JP2017088633A5 - - Google Patents
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- Publication number
- JP2017088633A5 JP2017088633A5 JP2017036705A JP2017036705A JP2017088633A5 JP 2017088633 A5 JP2017088633 A5 JP 2017088633A5 JP 2017036705 A JP2017036705 A JP 2017036705A JP 2017036705 A JP2017036705 A JP 2017036705A JP 2017088633 A5 JP2017088633 A5 JP 2017088633A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- compound
- dioxooctahydro
- benzylcarbamoyl
- pyrazino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
- 229940123513 Beta-catenin antagonist Drugs 0.000 claims 2
- 235000021314 Palmitic acid Nutrition 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- -1 benzylcarbamoyl Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- SZHOJFHSIKHZHA-UHFFFAOYSA-N tridecanoic acid Chemical compound CCCCCCCCCCCCC(O)=O SZHOJFHSIKHZHA-UHFFFAOYSA-N 0.000 claims 2
- FRASJONUBLZVQX-UHFFFAOYSA-N 1,4-naphthoquinone Chemical compound C1=CC=C2C(=O)C=CC(=O)C2=C1 FRASJONUBLZVQX-UHFFFAOYSA-N 0.000 claims 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N Valeric acid Natural products CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims 1
- FBUKVWPVBMHYJY-UHFFFAOYSA-N noncarboxylic acid Natural products CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims 1
- 125000004943 pyrimidin-6-yl group Chemical group N1=CN=CC=C1* 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 210000001988 somatic stem cell Anatomy 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41433410P | 2010-11-16 | 2010-11-16 | |
| US41434810P | 2010-11-16 | 2010-11-16 | |
| US61/414,334 | 2010-11-16 | ||
| US61/414,348 | 2010-11-16 | ||
| US201161545033P | 2011-10-07 | 2011-10-07 | |
| US61/545,033 | 2011-10-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539987A Division JP6163105B2 (ja) | 2010-11-16 | 2011-11-16 | 体性幹細胞の非対称分裂を促進するためのｃｂｐ／カテニン拮抗剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017088633A JP2017088633A (ja) | 2017-05-25 |
| JP2017088633A5 true JP2017088633A5 (enExample) | 2017-07-20 |
| JP6518706B2 JP6518706B2 (ja) | 2019-05-22 |
Family
ID=46084627
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539987A Active JP6163105B2 (ja) | 2010-11-16 | 2011-11-16 | 体性幹細胞の非対称分裂を促進するためのｃｂｐ／カテニン拮抗剤 |
| JP2017036705A Active JP6518706B2 (ja) | 2010-11-16 | 2017-02-28 | 体性幹細胞の非対称分裂を促進するためのｃｂｐ／カテニン拮抗剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539987A Active JP6163105B2 (ja) | 2010-11-16 | 2011-11-16 | 体性幹細胞の非対称分裂を促進するためのｃｂｐ／カテニン拮抗剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10092568B2 (enExample) |
| EP (1) | EP2640393B1 (enExample) |
| JP (2) | JP6163105B2 (enExample) |
| KR (1) | KR102077871B1 (enExample) |
| CN (1) | CN103476415B (enExample) |
| AU (2) | AU2011329854B2 (enExample) |
| BR (1) | BR112013012228B1 (enExample) |
| CA (1) | CA2817975C (enExample) |
| ES (1) | ES2935544T3 (enExample) |
| WO (1) | WO2012068299A2 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011329854B2 (en) * | 2010-11-16 | 2017-03-30 | University Of Southern California | CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells |
| CA2851187A1 (en) * | 2011-10-07 | 2013-04-11 | University Of Southern California | Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells |
| US20160074400A1 (en) * | 2012-08-06 | 2016-03-17 | University Of Southern California | Wnt modulators for the protection, mitigation and treatment of radiation injury |
| WO2014061825A1 (en) * | 2012-10-19 | 2014-04-24 | Hiroyuki Kouji | Treatment of viral and infectious diseases using an inhibitor of cbp/catenin |
| WO2014061827A1 (en) * | 2012-10-19 | 2014-04-24 | Hiroyuki Kouji | Treatment of pulmonary fibrosis using an inhibitor of cbp/catenin |
| WO2014061824A1 (en) * | 2012-10-19 | 2014-04-24 | Hiroyuki Kouji | Methods for treating eye disorders |
| CN104902902A (zh) * | 2012-10-19 | 2015-09-09 | 株式会社棱镜制药 | 使用cbp/连环蛋白的抑制剂治疗硬皮病 |
| CA2889010A1 (en) * | 2012-10-19 | 2014-04-24 | Prism Pharma Co., Ltd. | Treatment of hyperproliferative and pre-cancerous skin diseases using an inhibitor of cbp/catenin |
