BRPI0413969A - modulação da transcrição ativada por -catenina/tcf - Google Patents
modulação da transcrição ativada por -catenina/tcfInfo
- Publication number
- BRPI0413969A BRPI0413969A BRPI0413969-0A BRPI0413969A BRPI0413969A BR PI0413969 A BRPI0413969 A BR PI0413969A BR PI0413969 A BRPI0413969 A BR PI0413969A BR PI0413969 A BRPI0413969 A BR PI0413969A
- Authority
- BR
- Brazil
- Prior art keywords
- tcf
- catenin
- activated
- transcription
- transcription modulation
- Prior art date
Links
- 238000013518 transcription Methods 0.000 title abstract 3
- 230000035897 transcription Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"MODULAçãO DA TRANSCRIçãO ATIVADA POR <225>CATENINA/TCF". A presente invenção propõe compostos e métodos para a modulação da transcrição ativada por <225>-catenina/TCF, tal como a inibição seletiva de genes visada pelo trajeto de Wnt/<225>-catenina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49845103P | 2003-08-28 | 2003-08-28 | |
PCT/US2004/028142 WO2005021025A2 (en) | 2003-08-28 | 2004-08-27 | MODULATION OF β-CATENIN/TCF ACTIVATED TRANSCRIPTION |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0413969A true BRPI0413969A (pt) | 2006-10-31 |
Family
ID=34272675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0413969-0A BRPI0413969A (pt) | 2003-08-28 | 2004-08-27 | modulação da transcrição ativada por -catenina/tcf |
Country Status (11)
Country | Link |
---|---|
US (1) | US7531320B2 (pt) |
EP (1) | EP1660502A2 (pt) |
JP (1) | JP2007503816A (pt) |
KR (1) | KR20060121842A (pt) |
CN (1) | CN1871239A (pt) |
AU (1) | AU2004268647B2 (pt) |
BR (1) | BRPI0413969A (pt) |
CA (1) | CA2537099A1 (pt) |
NZ (1) | NZ545568A (pt) |
RU (1) | RU2383547C2 (pt) |
WO (1) | WO2005021025A2 (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7232822B2 (en) | 2001-10-12 | 2007-06-19 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
US7576084B2 (en) | 2001-10-12 | 2009-08-18 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
US8080657B2 (en) * | 2001-10-12 | 2011-12-20 | Choongwae Pharma Corporation | Compounds of reverse turn mimetics and the use thereof |
US7566711B2 (en) * | 2001-10-12 | 2009-07-28 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
US7671054B1 (en) * | 2001-10-12 | 2010-03-02 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
US20060030042A1 (en) * | 2003-12-19 | 2006-02-09 | Ali Brivanlou | Maintenance of embryonic stem cells by the GSK-3 inhibitor 6-bromoindirubin-3'-oxime |
US7585630B2 (en) * | 2005-06-20 | 2009-09-08 | Decode Genetics Ehf. | Genetic variants in the TCF7L2 gene as diagnostic markers for risk of type 2 diabetes mellitus |
KR101486490B1 (ko) * | 2005-11-08 | 2015-01-27 | 제이더블유중외제약 주식회사 | α-헬릭스 유사체 및 암 줄기세포의 치료에 관한 방법 |
JP2009538903A (ja) * | 2006-05-30 | 2009-11-12 | チュンウェ ファーマ コーポレーション | 幹細胞分化の誘導または抑制のための組成物 |
JP2010509919A (ja) | 2006-11-15 | 2010-04-02 | マサチューセッツ・アイ・アンド・イア・インファーマリー | 内耳細胞の生成 |
AU2009255042B2 (en) | 2008-06-06 | 2014-05-15 | Prism Biolab Corporation | Alpha helix mimetics and methods relating thereto |
CN102186853A (zh) | 2008-10-14 | 2011-09-14 | 株式会社棱镜生物实验室 | 治疗癌症α-螺旋模拟物 |
US10143711B2 (en) | 2008-11-24 | 2018-12-04 | Massachusetts Eye & Ear Infirmary | Pathways to generate hair cells |
WO2010120112A2 (en) * | 2009-04-15 | 2010-10-21 | Choongwae Pharma Corporation | Novel compounds of reverse-turn mimetics, method for manufacturing the same and use thereof |
CN102482258B (zh) * | 2009-05-07 | 2014-06-25 | 株式会社棱镜制药 | α-螺旋模拟物和与其相关的方法 |
KR102168006B1 (ko) | 2010-10-07 | 2020-10-20 | 유니버시티 오브 써던 캘리포니아 | 체세포 줄기 세포의 비대칭 분열을 향상시키기 위한 cbp/카테닌 길항제 |
