ZA201603116B - Engineered high-affinity human t cell receptors - Google Patents

Engineered high-affinity human t cell receptors

Info

Publication number
ZA201603116B
ZA201603116B ZA2016/03116A ZA201603116A ZA201603116B ZA 201603116 B ZA201603116 B ZA 201603116B ZA 2016/03116 A ZA2016/03116 A ZA 2016/03116A ZA 201603116 A ZA201603116 A ZA 201603116A ZA 201603116 B ZA201603116 B ZA 201603116B
Authority
ZA
South Africa
Prior art keywords
cell receptors
affinity human
engineered high
engineered
affinity
Prior art date
Application number
ZA2016/03116A
Other languages
English (en)
Inventor
David M Kranz
Daniel T Harris
Sheena N Smith
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Publication of ZA201603116B publication Critical patent/ZA201603116B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ZA2016/03116A 2013-11-22 2016-05-10 Engineered high-affinity human t cell receptors ZA201603116B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361907887P 2013-11-22 2013-11-22
PCT/US2014/066892 WO2015077607A1 (en) 2013-11-22 2014-11-21 Engineered high-affinity human t cell receptors

Publications (1)

Publication Number Publication Date
ZA201603116B true ZA201603116B (en) 2018-12-19

Family

ID=53180203

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA2016/03116A ZA201603116B (en) 2013-11-22 2016-05-10 Engineered high-affinity human t cell receptors
ZA2016/03169A ZA201603169B (en) 2013-11-22 2016-05-11 Engineered high-affinity human t cell receptors

Family Applications After (1)

Application Number Title Priority Date Filing Date
ZA2016/03169A ZA201603169B (en) 2013-11-22 2016-05-11 Engineered high-affinity human t cell receptors

Country Status (20)

Country Link
US (4) US10023625B2 (https=)
EP (2) EP3071593B1 (https=)
JP (4) JP6476182B2 (https=)
KR (2) KR102415259B1 (https=)
CN (2) CN105873945B (https=)
AU (4) AU2014352826B2 (https=)
BR (1) BR112016011567A2 (https=)
CA (2) CA2930847A1 (https=)
DK (1) DK3071593T3 (https=)
ES (1) ES2729406T3 (https=)
IL (2) IL245467B (https=)
MX (3) MX383471B (https=)
PL (1) PL3071593T3 (https=)
PT (1) PT3071593T (https=)
RU (2) RU2729383C2 (https=)
SA (1) SA516371174B1 (https=)
SG (2) SG10201804330YA (https=)
TR (1) TR201908404T4 (https=)
WO (2) WO2015077615A1 (https=)
ZA (2) ZA201603116B (https=)

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JP2017501130A (ja) 2017-01-12
IL245468B (en) 2020-10-29
MX2016006625A (es) 2016-12-02
US20220396606A1 (en) 2022-12-15
SG10201804335QA (en) 2018-06-28
MX2021006932A (es) 2021-07-07
CN105899530B (zh) 2020-05-08
RU2740648C2 (ru) 2021-01-19
CN105873945B (zh) 2020-07-17
WO2015077607A1 (en) 2015-05-28
IL245467A0 (en) 2016-06-30
WO2015077615A1 (en) 2015-05-28
IL245468A0 (en) 2016-06-30
SG10201804330YA (en) 2018-07-30
AU2019272003B2 (en) 2021-05-06
RU2016124179A (ru) 2017-12-27
SA516371174B1 (ar) 2019-04-14
CN105899530A (zh) 2016-08-24
RU2729383C2 (ru) 2020-08-06
RU2016124163A (ru) 2017-12-27
CA2930852A1 (en) 2015-05-28
US20160280755A1 (en) 2016-09-29
NZ719720A (en) 2020-09-25
JP2020007374A (ja) 2020-01-16
CA2930847A1 (en) 2015-05-28
CA2930852C (en) 2024-01-23
EP3071593B1 (en) 2019-03-13
BR112016011567A2 (pt) 2017-10-24
MX2016006620A (es) 2017-05-11
AU2014352834A1 (en) 2016-05-26
NZ719707A (en) 2020-09-25
US10344075B2 (en) 2019-07-09
MX383471B (es) 2025-03-14
ES2729406T3 (es) 2019-11-04
AU2014352826A1 (en) 2016-05-26
US20160280756A1 (en) 2016-09-29
JP6476182B2 (ja) 2019-02-27
JP6970724B2 (ja) 2021-11-24
JP2022023196A (ja) 2022-02-07
JP6697386B2 (ja) 2020-05-20
MX371202B (es) 2020-01-22
CN105873945A (zh) 2016-08-17
EP3071594A1 (en) 2016-09-28
US20190055298A1 (en) 2019-02-21
KR102415259B1 (ko) 2022-06-30
PL3071593T3 (pl) 2019-11-29
EP3071594A4 (en) 2017-05-03
AU2014352834B2 (en) 2019-08-29
KR20160087866A (ko) 2016-07-22
BR112016011583A2 (pt) 2017-09-26
AU2019272003A1 (en) 2019-12-19
EP3071593A1 (en) 2016-09-28
ZA201603169B (en) 2020-05-27
JP2017501129A (ja) 2017-01-12
AU2014352826B2 (en) 2019-08-01
TR201908404T4 (tr) 2019-07-22
AU2021202274A1 (en) 2021-05-06
DK3071593T3 (da) 2019-06-11
IL245467B (en) 2020-04-30
US10023625B2 (en) 2018-07-17
PT3071593T (pt) 2019-06-27
EP3071593A4 (en) 2017-05-03
KR20160085345A (ko) 2016-07-15

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