| WO2014061823A1 (en) * | 2012-10-19 | 2014-04-24 | Hiroyuki Kouji | Method for treating type i and type ii diabetes |
| JP2016523125A (ja) | 2013-05-30 | 2016-08-08 | グラハム エイチ． クリーシー | 局所神経性刺激 |
| US11229789B2 (en) | 2013-05-30 | 2022-01-25 | Neurostim Oab, Inc. | Neuro activator with controller |
| CN104231048B (zh) * | 2013-06-05 | 2017-05-24 | 财团法人工业技术研究院 | 生发胜肽及药物组合物 |
| EP3129026A4 (en) * | 2014-04-11 | 2018-01-10 | Bcs Business Consulting Services Pte Ltd | Hair enhancing formulation |
| RU2549987C1 (ru) * | 2014-06-17 | 2015-05-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Башкирский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Средство для ускорения заживления ран и регенерации тканей |
| US11077301B2 (en) | 2015-02-21 | 2021-08-03 | NeurostimOAB, Inc. | Topical nerve stimulator and sensor for bladder control |
| WO2017025963A1 (en) * | 2015-08-10 | 2017-02-16 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Methods and pharmaceutical compositions for improving wound healing using cd24 |
| US10500203B2 (en) | 2015-09-09 | 2019-12-10 | Rush University Medical Center | Compositions and methods for treating bone diseases |
| JP6785487B2 (ja) * | 2015-09-18 | 2020-11-18 | 国立大学法人鳥取大学 | 低分子化合物による癌と線維化の抑制と再生促進の効果 |
| WO2017128163A1 (zh) * | 2016-01-28 | 2017-08-03 | 天津国际生物医药联合研究院 | 含笑内酯二甲基胺的应用 |
| CN105854018B (zh) * | 2016-03-28 | 2018-11-13 | 杭州师范大学 | Wnt抑制剂在制备治疗造血再生障碍性疾病药物中的应用 |
| WO2017184808A1 (en) * | 2016-04-20 | 2017-10-26 | University Of Southern California | Compounds and methods for increasing hematopoiesis |
| WO2019018441A1 (en) * | 2017-07-17 | 2019-01-24 | Massachusetts Institute Of Technology | ATLAS OF HEAVY AND ILLUMINATED HEAVY BARRIER TISSUE CELLS |
| KR102562469B1 (ko) | 2017-11-07 | 2023-08-01 | 뉴로스팀 오에이비, 인크. | 적응형 회로를 구비한 비침습성 신경 활성화기 |
| JP7605576B2 (ja) | 2018-07-25 | 2024-12-24 | ポーラ化成工業株式会社 | 皮膚老化改善剤のスクリーニング方法 |
| CN114126704B (zh) | 2019-06-26 | 2026-02-03 | 神经科学技术有限责任公司 | 具有自适应电路的非侵入性神经激活器 |
| EP4017580A4 (en) | 2019-12-16 | 2023-09-06 | Neurostim Technologies LLC | NON-INVASIVE NERVE ACTIVATOR WITH ENHANCED CHARGE DELIVERY |
| KR102612610B1 (ko) * | 2020-02-07 | 2023-12-12 | 주식회사 한스파마 | 신경줄기세포의 제조방법 및 이로부터 얻어진 신경줄기세포 배양액을 유효성분으로 포함하는 피부 재생, 항산화, 항염증 및 상처 치료용 조성물 |
| CA3175150A1 (en) | 2020-03-12 | 2021-09-16 | 3+2 Pharma LLC | Cbp/catenin signaling pathway inhibitors and uses thereof |
| WO2021183791A1 (en) | 2020-03-12 | 2021-09-16 | City Of Hope | Wnt/cbp/catenin signaling pathway inhibitors and uses thereof |
| US11639356B2 (en) * | 2020-10-05 | 2023-05-02 | Genesis Molecular Technologies, Inc. | Substituted imidazo[1,2-a]pyrazines and pyrazino[1,2-a]pyrimidines as topical agents for dermatological applications |
| JPWO2022092294A1 (enExample) * | 2020-10-30 | 2022-05-05 | ||
| WO2023114456A1 (en) * | 2021-12-17 | 2023-06-22 | Athira Pharma, Inc. | Uses of bicyclic compounds for the treatment of diseases |
| JP7178143B1 (ja) | 2022-03-17 | 2022-11-25 | 学校法人関西医科大学 | 爪幹細胞及び毛髪の成長を助長する外用剤 |
| JP2025536556A (ja) | 2022-10-25 | 2025-11-07 | ヴェラダーミクス インコーポレイテッド | 放出調節ミノキシジル用組成物および使用方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0267878A1 (en) | 1986-11-14 | 1988-05-18 | Ciba-Geigy Ag | N9-cyclopentyl-substituted adenine derivatives |
| US5262321A (en) | 1991-05-31 | 1993-11-16 | Dana-Farber Cancer Institute | DNA encoding p107 tumor suppressor |
| US5750336A (en) | 1994-02-10 | 1998-05-12 | The Salk Institute For Biological Studies | Assays for the identification of compounds which inhibit activation of cAMP and mitogen responsive genes |
| US5658784A (en) | 1994-04-14 | 1997-08-19 | Dana-Farber Cancer Institute, Inc. | Nucleic acid encoding transcription factor p300 and uses of p300 |
| IT1271007B (it) | 1994-09-13 | 1997-05-26 | Zambon Spa | Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare |
| US6184223B1 (en) * | 1995-10-27 | 2001-02-06 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| IL137164A0 (en) | 1998-01-23 | 2001-07-24 | Newbiotics Inc | Enzyme catalyzed therapeutic agents |
