JP2017043632A5 - - Google Patents
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- JP2017043632A5 JP2017043632A5 JP2016225290A JP2016225290A JP2017043632A5 JP 2017043632 A5 JP2017043632 A5 JP 2017043632A5 JP 2016225290 A JP2016225290 A JP 2016225290A JP 2016225290 A JP2016225290 A JP 2016225290A JP 2017043632 A5 JP2017043632 A5 JP 2017043632A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- factor
- inhibitor
- amino acid
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 229940123583 Factor Xa inhibitor Drugs 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 4
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- QNZCBYKSOIHPEH-UHFFFAOYSA-N Apixaban Chemical compound C1=CC(OC)=CC=C1N1C(C(=O)N(CC2)C=3C=CC(=CC=3)N3C(CCCC3)=O)=C2C(C(N)=O)=N1 QNZCBYKSOIHPEH-UHFFFAOYSA-N 0.000 claims 2
- HGVDHZBSSITLCT-JLJPHGGASA-N Edoxaban Chemical compound N([C@H]1CC[C@@H](C[C@H]1NC(=O)C=1SC=2CN(C)CCC=2N=1)C(=O)N(C)C)C(=O)C(=O)NC1=CC=C(Cl)C=N1 HGVDHZBSSITLCT-JLJPHGGASA-N 0.000 claims 2
- 208000032843 Hemorrhage Diseases 0.000 claims 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000010100 anticoagulation Effects 0.000 claims 2
- 229960003886 apixaban Drugs 0.000 claims 2
- 229950011103 betrixaban Drugs 0.000 claims 2
- XHOLNRLADUSQLD-UHFFFAOYSA-N betrixaban Chemical compound C=1C=C(Cl)C=NC=1NC(=O)C1=CC(OC)=CC=C1NC(=O)C1=CC=C(C(=N)N(C)C)C=C1 XHOLNRLADUSQLD-UHFFFAOYSA-N 0.000 claims 2
- 208000034158 bleeding Diseases 0.000 claims 2
- 230000000740 bleeding effect Effects 0.000 claims 2
- 229960000622 edoxaban Drugs 0.000 claims 2
- 229960000610 enoxaparin Drugs 0.000 claims 2
- KANJSNBRCNMZMV-ABRZTLGGSA-N fondaparinux Chemical group O[C@@H]1[C@@H](NS(O)(=O)=O)[C@@H](OC)O[C@H](COS(O)(=O)=O)[C@H]1O[C@H]1[C@H](OS(O)(=O)=O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O4)NS(O)(=O)=O)[C@H](O3)C(O)=O)O)[C@@H](COS(O)(=O)=O)O2)NS(O)(=O)=O)[C@H](C(O)=O)O1 KANJSNBRCNMZMV-ABRZTLGGSA-N 0.000 claims 2
- 229960001318 fondaparinux Drugs 0.000 claims 2
- 238000010253 intravenous injection Methods 0.000 claims 2
- 239000003055 low molecular weight heparin Substances 0.000 claims 2
- 229940127215 low-molecular weight heparin Drugs 0.000 claims 2
- MVPQUSQUURLQKF-MCPDASDXSA-E nonasodium;(2s,3s,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[(2r,3s,4s,5r,6r)-2-carboxylato-4,5-dimethoxy-6-[(2r,3r,4s,5r,6s)-6-methoxy-4,5-disulfonatooxy-2-(sulfonatooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-disulfonatooxy-2-(sulfonatooxymethyl)oxan-3-yl]oxy-4,5-di Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)O[C@@H]1[C@@H](OS([O-])(=O)=O)[C@@H](OC)O[C@H](COS([O-])(=O)=O)[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@@H]2[C@@H]([C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3[C@@H]([C@@H](OC)[C@H](O[C@@H]4[C@@H]([C@@H](OC)[C@H](OC)[C@@H](COS([O-])(=O)=O)O4)OC)[C@H](O3)C([O-])=O)OC)[C@@H](COS([O-])(=O)=O)O2)OS([O-])(=O)=O)[C@H](C([O-])=O)O1 MVPQUSQUURLQKF-MCPDASDXSA-E 0.000 claims 2
- -1 rNAPc2 Proteins 0.000 claims 2
- 229960001148 rivaroxaban Drugs 0.000 claims 2
- KGFYHTZWPPHNLQ-AWEZNQCLSA-N rivaroxaban Chemical compound S1C(Cl)=CC=C1C(=O)NC[C@@H]1OC(=O)N(C=2C=CC(=CC=2)N2C(COCC2)=O)C1 KGFYHTZWPPHNLQ-AWEZNQCLSA-N 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- LJCBAPRMNYSDOP-LVCYMWGESA-N (2s)-3-(7-carbamimidoylnaphthalen-2-yl)-2-[4-[(3s)-1-ethanimidoylpyrrolidin-3-yl]oxyphenyl]propanoic acid;hydron;chloride;pentahydrate Chemical compound O.O.O.O.O.Cl.C1N(C(=N)C)CC[C@@H]1OC1=CC=C([C@H](CC=2C=C3C=C(C=CC3=CC=2)C(N)=N)C(O)=O)C=C1 LJCBAPRMNYSDOP-LVCYMWGESA-N 0.000 claims 1
- 108010074860 Factor Xa Proteins 0.000 claims 1
- 101001024703 Homo sapiens Nck-associated protein 5 Proteins 0.000 claims 1
- 102100036946 Nck-associated protein 5 Human genes 0.000 claims 1
- 102000002262 Thromboplastin Human genes 0.000 claims 1
