AU2011329854B2 - CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells - Google Patents

CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells Download PDF

Info

Publication number
AU2011329854B2
AU2011329854B2 AU2011329854A AU2011329854A AU2011329854B2 AU 2011329854 B2 AU2011329854 B2 AU 2011329854B2 AU 2011329854 A AU2011329854 A AU 2011329854A AU 2011329854 A AU2011329854 A AU 2011329854A AU 2011329854 B2 AU2011329854 B2 AU 2011329854B2
Authority
AU
Australia
Prior art keywords
catenin
optionally substituted
cbp
cells
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2011329854A
Other languages
English (en)
Other versions
AU2011329854A1 (en
Inventor
Michael Kahn
Michael Mcmillan
Jia-Ling Teo
Yongfeng Wu
Yi Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Southern California USC
Original Assignee
University of Southern California USC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Southern California USC filed Critical University of Southern California USC
Publication of AU2011329854A1 publication Critical patent/AU2011329854A1/en
Priority to AU2017201750A priority Critical patent/AU2017201750B9/en
Application granted granted Critical
Publication of AU2011329854B2 publication Critical patent/AU2011329854B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/55171,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/50Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/16Emollients or protectives, e.g. against radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/18Antioxidants, e.g. antiradicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
AU2011329854A 2010-11-16 2011-11-16 CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells Active AU2011329854B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017201750A AU2017201750B9 (en) 2010-11-16 2017-03-15 CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41433410P 2010-11-16 2010-11-16
US41434810P 2010-11-16 2010-11-16
US61/414,348 2010-11-16
US61/414,334 2010-11-16
US201161545033P 2011-10-07 2011-10-07
US61/545,033 2011-10-07
PCT/US2011/061062 WO2012068299A2 (en) 2010-11-16 2011-11-16 Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017201750A Division AU2017201750B9 (en) 2010-11-16 2017-03-15 CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells

Publications (2)

Publication Number Publication Date
AU2011329854A1 AU2011329854A1 (en) 2013-07-04
AU2011329854B2 true AU2011329854B2 (en) 2017-03-30

Family

ID=46084627

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2011329854A Active AU2011329854B2 (en) 2010-11-16 2011-11-16 CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells
AU2017201750A Active AU2017201750B9 (en) 2010-11-16 2017-03-15 CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017201750A Active AU2017201750B9 (en) 2010-11-16 2017-03-15 CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells

Country Status (10)

