CY1123978T1 - Σταθερα και διαλυτα αντισωματα που αναστελλουν ton tnf - Google Patents

Σταθερα και διαλυτα αντισωματα που αναστελλουν ton tnf

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Publication number
CY1123978T1
CY1123978T1 CY20211100234T CY211100234T CY1123978T1 CY 1123978 T1 CY1123978 T1 CY 1123978T1 CY 20211100234 T CY20211100234 T CY 20211100234T CY 211100234 T CY211100234 T CY 211100234T CY 1123978 T1 CY1123978 T1 CY 1123978T1
Authority
CY
Cyprus
Prior art keywords
tnf
antibodies
ton
inhibit
fixed
Prior art date
Application number
CY20211100234T
Other languages
English (en)
Inventor
Leonardo Borras
Tea Gunde
David Urech
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41100661&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1123978(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1123978T1 publication Critical patent/CY1123978T1/el

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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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Abstract

Η παρούσα εφεύρεση αναφέρεται σε ιδιαίτερα σταθερά και διαλυτά αντισώματα scFv και θραύσματα Fab ειδικά για TNF, τα οποία περιλαμβάνουν ειδικές αλληλουχίες ελαφριάς αλυσίδας και βαριάς αλυσίδας που βελτιστοποιούνται για σταθερότητα, διαλυτότητα, in vitro και in vivo πρόσδεση του TNF, και χαμηλή ανοσογονικότητα. Τα εν λόγω αντισώματα είναι σχεδιασμένα για τη διάγνωση ή/και θεραπευτική άγων ή μεσολαβούμενων από TNF διαταραχών. Τα νουκλεϊνικά οξέα, φορείς και κύτταρα ξενιστές για έκφραση των ανασυνδυασμένων αντισωμάτων της εφεύρεσης, μέθοδοι για την απομόνωση τους και τη χρήση των εν λόγω αντισωμάτων στην ιατρική αποκαλύπτονται επίσης.
CY20211100234T 2008-06-25 2021-03-18 Σταθερα και διαλυτα αντισωματα που αναστελλουν ton tnf CY1123978T1 (el)

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US7569708P 2008-06-25 2008-06-25
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US15504109P 2009-02-24 2009-02-24
PCT/CH2009/000219 WO2009155723A2 (en) 2008-06-25 2009-06-25 STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFα
EP09768692.7A EP2307457B2 (en) 2008-06-25 2009-06-25 Stable and soluble antibodies inhibiting tnf

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PH12014501962B1 (en) 2015-03-16
CN107936117B (zh) 2022-12-23

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