JP2016502515A5 - - Google Patents
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- Publication number
- JP2016502515A5 JP2016502515A5 JP2015540158A JP2015540158A JP2016502515A5 JP 2016502515 A5 JP2016502515 A5 JP 2016502515A5 JP 2015540158 A JP2015540158 A JP 2015540158A JP 2015540158 A JP2015540158 A JP 2015540158A JP 2016502515 A5 JP2016502515 A5 JP 2016502515A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antigen
- sequence
- identity
- sequences
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 15
- 102000025171 antigen binding proteins Human genes 0.000 claims 13
- 108091000831 antigen binding proteins Proteins 0.000 claims 13
- 210000004408 hybridoma Anatomy 0.000 claims 7
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 6
- 102000003839 Human Proteins Human genes 0.000 claims 2
- 108090000144 Human Proteins Proteins 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12290383 | 2012-11-05 | ||
| EP12290383.4 | 2012-11-05 | ||
| PCT/EP2013/073036 WO2014068139A1 (en) | 2012-11-05 | 2013-11-05 | Novel antigen binding proteins and their use as addressing product for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016502515A JP2016502515A (ja) | 2016-01-28 |
| JP2016502515A5 true JP2016502515A5 (https=) | 2016-12-22 |
| JP6445444B2 JP6445444B2 (ja) | 2018-12-26 |
Family
ID=47278721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540158A Active JP6445444B2 (ja) | 2012-11-05 | 2013-11-05 | 新規抗原結合タンパク質および癌の治療のためのアドレッシング産物（ａｄｄｒｅｓｓｉｎｇｐｒｏｄｕｃｔ）としてのそれらの使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9624308B2 (https=) |
| EP (1) | EP2914630B1 (https=) |
| JP (1) | JP6445444B2 (https=) |
| KR (1) | KR102167228B1 (https=) |
| CN (1) | CN104955842B (https=) |
| AR (1) | AR093357A1 (https=) |
| BR (1) | BR112015010046B1 (https=) |
| CA (1) | CA2890265C (https=) |
| DK (1) | DK2914630T3 (https=) |
| ES (1) | ES2871815T3 (https=) |
| HU (1) | HUE054115T2 (https=) |
| PL (1) | PL2914630T3 (https=) |
| TW (1) | TWI609887B (https=) |
| WO (1) | WO2014068139A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160106861A1 (en) * | 2013-04-26 | 2016-04-21 | Spirogen Sarl | Axl antibody-drug conjugate and its use for the treatment of cancer |
| MX370807B (es) | 2014-07-11 | 2020-01-08 | Genmab As | Anticuerpos que se unen a axl. |
| JP6864953B2 (ja) * | 2014-12-09 | 2021-04-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Ａｘｌに対するヒトモノクローナル抗体 |
| JP6931609B2 (ja) | 2014-12-18 | 2021-09-08 | ベルゲン テクノロジオーヴァーフォリング エイエス | 抗Ａｘｌアンタゴニスト抗体 |
| WO2016187356A1 (en) * | 2015-05-18 | 2016-11-24 | Agensys, Inc. | Antibodies that bind to axl proteins |
| WO2016187354A1 (en) | 2015-05-18 | 2016-11-24 | Agensys, Inc. | Antibodies that bind to axl proteins |
| CN108368171A (zh) * | 2015-07-10 | 2018-08-03 | 根马布股份公司 | 用于癌症治疗的axl特异性抗体-药物缀合物 |
| GB201610902D0 (en) * | 2016-06-22 | 2016-08-03 | Bergen Teknologioverforing As And Bergenbio As | Anti-Axl Antagonistic Antibodies |
| CN110483639A (zh) | 2018-05-15 | 2019-11-22 | 复旦大学 | 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 |
| GB201912059D0 (en) | 2019-08-22 | 2019-10-09 | Bergenbio As | Combaination therapy of a patient subgroup |
| GB202004189D0 (en) | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
| WO2021202592A2 (en) * | 2020-03-30 | 2021-10-07 | Oregon Health & Science University | Monoclonal antibodies for intracellular delivery of payloads |
| WO2021204713A1 (en) | 2020-04-08 | 2021-10-14 | Bergenbio Asa | Axl inhibitors for antiviral therapy |
| GB202006072D0 (en) | 2020-04-24 | 2020-06-10 | Bergenbio Asa | Method of selecting patients for treatment with cmbination therapy |
| GB202104037D0 (en) | 2021-03-23 | 2021-05-05 | Bergenbio Asa | Combination therapy |
| WO2022212790A1 (en) * | 2021-03-31 | 2022-10-06 | President And Fellows Of Harvard College | Methods of modulating hair growth |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970198A (en) | 1985-10-17 | 1990-11-13 | American Cyanamid Company | Antitumor antibiotics (LL-E33288 complex) |
| US5079233A (en) | 1987-01-30 | 1992-01-07 | American Cyanamid Company | N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same |
| US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| GB8924581D0 (en) | 1989-11-01 | 1989-12-20 | Pa Consulting Services | Bleaching of hair |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化ｂ−ｂ１０ |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| BRPI1013428A2 (pt) * | 2009-05-11 | 2019-07-02 | U3 Pharma Gmbh | anticorpos humanizados para axl |
| KR20120024763A (ko) * | 2009-05-15 | 2012-03-14 | 추가이 세이야쿠 가부시키가이샤 | 항ａｘｌ 항체 |
| WO2011014457A1 (en) * | 2009-07-27 | 2011-02-03 | Genentech, Inc. | Combination treatments |
| US20110302970A1 (en) | 2010-06-15 | 2011-12-15 | Keybrid, Inc. | Key - Key holder Combination |
| BR112012027995A2 (pt) * | 2010-06-18 | 2017-01-10 | Genentech Inc | anticorpo e ácido nucleíco isolado, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, uso do anticorpo, método de tratamento de um indivíduo com câncer, de um indivíduo possuíndo um distúrbio imune, de inibição da angiogênese e para inibir a ativação constitutiva de axl |
| EP2589609A1 (en) * | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Antigen binding protein and its use as addressing product for the treatment of cancer |
-
2013
- 2013-11-05 PL PL13789243T patent/PL2914630T3/pl unknown
- 2013-11-05 HU HUE13789243A patent/HUE054115T2/hu unknown
- 2013-11-05 CA CA2890265A patent/CA2890265C/en active Active
- 2013-11-05 CN CN201380067776.9A patent/CN104955842B/zh active Active
- 2013-11-05 KR KR1020157012651A patent/KR102167228B1/ko active Active
- 2013-11-05 EP EP13789243.6A patent/EP2914630B1/en active Active
- 2013-11-05 AR ARP130104035A patent/AR093357A1/es active IP Right Grant
- 2013-11-05 BR BR112015010046-5A patent/BR112015010046B1/pt active IP Right Grant
- 2013-11-05 ES ES13789243T patent/ES2871815T3/es active Active
- 2013-11-05 DK DK13789243.6T patent/DK2914630T3/da active
- 2013-11-05 WO PCT/EP2013/073036 patent/WO2014068139A1/en not_active Ceased
- 2013-11-05 US US14/440,491 patent/US9624308B2/en active Active
- 2013-11-05 TW TW102140130A patent/TWI609887B/zh active
- 2013-11-05 JP JP2015540158A patent/JP6445444B2/ja active Active
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