JP2017025071A5 - - Google Patents
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- Publication number
- JP2017025071A5 JP2017025071A5 JP2016159713A JP2016159713A JP2017025071A5 JP 2017025071 A5 JP2017025071 A5 JP 2017025071A5 JP 2016159713 A JP2016159713 A JP 2016159713A JP 2016159713 A JP2016159713 A JP 2016159713A JP 2017025071 A5 JP2017025071 A5 JP 2017025071A5
- Authority
- JP
- Japan
- Prior art keywords
- anticancer agent
- agent according
- group
- hydrogen
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002246 antineoplastic agent Substances 0.000 claims 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000004005 microsphere Substances 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 2
- 239000010419 fine particle Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 229940127093 camptothecin Drugs 0.000 claims 1
- -1 camptothecin compound Chemical class 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000007942 carboxylates Chemical class 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 239000006194 liquid suspension Substances 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 1
- 238000010526 radical polymerization reaction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 229960000303 topotecan Drugs 0.000 claims 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04255411.3 | 2004-09-07 | ||
| EP04255411 | 2004-09-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015080262A Division JP2015180625A (ja) | 2004-09-07 | 2015-04-09 | 塞栓剤からの薬物送達 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017025071A JP2017025071A (ja) | 2017-02-02 |
| JP2017025071A5 true JP2017025071A5 (enExample) | 2017-03-09 |
Family
ID=34930630
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007529390A Expired - Lifetime JP5221134B2 (ja) | 2004-09-07 | 2005-09-06 | 塞栓剤からの薬物送達 |
| JP2012167295A Expired - Lifetime JP5792691B2 (ja) | 2004-09-07 | 2012-07-27 | 塞栓剤からの薬物送達 |
| JP2015080262A Pending JP2015180625A (ja) | 2004-09-07 | 2015-04-09 | 塞栓剤からの薬物送達 |
| JP2016159713A Pending JP2017025071A (ja) | 2004-09-07 | 2016-08-16 | 塞栓剤からの薬物送達 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007529390A Expired - Lifetime JP5221134B2 (ja) | 2004-09-07 | 2005-09-06 | 塞栓剤からの薬物送達 |
| JP2012167295A Expired - Lifetime JP5792691B2 (ja) | 2004-09-07 | 2012-07-27 | 塞栓剤からの薬物送達 |
| JP2015080262A Pending JP2015180625A (ja) | 2004-09-07 | 2015-04-09 | 塞栓剤からの薬物送達 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20070275991A1 (enExample) |
| EP (3) | EP2269580A3 (enExample) |
| JP (4) | JP5221134B2 (enExample) |
| CN (2) | CN101052378A (enExample) |
| AT (1) | ATE505185T1 (enExample) |
| AU (1) | AU2005281483B2 (enExample) |
| CA (1) | CA2579533C (enExample) |
| DE (1) | DE602005027477D1 (enExample) |
| ES (1) | ES2361919T3 (enExample) |
| HK (1) | HK1198691A1 (enExample) |
| WO (1) | WO2006027567A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1267839B1 (en) | 2000-03-24 | 2007-10-03 | Biosphere Medical, Inc. | Microspheres for active embolization |
| US20070281028A1 (en) * | 2004-08-04 | 2007-12-06 | Biocompatibles Uk Limited | Drug Delivery of a Cox Inhibitor from Embolic Agents |
| KR20140090270A (ko) | 2005-05-09 | 2014-07-16 | 바이오스피어 메디칼 에스.에이. | 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및 방법 |
| PL2034951T3 (pl) * | 2006-06-22 | 2013-06-28 | Biocompatibles Uk Ltd | Produkt farmaceutyczny ulegający rehydratacji |