| EP1286954B1 (en) | 2000-05-15 | 2004-04-14 | Paratek Pharmaceuticals, Inc. | 7-substituted fused ring tetracycline compounds |
| CN1333270A (zh) * | 2000-07-07 | 2002-01-30 | 上海博德基因开发有限公司 | 一种新的多肽——人cbp20蛋白47.74和编码这种多肽的多核苷酸 |
| US7671054B1 (en) | 2001-10-12 | 2010-03-02 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US20040072831A1 (en) | 2001-10-12 | 2004-04-15 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US7566711B2 (en) | 2001-10-12 | 2009-07-28 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US7576084B2 (en) | 2001-10-12 | 2009-08-18 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US7232822B2 (en) | 2001-10-12 | 2007-06-19 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| TW200304371A (en) | 2002-02-22 | 2003-10-01 | Akzo Nobel Nv | Substituted 10-ary1-11H-benzo [b] fluorenes and 7-ary1-5, 6-dihydro-benz [a] anthracenes for selective effects on estrogen receptors |
| US6762185B1 (en) * | 2002-03-01 | 2004-07-13 | Choongwae Pharma Corporation | Compounds useful for treatment of cancer, compositions containing the same, and methods of their use |
| AU2003284120A1 (en) | 2002-10-17 | 2004-05-04 | Myriad Genetics, Inc. | Reverse-turn mimetics and composition and methods relating thereto |
| CN1871239A (zh) | 2003-08-28 | 2006-11-29 | (株)中外制药 | β－联蛋白/TCF激活转录的调节 |
| JP3722146B1 (ja) | 2004-06-16 | 2005-11-30 | セイコーエプソン株式会社 | プロジェクタおよび画像補正方法 |
| US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
| US7563825B1 (en) * | 2005-03-18 | 2009-07-21 | Choongwae Pharma Corporation | Modulation of beta-catenin coactivator interactions to effect stem cell growth or differentiation |
| WO2006101858A1 (en) * | 2005-03-18 | 2006-09-28 | Institute For Chemical Genomics | Alpha-helix mimetics and methods relating to the treatment of fibrosis |
| WO2007056513A1 (en) | 2005-11-08 | 2007-05-18 | Institute For Chemical Genomics | α-HELIX MIMETICS AND METHODS RELATING TO THE TREATMENT OF FIBROTIC DISORDERS |
| EP1960777B1 (en) | 2005-11-28 | 2009-10-21 | Choongwae Pharma Corporation | Serum-free expansion of cells in culture |
| US20090215783A1 (en) | 2006-05-30 | 2009-08-27 | Choongwae Pharma Corporation | Composition for induction or inhibition of stem cell differentiation |
| US7947277B2 (en) * | 2006-09-08 | 2011-05-24 | Genentech, Inc. | Wnt antagonists and their use in the diagnosis and treatment of Wnt-mediated disorders |
| CN101130799A (zh) * | 2007-08-06 | 2008-02-27 | 大连理工大学 | 利用几丁质生产生物能源物质的方法 |
| US8691819B2 (en) * | 2008-10-14 | 2014-04-08 | Prism Biolab Corporation | Alpha helix mimetic compositions for treating cancer and other CBP/catenin-mediated diseases and conditions |
| WO2010124365A1 (en) * | 2009-04-27 | 2010-11-04 | Ottawa Hospital Research Institute | Compositions and methods for modulating stem cells and uses thereof |
| WO2010128685A1 (en) | 2009-05-07 | 2010-11-11 | Prism Biolab Corporation | Alpha helix mimetics and methods relating thereto |
| AU2011329854B2 (en) * | 2010-11-16 | 2017-03-30 | University Of Southern California | CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells |
| WO2012115286A1 (en) * | 2011-02-25 | 2012-08-30 | Prism Biolab Corporation | Alpha helix mimetics and methods relating thereto |
-
2011
- 2011-11-16 AU AU2011329854A patent/AU2011329854B2/en active Active
- 2011-11-16 EP EP11841767.4A patent/EP2640393B1/en active Active
- 2011-11-16 ES ES11841767T patent/ES2935544T3/es active Active
- 2011-11-16 JP JP2013539987A patent/JP6163105B2/ja active Active
- 2011-11-16 CN CN201180065118.7A patent/CN103476415B/zh active Active
- 2011-11-16 WO PCT/US2011/061062 patent/WO2012068299A2/en not_active Ceased
- 2011-11-16 BR BR112013012228-5A patent/BR112013012228B1/pt active IP Right Grant
- 2011-11-16 CA CA2817975A patent/CA2817975C/en active Active
- 2011-11-16 KR KR1020137015423A patent/KR102077871B1/ko active Active
-
2013
- 2013-05-15 US US13/895,220 patent/US10092568B2/en active Active
-
2017
- 2017-02-28 JP JP2017036705A patent/JP6518706B2/ja active Active
- 2017-03-15 AU AU2017201750A patent/AU2017201750B9/en active Active
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