JP2014532649A5 - - Google Patents
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- JP2014532649A5 JP2014532649A5 JP2014538974A JP2014538974A JP2014532649A5 JP 2014532649 A5 JP2014532649 A5 JP 2014532649A5 JP 2014538974 A JP2014538974 A JP 2014538974A JP 2014538974 A JP2014538974 A JP 2014538974A JP 2014532649 A5 JP2014532649 A5 JP 2014532649A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- monoclonal antibody
- antibody according
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161551918P | 2011-10-26 | 2011-10-26 | |
| US61/551,918 | 2011-10-26 | ||
| US201261699300P | 2012-09-11 | 2012-09-11 | |
| US61/699,300 | 2012-09-11 | ||
| PCT/US2012/061782 WO2013063186A2 (en) | 2011-10-26 | 2012-10-25 | Monoclonal antibodies and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532649A JP2014532649A (ja) | 2014-12-08 |
| JP2014532649A5 true JP2014532649A5 (https=) | 2016-02-12 |
| JP6316195B2 JP6316195B2 (ja) | 2018-04-25 |
Family
ID=48168777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014538974A Active JP6316195B2 (ja) | 2011-10-26 | 2012-10-25 | モノクローナル抗体および使用の方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9790280B2 (https=) |
| EP (3) | EP4530630A3 (https=) |
| JP (1) | JP6316195B2 (https=) |
| AU (1) | AU2012328819B2 (https=) |
| BR (1) | BR112014010008A2 (https=) |
| CA (1) | CA2853637C (https=) |
| RU (1) | RU2623122C2 (https=) |
| WO (1) | WO2013063186A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2853637C (en) * | 2011-10-26 | 2023-04-04 | Novartis Ag | Anti-canine cd20 monoclonal antibodies and methods of use |
| SG11201601763SA (en) * | 2013-09-20 | 2016-04-28 | Bristol Myers Squibb Co | Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors |
| JP6701079B2 (ja) | 2013-12-20 | 2020-05-27 | インターベット インターナショナル ベー. フェー. | ヒトpd−1に対するイヌ化マウス抗体 |
| CN112142843B (zh) | 2013-12-24 | 2024-10-18 | 阿尔金克斯有限公司 | FcRn拮抗剂及使用方法 |
| US10550194B2 (en) | 2014-09-30 | 2020-02-04 | Intervet Inc. | PD-L1 antibodies binding canine PD-L1 |
| MY188761A (en) * | 2015-03-09 | 2021-12-29 | Argenx Bvba | Method of reducing serum levels of fc-containing agents using fcrn antagonists |
| WO2017102920A1 (en) | 2015-12-18 | 2017-06-22 | Intervet International B.V. | Caninized human antibodies to human and canine il-4r alpha |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| NZ744192A (en) * | 2016-02-18 | 2019-11-29 | Elanco Us Inc | Chimeric canine anti-cd20 antibody |
| SMT202300418T1 (it) | 2017-05-30 | 2024-01-10 | Bristol Myers Squibb Co | Trattamento di tumori positivi per lag-3 |
| EP3630179A2 (en) | 2017-05-30 | 2020-04-08 | Bristol-Myers Squibb Company | Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody |
| BR112020002871A2 (pt) | 2017-08-15 | 2020-07-28 | Kindred Biosciences, Inc. | variantes fc de igg para uso veterinário |
| US12240875B2 (en) | 2017-12-08 | 2025-03-04 | argenx BV | Use of FCRN antagonists for treatment of generalized myasthenia gravis |
| CA3101462A1 (en) | 2018-06-08 | 2019-12-12 | Argenx Bvba | Compositions and methods for treating immune thrombocytopenia |
| CN113194984A (zh) * | 2018-10-18 | 2021-07-30 | 金德雷德生物科学股份有限公司 | 兽用的与新生儿Fc受体(FcRn)结合改变的Fc变体 |
| MX2021007680A (es) * | 2018-12-27 | 2021-10-13 | Kindred Biosciences Inc | Variantes de igg fc para uso veterinario. |
| CN114126647A (zh) | 2019-06-07 | 2022-03-01 | 阿尔金克斯有限公司 | 适用于皮下施用的FcRn抑制剂的药物制剂 |
| JP2021059499A (ja) | 2019-10-03 | 2021-04-15 | 日本全薬工業株式会社 | イヌcd20に対するモノクローナル抗体又は抗体フラグメント |
| BR112022013554A2 (pt) | 2020-01-08 | 2022-09-06 | argenx BV | Métodos para tratar distúrbios do pênfigo |
| US20230348577A1 (en) | 2020-02-19 | 2023-11-02 | Adivo Gmbh | Modified fc regions |
