JP2017501130A5 - - Google Patents
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- Publication number
- JP2017501130A5 JP2017501130A5 JP2016533163A JP2016533163A JP2017501130A5 JP 2017501130 A5 JP2017501130 A5 JP 2017501130A5 JP 2016533163 A JP2016533163 A JP 2016533163A JP 2016533163 A JP2016533163 A JP 2016533163A JP 2017501130 A5 JP2017501130 A5 JP 2017501130A5
- Authority
- JP
- Japan
- Prior art keywords
- cell receptor
- modified
- cell
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 57
- 108091008874 T cell receptors Proteins 0.000 claims description 55
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 20
- 239000000427 antigen Substances 0.000 claims description 15
- 108091007433 antigens Proteins 0.000 claims description 15
- 102000036639 antigens Human genes 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 13
- 229940124597 therapeutic agent Drugs 0.000 claims description 13
- 210000004027 cell Anatomy 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- 201000011510 cancer Diseases 0.000 claims description 11
- 230000035772 mutation Effects 0.000 claims description 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 7
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims description 6
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 230000008685 targeting Effects 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 102220498148 Electron transfer flavoprotein subunit beta_S95T_mutation Human genes 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 102220025225 rs199476363 Human genes 0.000 claims description 2
- 102220124963 rs886043815 Human genes 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 description 3
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019190139A JP6970724B2 (ja) | 2013-11-22 | 2019-10-17 | 改変された高親和性ヒトｔ細胞受容体 |
| JP2021178468A JP2022023196A (ja) | 2013-11-22 | 2021-11-01 | 改変された高親和性ヒトｔ細胞受容体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361907887P | 2013-11-22 | 2013-11-22 | |
| US61/907,887 | 2013-11-22 | ||
| PCT/US2014/066903 WO2015077615A1 (en) | 2013-11-22 | 2014-11-21 | Engineered high-affinity human t cell receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019190139A Division JP6970724B2 (ja) | 2013-11-22 | 2019-10-17 | 改変された高親和性ヒトｔ細胞受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501130A JP2017501130A (ja) | 2017-01-12 |
| JP2017501130A5 true JP2017501130A5 (https=) | 2017-12-21 |
| JP6697386B2 JP6697386B2 (ja) | 2020-05-20 |
Family
ID=53180203
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533150A Active JP6476182B2 (ja) | 2013-11-22 | 2014-11-21 | 改変された高親和性ヒトｔ細胞受容体 |
| JP2016533163A Expired - Fee Related JP6697386B2 (ja) | 2013-11-22 | 2014-11-21 | 改変された高親和性ヒトｔ細胞受容体 |
| JP2019190139A Expired - Fee Related JP6970724B2 (ja) | 2013-11-22 | 2019-10-17 | 改変された高親和性ヒトｔ細胞受容体 |
| JP2021178468A Pending JP2022023196A (ja) | 2013-11-22 | 2021-11-01 | 改変された高親和性ヒトｔ細胞受容体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533150A Active JP6476182B2 (ja) | 2013-11-22 | 2014-11-21 | 改変された高親和性ヒトｔ細胞受容体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019190139A Expired - Fee Related JP6970724B2 (ja) | 2013-11-22 | 2019-10-17 | 改変された高親和性ヒトｔ細胞受容体 |
| JP2021178468A Pending JP2022023196A (ja) | 2013-11-22 | 2021-11-01 | 改変された高親和性ヒトｔ細胞受容体 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US10023625B2 (https=) |
| EP (2) | EP3071593B1 (https=) |
| JP (4) | JP6476182B2 (https=) |
| KR (2) | KR102415259B1 (https=) |
| CN (2) | CN105873945B (https=) |
| AU (4) | AU2014352826B2 (https=) |
| BR (1) | BR112016011567A2 (https=) |
| CA (2) | CA2930847A1 (https=) |
| DK (1) | DK3071593T3 (https=) |
| ES (1) | ES2729406T3 (https=) |
