CY1125429T1 - Μουτεϊνες ιντερλευκινης-21 και μεθοδοι θεραπευτικης αγωγης - Google Patents

Μουτεϊνες ιντερλευκινης-21 και μεθοδοι θεραπευτικης αγωγης

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Publication number
CY1125429T1
CY1125429T1 CY20221100274T CY221100274T CY1125429T1 CY 1125429 T1 CY1125429 T1 CY 1125429T1 CY 20221100274 T CY20221100274 T CY 20221100274T CY 221100274 T CY221100274 T CY 221100274T CY 1125429 T1 CY1125429 T1 CY 1125429T1
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CY
Cyprus
Prior art keywords
methods
muteins
interleukin
therapeutic treatment
treating
Prior art date
Application number
CY20221100274T
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English (en)
Inventor
Khaled M.K.Z. ALI
Neeraj Jagdish AGRAWAL
Gunasekaran Kannan
Ian Foltz
Zhulun Wang
Daren BATES
Marissa Mock
Shunseke TAKENAKA
Original Assignee
Amgen Inc.
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Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of CY1125429T1 publication Critical patent/CY1125429T1/el

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10041—Use of virus, viral particle or viral elements as a vector

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Abstract

Στο παρόν παρέχονται μουτεΐνες IL-21 και πρωτεΐνες σύντηξης που τις περιλαμβάνουν για χρήση σε μεθόδους θεραπευτικής αγωγής μιας ασθένειας. Σχετικά συζεύγματα, νουκλεϊνικά οξέα, φορείς, κύτταρα ξενιστές, φαρμακευτικές συνθέσεις και κιτ παρέχονται επίσης στο παρόν. Μέθοδοι παρασκευής των μουτεϊνών IL-21 και πρωτεϊνών σύντηξης που τις περιλαμβάνουν, καθώς και μέθοδοι θεραπευτικής αγωγής ενός υποκειμένου που το έχει ανάγκη, παρέχονται από την παρούσα αποκάλυψη. Περαιτέρω παρέχονται πρωτεΐνες δέσμευσης αντιγόνου PD-1.
CY20221100274T 2017-08-03 2022-04-12 Μουτεϊνες ιντερλευκινης-21 και μεθοδοι θεραπευτικης αγωγης CY1125429T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762540692P 2017-08-03 2017-08-03
US201862616733P 2018-01-12 2018-01-12
PCT/US2018/045105 WO2019028316A1 (en) 2017-08-03 2018-08-03 INTERLEUKIN-21 MUTÉINS AND METHODS OF TREATMENT

Publications (1)

Publication Number Publication Date
CY1125429T1 true CY1125429T1 (el) 2024-02-16

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Country Status (33)

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US (2) US11541103B2 (el)
EP (2) EP3661954B1 (el)
JP (2) JP7079171B2 (el)
KR (2) KR102414120B1 (el)
CN (2) CN111164100B (el)
AU (2) AU2018311079B2 (el)
BR (2) BR122021015266B1 (el)
CA (1) CA3071376A1 (el)
CL (2) CL2020000252A1 (el)
CO (1) CO2020001113A2 (el)
CR (1) CR20200099A (el)
CY (1) CY1125429T1 (el)
DK (1) DK3661954T3 (el)
ES (2) ES2910969T3 (el)
HR (1) HRP20220404T1 (el)
HU (1) HUE058233T2 (el)
IL (2) IL272137B1 (el)
JO (1) JOP20200020B1 (el)
LT (1) LT3661954T (el)
MA (1) MA56289B1 (el)
MX (2) MX2020001328A (el)
MY (1) MY195974A (el)
PH (1) PH12020500231A1 (el)
PL (1) PL3661954T3 (el)
PT (1) PT3661954T (el)
RS (1) RS63101B1 (el)
SA (2) SA522432917B1 (el)
SG (1) SG11202000821SA (el)
SI (1) SI3661954T1 (el)
TN (1) TN2020000015A1 (el)
TW (3) TW202342501A (el)
UY (1) UY37829A (el)
WO (1) WO2019028316A1 (el)

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