Country Link
US (1) US10092568B2 (enExample)
EP (1) EP2640393B1 (enExample)
JP (2) JP6163105B2 (enExample)
KR (1) KR102077871B1 (enExample)
CN (1) CN103476415B (enExample)
AU (2) AU2011329854B2 (enExample)
BR (1) BR112013012228B1 (enExample)
CA (1) CA2817975C (enExample)
ES (1) ES2935544T3 (enExample)
WO (1) WO2012068299A2 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013012228B1 (pt) * 2010-11-16 2023-02-28 University Of Southern California Método cosmético para tratar uma condição da pele e usos de um composto antagonista de cbp/catenina de molécula pequena
AU2012319069A1 (en) 2011-10-07 2014-05-29 University Of Southern California CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells
WO2014025832A1 (en) * 2012-08-06 2014-02-13 University Of Southern California Wnt modulators for the protection, mitigation and treatment of radiation injury
WO2014061825A1 (en) * 2012-10-19 2014-04-24 Hiroyuki Kouji Treatment of viral and infectious diseases using an inhibitor of cbp/catenin
JP2016502497A (ja) * 2012-10-19 2016-01-28 株式会社PRISM Pharma I型およびii型糖尿病を治療する方法
EP2908822A4 (en) * 2012-10-19 2016-04-27 Prism Pharma Co Ltd TREATMENT OF HYPERPROLIFERATIVE AND PRECANCEROUS DISEASES OF THE SKIN USING A CBP / CATENIN INHIBITOR
EP2908820A1 (en) * 2012-10-19 2015-08-26 Prism Pharma Co., Ltd. Treatment of pulmonary fibrosis using an inhibitor of cbp/catenin
AU2013332731A1 (en) * 2012-10-19 2015-06-04 Prism Pharma Co., Ltd. Methods for treating eye disorders
JP2015536300A (ja) * 2012-10-19 2015-12-21 株式会社PRISM Pharma Cbp/カテニン阻害剤を用いる強皮症の治療
US11229789B2 (en) 2013-05-30 2022-01-25 Neurostim Oab, Inc. Neuro activator with controller
PL3003473T3 (pl) 2013-05-30 2019-05-31 Neurostim Solutions LLC Miejscowa stymulacja neurologiczna
CN104231048B (zh) * 2013-06-05 2017-05-24 财团法人工业技术研究院 生发胜肽及药物组合物
WO2015157771A1 (en) * 2014-04-11 2015-10-15 Bcs Business Consulting Services Pte Ltd Hair enhancing formulation
RU2549987C1 (ru) * 2014-06-17 2015-05-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Башкирский государственный медицинский университет" Министерства здравоохранения Российской Федерации Средство для ускорения заживления ран и регенерации тканей
US11077301B2 (en) 2015-02-21 2021-08-03 NeurostimOAB, Inc. Topical nerve stimulator and sensor for bladder control
US10639350B2 (en) 2015-08-10 2020-05-05 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Methods and pharmaceutical compositions for improving wound healing using CD24
WO2017044302A1 (en) * 2015-09-09 2017-03-16 Rush University Medical Center Compositions and methods for treating bone diseases
EP3366687B1 (en) * 2015-09-18 2020-04-29 National University Corporation Tottori University Suppression and regeneration promoting effect of low molecular weight compound on cancer and fibrosis
EP3320901B1 (en) * 2016-01-28 2020-03-04 Accendatech Dimethylaminomicheliolide for use in the treatment of pulmonary fibrosis
CN105854018B (zh) * 2016-03-28 2018-11-13 杭州师范大学 Wnt抑制剂在制备治疗造血再生障碍性疾病药物中的应用
US20190125753A1 (en) * 2016-04-20 2019-05-02 University Of Southern California Compounds and methods for increasing hematopoiesis
WO2019018441A1 (en) * 2017-07-17 2019-01-24 Massachusetts Institute Of Technology ATLAS OF HEAVY AND ILLUMINATED HEAVY BARRIER TISSUE CELLS
CN111601636A (zh) 2017-11-07 2020-08-28 Oab神经电疗科技公司 具有自适应电路的非侵入性神经激活器
JP7605576B2 (ja) 2018-07-25 2024-12-24 ポーラ化成工業株式会社 皮膚老化改善剤のスクリーニング方法
EP3990100A4 (en) 2019-06-26 2023-07-19 Neurostim Technologies LLC Non-invasive nerve activator with adaptive circuit
CA3152451A1 (en) 2019-12-16 2021-06-24 Michael Bernard Druke Non-invasive nerve activator with boosted charge delivery
KR102612610B1 (ko) * 2020-02-07 2023-12-12 주식회사 한스파마 신경줄기세포의 제조방법 및 이로부터 얻어진 신경줄기세포 배양액을 유효성분으로 포함하는 피부 재생, 항산화, 항염증 및 상처 치료용 조성물
WO2021183791A1 (en) 2020-03-12 2021-09-16 City Of Hope Wnt/cbp/catenin signaling pathway inhibitors and uses thereof
CA3194606A1 (en) * 2020-10-05 2022-04-14 Fuqiang Ruan Topical agents for dermatological applications
US20230390296A1 (en) * 2020-10-30 2023-12-07 Keio University Novel treatment and prevention of sarcopenia-related diseases
WO2023114456A1 (en) * 2021-12-17 2023-06-22 Athira Pharma, Inc. Uses of bicyclic compounds for the treatment of diseases
JP7178143B1 (ja) 2022-03-17 2022-11-25 学校法人関西医科大学 爪幹細胞及び毛髪の成長を助長する外用剤

