JP2017203040A5 - - Google Patents
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- Publication number
- JP2017203040A5 JP2017203040A5 JP2017154423A JP2017154423A JP2017203040A5 JP 2017203040 A5 JP2017203040 A5 JP 2017203040A5 JP 2017154423 A JP2017154423 A JP 2017154423A JP 2017154423 A JP2017154423 A JP 2017154423A JP 2017203040 A5 JP2017203040 A5 JP 2017203040A5
- Authority
- JP
- Japan
- Prior art keywords
- complex
- biocompatible polymer
- functional group
- fluorescent molecule
- composite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229920000249 biocompatible polymer Polymers 0.000 claims 10
- 125000000524 functional group Chemical group 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 6
- YSFGBPCBPNVLOK-UHFFFAOYSA-N 6-hydroxy-2-methylhex-2-enamide Chemical compound NC(=O)C(C)=CCCCO YSFGBPCBPNVLOK-UHFFFAOYSA-N 0.000 claims 4
- 229920001577 copolymer Polymers 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 125000006850 spacer group Chemical group 0.000 claims 4
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 claims 3
- 229930002875 chlorophyll Natural products 0.000 claims 3
- 235000019804 chlorophyll Nutrition 0.000 claims 3
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 150000004032 porphyrins Chemical class 0.000 claims 3
- 229950003776 protoporphyrin Drugs 0.000 claims 3
- IICCLYANAQEHCI-UHFFFAOYSA-N 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical group O1C(=O)C(C(=C(Cl)C(Cl)=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 IICCLYANAQEHCI-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- 238000001917 fluorescence detection Methods 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid group Chemical group C(\C=C/C(=O)O)(=O)O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- 239000003068 molecular probe Substances 0.000 claims 2
- 229930187593 rose bengal Natural products 0.000 claims 2
- 229940081623 rose bengal Drugs 0.000 claims 2
- STRXNPAVPKGJQR-UHFFFAOYSA-N rose bengal A Natural products O1C(=O)C(C(=CC=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 STRXNPAVPKGJQR-UHFFFAOYSA-N 0.000 claims 2
- KKAJSJJFBSOMGS-UHFFFAOYSA-N 3,6-diamino-10-methylacridinium chloride Chemical compound [Cl-].C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 KKAJSJJFBSOMGS-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229940023020 acriflavine Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229940106705 chlorophyll Drugs 0.000 claims 1
- 239000000693 micelle Substances 0.000 claims 1
- 239000011259 mixed solution Substances 0.000 claims 1
- 238000002428 photodynamic therapy Methods 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011193237 | 2011-09-05 | ||
| JP2011193237 | 2011-09-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016016296A Division JP2016128487A (ja) | 2011-09-05 | 2016-01-29 | 高分子型蛍光分子プローブ |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018202044A Division JP6708330B2 (ja) | 2011-09-05 | 2018-10-26 | 高分子型蛍光分子プローブ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017203040A JP2017203040A (ja) | 2017-11-16 |
| JP2017203040A5 true JP2017203040A5 (https=) | 2018-01-25 |
Family
ID=47832193
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532630A Active JP5904602B2 (ja) | 2011-09-05 | 2012-09-05 | 高分子型蛍光分子プローブ |