| US20230331846A1 (en) * | 2020-05-04 | 2023-10-19 | Inhibrx, Inc. | Canine PD-1-Binding Polypeptides and Uses Thereof |
| US20220024904A1 (en) * | 2020-07-06 | 2022-01-27 | Research Foundation Of The City University Of New York | Reagent for bioconjugation via irreversible rebridging of disulfide linkages |
| WO2022087402A1 (en) | 2020-10-23 | 2022-04-28 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for lung cancer |
| EP4355782A1 (en) | 2021-06-17 | 2024-04-24 | Petmedix Ltd. | Anti canine cd20 antibodies |
| JP2024530036A (ja) * | 2021-08-06 | 2024-08-14 | ペットメディックス・リミテッド | 抗体Fcバリアント |
| CA3258000A1 (en) | 2022-06-15 | 2023-12-21 | argenx BV | FCRN/ANTIGEN BINDING MOLECULES AND METHODS OF USE |
| EP4642795A2 (en) | 2022-12-27 | 2025-11-05 | Invetx, Inc. | Polypeptides with altered binding to neonatal fc receptor (fcrn) and methods of use |
| AU2024210302A1 (en) | 2023-01-20 | 2025-09-04 | Invetx, Inc. | Bispecific binding agents for use in companion animals |
| EP4656205A1 (en) | 2023-01-25 | 2025-12-03 | Nippon Zenyaku Kogyo Co., Ltd. | Method for treating canine b cell lymphoma |
| WO2025121944A1 (ko) * | 2023-12-08 | 2025-06-12 | 주식회사 박셀바이오 | 개 cd20을 표적으로 하는 항체, 키메라 항원 수용체 및 이의 용도 |
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| US4281061A (en) * | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
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| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US6893625B1 (en) | 1986-10-27 | 2005-05-17 | Royalty Pharma Finance Trust | Chimeric antibody with specificity to human B cell surface antigen |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| AU640397B2 (en) | 1989-08-25 | 1993-08-26 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Dog-mouse heterohybridoma and gene fragment coding for constant region of canine immunoglobulin |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
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| US6136310A (en) | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
| IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
| US5756096A (en) | 1991-07-25 | 1998-05-26 | Idec Pharmaceuticals Corporation | Recombinant antibodies for human therapy |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| US7744877B2 (en) | 1992-11-13 | 2010-06-29 | Biogen Idec Inc. | Expression and use of anti-CD20 Antibodies |
| MD1367C2 (ro) | 1992-11-13 | 2000-11-30 | Idec Pharmaceuticals Corporation | Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom. |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| CA2245835A1 (en) * | 1995-06-14 | 1997-01-03 | The Regents Of The University Of California | Novel high affinity human antibodies to tumor antigens |
| US6306393B1 (en) | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| CA2340091C (en) | 1998-08-11 | 2013-02-05 | Idec Pharmaceuticals Corporation | Combination therapies for b-cell lymphomas comprising administration of anti-cd20 antibody |
| US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
| US7829064B2 (en) | 1999-05-10 | 2010-11-09 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods |
| US8383081B2 (en) | 1999-05-10 | 2013-02-26 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods of use |
| US8119101B2 (en) | 1999-05-10 | 2012-02-21 | The Ohio State University | Anti-CD74 immunoconjugates and methods of use |
| CA2375912C (en) | 1999-06-09 | 2014-03-11 | Immunomedics, Inc. | Immunotherapy of autoimmune disorders using antibodies which target b-cells |
| US8501471B2 (en) | 2000-10-18 | 2013-08-06 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8H9 |
| US8165535B2 (en) | 2006-06-04 | 2012-04-24 | Samsung Electro-Mechanics | Systems, methods and apparatuses for complementary metal oxide semiconductor (CMOS) antenna switches using switched resonators |
