JP2019508045A5 - - Google Patents

Info

Publication number

JP2019508045A5

JP2019508045A5 JP2018547354A JP2018547354A JP2019508045A5 JP 2019508045 A5 JP2019508045 A5 JP 2019508045A5 JP 2018547354 A JP2018547354 A JP 2018547354A JP 2018547354 A JP2018547354 A JP 2018547354A JP 2019508045 A5 JP2019508045 A5 JP 2019508045A5

Authority

JP

Japan

Prior art keywords

small rna

rna sequence

viral vector

sequence

item

Prior art date

2017-03-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108091032955 Bacterial small RNA Proteins 0.000 claims description 35
• 239000013603 viral vector Substances 0.000 claims description 26
• 239000003814 drug Substances 0.000 claims description 10
• 239000002245 particle Substances 0.000 claims description 10
• 229940079593 drug Drugs 0.000 claims description 9
• 101100239628 Danio rerio myca gene Proteins 0.000 claims description 8
• 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 8
• 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims description 8
• 239000000203 mixture Substances 0.000 claims description 8
• 230000001225 therapeutic effect Effects 0.000 claims description 7
• 102100035111 Farnesyl pyrophosphate synthase Human genes 0.000 claims description 5
• 206010028980 Neoplasm Diseases 0.000 claims description 5
• 201000011510 cancer Diseases 0.000 claims description 5
• 101001023007 Homo sapiens Farnesyl pyrophosphate synthase Proteins 0.000 claims description 4
• 239000013598 vector Substances 0.000 claims description 4
• XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims description 3
• 229960004276 zoledronic acid Drugs 0.000 claims description 3
• 101710091045 Envelope protein Proteins 0.000 claims description 2
• 101710188315 Protein X Proteins 0.000 claims description 2
• 108091027967 Small hairpin RNA Proteins 0.000 claims description 2
• 102100021696 Syncytin-1 Human genes 0.000 claims description 2
• 108091070501 miRNA Proteins 0.000 claims description 2
• 239000002679 microRNA Substances 0.000 claims description 2
• 239000004055 small Interfering RNA Substances 0.000 claims description 2
• 230000002401 inhibitory effect Effects 0.000 claims 3
• 108010026318 Geranyltranstransferase Proteins 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 108020004999 messenger RNA Proteins 0.000 description 11
• 238000000034 method Methods 0.000 description 9
• 230000000295 complement effect Effects 0.000 description 6
• 241000713666 Lentivirus Species 0.000 description 4
• 241000700605 Viruses Species 0.000 description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1