MX2020008241A - Proceso continuo para la preparacion de trazodona. - Google Patents

Proceso continuo para la preparacion de trazodona.

Info

Publication number
MX2020008241A
MX2020008241A MX2020008241A MX2020008241A MX2020008241A MX 2020008241 A MX2020008241 A MX 2020008241A MX 2020008241 A MX2020008241 A MX 2020008241A MX 2020008241 A MX2020008241 A MX 2020008241A MX 2020008241 A MX2020008241 A MX 2020008241A
Authority
MX
Mexico
Prior art keywords
trazodone
preparation
continuous process
relates
present
Prior art date
Application number
MX2020008241A
Other languages
English (en)
Inventor
Guido Furlotti
Claudia Cavarischia
Tommaso Iacoangeli
Leonardo Mario Moro
Torchiarolo Giuliano Caracciolo
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of MX2020008241A publication Critical patent/MX2020008241A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/02—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds
    • B01J8/0292—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds with stationary packing material in the bed, e.g. bricks, wire rings, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J14/00—Chemical processes in general for reacting liquids with liquids; Apparatus specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2204/00—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices
    • B01J2204/007—Aspects relating to the heat-exchange of the feed or outlet devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00027—Process aspects
    • B01J2219/00029—Batch processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00027—Process aspects
    • B01J2219/00033—Continuous processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B01J2219/00792—One or more tube-shaped elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B01J2219/00813—Fluidic connections
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00867—Microreactors placed in series, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00869—Microreactors placed in parallel, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00871—Modular assembly
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/18—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles
    • B01J8/24—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles according to "fluidised-bed" technique

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Combustion & Propulsion (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a un proceso mejorado para la preparación de trazodona. En particular, la presente invención se refiere a un proceso continuo para la preparación de trazodona. Más en particular, la presente invención se refiere a un nuevo método para la preparación de trazodona, dicho método que comprende al menos una etapa que consiste en un proceso continuo realizado en un reactor de flujo.
MX2020008241A 2018-02-07 2019-02-05 Proceso continuo para la preparacion de trazodona. MX2020008241A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18155470 2018-02-07
PCT/EP2019/052690 WO2019154770A1 (en) 2018-02-07 2019-02-05 Continuous process for the preparation of trazodone

Publications (1)

Publication Number Publication Date
MX2020008241A true MX2020008241A (es) 2022-07-25

Family

ID=61187146

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020008241A MX2020008241A (es) 2018-02-07 2019-02-05 Proceso continuo para la preparacion de trazodona.

Country Status (25)

Country Link
US (1) US20210032243A1 (es)
EP (1) EP3749668B1 (es)
JP (1) JP7301858B2 (es)
KR (1) KR102646651B1 (es)
CN (1) CN111886235B (es)
AU (1) AU2019217490B2 (es)
BR (1) BR112020015885A2 (es)
CA (1) CA3089552A1 (es)
DK (1) DK3749668T3 (es)
EA (1) EA202091834A1 (es)
ES (1) ES2916406T3 (es)
GE (1) GEP20227417B (es)
HR (1) HRP20220733T1 (es)
HU (1) HUE058990T2 (es)
IL (1) IL276483B2 (es)
LT (1) LT3749668T (es)
MD (1) MD3749668T2 (es)
MX (1) MX2020008241A (es)
PL (1) PL3749668T3 (es)
PT (1) PT3749668T (es)
RS (1) RS63323B1 (es)
SG (1) SG11202006948XA (es)
SI (1) SI3749668T1 (es)
UA (1) UA126870C2 (es)
WO (1) WO2019154770A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116253696A (zh) * 2021-12-10 2023-06-13 安徽省化工研究院 一种噁草酮的连续流制备方法
CN114891019B (zh) * 2022-02-25 2024-06-04 复旦大学 一种乙烯基硫醚化合物的连续流制备方法
CN117358178A (zh) * 2023-12-08 2024-01-09 天津凯莱英医药科技发展有限公司 丙硫菌唑的连续化合成系统及方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1066857B (it) 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
US4254124A (en) 1979-09-24 1981-03-03 Mead Johnson & Company Antidepressant agent
US4252806A (en) * 1979-09-24 1981-02-24 Mead Johnson & Company Triazoloquinolones
HU201324B (en) * 1988-07-29 1990-10-28 Egyt Gyogyszervegyeszeti Gyar New process for production of substituated 1,2,4-triasole (4,3-a)-piridin-2 (2h)-on
CA2182241C (en) * 1996-07-29 2002-09-17 Bo Lei Methods for the manufacture of nefazodone
IT1314283B1 (it) 1999-12-16 2002-12-06 Acraf Trazodone cloridrato ed un procedimento per prepararlo.
ITMI20071603A1 (it) * 2007-08-03 2009-02-04 Acraf Trazodone e trazodone cloridrato in forma purificata
WO2017166050A1 (zh) * 2016-03-29 2017-10-05 深圳市泛谷药业股份有限公司 一种盐酸曲唑酮的制备方法
CN105777745A (zh) 2016-03-29 2016-07-20 深圳市泛谷药业股份有限公司 一种盐酸曲唑酮的制备方法

