JP2017523781A5 - - Google Patents
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- Publication number
- JP2017523781A5 JP2017523781A5 JP2017505552A JP2017505552A JP2017523781A5 JP 2017523781 A5 JP2017523781 A5 JP 2017523781A5 JP 2017505552 A JP2017505552 A JP 2017505552A JP 2017505552 A JP2017505552 A JP 2017505552A JP 2017523781 A5 JP2017523781 A5 JP 2017523781A5
- Authority
- JP
- Japan
- Prior art keywords
- aptamer
- nucleic acid
- seq
- dimer
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091023037 Aptamer Proteins 0.000 claims 32
- 108091008104 nucleic acid aptamers Proteins 0.000 claims 15
- 239000000539 dimer Substances 0.000 claims 11
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical group 0.000 claims 7
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462031427P | 2014-07-31 | 2014-07-31 | |
| US62/031,427 | 2014-07-31 | ||
| PCT/US2015/043162 WO2016019270A1 (en) | 2014-07-31 | 2015-07-31 | An antagonistic pd-1 aptamer and its applications in cancer therapy related applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523781A JP2017523781A (ja) | 2017-08-24 |
| JP2017523781A5 true JP2017523781A5 (https=) | 2018-09-13 |
| JP6680760B2 JP6680760B2 (ja) | 2020-04-15 |
Family
ID=55218360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505552A Expired - Fee Related JP6680760B2 (ja) | 2014-07-31 | 2015-07-31 | アンタゴニストｉｃ ｐｄ−１アプタマー及びその癌治療関連用途への応用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10329570B2 (https=) |
| EP (1) | EP3174985A4 (https=) |
| JP (1) | JP6680760B2 (https=) |
| KR (1) | KR20170055474A (https=) |
| CN (1) | CN107002083A (https=) |
| CA (1) | CA2956718A1 (https=) |
| TW (1) | TWI703214B (https=) |
| WO (1) | WO2016019270A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2991628C (en) | 2015-07-16 | 2020-04-07 | Bioxcel Therapeutics, Inc. | A novel approach for treatment of cancer using immunomodulation |
| US11219635B2 (en) | 2016-02-19 | 2022-01-11 | City Of Hope | Bi-specific aptamer |
| EP3509700A1 (en) * | 2016-09-06 | 2019-07-17 | The Methodist Hospital System | Pd-1 specific aptamers |
| EP3512526A4 (en) * | 2016-09-16 | 2020-05-27 | Duke University | VON WILLEBRAND FACTOR (VWF) TARGETING AGENTS AND METHODS OF USE |
| CN107794267B (zh) * | 2017-03-14 | 2021-03-26 | 湖南大学 | 一种靶向pd1-pdl1的双特异性核酸适体及其衍生物 |
| KR20200068647A (ko) | 2017-08-11 | 2020-06-15 | 시티 오브 호프 | 트랜스페린 수용체 (TfR)에 대한 RNA 앱타머 |
| US11007211B2 (en) * | 2018-01-07 | 2021-05-18 | City Of Hope | CCR7 aptamers and uses thereof |
| EP3683310A1 (en) | 2019-01-21 | 2020-07-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamer and use of the aptamer in the diagnosis and treatment of cancer |
| CN111154765B (zh) * | 2019-12-30 | 2023-08-01 | 广西医科大学 | T细胞免疫检查点pd-1的适配体筛选、鉴定方法及抗肿瘤应用 |
| MX2022010955A (es) | 2020-03-03 | 2022-10-07 | Array Biopharma Inc | Metodos para tratar el cancer usando (r)-n-(3-fluoro-4-((3- ((1-hidroxipropan-2-il)amino)-1h-pirazolo[3,4-b]piridin-4-il)oxi) fenil)-3-(4-fluorofenil)-1-isopropil-2,4-dioxo-1,2,3,4-tetrahidro pirimidin-5-carboxamida. |
| CN111593053B (zh) * | 2020-05-27 | 2022-02-15 | 武汉大学 | 识别人程序性死亡受体1的dna适配体及方法和应用 |