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413963B2 (en) * 1995-10-27 2002-07-02 Molecumetics, Ltd. Reverse-turn mimetics and methods relating thereto
WO2006101858A1 (en) * 2005-03-18 2006-09-28 Institute For Chemical Genomics Alpha-helix mimetics and methods relating to the treatment of fibrosis
US20070021431A1 (en) * 2001-10-12 2007-01-25 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
WO2010044485A1 (en) * 2008-10-14 2010-04-22 Prism Biolab Corporation Alpha helix mimetics in the treatment of cancer
WO2012115286A1 (en) * 2011-02-25 2012-08-30 Prism Biolab Corporation Alpha helix mimetics and methods relating thereto

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0267878A1 (en) 1986-11-14 1988-05-18 Ciba-Geigy Ag N9-cyclopentyl-substituted adenine derivatives
US5262321A (en) 1991-05-31 1993-11-16 Dana-Farber Cancer Institute DNA encoding p107 tumor suppressor
US5750336A (en) 1994-02-10 1998-05-12 The Salk Institute For Biological Studies Assays for the identification of compounds which inhibit activation of cAMP and mitogen responsive genes
US5658784A (en) 1994-04-14 1997-08-19 Dana-Farber Cancer Institute, Inc. Nucleic acid encoding transcription factor p300 and uses of p300
IT1271007B (it) 1994-09-13 1997-05-26 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare
US6245750B1 (en) 1998-01-23 2001-06-12 Newbiotics, Inc. Enzyme catalyzed therapeutic agents
DE60102815D1 (de) 2000-05-15 2004-05-19 Paratek Pharm Innc 7-substituierte kondensierte ring-tetrazyclin- verbindungen
CN1333270A (zh) * 2000-07-07 2002-01-30 上海博德基因开发有限公司 一种新的多肽——人cbp20蛋白47.74和编码这种多肽的多核苷酸
US7566711B2 (en) 2001-10-12 2009-07-28 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7671054B1 (en) 2001-10-12 2010-03-02 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US20040072831A1 (en) 2001-10-12 2004-04-15 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7576084B2 (en) 2001-10-12 2009-08-18 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
TW200304371A (en) 2002-02-22 2003-10-01 Akzo Nobel Nv Substituted 10-ary1-11H-benzo [b] fluorenes and 7-ary1-5, 6-dihydro-benz [a] anthracenes for selective effects on estrogen receptors
US6762185B1 (en) * 2002-03-01 2004-07-13 Choongwae Pharma Corporation Compounds useful for treatment of cancer, compositions containing the same, and methods of their use
WO2004035587A1 (en) 2002-10-17 2004-04-29 Myriad Genetics, Inc. Reverse-turn mimetics and composition and methods relating thereto
CA2537099A1 (en) 2003-08-28 2005-03-10 Choongwae Pharma Corporation Modulation of .beta.-catenin/tcf activated transcription
JP3722146B1 (ja) 2004-06-16 2005-11-30 セイコーエプソン株式会社 プロジェクタおよび画像補正方法
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
US7563825B1 (en) * 2005-03-18 2009-07-21 Choongwae Pharma Corporation Modulation of beta-catenin coactivator interactions to effect stem cell growth or differentiation
WO2007056513A1 (en) 2005-11-08 2007-05-18 Institute For Chemical Genomics α-HELIX MIMETICS AND METHODS RELATING TO THE TREATMENT OF FIBROTIC DISORDERS
DE602006009965D1 (de) 2005-11-28 2009-12-03 Choongwae Pharma Corp Serumfreie expansion von zellen in kultur
WO2007139346A1 (en) 2006-05-30 2007-12-06 Choongwae Pharma Corporation Composition for induction or inhibition of stem cell differentiation
PE20120807A1 (es) * 2006-09-08 2012-07-26 Genentech Inc Antagonistas del gen wnt y su uso en el diagnostico y tratamiento de trastornos mediados por el wnt
CN101130799A (zh) * 2007-08-06 2008-02-27 大连理工大学 利用几丁质生产生物能源物质的方法
CA2760042C (en) * 2009-04-27 2020-03-10 Ottawa Hospital Research Institute Compositions and methods for modulating stem cells and uses thereof
JP5768239B2 (ja) 2009-05-07 2015-08-26 株式会社 PRISM BioLab アルファへリックスミメティック及び関連の方法
BR112013012228B1 (pt) * 2010-11-16 2023-02-28 University Of Southern California Método cosmético para tratar uma condição da pele e usos de um composto antagonista de cbp/catenina de molécula pequena

