX MX2022000080A patent/MX2022000080A/es unknown
- 2016-07-21 MX MX2021012539A patent/MX2021012539A/es unknown
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2018
- 2018-12-20 US US16/227,127 patent/US10905690B2/en active Active
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2019
- 2019-03-11 JP JP2019043466A patent/JP6936825B2/ja active Active
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2020
- 2020-06-09 JP JP2020099865A patent/JP7104743B2/ja active Active
- 2020-07-20 AU AU2020207774A patent/AU2020207774B2/en active Active
- 2020-10-20 US US17/074,845 patent/US11730739B2/en active Active
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2021
- 2021-08-04 US US17/393,553 patent/US11311544B2/en active Active
- 2021-09-29 IL IL286782A patent/IL286782A/en unknown
- 2021-11-12 JP JP2021184620A patent/JP2022010260A/ja not_active Withdrawn
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2022
- 2022-10-31 AU AU2022263460A patent/AU2022263460B2/en active Active
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2023
- 2023-07-14 US US18/222,011 patent/US20240058342A1/en active Pending
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2024
- 2024-05-15 JP JP2024079330A patent/JP2024098001A/ja active Pending
- 2024-09-17 AU AU2024219813A patent/AU2024219813A1/en active Pending
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