MX2016015762A - Derivados de alquilo y arilo de compuestos de 1-oxa-4,9-diazaspiro undecano que tienen actividad multimodal contra el dolor. - Google Patents

Derivados de alquilo y arilo de compuestos de 1-oxa-4,9-diazaspiro undecano que tienen actividad multimodal contra el dolor.

Info

Publication number
MX2016015762A
MX2016015762A MX2016015762A MX2016015762A MX2016015762A MX 2016015762 A MX2016015762 A MX 2016015762A MX 2016015762 A MX2016015762 A MX 2016015762A MX 2016015762 A MX2016015762 A MX 2016015762A MX 2016015762 A MX2016015762 A MX 2016015762A
Authority
MX
Mexico
Prior art keywords
oxa
alkyl
compounds
activity against
aryl derivatives
Prior art date
Application number
MX2016015762A
Other languages
English (en)
Inventor
Virgili-Bernado Marina
ALONSO-XALMA Mónica
ALEGRET-MOLINA Carlos
Almansa-Rosales Carmen
GARCIA-LOPEZ Mónica
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of MX2016015762A publication Critical patent/MX2016015762A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula general (I) con actividad farmacológica dual contra tanto el receptor sigma (s) como el receptor opioide µ y más particularmente a compuestos de diazaspiro undecano que presentan esta actividad farmacológica, a procesos para preparar tales compuestos, a composiciones farmacéuticas que los comprenden y a su uso en terapia, en particular para el tratamiento del dolor. (ver Fórmula).
MX2016015762A 2014-06-02 2015-06-02 Derivados de alquilo y arilo de compuestos de 1-oxa-4,9-diazaspiro undecano que tienen actividad multimodal contra el dolor. MX2016015762A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14382207 2014-06-02
PCT/EP2015/001113 WO2015185207A1 (en) 2014-06-02 2015-06-02 Alkyl and aryl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain

Publications (1)

Publication Number Publication Date
MX2016015762A true MX2016015762A (es) 2017-04-10

Family

ID=50972616

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016015762A MX2016015762A (es) 2014-06-02 2015-06-02 Derivados de alquilo y arilo de compuestos de 1-oxa-4,9-diazaspiro undecano que tienen actividad multimodal contra el dolor.

Country Status (11)

Country Link
US (2) US10703765B2 (es)
EP (1) EP3149007B1 (es)
JP (1) JP6535687B2 (es)
CN (1) CN106459093A (es)
AR (1) AR100714A1 (es)
CA (1) CA2949570A1 (es)
ES (1) ES2784250T3 (es)
MX (1) MX2016015762A (es)
PT (1) PT3149007T (es)
TW (1) TW201615643A (es)
WO (1) WO2015185207A1 (es)

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TW201615642A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物
TWI685497B (zh) 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
MA43158B1 (fr) * 2015-10-23 2020-03-31 Esteve Pharmaceuticals Sa Composés oxa-diazadispiro possédant une activité contre la douleur
MX2018004776A (es) * 2015-10-23 2018-06-19 Esteve Labor Dr Compuestos oxaazaespiricos con actividad contral el dolor.
MX2018005439A (es) 2015-11-16 2018-11-09 Esteve Labor Dr Compuestos oxadiazoespiricos para el tratamiento del abuso y la adiccion a las drogas.
CN107216335B (zh) * 2017-06-29 2019-04-30 上海药明康德新药开发有限公司 一种叔丁基1-(羟甲基)-3-氧杂-9-氮杂螺[5.5]十一烷-9-甲酸基酯制法
TW201908295A (zh) * 2017-07-12 2019-03-01 德商歌林達有限公司 １，３－二氮雜－螺－［３．４］－辛烷衍生物
IL273751B2 (en) * 2017-10-17 2024-02-01 Esteve Pharmaceuticals Sa Salts of (R)-9-(5,2-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-9,4-diazaspiro[5.5]undecan-3-one
AR115012A1 (es) * 2018-03-23 2020-11-18 Esteve Pharmaceuticals Sa Derivados de aminopropoxifenilo y bencil 1-oxa-4,9-diazaespiroundecano con actividad multimodal contra el dolor
WO2021018824A1 (en) * 2019-07-31 2021-02-04 Esteve Pharmaceuticals, S.A. Use of (r)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one for the treatment of nociceptive pain, neuropathic pain, osteoarthritis pain and cancer pain, while having reduced side effects compared to opioids
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

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US4353900A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
WO1993013101A1 (en) * 1991-12-27 1993-07-08 Yoshitomi Pharmaceutical Industries, Ltd. Pyridonecarboxylate compound, pharmaceutical use thereof, and spiro compound
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TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
TWI685497B (zh) 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
TW201615642A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物
CA2967857A1 (en) 2014-11-21 2016-05-26 Laboratorios Del Dr. Esteve, S.A. 1,9-diazaspiro undecane compounds having multimodal activity against pain
MA43158B1 (fr) 2015-10-23 2020-03-31 Esteve Pharmaceuticals Sa Composés oxa-diazadispiro possédant une activité contre la douleur

Also Published As

Publication number Publication date
CA2949570A1 (en) 2015-12-10
ES2784250T3 (es) 2020-09-23
JP2017516819A (ja) 2017-06-22
WO2015185207A1 (en) 2015-12-10
JP6535687B2 (ja) 2019-06-26
CN106459093A (zh) 2017-02-22
US20170101420A1 (en) 2017-04-13
US10703765B2 (en) 2020-07-07
US20200339597A1 (en) 2020-10-29
TW201615643A (zh) 2016-05-01
EP3149007B1 (en) 2020-01-08
AR100714A1 (es) 2016-10-26
EP3149007A1 (en) 2017-04-05
PT3149007T (pt) 2020-04-16

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