Also Published As

Publication number Publication date
AU2019217490A1 (en) 2020-09-17
PT3749668T (pt) 2022-06-02
MD3749668T2 (ro) 2022-08-31
AU2019217490B2 (en) 2023-06-29
CN111886235B (zh) 2023-06-30
DK3749668T3 (da) 2022-06-20
EP3749668A1 (en) 2020-12-16
UA126870C2 (uk) 2023-02-15
IL276483B1 (en) 2023-05-01
WO2019154770A1 (en) 2019-08-15
RS63323B1 (sr) 2022-07-29
EP3749668B1 (en) 2022-04-06
JP7301858B2 (ja) 2023-07-03
SG11202006948XA (en) 2020-08-28
CA3089552A1 (en) 2019-08-15
HRP20220733T1 (hr) 2022-09-02
PL3749668T3 (pl) 2022-07-25
KR20200130249A (ko) 2020-11-18
LT3749668T (lt) 2022-08-10
IL276483A (en) 2020-09-30
SI3749668T1 (sl) 2022-09-30
JP2021512888A (ja) 2021-05-20
ES2916406T3 (es) 2022-06-30
CN111886235A (zh) 2020-11-03
KR102646651B1 (ko) 2024-03-13
IL276483B2 (en) 2023-09-01
BR112020015885A2 (pt) 2020-12-08
HUE058990T2 (hu) 2022-09-28
US20210032243A1 (en) 2021-02-04
AU2019217490A2 (en) 2020-09-24
GEP20227417B (en) 2022-09-26
EA202091834A1 (ru) 2020-10-22

Similar Documents

Publication Publication Date Title
MX2018004264A (es) Metodo para producir plantas completas a partir de protoplastos.
MY190659A (en) Method for producing biohydrocarbons
MX2019011778A (es) Composicion para producir tagatosa y procedimiento de produccion de tagatosa usando la misma.
MX2019006609A (es) Polvo de acero inoxidable para producir acero inoxidable sinterizado duplex.
MX2020008241A (es) Proceso continuo para la preparacion de trazodona.
MX2019011758A (es) Composicion para producir tagatosa y procedimiento de produccion de tagatosa usando la misma.
EP3725782A4 (en) NEW PROCESS FOR THE PREPARATION OF 5,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLE
PH12017501678A1 (en) Recombinant microorganism for improved production of finie chemicals
EP3789382A4 (en) PREPARATION OF 5,5-DI-SUBSTITUTED 4,5-DIHYDROISOXAZOLE
EA201890938A1 (ru) Способ удаления соединений серы из технологических потоков
EP3127609A4 (en) Catalyst for hydrogen combustion, process for producing same, and method for hydrogen combustion
MY183219A (en) Transformant for expressing cis-prenyltransferase and nogo b receptor
MX2019004182A (es) Proceso para la fabricacion de 2,6-dimetil-5-hepten-1-al.
MY188407A (en) Novel lactobacillus sp. microorganisms, and composition for animal feed comprising same
MX2023009432A (es) Metodo para crear un compuesto a base de mercurio, compuesto a base de mercurio, metodos de uso del compuesto a base de mercurio y usos del compuesto a base de mercurio.
GB2605051B (en) Method for producing 3,5-dihydroxy-4-methoxybenzyl alcohol from plankton
EA201692246A1 (ru) Способ получения 2,6-диметилбензохинона
EA201691644A1 (ru) Контроль сшивки в процессе производства ударопрочного полистирола
MX2018001968A (es) Metodo de produccion de compuestos organicos.
MX2018013334A (es) Metodo para producir derivados de espirociclicos cis-alcoxi-sustituidos 1-h-pirrolidina-2,4-diona.
MY177218A (en) Method for producing specific ?,?-unsaturated aldehydes by rearrangement process
SG11201709899QA (en) Microorganism producing o-acetyl-homoserine, and method for producing o-acetyl-homoserine by using same
MX2017008776A (es) Relleno para preparar un producto refractario, un procedimiento para preparar un producto refractario, un producto refractario, y uso de un producto refractario.
MY187078A (en) Process of production of 7,8-dihydro-c15-aldehyde
MY188965A (en) Method for treating off gas and producing hydrogen