EP2628741B1 (en) | 2010-10-14 | 2015-10-07 | JW Pharmaceutical Corporation | Novel compound of a reverse-turn mimetic and a production method and use therefor |
CN103476415B (zh) | 2010-11-16 | 2017-09-22 | 南加州大学 | 用于增强成体干细胞的不对称分裂的cbp/连环蛋白拮抗剂 |
CN103517904A (zh) * | 2011-02-25 | 2014-01-15 | 株式会社棱镜制药 | α-螺旋模拟物和与其相关的方法 |
JP6355555B2 (ja) | 2011-04-01 | 2018-07-11 | キアゲン | Wnt/b−カテニンシグナル伝達経路に関する遺伝子発現シグネチャーおよびその使用 |
EP2698365B8 (en) * | 2011-04-15 | 2018-02-14 | National University Corporation Tottori University | Synthesis and analysis of novel compound capable of inducing differentiation of human mesenchymal stem cell into hepatocyte |
CN103958517B (zh) | 2011-10-07 | 2016-10-19 | 南加州大学 | 用于增强成体干细胞的不对称分裂的cbp/连环蛋白拮抗剂 |
EP2892506B1 (en) | 2012-09-07 | 2021-11-03 | Massachusetts Eye & Ear Infirmary | Treating hearing loss with the gamma-secretase inhibitor ly411575 |
CN104004098B (zh) * | 2014-05-29 | 2016-05-18 | 清华大学 | 一种利用BiFC指示细胞中Wnt信号活性状态的载体组合物及应用 |
WO2016022776A2 (en) | 2014-08-06 | 2016-02-11 | Massachusetts Eye And Ear Infirmary | Increasing atoh1 life to drive sensorineural hair cell differentiantion |
US11185536B2 (en) | 2015-12-04 | 2021-11-30 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
EP3407901B1 (en) | 2016-01-29 | 2021-07-21 | Massachusetts Eye & Ear Infirmary | Expansion and differentiation of inner ear supporting cells and methods of use thereof |
WO2020130119A1 (ja) * | 2018-12-20 | 2020-06-25 | 学校法人京都薬科大学 | Wntシグナル伝達経路阻害剤 |
CN116925081A (zh) * | 2022-04-11 | 2023-10-24 | 中国科学院上海药物研究所 | 一种环肽类化合物及其应用 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
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US21773A (en) * | 1858-10-12 | Improvement in compound shells for ordnance | ||
US27819A (en) * | 1860-04-10 | Hose-tubing | ||
US65416A (en) * | 1867-06-04 | mobton | ||
US39274A (en) * | 1863-07-21 | Improved cask | ||
US105103A (en) * | 1870-07-05 | Improvement in plows | ||
US22620A (en) * | 1859-01-18 | Improvement in lubricating compounds | ||
US72831A (en) * | 1867-12-31 | ferry | ||
US68695A (en) * | 1867-09-10 | brown | ||
US5475085A (en) * | 1991-02-07 | 1995-12-12 | Molecumetics, Ltd. | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
WO1992013878A2 (en) * | 1991-02-07 | 1992-08-20 | Board Of Trustees Of The University Of Illinois | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
JPH07509723A (ja) | 1992-08-06 | 1995-10-26 | モレキュメティクス,リミティド | 反転型ターンの立体配座的に拘束されたミメティックスと前者を含有するペプチド |
US5446128A (en) | 1993-06-18 | 1995-08-29 | The Board Of Trustees Of The University Of Illinois | Alpha-helix mimetics and methods relating thereto |
US5750336A (en) | 1994-02-10 | 1998-05-12 | The Salk Institute For Biological Studies | Assays for the identification of compounds which inhibit activation of cAMP and mitogen responsive genes |
US5693325A (en) | 1994-03-15 | 1997-12-02 | Molecumetics, Ltd. | Peptide vaccines and methods relating thereto |
US5658784A (en) * | 1994-04-14 | 1997-08-19 | Dana-Farber Cancer Institute, Inc. | Nucleic acid encoding transcription factor p300 and uses of p300 |
US6020331A (en) | 1995-03-24 | 2000-02-01 | Molecumetics, Ltd. | β-sheet mimetics and use thereof as protease inhibitors |
US6245764B1 (en) | 1995-03-24 | 2001-06-12 | Molecumetics Ltd. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
US6013458A (en) | 1995-10-27 | 2000-01-11 | Molecumetics, Ltd. | Reverse-turn mimetics and methods relating thereto |
US5840833A (en) | 1995-10-27 | 1998-11-24 | Molecumetics, Ltd | Alpha-helix mimetics and methods relating thereto |
US6184223B1 (en) | 1995-10-27 | 2001-02-06 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
