JP2017043632A5 - - Google Patents
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- JP2017043632A5 JP2017043632A5 JP2016225290A JP2016225290A JP2017043632A5 JP 2017043632 A5 JP2017043632 A5 JP 2017043632A5 JP 2016225290 A JP2016225290 A JP 2016225290A JP 2016225290 A JP2016225290 A JP 2016225290A JP 2017043632 A5 JP2017043632 A5 JP 2017043632A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- factor
- inhibitor
- amino acid
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97634307P | 2007-09-28 | 2007-09-28 | |
| US60/976,343 | 2007-09-28 | ||
| US9057408P | 2008-08-20 | 2008-08-20 | |
| US61/090,574 | 2008-08-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014166333A Division JP6047127B2 (ja) | 2007-09-28 | 2014-08-19 | 第Xa因子阻害剤に対する抗体およびその使用の方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018033229A Division JP2018100290A (ja) | 2007-09-28 | 2018-02-27 | 第Xa因子阻害剤に対する抗体およびその使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017043632A JP2017043632A (ja) | 2017-03-02 |
| JP2017043632A5 true JP2017043632A5 (enExample) | 2017-07-27 |
| JP6300885B2 JP6300885B2 (ja) | 2018-03-28 |
Family
ID=40481812
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527220A Active JP5637561B2 (ja) | 2007-09-28 | 2008-09-26 | 第Xa因子阻害剤に対する解毒剤およびその使用の方法 |
| JP2014166333A Active JP6047127B2 (ja) | 2007-09-28 | 2014-08-19 | 第Xa因子阻害剤に対する抗体およびその使用の方法 |
| JP2016225290A Active JP6300885B2 (ja) | 2007-09-28 | 2016-11-18 | 第Xa因子阻害剤に対する抗体およびその使用の方法 |
| JP2018033229A Pending JP2018100290A (ja) | 2007-09-28 | 2018-02-27 | 第Xa因子阻害剤に対する抗体およびその使用の方法 |
| JP2020042919A Pending JP2020109113A (ja) | 2007-09-28 | 2020-03-12 | 第Xa因子阻害剤に対する抗体およびその使用の方法 |
| JP2022121451A Pending JP2022153574A (ja) | 2007-09-28 | 2022-07-29 | 第Xa因子阻害剤に対する抗体およびその使用の方法 |
| JP2025008426A Pending JP2025063249A (ja) | 2007-09-28 | 2025-01-21 | 第Xa因子阻害剤に対する抗体およびその使用の方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527220A Active JP5637561B2 (ja) | 2007-09-28 | 2008-09-26 | 第Xa因子阻害剤に対する解毒剤およびその使用の方法 |
| JP2014166333A Active JP6047127B2 (ja) | 2007-09-28 | 2014-08-19 | 第Xa因子阻害剤に対する抗体およびその使用の方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018033229A Pending JP2018100290A (ja) | 2007-09-28 | 2018-02-27 | 第Xa因子阻害剤に対する抗体およびその使用の方法 |
| JP2020042919A Pending JP2020109113A (ja) | 2007-09-28 | 2020-03-12 | 第Xa因子阻害剤に対する抗体およびその使用の方法 |
| JP2022121451A Pending JP2022153574A (ja) | 2007-09-28 | 2022-07-29 | 第Xa因子阻害剤に対する抗体およびその使用の方法 |
| JP2025008426A Pending JP2025063249A (ja) | 2007-09-28 | 2025-01-21 | 第Xa因子阻害剤に対する抗体およびその使用の方法 |
Country Status (26)
| Country | Link |
|---|---|
| US (8) | US8153590B2 (enExample) |
| EP (4) | EP3078743B1 (enExample) |
| JP (7) | JP5637561B2 (enExample) |
| KR (4) | KR101698214B1 (enExample) |
| CN (4) | CN102533702A (enExample) |
| AU (7) | AU2008304192B9 (enExample) |
| BR (2) | BRPI0816837B1 (enExample) |
| CA (1) | CA2697583C (enExample) |
| CY (3) | CY1118482T1 (enExample) |
| DK (3) | DK2915564T3 (enExample) |
| ES (3) | ES2796623T3 (enExample) |
| FR (1) | FR20C1045I2 (enExample) |
| HR (2) | HRP20161255T1 (enExample) |
| HU (4) | HUE052423T2 (enExample) |
| IL (4) | IL203993A (enExample) |
| LT (3) | LT2193196T (enExample) |
| MX (1) | MX2010003095A (enExample) |