| EP4419112A4 (en) * | 2021-10-22 | 2025-08-27 | Ohio State Innovation Foundation | IMMUNOTHERAPY FOR CANCER TREATMENT |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| AU1959897A (en) * | 1996-02-22 | 1997-09-10 | Board Of Trustees Of Michigan State University | Gene specific universal mammalian sequence-tagged sites |
| EP1268856A2 (de) * | 2000-04-07 | 2003-01-02 | Epigenomics AG | Detektion von snp's und cytosin-methylierungen |
| US7235358B2 (en) * | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| US20040180360A1 (en) * | 2002-11-21 | 2004-09-16 | Charles Wilson | Multivalent aptamer therapeutics with improved pharmacodynamic properties and methods of making and using the same |
| US8039443B2 (en) * | 2002-11-21 | 2011-10-18 | Archemix Corporation | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| JP2007525177A (ja) * | 2003-04-21 | 2007-09-06 | アーケミックス コーポレイション | 血小板由来増殖因子に対する安定化アプタマーおよび腫瘍治療剤としてのそれらの使用 |
| MEP0208A (xx) * | 2005-08-26 | 2010-02-10 | Archemix Corp | Aptameri koji vezuje trombin sa visokim afininitetom |
| JP2009536222A (ja) * | 2006-05-05 | 2009-10-08 | アイシス ファーマシューティカルズ， インコーポレーテッド | Ｐｃｓｋ９の発現を調節するための化合物および方法 |
| EP2406396A2 (en) * | 2009-03-12 | 2012-01-18 | Brainco Biopharma, S.L. | A genotyping tool for improving the prognostic and clinical management of ms patients |
| WO2010144295A1 (en) * | 2009-06-09 | 2010-12-16 | University Of Miami | Aptamer-targeted costimulatory ligand aptamer |
| EP2354247A1 (en) * | 2010-02-11 | 2011-08-10 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Means and methods for typing a sample for rheumatoid arthritis or spondyloarthritis |
| US20140148503A1 (en) * | 2011-07-20 | 2014-05-29 | University Of Iowa Research Foundation | Nucleic acid aptamers |
| CN104145020B (zh) * | 2012-02-16 | 2020-06-02 | 先正达参股股份有限公司 | 工程化的杀有害生物蛋白质 |
| US20150086584A1 (en) | 2012-03-22 | 2015-03-26 | University Of Miami | Multi-specific binding agents |
| EA201492122A1 (ru) * | 2012-05-16 | 2015-10-30 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии utrn |
| EP4170031A1 (en) * | 2012-10-23 | 2023-04-26 | Caris Science, Inc. | Aptamers and uses thereof |
| JP2015536952A (ja) * | 2012-11-05 | 2015-12-24 | プロナイ セラピューティクス インコーポレイテッド | オリゴヌクレオチド癌療法の投薬および実施 |
| WO2014082083A1 (en) * | 2012-11-26 | 2014-05-30 | Caris Science, Inc. | Biomarker compositions and methods |
| CA2954791C (en) * | 2014-07-14 | 2025-11-18 | The Regents Of The University Of California | CRISPR/CAS TRANSCRIPTIONAL MODULATION |
-
2015
- 2015-07-31 KR KR1020177005533A patent/KR20170055474A/ko not_active Withdrawn
- 2015-07-31 TW TW104124956A patent/TWI703214B/zh not_active IP Right Cessation
- 2015-07-31 CN CN201580041386.3A patent/CN107002083A/zh active Pending
- 2015-07-31 WO PCT/US2015/043162 patent/WO2016019270A1/en not_active Ceased
- 2015-07-31 JP JP2017505552A patent/JP6680760B2/ja not_active Expired - Fee Related
- 2015-07-31 CA CA2956718A patent/CA2956718A1/en not_active Abandoned
- 2015-07-31 EP EP15828285.5A patent/EP3174985A4/en not_active Withdrawn
- 2015-07-31 US US15/500,354 patent/US10329570B2/en active Active
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