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413963B2 (en) * 1995-10-27 2002-07-02 Molecumetics, Ltd. Reverse-turn mimetics and methods relating thereto
US20070021431A1 (en) * 2001-10-12 2007-01-25 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
WO2006101858A1 (en) * 2005-03-18 2006-09-28 Institute For Chemical Genomics Alpha-helix mimetics and methods relating to the treatment of fibrosis
WO2010044485A1 (en) * 2008-10-14 2010-04-22 Prism Biolab Corporation Alpha helix mimetics in the treatment of cancer
WO2012115286A1 (en) * 2011-02-25 2012-08-30 Prism Biolab Corporation Alpha helix mimetics and methods relating thereto

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Botchkareva et al (2007) Journal of Investigative Dermatology, 127:479-482 *
CHO et al (2009) Biochemical and Biophysical Research Communications, 390:500-505 *
Wend et al (2010) Seminars in Cell & Developmental Biology, 21:855-863 *

Also Published As

Publication number Publication date
US10092568B2 (en) 2018-10-09
AU2017201750A1 (en) 2017-03-30
CN103476415B (zh) 2017-09-22
EP2640393A4 (en) 2015-05-27
WO2012068299A2 (en) 2012-05-24
AU2011329854A1 (en) 2013-07-04
CN103476415A (zh) 2013-12-25
JP6518706B2 (ja) 2019-05-22
JP2013542999A (ja) 2013-11-28
WO2012068299A9 (en) 2013-06-20
EP2640393A2 (en) 2013-09-25
KR102077871B1 (ko) 2020-02-14
CA2817975A1 (en) 2012-05-24
US20130280233A1 (en) 2013-10-24
KR20130140079A (ko) 2013-12-23
JP6163105B2 (ja) 2017-07-12
CA2817975C (en) 2020-03-31
AU2017201750B9 (en) 2019-01-31
JP2017088633A (ja) 2017-05-25
ES2935544T3 (es) 2023-03-07
BR112013012228A2 (pt) 2021-05-18
BR112013012228B1 (pt) 2023-02-28
AU2017201750B2 (en) 2019-01-17
EP2640393B1 (en) 2022-10-12

Similar Documents

Publication Publication Date Title
AU2017201750B2 (en) CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells
US9371330B2 (en) Substituted pyrazino[1,2-a]pyrimidines useful as CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells
Lu et al. Induction of inflammatory cytokines by a keratin mutation and their repression by a small molecule in a mouse model for EBS
Kang et al. Opposite effects of non-thermal plasma on cell migration and collagen production in keloid and normal fibroblasts
EP3111956A1 (en) Bmi 1 protein expression modulators
CA2904794A1 (en) Modulators of the eif2alpha pathway
JP5792185B2 (ja) 線維増殖性障害および癌からなる群から選択されるβ−カテニン媒介障害を治療するための医薬組成物
JP7746165B2 (ja) Nurr1受容体調節因子
KR102168006B1 (ko) 체세포 줄기 세포의 비대칭 분열을 향상시키기 위한 cbp/카테닌 길항제
EP3112343A1 (en) Amide derivatives
Zhao et al. Effects of MITF on marker protein expression of multivesicular bodies and miRNA omics of extracellular vesicles of mice melanocyte cell line
KR101629540B1 (ko) 신규 벤조 이미다조 이미다졸 유도체 및 이를 유효성분으로 함유하는 피부 미백용 조성물
Siedlar The role of NOX4 in skin fibroblasts
Çetinkaya et al. Endoplazmik retikulum stresinin tümör sürecindeki rolü ve antikanser uygulamaları
HK1224224B (zh) 使用奈福泮化合物治疗侵袭型纤维瘤病和β-联蛋白介导的疾病的方法

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)