HRP20211601T1 - Rekombinantni proteini bez fenilalanina (phe) za liječenje fenilketonurije - Google Patents
Rekombinantni proteini bez fenilalanina (phe) za liječenje fenilketonurije Download PDFInfo
- Publication number
- HRP20211601T1 HRP20211601T1 HRP20211601TT HRP20211601T HRP20211601T1 HR P20211601 T1 HRP20211601 T1 HR P20211601T1 HR P20211601T T HRP20211601T T HR P20211601TT HR P20211601 T HRP20211601 T HR P20211601T HR P20211601 T1 HRP20211601 T1 HR P20211601T1
- Authority
- HR
- Croatia
- Prior art keywords
- seq
- sequence
- protein
- phenylalanine
- sequences
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title claims 5
- 108090000623 proteins and genes Proteins 0.000 title claims 5
- 201000011252 Phenylketonuria Diseases 0.000 title 1
- 235000008729 phenylalanine Nutrition 0.000 claims 8
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 6
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 6
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 6
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 6
- 235000018102 proteins Nutrition 0.000 claims 4
- 244000005700 microbiome Species 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 241000194108 Bacillus licheniformis Species 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 150000002994 phenylalanines Chemical class 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2414—Alpha-amylase (3.2.1.1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21062—Subtilisin (3.4.21.62)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (11)
1. Rekombinantni protein bez fenilalanina, pri čemu se protein odabire iz sljedova koji pokazuju barem 85-postotnu identičnost sa slijedom SEQ ID BR: 12 i pri čemu su se svi fenilalanini zamijenili velikim neutralnim aminokiselinama (LNAA) koje su odabrane iz slijeda Tyr, Trp, Thr, Ile, Leu, Val, Met ili His.
2. Rekombinantni protein bez fenilalanina prema zahtjevu 1., pri čemu se protein odabire iz sljedova koji pokazuju barem 95-postotnu identičnost sa slijedom SEQ ID BR: 12 i pri čemu su se svi fenilalanini zamijenili velikim neutralnim aminokiselinama (LNAA) koje su odabrane iz slijeda Tyr, Trp, Thr, Ile, Leu, Val, Met ili His.
3. Rekombinantni protein bez fenilalanina prema bilo kojem od zahtjeva 1. – 2. koji pokazuje barem 85-postotnu identičnost sa sljedovima SEQ ID BR: 28 – 29 ili sa slijedom SEQ ID BR: 76.
4. Rekombinantni protein bez fenilalanina prema zahtjevu 3. koji pokazuje barem 95-postotnu identičnost sa sljedovima SEQ ID BR: 28 – 30 ili sa slijedom SEQ ID BR: 76.
5. Rekombinantni protein bez fenilalanina koji pokazuje 100-postotnu identičnost sa sljedovima SEQ ID BR: 28 – 30 ili sa slijedom SEQ ID BR: 76.
6. Izolirana nukleinska kiselina koja sadrži slijed nukleinske kiseline koji kodira protein kako je definirano u bilo kojem od zahtjeva 1. – 5.
7. Vektor koji sadrži slijed nukleinske kiseline koji kodira protein kako je definirano u bilo kojem od zahtjeva 1. – 5.
8. Vektor prema zahtjevu 7., pri čemu se vektor odabire iz skupine koja se sastoji od sljedova SEQ ID BR: 15 (pHT01), SEQ ID BR: 16 (pHT43), SEQ ID BR: 17 (pHT100), SEQ ID BR: 18 (pHT223), SEQ ID BR: 19 (pHT250), SEQ ID BR: 20 (pHT431), SEQ ID BR: 21 (pHT432) i SEQ ID BR: 22 (pHT433).
9. Rekombinantni mikroorganizam koji sadrži vektor iz zahtjeva 7. ili 8., pri čemu je rekombinantni mikroorganizam B. licheniformis.