- 108010000499 Thromboplastin Proteins 0.000 claims 1
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- QQBKAVAGLMGMHI-WIYYLYMNSA-N eribaxaban Chemical compound N1([C@H](C[C@H](C1)OC)C(=O)NC=1C(=CC(=CC=1)N1C(C=CC=C1)=O)F)C(=O)NC1=CC=C(Cl)C=C1 QQBKAVAGLMGMHI-WIYYLYMNSA-N 0.000 claims 1
- 229940087051 fragmin Drugs 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97634307P | 2007-09-28 | 2007-09-28 | |
| US60/976,343 | 2007-09-28 | ||
| US9057408P | 2008-08-20 | 2008-08-20 | |
| US61/090,574 | 2008-08-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014166333A Division JP6047127B2 (ja) | 2007-09-28 | 2014-08-19 | 第Ｘａ因子阻害剤に対する抗体およびその使用の方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018033229A Division JP2018100290A (ja) | 2007-09-28 | 2018-02-27 | 第Ｘａ因子阻害剤に対する抗体およびその使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017043632A JP2017043632A (ja) | 2017-03-02 |
| JP2017043632A5 true JP2017043632A5 (enExample) | 2017-07-27 |
| JP6300885B2 JP6300885B2 (ja) | 2018-03-28 |
Family
ID=40481812
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527220A Active JP5637561B2 (ja) | 2007-09-28 | 2008-09-26 | 第Ｘａ因子阻害剤に対する解毒剤およびその使用の方法 |
| JP2014166333A Active JP6047127B2 (ja) | 2007-09-28 | 2014-08-19 | 第Ｘａ因子阻害剤に対する抗体およびその使用の方法 |
| JP2016225290A Active JP6300885B2 (ja) | 2007-09-28 | 2016-11-18 | 第Ｘａ因子阻害剤に対する抗体およびその使用の方法 |
| JP2018033229A Pending JP2018100290A (ja) | 2007-09-28 | 2018-02-27 | 第Ｘａ因子阻害剤に対する抗体およびその使用の方法 |
| JP2020042919A Pending JP2020109113A (ja) | 2007-09-28 | 2020-03-12 | 第Ｘａ因子阻害剤に対する抗体およびその使用の方法 |
| JP2022121451A Pending JP2022153574A (ja) | 2007-09-28 | 2022-07-29 | 第Ｘａ因子阻害剤に対する抗体およびその使用の方法 |
| JP2025008426A Pending JP2025063249A (ja) | 2007-09-28 | 2025-01-21 | 第Ｘａ因子阻害剤に対する抗体およびその使用の方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527220A Active JP5637561B2 (ja) | 2007-09-28 | 2008-09-26 | 第Ｘａ因子阻害剤に対する解毒剤およびその使用の方法 |
| JP2014166333A Active JP6047127B2 (ja) | 2007-09-28 | 2014-08-19 | 第Ｘａ因子阻害剤に対する抗体およびその使用の方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018033229A Pending JP2018100290A (ja) | 2007-09-28 | 2018-02-27 | 第Ｘａ因子阻害剤に対する抗体およびその使用の方法 |
| JP2020042919A Pending JP2020109113A (ja) | 2007-09-28 | 2020-03-12 | 第Ｘａ因子阻害剤に対する抗体およびその使用の方法 |
| JP2022121451A Pending JP2022153574A (ja) | 2007-09-28 | 2022-07-29 | 第Ｘａ因子阻害剤に対する抗体およびその使用の方法 |
| JP2025008426A Pending JP2025063249A (ja) | 2007-09-28 | 2025-01-21 | 第Ｘａ因子阻害剤に対する抗体およびその使用の方法 |
Country Status (26)
| Country | Link |
|---|---|
| US (8) | US8153590B2 (enExample) |
| EP (4) | EP3824902A1 (enExample) |
| JP (7) | JP5637561B2 (enExample) |
| KR (4) | KR101698214B1 (enExample) |
| CN (4) | CN102559644B (enExample) |
| AU (7) | AU2008304192B9 (enExample) |
| BR (2) | BR122022001846B1 (enExample) |
| CA (1) | CA2697583C (enExample) |
| CY (3) | CY1118482T1 (enExample) |
| DK (3) | DK2915564T3 (enExample) |
| ES (3) | ES2597436T3 (enExample) |
| FR (1) | FR20C1045I2 (enExample) |
| HR (2) | HRP20161255T1 (enExample) |
| HU (4) | HUE031647T2 (enExample) |
| IL (4) | IL203993A (enExample) |
| LT (3) | LT2193196T (enExample) |
| MX (1) | MX2010003095A (enExample) |
| NL (1) | NL301063I2 (enExample) |
| NO (2) | NO2019040I1 (enExample) |
| NZ (1) | NZ583944A (enExample) |
| PL (3) | PL2915564T3 (enExample) |
| PT (3) | PT3078743T (enExample) |
| SG (1) | SG185263A1 (enExample) |
| SI (3) | SI2915564T1 (enExample) |
| WO (1) | WO2009042962A2 (enExample) |
| ZA (2) | ZA201002039B (enExample) |
Families Citing this family (61)
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| US7696352B2 (en) * | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
| WO2007131179A1 (en) | 2006-05-05 | 2007-11-15 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