| JP2016016296A Pending JP2016128487A (ja) | 2011-09-05 | 2016-01-29 | 高分子型蛍光分子プローブ |
| JP2017154423A Pending JP2017203040A (ja) | 2011-09-05 | 2017-08-09 | 高分子型蛍光分子プローブ |
| JP2018202044A Active JP6708330B2 (ja) | 2011-09-05 | 2018-10-26 | 高分子型蛍光分子プローブ |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532630A Active JP5904602B2 (ja) | 2011-09-05 | 2012-09-05 | 高分子型蛍光分子プローブ |
| JP2016016296A Pending JP2016128487A (ja) | 2011-09-05 | 2016-01-29 | 高分子型蛍光分子プローブ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018202044A Active JP6708330B2 (ja) | 2011-09-05 | 2018-10-26 | 高分子型蛍光分子プローブ |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9636426B2 (https=) |
| EP (1) | EP2774625B1 (https=) |
| JP (4) | JP5904602B2 (https=) |
| AU (1) | AU2012305327B2 (https=) |
| CA (2) | CA2977873C (https=) |
| DK (1) | DK2774625T3 (https=) |
| ES (1) | ES2627026T3 (https=) |
| HU (1) | HUE032791T2 (https=) |
| PT (1) | PT2774625T (https=) |
| WO (1) | WO2013035750A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2835643A4 (en) * | 2012-04-06 | 2015-12-09 | Konica Minolta Inc | METHOD FOR DETECTING OR QUANTITATING ANALYSTS, KIT FOR DETECTING OR QUANTIFYING ANALYSTS AND TEST STRIPS FOR SIDEFLOW CHROMATOGRAPHY FOR DETECTING OR QUANTIFYING ANALYTES |
| JP2014219344A (ja) * | 2013-05-10 | 2014-11-20 | 株式会社 バイオラジカル研究所 | 活性酸素の測定方法 |
| EP3072910A4 (en) * | 2013-11-19 | 2018-02-21 | Hiroshi Maeda | Derivative of styrene-maleic acid copolymer |
| JP6803856B2 (ja) | 2015-05-11 | 2020-12-23 | ディクロニス サーグル | 循環系視覚化のための組成物 |
| KR101709165B1 (ko) * | 2015-06-30 | 2017-03-08 | 광주과학기술원 | 장 천공 진단 방법 |
| KR101668561B1 (ko) * | 2015-07-13 | 2016-10-21 | 원광대학교산학협력단 | 녹색형광단백질을 발현하는 유전자 및 로즈 벵갈을 이용한 암 질환의 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법 |
| CN105457027B (zh) * | 2015-12-30 | 2018-11-09 | 江苏大学 | 一种以卟啉为核的星型乳糖拟糖肽聚合物的制备方法 |
| JP2017128532A (ja) * | 2016-01-20 | 2017-07-27 | キヤノン株式会社 | 光学イメージング用造影剤の製造方法、及び光学イメージング用造影剤 |
| ES2971441T3 (es) * | 2016-05-06 | 2024-06-05 | Biodynamic Res Foundation | Composición farmacéutica que contiene un fármaco macromolecular |
| CN105985598B (zh) * | 2016-06-17 | 2021-05-28 | 燕山大学 | 一种染料-石墨烯-聚乙烯醇三元荧光复合物及制备方法 |
| CN105985599B (zh) * | 2016-06-17 | 2021-05-28 | 燕山大学 | 一种荧光高分子复合物及其制备方法 |
| JP6498654B2 (ja) | 2016-11-17 | 2019-04-10 | 一般財団法人バイオダイナミックス研究所 | 内視鏡による光照射治療用光照射プローブ |
| KR101911725B1 (ko) * | 2017-01-16 | 2018-12-28 | 주식회사 코어파마 | 적색형광단백질을 발현하는 유전자 및 틴 에틸 에티오푸르푸린을 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법 |
| JP7046321B2 (ja) * | 2018-01-12 | 2022-04-04 | 国立大学法人 筑波大学 | 修飾されたスチレン－無水マレイン酸共重合体及びその使用 |
| KR102204680B1 (ko) * | 2018-10-18 | 2021-01-19 | 한국전기연구원 | 내시경 영상 시스템, 방법, 및 상기 방법을 수행하기 위한 프로그램을 기록한 기록 매체 |
| US20200222564A1 (en) * | 2019-01-15 | 2020-07-16 | Tianjin University | Compound Amphiphilic Peptide Nanomicelle, Preparation and Use Thereof |
| KR20230043822A (ko) | 2020-07-31 | 2023-03-31 | 도레이 카부시키가이샤 | 복합체에 포함되는 약물의 순도 평가 방법 및 복합체의 제조 방법 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3557065A (en) * | 1969-09-29 | 1971-01-19 | Fmc Corp | Process for preparation of poly(maleic acid) |
| US4315998A (en) * | 1974-06-12 | 1982-02-16 | Research Corporation | Polymer-bound photosensitizing catalysts |
| US5258453A (en) * | 1992-01-21 | 1993-11-02 | University Of Utah | Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light |
