KR102405762B1 - 펩타이드 모방체 화합물 및 이의 항체-약물 컨쥬게이트 - Google Patents

펩타이드 모방체 화합물 및 이의 항체-약물 컨쥬게이트 Download PDF

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KR102405762B1
KR102405762B1 KR1020217030522A KR20217030522A KR102405762B1 KR 102405762 B1 KR102405762 B1 KR 102405762B1 KR 1020217030522 A KR1020217030522 A KR 1020217030522A KR 20217030522 A KR20217030522 A KR 20217030522A KR 102405762 B1 KR102405762 B1 KR 102405762B1
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antibody
amino acid
seq
alkyl
acid sequence
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KR20210129700A (ko
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존 플라이게어
자넷 건즈너-토스테
토마스 필로
브라이언 사피나
비샬 베르마
빈칭 웨이
구일링 자오
리에나 스타벤
필립 윌슨 하워드
루크 마스터슨
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제넨테크, 인크.
메디뮨 리미티드
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    • A—HUMAN NECESSITIES
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020217030522A 2013-12-16 2014-12-16 펩타이드 모방체 화합물 및 이의 항체-약물 컨쥬게이트 Active KR102405762B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361916675P 2013-12-16 2013-12-16
US61/916,675 2013-12-16
KR1020167018766A KR102337414B1 (ko) 2013-12-16 2014-12-16 펩타이드 모방체 화합물 및 이의 항체-약물 컨쥬게이트
PCT/US2014/070493 WO2015095124A1 (en) 2013-12-16 2014-12-16 Peptidomimetic compounds and antibody-drug conjugates thereof

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KR1020167018766A Division KR102337414B1 (ko) 2013-12-16 2014-12-16 펩타이드 모방체 화합물 및 이의 항체-약물 컨쥬게이트

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KR20210129700A KR20210129700A (ko) 2021-10-28
KR102405762B1 true KR102405762B1 (ko) 2022-06-07

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