JP2017503009A5 - - Google Patents
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- JP2017503009A5 JP2017503009A5 JP2016558545A JP2016558545A JP2017503009A5 JP 2017503009 A5 JP2017503009 A5 JP 2017503009A5 JP 2016558545 A JP2016558545 A JP 2016558545A JP 2016558545 A JP2016558545 A JP 2016558545A JP 2017503009 A5 JP2017503009 A5 JP 2017503009A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- antibody
- nhc
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 19
- 229940125644 antibody drug Drugs 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- -1 cyano, sulfonyl Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000006725 C1-C10 alkenyl group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 2
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 2
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 2
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 102100020998 Aspartate beta-hydroxylase domain-containing protein 1 Human genes 0.000 claims 1
- 102100025218 B-cell differentiation antigen CD72 Human genes 0.000 claims 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
- 102100027052 Bone morphogenetic protein receptor type-1B Human genes 0.000 claims 1
- 102100031658 C-X-C chemokine receptor type 5 Human genes 0.000 claims 1
- 102100024220 CD180 antigen Human genes 0.000 claims 1
- 102100025473 Carcinoembryonic antigen-related cell adhesion molecule 6 Human genes 0.000 claims 1
- 102100032768 Complement receptor type 2 Human genes 0.000 claims 1
- 102100020743 Dipeptidase 1 Human genes 0.000 claims 1
- 102100031517 Fc receptor-like protein 1 Human genes 0.000 claims 1
- 101710120224 Fc receptor-like protein 1 Proteins 0.000 claims 1
- 102100031511 Fc receptor-like protein 2 Human genes 0.000 claims 1
- 102100031507 Fc receptor-like protein 5 Human genes 0.000 claims 1
- 102100031546 HLA class II histocompatibility antigen, DO beta chain Human genes 0.000 claims 1
- 101000783987 Homo sapiens Aspartate beta-hydroxylase domain-containing protein 1 Proteins 0.000 claims 1
- 101000934359 Homo sapiens B-cell differentiation antigen CD72 Proteins 0.000 claims 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
- 101000984546 Homo sapiens Bone morphogenetic protein receptor type-1B Proteins 0.000 claims 1
- 101000922405 Homo sapiens C-X-C chemokine receptor type 5 Proteins 0.000 claims 1
- 101000980829 Homo sapiens CD180 antigen Proteins 0.000 claims 1
- 101000914326 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 6 Proteins 0.000 claims 1
- 101000941929 Homo sapiens Complement receptor type 2 Proteins 0.000 claims 1
- 101100499854 Homo sapiens DPEP1 gene Proteins 0.000 claims 1
- 101000846911 Homo sapiens Fc receptor-like protein 2 Proteins 0.000 claims 1
- 101000846908 Homo sapiens Fc receptor-like protein 5 Proteins 0.000 claims 1
- 101000866281 Homo sapiens HLA class II histocompatibility antigen, DO beta chain Proteins 0.000 claims 1
- 101001091205 Homo sapiens KiSS-1 receptor Proteins 0.000 claims 1
- 101001063456 Homo sapiens Leucine-rich repeat-containing G-protein coupled receptor 5 Proteins 0.000 claims 1
- 101001065550 Homo sapiens Lymphocyte antigen 6K Proteins 0.000 claims 1
- 101000620359 Homo sapiens Melanocyte protein PMEL Proteins 0.000 claims 1
- 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 claims 1
- 101000628535 Homo sapiens Metalloreductase STEAP2 Proteins 0.000 claims 1
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101000829779 Homo sapiens Probable G-protein coupled receptor 19 Proteins 0.000 claims 1
- 101000825475 Homo sapiens Protein shisa-2 homolog Proteins 0.000 claims 1
- 101000579425 Homo sapiens Proto-oncogene tyrosine-protein kinase receptor Ret Proteins 0.000 claims 1
- 101000853730 Homo sapiens RING finger and transmembrane domain-containing protein 2 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101000713169 Homo sapiens Solute carrier family 52, riboflavin transporter, member 2 Proteins 0.000 claims 1