| IL (2) | IL245467B (https=) |
| MX (3) | MX383471B (https=) |
| PL (1) | PL3071593T3 (https=) |
| PT (1) | PT3071593T (https=) |
| RU (2) | RU2729383C2 (https=) |
| SA (1) | SA516371174B1 (https=) |
| SG (2) | SG10201804330YA (https=) |
| TR (1) | TR201908404T4 (https=) |
| WO (2) | WO2015077615A1 (https=) |
| ZA (2) | ZA201603116B (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1951281B1 (en) | 2005-10-17 | 2015-04-15 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
| WO2007120673A2 (en) | 2006-04-10 | 2007-10-25 | Sloan Kettering Institute For Cancer Research | Immunogenic wt-1 peptides and methods of use thereof |
| AU2013207669C1 (en) | 2012-01-13 | 2018-05-31 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| RS61173B1 (sr) | 2013-01-15 | 2021-01-29 | Memorial Sloan Kettering Cancer Center | Imunogeni wt-1 peptidi i postupci za njihovu upotrebu |
| US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| KR102415259B1 (ko) | 2013-11-22 | 2022-06-30 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 조작된 고-친화도의 인간 t 세포 수용체 |
| ES3063691T3 (en) * | 2015-09-22 | 2026-04-20 | Univ Wuerzburg J Maximilians | A method for high level and stable gene transfer in lymphocytes |
| CA2998270A1 (en) * | 2015-10-01 | 2017-04-06 | Ospedale San Raffaele S.R.L. | Tcr and uses thereof |
| GB201520570D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| WO2017112944A1 (en) * | 2015-12-23 | 2017-06-29 | Fred Hutchinson Cancer Research Center | High affinity t cell receptors and uses thereof |
| EP3475706B1 (en) * | 2016-06-27 | 2021-08-11 | Juno Therapeutics, Inc. | Mhc-e restricted epitopes, binding molecules and related methods and uses |
| RU2019116312A (ru) | 2016-11-14 | 2020-12-14 | Фред Хатчинсон Кэнсер Рисерч Сентер | Высокоаффинные tcr, специфичные к t-антигену полиомавируса клеток меркеля, и их применения |
| JP7037577B2 (ja) * | 2017-03-15 | 2022-03-16 | フレッド ハッチンソン キャンサー リサーチ センター | 高親和性ｍａｇｅ－ａ１特異的ｔｃｒ及びその使用 |
| JP7328211B2 (ja) * | 2017-04-24 | 2023-08-16 | オスペダーレ サン ラファエレ エス．アール．エル | Ｔｃｒ及びペプチド |
| JP7181517B2 (ja) * | 2018-01-23 | 2022-12-01 | 国立大学法人三重大学 | Ｔ細胞レセプター |
| CN112739339B (zh) * | 2018-07-23 | 2024-12-27 | 海德堡医药研究有限责任公司 | 抗cd137抗体药物缀合物(adc)在同种异体细胞疗法中的用途 |
| WO2020185796A1 (en) | 2019-03-11 | 2020-09-17 | Fred Hutchinson Cancer Research Center | High avidity wt1 t cell receptors and uses thereof |
| GB201911066D0 (en) | 2019-08-02 | 2019-09-18 | Achilles Therapeutics Ltd | T cell therapy |
| JP7737978B2 (ja) * | 2019-08-20 | 2025-09-11 | フレッド ハッチンソン キャンサー センター | Ｗｔ－１に特異的なｔ細胞免疫療法 |
| AU2021218412A1 (en) * | 2020-02-12 | 2022-09-08 | Abbvie Inc. | Bispecific binding molecules |
| CN115461062A (zh) | 2020-04-28 | 2022-12-09 | 阿基里斯治疗英国有限公司 | T细胞疗法 |
| CN112239495B (zh) * | 2020-10-29 | 2022-04-12 | 上海药明生物技术有限公司 | 稳定的tcr结构及应用 |
| GB202109886D0 (en) | 2021-07-08 | 2021-08-25 | Achilles Therapeutics Uk Ltd | Assay |
| EP4320435A1 (en) | 2021-04-09 | 2024-02-14 | Achilles Therapeutics UK Limited | Batch release assay for pharmaceutical products relating to t cell therapies |
| US20240287456A1 (en) | 2021-06-22 | 2024-08-29 | Achilles Therapeutics Uk Limited | A method for producing antigen-specific t cells |
| US20250073333A1 (en) * | 2021-07-19 | 2025-03-06 | Board Of Regents, The University Of Texas System | Peptides and engineered t cell receptors targeting fanci, rad51, and pbk antigens and methods of use |
| CN119220425A (zh) * | 2023-07-28 | 2024-12-31 | 佳吾益(北京)科技有限公司 | 发现mhc新抗原肽表位的工程化细胞 |
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| HRP20171164T1 (hr) | 2010-09-20 | 2017-10-20 | Biontech Cell & Gene Therapies Gmbh | Antigen-specifični t stanični receptori i t stanični epitopi |