10. Rekombinantni mikroorganizam prema zahtjevu 9., odnosno B. licheniformis CICC10266.
11. Medicinska hrana koja sadrži rekombinantni protein bez fenilalanina kako je definirano u bilo kojem od zahtjeva 1.–5.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462053433P | 2014-09-22 | 2014-09-22 | |
EP15767155.3A EP3197472B1 (en) | 2014-09-22 | 2015-09-22 | Recombinant phe-free proteins for use in the treatment of phenylketonuria |
PCT/EP2015/071788 WO2016046234A2 (en) | 2014-09-22 | 2015-09-22 | Recombinant phe-free proteins for use in the treatment of phenylketonuria |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20211601T1 true HRP20211601T1 (hr) | 2022-01-21 |
Family
ID=55582188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20211601TT HRP20211601T1 (hr) | 2014-09-22 | 2015-09-22 | Rekombinantni proteini bez fenilalanina (phe) za liječenje fenilketonurije |
Country Status (9)
Country | Link |
---|---|
US (1) | US10174354B2 (hr) |
EP (1) | EP3197472B1 (hr) |
DK (1) | DK3197472T3 (hr) |
ES (1) | ES2896401T3 (hr) |
HR (1) | HRP20211601T1 (hr) |
LT (1) | LT3197472T (hr) |
PL (1) | PL3197472T3 (hr) |
SI (1) | SI3197472T1 (hr) |
WO (1) | WO2016046234A2 (hr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010045659A1 (en) | 2008-10-17 | 2010-04-22 | American Gene Technologies International Inc. | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
WO2017007994A1 (en) | 2015-07-08 | 2017-01-12 | American Gene Technologies International Inc. | Hiv pre-immunization and immunotherapy |
US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
CN108883100B (zh) | 2016-01-15 | 2022-11-25 | 美国基因技术国际有限公司 | 用于活化γ-δT细胞的方法和组合物 |
JP7153332B2 (ja) | 2016-02-08 | 2022-10-14 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Hivワクチン接種および免疫療法 |
EP4036231A1 (en) | 2016-03-09 | 2022-08-03 | American Gene Technologies International Inc. | Combination vectors and methods for treating cancer |
US11976292B2 (en) | 2016-06-08 | 2024-05-07 | American Gene Technologies International Inc. | Non-integrating viral delivery system and methods related thereto |
AU2017292582C1 (en) | 2016-07-08 | 2021-11-11 | American Gene Technologies International Inc. | HIV pre-immunization and immunotherapy |
WO2018017882A1 (en) | 2016-07-21 | 2018-01-25 | American Gene Technologies International Inc. | Viral vectors for treating parkinson's disease |
DK3290436T3 (da) | 2016-09-01 | 2019-08-19 | Metax Inst Fuer Diaetetik Gmbh | Phenylalanin-fri protein til behandlingen af pku |
WO2018187231A2 (en) * | 2017-04-03 | 2018-10-11 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
CN110746494B (zh) * | 2019-09-27 | 2021-07-20 | 深圳市诺维健生物技术有限责任公司 | 一组特殊膳食蛋白质 |
CN110747218A (zh) * | 2019-09-27 | 2020-02-04 | 深圳市诺维健生物技术有限责任公司 | 一种特殊膳食蛋白质的生产方法与应用 |
CN110846299B (zh) * | 2019-11-22 | 2021-09-24 | 江南大学 | 一种前导肽突变体及其在角蛋白酶生产中的应用 |
WO2021224152A1 (en) * | 2020-05-05 | 2021-11-11 | Basf Se | Improving expression in fermentation processes |
WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9310472D0 (en) * | 1993-05-20 | 1993-07-07 | Univ Warwick | Phenylalanine-free protein and dna coding thereof |
GB9314802D0 (en) * | 1993-07-16 | 1993-08-25 | Pharmaceutical Proteins Ltd | Modified proteins |
AU1939895A (en) * | 1994-03-01 | 1995-09-18 | E.R. Squibb & Sons, Inc. | Enzymatic debridement compositions and methods |
WO1996017064A1 (en) * | 1994-12-02 | 1996-06-06 | Indiana University Foundation | Phenylalanine free proteins |
