SG10201804330YA - Engineered high-affinity human t cell receptors - Google Patents

Engineered high-affinity human t cell receptors

Info

Publication number
SG10201804330YA
SG10201804330YA SG10201804330YA SG10201804330YA SG10201804330YA SG 10201804330Y A SG10201804330Y A SG 10201804330YA SG 10201804330Y A SG10201804330Y A SG 10201804330YA SG 10201804330Y A SG10201804330Y A SG 10201804330YA SG 10201804330Y A SG10201804330Y A SG 10201804330YA
Authority
SG
Singapore
Prior art keywords
tcrs
cell receptors
affinity
affinity human
engineered
Prior art date
Application number
SG10201804330YA
Other languages
English (en)
Inventor
Sheena N Smith
Daniel T Harris
David M Kranz
Thomas M Schmitt
Philip D Greenberg
Original Assignee
Univ Illinois
Hutchinson Fred Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois, Hutchinson Fred Cancer Res filed Critical Univ Illinois
Publication of SG10201804330YA publication Critical patent/SG10201804330YA/en

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG10201804330YA 2013-11-22 2014-11-21 Engineered high-affinity human t cell receptors SG10201804330YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361907887P 2013-11-22 2013-11-22

Publications (1)

Publication Number Publication Date
SG10201804330YA true SG10201804330YA (en) 2018-07-30

Family

ID=53180203

Family Applications (2)

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SG10201804330YA SG10201804330YA (en) 2013-11-22 2014-11-21 Engineered high-affinity human t cell receptors
SG10201804335QA SG10201804335QA (en) 2013-11-22 2014-11-21 Engineered high-affinity human t cell receptors

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201804335QA SG10201804335QA (en) 2013-11-22 2014-11-21 Engineered high-affinity human t cell receptors

Country Status (20)

Country Link
US (4) US10023625B2 (https=)
EP (2) EP3071593B1 (https=)
JP (4) JP6476182B2 (https=)
KR (2) KR102415259B1 (https=)
CN (2) CN105873945B (https=)
AU (4) AU2014352826B2 (https=)
BR (1) BR112016011567A2 (https=)
CA (2) CA2930847A1 (https=)
DK (1) DK3071593T3 (https=)
ES (1) ES2729406T3 (https=)
IL (2) IL245467B (https=)
MX (3) MX383471B (https=)
PL (1) PL3071593T3 (https=)
PT (1) PT3071593T (https=)
RU (2) RU2729383C2 (https=)
SA (1) SA516371174B1 (https=)
SG (2) SG10201804330YA (https=)
TR (1) TR201908404T4 (https=)
WO (2) WO2015077615A1 (https=)
ZA (2) ZA201603116B (https=)

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JP2017501130A (ja) 2017-01-12
IL245468B (en) 2020-10-29
MX2016006625A (es) 2016-12-02
US20220396606A1 (en) 2022-12-15
SG10201804335QA (en) 2018-06-28
MX2021006932A (es) 2021-07-07
CN105899530B (zh) 2020-05-08
RU2740648C2 (ru) 2021-01-19
CN105873945B (zh) 2020-07-17
WO2015077607A1 (en) 2015-05-28
IL245467A0 (en) 2016-06-30
WO2015077615A1 (en) 2015-05-28
IL245468A0 (en) 2016-06-30
AU2019272003B2 (en) 2021-05-06
RU2016124179A (ru) 2017-12-27
SA516371174B1 (ar) 2019-04-14
CN105899530A (zh) 2016-08-24
RU2729383C2 (ru) 2020-08-06
RU2016124163A (ru) 2017-12-27
CA2930852A1 (en) 2015-05-28
US20160280755A1 (en) 2016-09-29
NZ719720A (en) 2020-09-25
JP2020007374A (ja) 2020-01-16
CA2930847A1 (en) 2015-05-28
CA2930852C (en) 2024-01-23
EP3071593B1 (en) 2019-03-13
BR112016011567A2 (pt) 2017-10-24
MX2016006620A (es) 2017-05-11
AU2014352834A1 (en) 2016-05-26
NZ719707A (en) 2020-09-25
US10344075B2 (en) 2019-07-09
MX383471B (es) 2025-03-14
ES2729406T3 (es) 2019-11-04
AU2014352826A1 (en) 2016-05-26
ZA201603116B (en) 2018-12-19
US20160280756A1 (en) 2016-09-29
JP6476182B2 (ja) 2019-02-27
JP6970724B2 (ja) 2021-11-24
JP2022023196A (ja) 2022-02-07
JP6697386B2 (ja) 2020-05-20
MX371202B (es) 2020-01-22
CN105873945A (zh) 2016-08-17
EP3071594A1 (en) 2016-09-28
US20190055298A1 (en) 2019-02-21
KR102415259B1 (ko) 2022-06-30
PL3071593T3 (pl) 2019-11-29
EP3071594A4 (en) 2017-05-03
AU2014352834B2 (en) 2019-08-29
KR20160087866A (ko) 2016-07-22
BR112016011583A2 (pt) 2017-09-26
AU2019272003A1 (en) 2019-12-19
EP3071593A1 (en) 2016-09-28
ZA201603169B (en) 2020-05-27
JP2017501129A (ja) 2017-01-12
AU2014352826B2 (en) 2019-08-01
TR201908404T4 (tr) 2019-07-22
AU2021202274A1 (en) 2021-05-06
DK3071593T3 (da) 2019-06-11
IL245467B (en) 2020-04-30
US10023625B2 (en) 2018-07-17
PT3071593T (pt) 2019-06-27
EP3071593A4 (en) 2017-05-03
KR20160085345A (ko) 2016-07-15

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