| ES2597436T3 (es) * | 2007-09-28 | 2017-01-18 | Portola Pharmaceuticals, Inc. | Antídotos para inhibidores del factor Xa y procedimientos de uso de los mismos |
| EP2364165B1 (en) | 2008-11-14 | 2018-01-03 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents |
| KR101792032B1 (ko) | 2008-12-19 | 2017-11-02 | 백스터 인터내셔널 인코포레이티드 | Ｔｆｐｉ 억제제 및 사용 방법 |
| PL3604510T3 (pl) | 2009-03-30 | 2025-07-28 | Alexion Pharmaceuticals, Inc. | Antidota na inhibitory czynnika xa i sposoby ich stosowania |
| PT2453910T (pt) * | 2009-07-15 | 2016-12-07 | Portola Pharm Inc | Formulação de dose unitária de antídoto contra inibidores de fator xa para uso na prevenção de sangramento |
| GB0916576D0 (en) * | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| EP2316931B1 (de) * | 2009-10-30 | 2016-12-28 | Senova Gesellschaft für Biowissenschaft und Technik mbH | Polymergekoppelte Peptidasen |
| WO2011075602A1 (en) * | 2009-12-17 | 2011-06-23 | Millennium Pharmaceuticals, Inc. | Methods of preparing factor xa inhibitors and salts thereof |
| CA2784921A1 (en) | 2009-12-17 | 2011-07-14 | Millennium Pharmaceuticals, Inc. | Salts and crystalline forms of a factor xa inhibitor |
| AR079944A1 (es) * | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | Anticuerpo neutralizante de la actividad de un anticoagulante |
| NZ603028A (en) | 2010-03-19 | 2014-11-28 | Baxter Healthcare Sa | Tfpi inhibitors and methods of use |
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| TW201240664A (en) * | 2010-09-01 | 2012-10-16 | Portola Pharm Inc | Methods and formulations of treating thrombosis with betrixaban and a P-glycoprotein inhibitor |
| CA2824885A1 (en) | 2011-01-19 | 2012-07-26 | Bayer Intellectual Property Gmbh | Binding proteins to inhibitors of coagulation factors |
| FR2972114B1 (fr) * | 2011-03-01 | 2013-03-15 | Univ Grenoble 1 | Un nouveau leurre moleculaire procoagulant pour le traitement des hemophiles a ou b avec ou sans inhibiteur |
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| AU2012315516B2 (en) * | 2011-09-30 | 2017-05-04 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating hemostasis |
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| HK1205188A1 (en) * | 2012-02-14 | 2015-12-11 | Portola Pharmaceuticals, Inc. | Process for making recombinant antidote to factor xa inhibitor |
| HK1204964A1 (en) * | 2012-02-16 | 2015-12-11 | Portola Pharmaceuticals, Inc. | Modulation of factor xa inhibitor mediated blood loss by partial and transient administration of antidote |
| AU2013235741C1 (en) | 2012-03-21 | 2017-12-21 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
| JP6261093B2 (ja) * | 2012-06-14 | 2018-01-17 | ポートラ ファーマシューティカルズ， インコーポレイテッド | 組み換え第Ｘａ因子誘導体の精製のための方法 |
| IN2015DN01404A (enExample) | 2012-07-25 | 2015-07-03 | Catalyst Biosciences Inc | |
| US9200268B2 (en) | 2012-12-27 | 2015-12-01 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
| FR3000895B1 (fr) * | 2013-01-11 | 2017-02-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies Sa | Utilisation d'antidotes d'inhibiteurs de la coagulation indiques dans la prevention ou le traitement de pathologies thromboemboliques |
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| HK1215196A1 (zh) | 2013-01-31 | 2016-08-19 | 辉瑞公司 | 用於抵消因子xa抑制的组合物和方法 |
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| MA40042B1 (fr) * | 2014-05-26 | 2020-08-31 | Academisch Ziekenhuis Leiden | Protéines prohémostatiques pour le traitement de saignement |
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| KR20250150675A (ko) * | 2014-08-20 | 2025-10-20 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 xa 해독제용 동결건조된 제형 |
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| CN113484386B (zh) * | 2021-05-21 | 2024-02-13 | 郑州轻工业大学 | 一种金属聚酞菁纳米材料的制备方法及其应用，适配体传感器及其制备方法 |
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