JP2019517790A5 - - Google Patents

Info

Publication number

JP2019517790A5

JP2019517790A5 JP2018559282A JP2018559282A JP2019517790A5 JP 2019517790 A5 JP2019517790 A5 JP 2019517790A5 JP 2018559282 A JP2018559282 A JP 2018559282A JP 2018559282 A JP2018559282 A JP 2018559282A JP 2019517790 A5 JP2019517790 A5 JP 2019517790A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

chain domain

nucleic acid

acid sequence

Prior art date

2017-05-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000003275 alpha amino acid group Chemical group 0.000 claims 32
• 108020004707 nucleic acids Proteins 0.000 claims 29
• 102000039446 nucleic acids Human genes 0.000 claims 29
• 150000007523 nucleic acids Chemical class 0.000 claims 29
• 210000004027 cell Anatomy 0.000 claims 18
• 108091008874 T cell receptors Proteins 0.000 claims 14
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 14
• 239000013598 vector Substances 0.000 claims 12
• 206010028980 Neoplasm Diseases 0.000 claims 8
• 201000011510 cancer Diseases 0.000 claims 8
• 239000012642 immune effector Substances 0.000 claims 8
• 229940121354 immunomodulator Drugs 0.000 claims 8
• 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 6
• 230000037431 insertion Effects 0.000 claims 5
• 238000003780 insertion Methods 0.000 claims 5
• 238000006467 substitution reaction Methods 0.000 claims 5
• 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 4
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 4
• 235000018102 proteins Nutrition 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 4
• 238000000034 method Methods 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 206010009944 Colon cancer Diseases 0.000 claims 2
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
• 102000025850 HLA-A2 Antigen Human genes 0.000 claims 2
• 108010074032 HLA-A2 Antigen Proteins 0.000 claims 2
• 208000008051 Hereditary Nonpolyposis Colorectal Neoplasms Diseases 0.000 claims 2
• 206010051922 Hereditary non-polyposis colorectal cancer syndrome Diseases 0.000 claims 2
• 201000005027 Lynch syndrome Diseases 0.000 claims 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 210000000822 natural killer cell Anatomy 0.000 claims 2
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000713666 Lentivirus Species 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 235000001014 amino acid Nutrition 0.000 claims 1
• 239000013599 cloning vector Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000037433 frameshift Effects 0.000 claims 1
• 210000005260 human cell Anatomy 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 108020004999 messenger RNA Proteins 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000035755 proliferation Effects 0.000 claims 1
• 230000004936 stimulating effect Effects 0.000 claims 1
• 241001430294 unidentified retrovirus Species 0.000 claims 1
• 101100112922 Candida albicans CDR3 gene Proteins 0.000 description 1