| EP1985286A1 (en) * | 2007-04-24 | 2008-10-29 | Biocompatibles UK Limited | Microspheres for treatment of brain tumours |
| TR201820076T4 (tr) * | 2007-08-16 | 2019-01-21 | Biocompatibles Uk Ltd | İlaç kombinasyonlarının salımı. |
| CN104382862A (zh) * | 2008-12-02 | 2015-03-04 | 生物相容英国有限公司 | 胰腺肿瘤治疗 |
| US9724421B2 (en) | 2010-11-29 | 2017-08-08 | Centre Hospitalier Universitaire Vaudois | Chemoembolization composition comprising anti-angiogenic agents |
| US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
| US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| CN102336904B (zh) * | 2011-09-29 | 2013-03-27 | 成都一平医药科技发展有限公司 | 一种喜树碱及其衍生物的多价peg修饰物及其用途 |
| CN102397593B (zh) * | 2011-11-11 | 2013-12-18 | 北京大学 | X线下可显影的栓塞微粒及其制备方法和应用 |
| US20150352050A1 (en) * | 2012-11-15 | 2015-12-10 | Utah-Inha Dds & Advanced Therapeutics Research Center | Biodegradable microbeads with improved anticancer drug adsorptivity, containing albumin and dextran sulfate, and preparation method therefor |
| US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
| WO2014084530A1 (ko) | 2012-11-27 | 2014-06-05 | 재단법인 유타 인하 디디에스 및 신의료기술개발공동연구소 | 음이온성 고분자를 포함하는 항암제 흡착능력이 향상된 생분해성 마이크로 비드 및 이의 제조방법 |
| CN105814120B (zh) | 2013-09-19 | 2019-07-05 | 泰尔茂株式会社 | 聚合物颗粒 |
| KR102340388B1 (ko) | 2013-09-19 | 2021-12-17 | 마이크로벤션, 인코포레이티드 | 중합체 필름 |
| EP3065719A4 (en) | 2013-11-08 | 2017-08-09 | Terumo Corporation | Polymer particles |
| US9566443B2 (en) | 2013-11-26 | 2017-02-14 | Corquest Medical, Inc. | System for treating heart valve malfunction including mitral regurgitation |
| US10842626B2 (en) | 2014-12-09 | 2020-11-24 | Didier De Canniere | Intracardiac device to correct mitral regurgitation |
| JP2016124818A (ja) * | 2014-12-26 | 2016-07-11 | 日本化薬株式会社 | 転移性肝癌治療薬及び転移性肝癌の治療方法 |
| WO2016154592A1 (en) | 2015-03-26 | 2016-09-29 | Microvention, Inc. | Embiolic particles |
| WO2016203337A2 (en) * | 2015-06-14 | 2016-12-22 | Mohan M Alapati | Compositions and methods for the treatment of cancer |
| WO2016203352A2 (en) * | 2015-06-14 | 2016-12-22 | Mohan M Alapati | Compositions and methods for the treatment of cancer |
| GB201515602D0 (en) | 2015-09-03 | 2015-10-21 | Biocompatibles Uk Ltd | Polymers and microspheres |
| AU2017336785B2 (en) | 2016-09-28 | 2019-12-05 | Terumo Corporation | Polymer particles |
| EP3630078B1 (en) | 2017-05-26 | 2024-09-11 | Bruin Biosciences, Inc. | Chemoembolization agents |
| CN107812232A (zh) * | 2017-11-08 | 2018-03-20 | 华威（深圳）医疗器械有限责任公司 | 可显影羧基改性聚乙烯醇微球栓塞剂及其制备工艺 |
| ES2969226T3 (es) * | 2018-11-30 | 2024-05-17 | Nextbiomedical Co Ltd | Partículas de hidrogel para quimioembolización que comprenden un polímero biodegradable |
| GB201918300D0 (en) * | 2019-12-12 | 2020-01-29 | Extruded Pharmaceuticals Ltd | Chemotherapeutic drug implant |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4032561A (en) * | 1975-05-27 | 1977-06-28 | The Upjohn Company | 17-Phenyl-18,19,20-trinor-cis-4,5-didehydro-PGF1.sub.α compounds |
| US4224427A (en) | 1978-06-01 | 1980-09-23 | Ciba-Geigy Corporation | Process for preparing hydrogels as spherical beads of large size |
| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US4978713A (en) | 1987-12-16 | 1990-12-18 | Ciba-Geigy Corporation | Polyvinyl alcohol derivatives containing pendant vinylic monomer reaction product units bound through ether groups and hydrogel contact lenses made therefrom |
| GB9023498D0 (en) | 1990-10-29 | 1990-12-12 | Biocompatibles Ltd | Soft contact lens material |