US20110171718A1 (en) * | 2009-07-31 | 2011-07-14 | Danisco Us Inc. | Proteases With Modified Pre-Pro Regions |
US20150126441A1 (en) * | 2012-03-26 | 2015-05-07 | Pronutria, Inc. | Nutritive Fragments and Proteins with Low or No Phenylalanine and Methods |
EP2922416A4 (en) * | 2012-11-20 | 2016-07-20 | Pronutria Inc | MANIPULATED SECRETATED PROTEINS AND METHOD |
-
2015
- 2015-09-22 HR HRP20211601TT patent/HRP20211601T1/hr unknown
- 2015-09-22 SI SI201531735T patent/SI3197472T1/sl unknown
- 2015-09-22 PL PL15767155T patent/PL3197472T3/pl unknown
- 2015-09-22 ES ES15767155T patent/ES2896401T3/es active Active
- 2015-09-22 LT LTEPPCT/EP2015/071788T patent/LT3197472T/lt unknown
- 2015-09-22 US US15/512,974 patent/US10174354B2/en active Active
- 2015-09-22 EP EP15767155.3A patent/EP3197472B1/en active Active
- 2015-09-22 WO PCT/EP2015/071788 patent/WO2016046234A2/en active Application Filing
- 2015-09-22 DK DK15767155.3T patent/DK3197472T3/da active
Also Published As
Publication number | Publication date |
---|---|
SI3197472T1 (sl) | 2022-01-31 |
LT3197472T (lt) | 2021-11-10 |
WO2016046234A3 (en) | 2016-08-11 |
US20180016613A1 (en) | 2018-01-18 |
ES2896401T3 (es) | 2022-02-24 |
US10174354B2 (en) | 2019-01-08 |
DK3197472T3 (da) | 2021-10-18 |
WO2016046234A2 (en) | 2016-03-31 |
EP3197472B1 (en) | 2021-08-04 |
PL3197472T3 (pl) | 2021-12-27 |
EP3197472A2 (en) | 2017-08-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20211601T1 (hr) | Rekombinantni proteini bez fenilalanina (phe) za liječenje fenilketonurije | |
EA201792651A1 (ru) | Аденовирусные полинуклеотиды и полипептиды | |
MX2022003908A (es) | Enzimas y aplicaciones de las mismas. | |
PH12018502361A1 (en) | Gdf15 fusion proteins and uses thereof | |
MX2018006840A (es) | Focalizacion de peptidos para dirigir virus adenoasociados. | |
PH12016502282A1 (en) | Improved immunoglobulin variable domains | |
MX2018010824A (es) | Proteinas de union inducibles y metodos de uso. | |
TN2017000085A1 (en) | Polypeptide having a polyester degrading activity and uses thereof | |
EP3936141A3 (en) | Anti-senescence compounds and uses thereof | |
HRP20210734T1 (hr) | Koštani morfogenetski proteini | |
MX2014011459A (es) | Proteinas nutritivas cargadas y metodos. | |
WO2015179635A3 (en) | Ras inhibitory peptides and uses thereof | |
PH12020500569A1 (en) | Influenza virus vaccines and uses thereof | |
HRP20240163T1 (hr) | Metode i pripravci za izazivanje zaštitnog imuniteta protiv infekcije filovirusom | |
WO2015185758A3 (en) | Preparation comprising factor viii and von willebrand factor peptides | |
EA201990856A1 (ru) | Новые противомикробные агенты против бактерий enterococcus | |
WO2016036635A8 (en) | Chromobacterium subtsugae genes | |
PH12018500468A1 (en) | Fusion protein | |
WO2016089968A3 (en) | Thermoreversible hydrogels from the arrested phase separation of elastin-like polypeptides | |
MX2017014417A (es) | Vacunas contra el dengue. | |
NZ744289A (en) | Composition containing amino acids | |
MX362058B (es) | Péptido pntx(19) sintético, composición farmacéutica y uso. | |
WO2014060851A3 (en) | Hepatitis c virus immunogenic compositions and methods of use thereof | |
CL2015003242A1 (es) | Virus aav/upr-plus, proteína de fusión upr-plus, método de tratamiento genético y su uso en el tratamiento enfermedades neurodegenerativas, tales como las enfermedades de parkinson y huntington, entre otras. | |
WO2015041924A3 (en) | Recombinant respiratory syncytial virus (rsv) and caccines |