MX2023012724A - Modulación de la calidad de producto de anticuerpos multiespecíficos asimétricos a través del uso de la temperatura. - Google Patents

Modulación de la calidad de producto de anticuerpos multiespecíficos asimétricos a través del uso de la temperatura.

Info

Publication number
MX2023012724A
MX2023012724A MX2023012724A MX2023012724A MX2023012724A MX 2023012724 A MX2023012724 A MX 2023012724A MX 2023012724 A MX2023012724 A MX 2023012724A MX 2023012724 A MX2023012724 A MX 2023012724A MX 2023012724 A MX2023012724 A MX 2023012724A
Authority
MX
Mexico
Prior art keywords
temperature
product quality
asymmetric
multispecific antibodies
modulating
Prior art date
Application number
MX2023012724A
Other languages
English (en)
Inventor
Li Zhang
Hedieh Barkhordarian
Ewelina Zasadzinska
Jonathan Diep
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2023012724A publication Critical patent/MX2023012724A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Processing Of Solid Wastes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere al campo de la fabricación de biofármacos. En particular, la invención se refiere al uso de la temperatura como palanca para modular la calidad de producto durante las operaciones corriente arriba.
MX2023012724A 2021-04-27 2022-04-26 Modulación de la calidad de producto de anticuerpos multiespecíficos asimétricos a través del uso de la temperatura. MX2023012724A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163180220P 2021-04-27 2021-04-27
PCT/US2022/026261 WO2022232083A1 (en) 2021-04-27 2022-04-26 Modulating product quality of asymmetric multispecific antibodies through the use of temperature

Publications (1)

Publication Number Publication Date
MX2023012724A true MX2023012724A (es) 2024-02-08

Family

ID=81654591

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023012724A MX2023012724A (es) 2021-04-27 2022-04-26 Modulación de la calidad de producto de anticuerpos multiespecíficos asimétricos a través del uso de la temperatura.

Country Status (9)

Country Link
US (1) US20240174752A1 (es)
EP (1) EP4330280A1 (es)
JP (1) JP2024516401A (es)
AR (1) AR125455A1 (es)
AU (1) AU2022263986A1 (es)
CA (1) CA3217850A1 (es)
MX (1) MX2023012724A (es)
TW (1) TW202309081A (es)
WO (1) WO2022232083A1 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1404813A4 (en) * 2001-06-13 2004-11-24 Genentech Inc METHOD FOR CULTIVATING ANIMAL CELLS AND POLYPEPTIDE PRODUCTION IN ANIMAL CELLS
EP3916011A1 (en) 2009-06-26 2021-12-01 Regeneron Pharmaceuticals, Inc. Readily isolated bispecific antibodies with native immunoglobulin format
CN118126157A (zh) 2017-08-03 2024-06-04 美国安进公司 白介素-21突变蛋白和治疗方法
US11518808B2 (en) 2018-01-12 2022-12-06 Amgen Inc. Anti-PD-1 antibodies and methods of treatment

Also Published As

Publication number Publication date
AR125455A1 (es) 2023-07-19
WO2022232083A9 (en) 2023-11-30
JP2024516401A (ja) 2024-04-15
WO2022232083A1 (en) 2022-11-03
EP4330280A1 (en) 2024-03-06
CA3217850A1 (en) 2022-11-03
AU2022263986A9 (en) 2023-11-16
TW202309081A (zh) 2023-03-01
US20240174752A1 (en) 2024-05-30
AU2022263986A1 (en) 2023-11-09

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