- 101000835745 Homo sapiens Teratocarcinoma-derived growth factor 1 Proteins 0.000 claims 1
- 101000834937 Homo sapiens Tomoregulin-1 Proteins 0.000 claims 1
- 101000834948 Homo sapiens Tomoregulin-2 Proteins 0.000 claims 1
- 102100034845 KiSS-1 receptor Human genes 0.000 claims 1
- 102100031036 Leucine-rich repeat-containing G-protein coupled receptor 5 Human genes 0.000 claims 1
- 102100032129 Lymphocyte antigen 6K Human genes 0.000 claims 1
- 102100022430 Melanocyte protein PMEL Human genes 0.000 claims 1
- 102100026712 Metalloreductase STEAP1 Human genes 0.000 claims 1
- 102100026711 Metalloreductase STEAP2 Human genes 0.000 claims 1
- 102100023123 Mucin-16 Human genes 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100037603 P2X purinoceptor 5 Human genes 0.000 claims 1
- 101710189969 P2X purinoceptor 5 Proteins 0.000 claims 1
- 102100023417 Probable G-protein coupled receptor 19 Human genes 0.000 claims 1
- 102100022938 Protein shisa-2 homolog Human genes 0.000 claims 1
- 102100028286 Proto-oncogene tyrosine-protein kinase receptor Ret Human genes 0.000 claims 1
- 102100035928 RING finger and transmembrane domain-containing protein 2 Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 102100036862 Solute carrier family 52, riboflavin transporter, member 2 Human genes 0.000 claims 1
- 102100026404 Teratocarcinoma-derived growth factor 1 Human genes 0.000 claims 1
- 102100026159 Tomoregulin-1 Human genes 0.000 claims 1
- 102100026160 Tomoregulin-2 Human genes 0.000 claims 1
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 1
- 101710178300 Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 1
- 102000003425 Tyrosinase Human genes 0.000 claims 1
- 108060008724 Tyrosinase Proteins 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical group [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 150000003462 sulfoxides Chemical class 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 0 C*NC([C@](*)*(C1)*1C(S(C)=C)=O)=O Chemical compound C*NC([C@](*)*(C1)*1C(S(C)=C)=O)=O 0.000 description 3
- XYYXDARQOHWBPO-UHFFFAOYSA-N Cc1nnc(C)[nH]1 Chemical compound Cc1nnc(C)[nH]1 XYYXDARQOHWBPO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361916675P | 2013-12-16 | 2013-12-16 | |
| US61/916,675 | 2013-12-16 | ||
| PCT/US2014/070493 WO2015095124A1 (en) | 2013-12-16 | 2014-12-16 | Peptidomimetic compounds and antibody-drug conjugates thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019233580A Division JP2020045370A (ja) | 2013-12-16 | 2019-12-24 | ペプチド模倣薬化合物及びその抗体−薬剤複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503009A JP2017503009A (ja) | 2017-01-26 |
| JP2017503009A5 true JP2017503009A5 (enExample) | 2018-02-08 |
| JP6681838B2 JP6681838B2 (ja) | 2020-04-15 |
Family
ID=52273598
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016558545A Active JP6681838B2 (ja) | 2013-12-16 | 2014-12-16 | ペプチド模倣薬化合物及びその抗体−薬剤複合体 |
| JP2019233580A Pending JP2020045370A (ja) | 2013-12-16 | 2019-12-24 | ペプチド模倣薬化合物及びその抗体−薬剤複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019233580A Pending JP2020045370A (ja) | 2013-12-16 | 2019-12-24 | ペプチド模倣薬化合物及びその抗体−薬剤複合体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10533058B2 (enExample) |
| EP (1) | EP3082872B1 (enExample) |
| JP (2) | JP6681838B2 (enExample) |
| KR (2) | KR102337414B1 (enExample) |
| CN (1) | CN105848685B (enExample) |
| BR (1) | BR112016014126B1 (enExample) |
| CA (1) | CA2931798C (enExample) |
| EA (1) | EA033456B1 (enExample) |
| HK (1) | HK1222577A1 (enExample) |
| MX (1) | MX381017B (enExample) |
| NZ (1) | NZ720743A (enExample) |
| WO (1) | WO2015095124A1 (enExample) |
| ZA (1) | ZA201603697B (enExample) |
Families Citing this family (78)