| US5559235A (en) * | 1991-10-29 | 1996-09-24 | Glaxo Wellcome Inc. | Water soluble camptothecin derivatives |
| GB9301701D0 (en) | 1993-01-28 | 1993-03-17 | Biocompatibles Ltd | New zwitterionic materials |
| GB9301702D0 (en) | 1993-01-28 | 1993-03-17 | Biocompatibles Ltd | New materials |
| TW272976B (enExample) | 1993-08-06 | 1996-03-21 | Ciba Geigy Ag | |
| GB9415926D0 (en) | 1994-08-04 | 1994-09-28 | Biocompatibles Ltd | New materials |
| CA2192725C (en) * | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| WO2000029481A1 (en) | 1998-11-13 | 2000-05-25 | Biocompatibles Limited | Anionic-cationic polyion complexes comprising zwitterionic monomer component |
| US6958212B1 (en) * | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| DE19905639A1 (de) * | 1999-02-11 | 2000-08-17 | Clariant Gmbh | Wasserlösliche oder wasserquellbare Polymerisate |
| FR2793684B1 (fr) | 1999-05-17 | 2001-08-10 | Ethypharm Lab Prod Ethiques | Utilisation de microspheres biodegradables liberant un agent anticancereux pour le traitement du glioblastome, procede de preparation de ces microspheres et suspension les contenant |
| US6191119B1 (en) * | 1999-10-15 | 2001-02-20 | Supergen, Inc. | Combination therapy including 9-nitro-20(S)-camptothecin |
| JP2002154963A (ja) * | 2000-11-14 | 2002-05-28 | Yakult Honsha Co Ltd | 徐放性抗腫瘍剤 |
| US7838699B2 (en) * | 2002-05-08 | 2010-11-23 | Biosphere Medical | Embolization using degradable crosslinked hydrogels |
| DE10230991A1 (de) | 2002-07-10 | 2004-02-12 | Robert Bosch Gmbh | Werkzeugaufnahme für eine Werkzeugmaschine |
| US20040076582A1 (en) * | 2002-08-30 | 2004-04-22 | Dimatteo Kristian | Agent delivery particle |
| ES2308149T3 (es) * | 2003-02-12 | 2008-12-01 | Biocompatibles Uk Limited | Composicion para la quimioemboloterapia de tumores solidos. |
| US20040161466A1 (en) * | 2003-02-14 | 2004-08-19 | Biocompatibles Uk Limited | Chemoembolisation |
-
2005
- 2005-09-06 CN CNA2005800374691A patent/CN101052378A/zh active Pending
- 2005-09-06 AT AT05777645T patent/ATE505185T1/de active
- 2005-09-06 DE DE602005027477T patent/DE602005027477D1/de not_active Expired - Lifetime
- 2005-09-06 WO PCT/GB2005/003431 patent/WO2006027567A2/en not_active Ceased
- 2005-09-06 EP EP10174312A patent/EP2269580A3/en not_active Ceased
- 2005-09-06 CN CN201410016386.5A patent/CN103860479A/zh active Pending
- 2005-09-06 ES ES05777645T patent/ES2361919T3/es not_active Expired - Lifetime
- 2005-09-06 CA CA2579533A patent/CA2579533C/en not_active Expired - Lifetime
- 2005-09-06 JP JP2007529390A patent/JP5221134B2/ja not_active Expired - Lifetime
- 2005-09-06 US US11/574,703 patent/US20070275991A1/en not_active Abandoned
- 2005-09-06 AU AU2005281483A patent/AU2005281483B2/en not_active Ceased
- 2005-09-06 EP EP05777645A patent/EP1796644B1/en not_active Expired - Lifetime
- 2005-09-06 EP EP15159809.1A patent/EP3085361A1/en not_active Ceased
-
2011
- 2011-10-27 US US13/282,953 patent/US20120276151A1/en not_active Abandoned
-
2012
- 2012-04-20 US US13/452,493 patent/US20120201867A1/en not_active Abandoned
- 2012-07-27 JP JP2012167295A patent/JP5792691B2/ja not_active Expired - Lifetime
-
2014
- 2014-12-04 HK HK14112213.0A patent/HK1198691A1/xx unknown
-
2015
- 2015-04-09 JP JP2015080262A patent/JP2015180625A/ja active Pending
-
2016
- 2016-08-16 JP JP2016159713A patent/JP2017025071A/ja active Pending
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