| NL (1) | NL301063I2 (enExample) |
| NO (2) | NO2019040I1 (enExample) |
| NZ (1) | NZ583944A (enExample) |
| PL (3) | PL3078743T3 (enExample) |
| PT (3) | PT2193196T (enExample) |
| SG (1) | SG185263A1 (enExample) |
| SI (3) | SI2915564T1 (enExample) |
| WO (1) | WO2009042962A2 (enExample) |
| ZA (2) | ZA201002039B (enExample) |
Families Citing this family (61)
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|---|---|---|---|---|
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| EP2016072B1 (en) | 2006-05-05 | 2014-07-16 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
| BRPI0816837B1 (pt) | 2007-09-28 | 2022-10-18 | Portola Pharmaceuticals, Inc | Composições farmacêuticas, polipeptídeo isolado de duas cadeias e uso de uma composição farmacêutica |
| US8455439B2 (en) | 2008-11-14 | 2013-06-04 | Portola Pharmaceuticals, Inc. | Antidotes for factor Xa inhibitors and methods of using the same in combination with blood coagulating agents |
| LT2379096T (lt) | 2008-12-19 | 2019-12-27 | Baxalta GmbH | Tfpi inhibitoriai ir vartojimo būdai |
| US8962563B2 (en) | 2009-12-21 | 2015-02-24 | Baxter International, Inc. | TFPI inhibitors and methods of use |
| PT3604510T (pt) | 2009-03-30 | 2025-06-24 | Alexion Pharma Inc | Antídotos para inibidores do fator xa e métodos de utilização dos mesmos |
| PT2453910T (pt) * | 2009-07-15 | 2016-12-07 | Portola Pharm Inc | Formulação de dose unitária de antídoto contra inibidores de fator xa para uso na prevenção de sangramento |
| GB0916576D0 (en) * | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| EP2316931B1 (de) | 2009-10-30 | 2016-12-28 | Senova Gesellschaft für Biowissenschaft und Technik mbH | Polymergekoppelte Peptidasen |
| US8742120B2 (en) | 2009-12-17 | 2014-06-03 | Millennium Pharmaceuticals, Inc. | Methods of preparing factor xa inhibitors and salts thereof |
| US8530501B2 (en) | 2009-12-17 | 2013-09-10 | Millennium Pharmaceuticals, Inc. | Salts and crystalline forms of a factor Xa inhibitor |
| AR079944A1 (es) | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | Anticuerpo neutralizante de la actividad de un anticoagulante |
| EP2547355B1 (en) | 2010-03-19 | 2017-01-11 | Baxalta GmbH | Tfpi inhibitors and methods of use |
| TW201221128A (en) | 2010-09-01 | 2012-06-01 | Portola Pharm Inc | Crystalline forms of a factor Xa inhibitor |
| AR082803A1 (es) * | 2010-09-01 | 2013-01-09 | Portola Pharm Inc | Metodos y formulaciones para el tratamiento de la trombosis con betrixaban y un inhibidor de la glicoproteina p |
| JP2014506448A (ja) * | 2011-01-19 | 2014-03-17 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 凝固因子の阻害剤に対する結合タンパク質 |
| FR2972114B1 (fr) * | 2011-03-01 | 2013-03-15 | Univ Grenoble 1 | Un nouveau leurre moleculaire procoagulant pour le traitement des hemophiles a ou b avec ou sans inhibiteur |
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| CN104080772B (zh) * | 2011-11-29 | 2016-10-05 | 佩罗斯菲尔股份有限公司 | 抗凝血逆转剂 |
| KR20140131957A (ko) | 2012-02-14 | 2014-11-14 | 포톨라 파마슈티컬스, 인코포레이티드 | Xa 인자 억제제에 대한 재조합 해독제를 제조하는 방법 |
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| PT2861614T (pt) * | 2012-06-14 | 2017-01-26 | Portola Pharm Inc | Método para a purificação de derivados do fator xa recombinantes |