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| US9399641B2 (en) | 2011-09-20 | 2016-07-26 | Medimmune Limited | Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates |
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| BR112016014126B1 (pt) * | 2013-12-16 | 2023-02-14 | Medimmune Limited | Composto não-peptídico, conjugados de anticorpo-fármaco do mesmo, uso dos ditos conjugados para o tratamento de câncer e composição farmacêutica que compreende os mesmos |
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| PT2528625E (pt) * | 2010-04-15 | 2013-10-17 | Spirogen Sarl | Pirrolobenzodiazepinas e conjugados das mesmas |
| CA3220104A1 (en) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| US9273210B2 (en) * | 2011-03-29 | 2016-03-01 | Covestro Deutschland Ag | Use of an aqueous preparation for the coating of wood surfaces to achieve a natural-touch effect |
| US9399641B2 (en) | 2011-09-20 | 2016-07-26 | Medimmune Limited | Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates |
| CA2850373C (en) * | 2011-10-14 | 2019-07-16 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| AU2012322934B2 (en) * | 2011-10-14 | 2016-09-08 | Medimmune Limited | Pyrrolobenzodiazepines |
| JP6104257B2 (ja) | 2011-10-14 | 2017-03-29 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピンおよびそのコンジュゲート |
| PE20150025A1 (es) | 2012-05-21 | 2015-02-09 | Genentech Inc | Anticuerpos e inmunoconjugados contra ly6e y metodos de uso |
| EP2906297B1 (en) * | 2012-10-12 | 2017-12-06 | ADC Therapeutics SA | Pyrrolobenzodiazepine-antibody conjugates |
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| US9803002B2 (en) | 2013-05-31 | 2017-10-31 | Genentench, Inc. | Anti-wall teichoic antibodies and conjugates |
| BR112016002829A2 (pt) | 2013-08-12 | 2017-09-19 | Genentech Inc | Composto e processo para preparar o composto de conjugado anticorpo-¿droga, composição farmacêutica, método de tratamento do câncer, kit para o tratamento do câncer, intermediário ligante¿-droga, porção e composto de porção droga de dímero cbi |
| BR112016014126B1 (pt) * | 2013-12-16 | 2023-02-14 | Medimmune Limited | Composto não-peptídico, conjugados de anticorpo-fármaco do mesmo, uso dos ditos conjugados para o tratamento de câncer e composição farmacêutica que compreende os mesmos |
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| BR112016012410A2 (pt) | 2013-12-16 | 2017-09-26 | Genentech Inc | conjugado de droga e anticorpo, composto conjugado de droga e anticorpo, composto não-peptídico, método de tratamento de doenças em seres humanos e composição farmacêutica |
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-
2014
- 2014-12-16 BR BR112016014126-1A patent/BR112016014126B1/pt not_active IP Right Cessation
- 2014-12-16 NZ NZ720743A patent/NZ720743A/en not_active IP Right Cessation
- 2014-12-16 EA EA201691059A patent/EA033456B1/ru not_active IP Right Cessation
- 2014-12-16 US US15/104,388 patent/US10533058B2/en active Active
- 2014-12-16 JP JP2016558545A patent/JP6681838B2/ja active Active
- 2014-12-16 CA CA2931798A patent/CA2931798C/en active Active
- 2014-12-16 HK HK16110846.7A patent/HK1222577A1/zh unknown
- 2014-12-16 KR KR1020167018766A patent/KR102337414B1/ko not_active Expired - Fee Related
- 2014-12-16 WO PCT/US2014/070493 patent/WO2015095124A1/en not_active Ceased
- 2014-12-16 KR KR1020217030522A patent/KR102405762B1/ko active Active
- 2014-12-16 EP EP14821453.9A patent/EP3082872B1/en active Active
- 2014-12-16 CN CN201480068353.3A patent/CN105848685B/zh active Active
- 2014-12-16 MX MX2016007851A patent/MX381017B/es unknown
-
2016
- 2016-05-31 ZA ZA201603697A patent/ZA201603697B/en unknown
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2019
- 2019-11-26 US US16/696,455 patent/US11692043B2/en active Active
- 2019-12-24 JP JP2019233580A patent/JP2020045370A/ja active Pending
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