| DE19731741A1 (de) * | 1997-07-23 | 1999-01-28 | Deutsches Krebsforsch | Konjugat zur Unterscheidung von krankhaftem und gesundem Gewebe |
| US6423547B1 (en) | 1998-04-03 | 2002-07-23 | Mallinckrodt Inc. | Non-covalent bioconjugates useful for diagnosis and therapy |
| ATE335513T1 (de) * | 1998-10-16 | 2006-09-15 | Gen Hospital Corp | Photosensitizer-konjugate zur zielrichtung von intrazellulare pathogene |
| US6217848B1 (en) * | 1999-05-20 | 2001-04-17 | Mallinckrodt Inc. | Cyanine and indocyanine dye bioconjugates for biomedical applications |
| GB0113121D0 (en) | 2001-05-30 | 2001-07-18 | Univ Leeds | Biologically active photosensitisers |
| JP5000050B2 (ja) * | 2001-08-31 | 2012-08-15 | 浩 前田 | 抗腫瘍剤及びその製造方法 |
| US7662360B2 (en) * | 2002-07-22 | 2010-02-16 | Psimei Pharmaceuticals Plc | Conjugates of N-hydroxypropymethacrylamide-methacrylate copolymer with nuclide activation agent and/or anti-cancer compounds |
| WO2004062588A2 (en) * | 2003-01-06 | 2004-07-29 | University Of Utah | Water-soluble polymeric bone-targeting drug delivery system |
| ES2642179T3 (es) | 2003-05-26 | 2017-11-15 | Hiroshi Maeda | Agente antitumoral y proceso para producir el mismo |
| WO2005058376A1 (en) * | 2003-12-17 | 2005-06-30 | Smithkline Beecham Corporation | Polymeric micellar complexes and drug delivery vehicles thereof |
| WO2006112361A1 (ja) | 2005-04-18 | 2006-10-26 | Hiroshi Maeda | 高分子型癌治療用医薬およびその製造方法 |
| WO2007023398A2 (en) * | 2005-05-16 | 2007-03-01 | Universite De Geneve | Compounds for photochemotherapy |
| GB0520436D0 (en) | 2005-10-07 | 2005-11-16 | Photobiotics Ltd | Biological materials and uses thereof |
| JP2007320902A (ja) | 2006-05-31 | 2007-12-13 | Utsunomiya Univ | クロロフィル・ナノ粒子及びの製造方法 |
| AU2009219682B2 (en) | 2008-02-27 | 2015-06-18 | Yeda Research & Development Co. Ltd | RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors |
| KR20100083632A (ko) * | 2009-01-14 | 2010-07-22 | 울산대학교 산학협력단 | 표적 단백질 분해효소 감응형 항암제 전구체 |
| US20130142734A1 (en) * | 2010-01-12 | 2013-06-06 | Ayelet David | Targeted delivery systems for diagnostic applications |
| JP2011193237A (ja) | 2010-03-15 | 2011-09-29 | Primeworks Kk | 移動体通信端末、及びその制御プログラム |
-
2012
- 2012-09-05 JP JP2013532630A patent/JP5904602B2/ja active Active
- 2012-09-05 CA CA2977873A patent/CA2977873C/en not_active Expired - Fee Related
- 2012-09-05 CA CA2851344A patent/CA2851344C/en active Active
- 2012-09-05 US US14/342,879 patent/US9636426B2/en active Active
- 2012-09-05 AU AU2012305327A patent/AU2012305327B2/en active Active
- 2012-09-05 ES ES12829505.2T patent/ES2627026T3/es active Active
- 2012-09-05 DK DK12829505.2T patent/DK2774625T3/en active
- 2012-09-05 HU HUE12829505A patent/HUE032791T2/en unknown
- 2012-09-05 PT PT128295052T patent/PT2774625T/pt unknown
- 2012-09-05 EP EP12829505.2A patent/EP2774625B1/en active Active
- 2012-09-05 WO PCT/JP2012/072640 patent/WO2013035750A1/ja not_active Ceased
-
2016
- 2016-01-29 JP JP2016016296A patent/JP2016128487A/ja active Pending
-
2017
- 2017-04-17 US US15/488,952 patent/US10946109B2/en not_active Expired - Fee Related
- 2017-08-09 JP JP2017154423A patent/JP2017203040A/ja active Pending
-
2018
- 2018-10-26 JP JP2018202044A patent/JP6708330B2/ja active Active
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