| US8287864B2 (en) | 2002-02-14 | 2012-10-16 | Immunomedics, Inc. | Structural variants of antibodies for improved therapeutic characteristics |
| KR101033196B1 (ko) | 2002-02-14 | 2011-05-09 | 이뮤노메딕스, 인코오포레이티드 | 항-cd20 항체 및 그 융합 단백질 및 이들의 이용방법 |
| KR101017732B1 (ko) | 2002-03-01 | 2011-02-28 | 이뮤노메딕스, 인코오포레이티드 | 내재화 항-cd74 항체 및 그 이용방법 |
| WO2003089930A1 (en) * | 2002-04-22 | 2003-10-30 | Georgetown University | Peripheral-type benzodiazepine receptor expression level as an index of organ damage and regeneration |
| CN101928344B (zh) | 2002-10-17 | 2014-08-13 | 根马布股份公司 | 抗cd20的人单克隆抗体 |
| US8084582B2 (en) | 2003-03-03 | 2011-12-27 | Xencor, Inc. | Optimized anti-CD20 monoclonal antibodies having Fc variants |
| JP4782700B2 (ja) | 2004-01-20 | 2011-09-28 | カロバイオス ファーマシューティカルズ インコーポレイティッド | 最低限必須な結合決定基を用いた抗体特異性の移入 |
| WO2005075640A1 (ja) | 2004-02-10 | 2005-08-18 | Nihon University | イヌcd20遺伝子 |
| EP1751187A2 (en) | 2004-05-28 | 2007-02-14 | Idexx Laboratories, Inc. | Canine cd20 compositions |
| US20060134098A1 (en) | 2004-11-16 | 2006-06-22 | Kalobios, Inc. | Immunoglobulin variable region cassette exchange |
| BRPI0720565A2 (pt) | 2006-12-20 | 2013-09-17 | Mmr Information Systems Inc | anticorpos e mÉtodos para a sua preparaÇço e seu uso |
| GB0708002D0 (en) * | 2007-04-25 | 2007-06-06 | Univ Sheffield | Antibodies |
| PT2227546T (pt) | 2007-12-21 | 2016-08-12 | Novartis Ag | Vector de expressão em mamíferos |
| DK2329020T3 (da) | 2008-08-28 | 2013-06-10 | Novartis Ag | Celleoverfladepræsentation af polypeptidisoformer ved hjælp af stopcodon-overspringelse |
| EP2725037A1 (en) | 2008-09-04 | 2014-04-30 | Vet Therapeutics, Inc. | Monoclonal antibodies binding canine CD20 |
| WO2010110838A2 (en) | 2009-03-25 | 2010-09-30 | Vet Therapeutics Inc. | Antibody constant domain regions and uses thereof |
| CA2754408A1 (en) * | 2009-03-30 | 2010-10-14 | Boehringer Ingelheim International Gmbh | Fusion proteins comprising canine fc portions |
| WO2010117448A2 (en) * | 2009-04-05 | 2010-10-14 | Provenance Biopharmaceuticals Corp. | Chimeric immunocytokines and methods of use thereof |
| WO2011057188A1 (en) * | 2009-11-06 | 2011-05-12 | Idexx Laboratories, Inc. | Canine anti-cd20 antibodies |
| JP5911813B2 (ja) * | 2010-03-04 | 2016-04-27 | ベット・セラピューティクス・インコーポレイテッドVet Therapeutics Inc. | Cd20に対するモノクローナル抗体 |
| US9616120B2 (en) * | 2010-03-04 | 2017-04-11 | Vet Therapeutics, Inc. | Monoclonal antibodies directed to CD20 |
| BR112012022342A2 (pt) | 2010-03-04 | 2017-02-14 | Vet Therapeutics Inc | anticorpos monoclonais dirigidos a cd52 |
| CA2853637C (en) * | 2011-10-26 | 2023-04-04 | Novartis Ag | Anti-canine cd20 monoclonal antibodies and methods of use |
-
2012
- 2012-10-25 CA CA2853637A patent/CA2853637C/en active Active
- 2012-10-25 EP EP24217016.5A patent/EP4530630A3/en active Pending
- 2012-10-25 RU RU2014120804A patent/RU2623122C2/ru active
- 2012-10-25 BR BR112014010008-0A patent/BR112014010008A2/en not_active Application Discontinuation
- 2012-10-25 JP JP2014538974A patent/JP6316195B2/ja active Active
- 2012-10-25 WO PCT/US2012/061782 patent/WO2013063186A2/en not_active Ceased
- 2012-10-25 EP EP18165199.3A patent/EP3378489A1/en not_active Withdrawn
- 2012-10-25 AU AU2012328819A patent/AU2012328819B2/en active Active
- 2012-10-25 EP EP12842976.8A patent/EP2771694A4/en not_active Ceased
- 2012-10-25 US US14/354,280 patent/US9790280B2/en active Active
-
2017
- 2017-08-24 US US15/685,257 patent/US11319377B2/en active Active
-
2022
- 2022-03-24 US US17/703,542 patent/US12600792B2/en active Active
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