| EP2844743B1 (en) | 2012-05-03 | 2021-01-13 | Fred Hutchinson Cancer Research Center | Enhanced affinity t cell receptors and methods for making the same |
| WO2014191465A1 (en) * | 2013-05-28 | 2014-12-04 | Møller Niels Iversen | Peptides derived from lawsonia intracellularis and their use in vaccination |
| PL228457B1 (pl) | 2013-08-30 | 2018-03-30 | Univ Jagiellonski | Tomograf hybrydowy TOF-PET/CT |
| KR102415259B1 (ko) | 2013-11-22 | 2022-06-30 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 조작된 고-친화도의 인간 t 세포 수용체 |
| ES2841274T3 (es) | 2014-08-04 | 2021-07-07 | Hutchinson Fred Cancer Res | Inmunoterapia con células T específica para WT-1 |
| CN110950964B (zh) * | 2018-09-26 | 2021-06-18 | 安源医药科技（上海）有限公司 | 突变型单链人凝血因子viii融合蛋白及其制备方法与用途 |
-
2014
- 2014-11-21 KR KR1020167016131A patent/KR102415259B1/ko active Active
- 2014-11-21 US US15/037,476 patent/US10023625B2/en active Active
- 2014-11-21 WO PCT/US2014/066903 patent/WO2015077615A1/en not_active Ceased
- 2014-11-21 AU AU2014352826A patent/AU2014352826B2/en active Active
- 2014-11-21 EP EP14863490.0A patent/EP3071593B1/en active Active
- 2014-11-21 MX MX2016006625A patent/MX383471B/es unknown
- 2014-11-21 JP JP2016533150A patent/JP6476182B2/ja active Active
- 2014-11-21 ES ES14863490T patent/ES2729406T3/es active Active
- 2014-11-21 AU AU2014352834A patent/AU2014352834B2/en not_active Ceased
- 2014-11-21 EP EP14864079.0A patent/EP3071594A4/en not_active Withdrawn
- 2014-11-21 CN CN201480071620.2A patent/CN105873945B/zh active Active
- 2014-11-21 DK DK14863490.0T patent/DK3071593T3/da active
- 2014-11-21 RU RU2016124163A patent/RU2729383C2/ru active
- 2014-11-21 PT PT14863490T patent/PT3071593T/pt unknown
- 2014-11-21 TR TR2019/08404T patent/TR201908404T4/tr unknown
- 2014-11-21 WO PCT/US2014/066892 patent/WO2015077607A1/en not_active Ceased
- 2014-11-21 SG SG10201804330YA patent/SG10201804330YA/en unknown
- 2014-11-21 CN CN201480071635.9A patent/CN105899530B/zh not_active Expired - Fee Related
- 2014-11-21 CA CA2930847A patent/CA2930847A1/en not_active Abandoned
- 2014-11-21 PL PL14863490T patent/PL3071593T3/pl unknown
- 2014-11-21 SG SG10201804335QA patent/SG10201804335QA/en unknown
- 2014-11-21 CA CA2930852A patent/CA2930852C/en active Active
- 2014-11-21 RU RU2016124179A patent/RU2740648C2/ru active
- 2014-11-21 MX MX2016006620A patent/MX371202B/es active IP Right Grant
- 2014-11-21 BR BR112016011567A patent/BR112016011567A2/pt not_active Application Discontinuation
- 2014-11-21 KR KR1020167016132A patent/KR20160085345A/ko not_active Ceased
- 2014-11-21 JP JP2016533163A patent/JP6697386B2/ja not_active Expired - Fee Related
- 2014-11-21 US US15/037,485 patent/US10344075B2/en active Active
-
2016
- 2016-05-04 IL IL245467A patent/IL245467B/en not_active IP Right Cessation
- 2016-05-04 IL IL245468A patent/IL245468B/en active IP Right Grant
- 2016-05-10 ZA ZA2016/03116A patent/ZA201603116B/en unknown
- 2016-05-11 ZA ZA2016/03169A patent/ZA201603169B/en unknown
- 2016-05-20 MX MX2021006932A patent/MX2021006932A/es unknown
- 2016-05-21 SA SA516371174A patent/SA516371174B1/ar unknown
-
2018
- 2018-05-25 US US15/990,524 patent/US20190055298A1/en not_active Abandoned
-
2019
- 2019-10-17 JP JP2019190139A patent/JP6970724B2/ja not_active Expired - Fee Related
- 2019-11-28 AU AU2019272003A patent/AU2019272003B2/en not_active Ceased
-
2021
- 2021-04-15 AU AU2021202274A patent/AU2021202274A1/en not_active Abandoned
- 2021-11-01 JP JP2021178468A patent/JP2022023196A/ja active Pending
-
2022
- 2022-01-27 US US17/586,652 patent/US20220396606A1/en not_active Abandoned
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