US5929237A (en) | 1995-10-27 | 1999-07-27 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
AU4043897A (en) | 1996-07-23 | 1998-02-10 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | P300/cbp-associated transcriptional co-factor p/caf and uses thereof |
US6117896A (en) | 1997-02-10 | 2000-09-12 | Molecumetics Ltd. | Methods for regulating transcription factors |
JPH1132767A (ja) * | 1997-07-16 | 1999-02-09 | Yamanouchi Pharmaceut Co Ltd | 組み換え型核内レセプター結合タンパク質を用いた核内レセプターの検出方法、およびその用途 |
CA2305711A1 (en) | 1997-10-07 | 1999-04-15 | Merck & Co., Inc. | Assays for nuclear receptor ligands using fret |
US6451972B1 (en) | 1998-11-16 | 2002-09-17 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors |
EP1054059A1 (en) * | 1999-05-17 | 2000-11-22 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Novel cDNAs encoding catenin-binding proteins with function in signalling and/or gene regulation |
US6294525B1 (en) | 1999-09-01 | 2001-09-25 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
US6872825B2 (en) | 1999-12-21 | 2005-03-29 | The Procter & Gamble Company | Peptide β-turn mimetic compounds and processes for making them |
DE10005631A1 (de) | 2000-02-09 | 2001-08-23 | Max Planck Gesellschaft | Arginin-Mimetika als Faktor X¶a¶-Inhibitoren |
DE60131658T2 (de) * | 2000-07-14 | 2008-10-30 | Chugai Seiyaku K.K. | P300 transgenes tier |
GB0103508D0 (en) * | 2001-02-13 | 2001-03-28 | Univ Dundee | Screening method and agents |
WO2003000730A1 (en) | 2001-06-21 | 2003-01-03 | The General Hospital Corporation | Compounds that modulate estrogen actions |
CA2453175A1 (en) | 2001-07-09 | 2003-01-23 | Pharmacia Italia Spa | Interaction inhibitors of tcf-4 with beta-catenin |
US20040072831A1 (en) * | 2001-10-12 | 2004-04-15 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
ES2310215T3 (es) * | 2001-10-12 | 2009-01-01 | Choongwae Pharma Corporation | Estructuras mimeticas de giro inverso y metodo relacionado. |
US20050202428A1 (en) | 2002-02-13 | 2005-09-15 | Axordia Limited | Pluripotential stem cells |
US6762185B1 (en) * | 2002-03-01 | 2004-07-13 | Choongwae Pharma Corporation | Compounds useful for treatment of cancer, compositions containing the same, and methods of their use |
-
2004
- 2004-08-27 RU RU2006109712/04A patent/RU2383547C2/ru not_active IP Right Cessation
- 2004-08-27 CA CA002537099A patent/CA2537099A1/en not_active Abandoned
- 2004-08-27 EP EP04782582A patent/EP1660502A2/en not_active Withdrawn
- 2004-08-27 CN CNA2004800306882A patent/CN1871239A/zh active Pending
- 2004-08-27 BR BRPI0413969-0A patent/BRPI0413969A/pt not_active IP Right Cessation
- 2004-08-27 WO PCT/US2004/028142 patent/WO2005021025A2/en active Search and Examination
- 2004-08-27 AU AU2004268647A patent/AU2004268647B2/en not_active Ceased
- 2004-08-27 US US10/928,626 patent/US7531320B2/en not_active Expired - Fee Related
- 2004-08-27 NZ NZ545568A patent/NZ545568A/en unknown
- 2004-08-27 JP JP2006524937A patent/JP2007503816A/ja active Pending
- 2004-08-27 KR KR1020067004085A patent/KR20060121842A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
RU2006109712A (ru) | 2007-10-10 |
NZ545568A (en) | 2009-06-26 |
JP2007503816A (ja) | 2007-03-01 |
EP1660502A2 (en) | 2006-05-31 |
US20050059628A1 (en) | 2005-03-17 |
CA2537099A1 (en) | 2005-03-10 |
CN1871239A (zh) | 2006-11-29 |
US7531320B2 (en) | 2009-05-12 |
KR20060121842A (ko) | 2006-11-29 |
AU2004268647A1 (en) | 2005-03-10 |
WO2005021025A3 (en) | 2005-07-07 |
WO2005021025A2 (en) | 2005-03-10 |
AU2004268647B2 (en) | 2010-07-01 |
RU2383547C2 (ru) | 2010-03-10 |
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