| US9145552B2 (en) * | 2012-07-25 | 2015-09-29 | Catalyst Biosciences, Inc. | Modified factor X polypeptides and uses thereof |
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| FR3000895B1 (fr) * | 2013-01-11 | 2017-02-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies Sa | Utilisation d'antidotes d'inhibiteurs de la coagulation indiques dans la prevention ou le traitement de pathologies thromboemboliques |
| SG10201705189XA (en) * | 2013-01-24 | 2017-07-28 | Portola Pharm Inc | INHIBITION OF TISSUE FACTOR PATHWAY INHIBITOR WITH FACTOR Xa DERIVATIVES |
| EP2950813B1 (en) * | 2013-01-31 | 2019-09-04 | Pfizer Inc | Compositions and methods for counteracting factor xa inhibition |
| FR3007410B1 (fr) * | 2013-06-21 | 2016-05-27 | Lab Francais Du Fractionnement | Facteur x depourvu de domaine gla |
| JP6429885B2 (ja) | 2013-09-24 | 2018-11-28 | ファイザー・インク | 組換えヒト凝固第xa因子タンパク質の不均一集団を含む組成物 |
| JP6629744B2 (ja) * | 2013-11-01 | 2020-01-15 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアThe Children’S Hospital Of Philadelphia | 第Xa因子の半減期を延ばす組成物および方法 |
| EP3744840A1 (en) * | 2014-05-26 | 2020-12-02 | Academisch Ziekenhuis Leiden | Prohemostatic proteins for the treatment of bleeding |
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| US10676731B2 (en) | 2014-08-19 | 2020-06-09 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor IX function |
| CA2961739C (en) | 2014-08-20 | 2024-04-30 | Portola Pharmaceuticals, Inc. | Lyophilized formulations for factor xa antidote |
| CN105030703B (zh) * | 2015-06-23 | 2018-03-23 | 上海旭东海普药业有限公司 | 一种防治疗栓塞性疾病的利伐沙班片及其制备方法 |
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| CN108883160B (zh) * | 2016-02-24 | 2022-06-28 | 博尔托拉制药公司 | 因子xa解毒剂的冻干制剂 |
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| PT3472314T (pt) | 2016-06-17 | 2021-06-18 | Alexion Pharma Inc | Preparação de derivados do fator xa |
| WO2018115235A1 (en) | 2016-12-22 | 2018-06-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antidotes to anti-coagulant drugs allowing diagnosis and treatment |
| US11168147B2 (en) | 2016-12-23 | 2021-11-09 | Novartis Ag | Factor XI antibodies and methods of use |
| US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
| KR102687487B1 (ko) * | 2017-08-21 | 2024-07-24 | 알렐 바이오테크놀로지 앤 파마슈티칼스, 인크. | 광-흡수 조성물 및 사용 방법 |
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| WO2019246094A1 (en) * | 2018-06-19 | 2019-12-26 | Portola Pharmaceuticals, Inc. | Antidotes to factor xa inhibitors |
| WO2020034989A1 (zh) * | 2018-08-14 | 2020-02-20 | 江苏恒瑞医药股份有限公司 | 一种可注射的药物组合物及其制备方法 |
| JP7641903B2 (ja) * | 2019-02-07 | 2025-03-07 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 頭蓋内出血の治療方法及び効果の評価方法 |
| US11655465B1 (en) | 2019-05-02 | 2023-05-23 | Iridia, Inc. | Enzymes and systems for synthesizing DNA |
| PT4010379T (pt) | 2019-08-08 | 2025-06-30 | Alexion Pharma Inc | Composições e métodos de preparação do fator xa e derivados |
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| CN113484386B (zh) * | 2021-05-21 | 2024-02-13 | 郑州轻工业大学 | 一种金属聚酞菁纳米材料的制备方法及其应用,适配体传感器及其制备方法 |
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