AU2005281483B2 - Drug delivery from embolic agents - Google Patents

Drug delivery from embolic agents Download PDF

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Publication number
AU2005281483B2
AU2005281483B2 AU2005281483A AU2005281483A AU2005281483B2 AU 2005281483 B2 AU2005281483 B2 AU 2005281483B2 AU 2005281483 A AU2005281483 A AU 2005281483A AU 2005281483 A AU2005281483 A AU 2005281483A AU 2005281483 B2 AU2005281483 B2 AU 2005281483B2
Authority
AU
Australia
Prior art keywords
group
microspheres
composition according
water
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005281483A
Other languages
English (en)
Other versions
AU2005281483A1 (en
Inventor
Maria Victoria Gonzalez-Fajardo
Andrew Lennard Lewis
Peter William Stratford
Yiqing Tang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocompatibles UK Ltd
Original Assignee
Biocompatibles UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles UK Ltd filed Critical Biocompatibles UK Ltd
Publication of AU2005281483A1 publication Critical patent/AU2005281483A1/en
Application granted granted Critical
Publication of AU2005281483B2 publication Critical patent/AU2005281483B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432—Inhibitors, antagonists
    • A61L2300/434—Inhibitors, antagonists of enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
AU2005281483A 2004-09-07 2005-09-06 Drug delivery from embolic agents Ceased AU2005281483B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04255411 2004-09-07
EP04255411.3 2004-09-07
PCT/GB2005/003431 WO2006027567A2 (en) 2004-09-07 2005-09-06 Drug delivery from embolic agents

Publications (2)

Publication Number Publication Date
AU2005281483A1 AU2005281483A1 (en) 2006-03-16
AU2005281483B2 true AU2005281483B2 (en) 2008-11-27

Family

ID=34930630

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005281483A Ceased AU2005281483B2 (en) 2004-09-07 2005-09-06 Drug delivery from embolic agents

Country Status (11)

Country Link
US (3) US20070275991A1 (enExample)
EP (3) EP3085361A1 (enExample)
JP (4) JP5221134B2 (enExample)
CN (2) CN101052378A (enExample)
AT (1) ATE505185T1 (enExample)
AU (1) AU2005281483B2 (enExample)
CA (1) CA2579533C (enExample)
DE (1) DE602005027477D1 (enExample)
ES (1) ES2361919T3 (enExample)
HK (1) HK1198691A1 (enExample)
WO (1) WO2006027567A2 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001072281A2 (en) 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for active embolization
WO2006013376A2 (en) * 2004-08-04 2006-02-09 Biocompatibles Uk Limited Drug delivery of a cox inhibitor from embolic agents
CN101237857A (zh) 2005-05-09 2008-08-06 生物领域医疗公司 使用微球和非离子型造影剂的组合物和方法
EP2034951B2 (en) 2006-06-22 2020-03-25 Biocompatibles UK Limited Rehydratable pharmaceutical product
EP1985286A1 (en) * 2007-04-24 2008-10-29 Biocompatibles UK Limited Microspheres for treatment of brain tumours
ES2706023T3 (es) * 2007-08-16 2019-03-27 Biocompatibles Uk Ltd Administración de combinaciones de fármacos
US20110293672A1 (en) * 2008-12-02 2011-12-01 Biocompatibles Uk Limited Pancreatic tumour treatment
ES2542242T3 (es) * 2010-11-29 2015-08-03 Centre Hospitalier Universitaire Vaudois Composición de quimioembolización que comprende agentes antiangiogénicos
US10314594B2 (en) 2012-12-14 2019-06-11 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
US10307167B2 (en) 2012-12-14 2019-06-04 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
US10813630B2 (en) 2011-08-09 2020-10-27 Corquest Medical, Inc. Closure system for atrial wall
CN102336904B (zh) * 2011-09-29 2013-03-27 成都一平医药科技发展有限公司 一种喜树碱及其衍生物的多价peg修饰物及其用途
CN102397593B (zh) * 2011-11-11 2013-12-18 北京大学 X线下可显影的栓塞微粒及其制备方法和应用
US20150352050A1 (en) * 2012-11-15 2015-12-10 Utah-Inha Dds & Advanced Therapeutics Research Center Biodegradable microbeads with improved anticancer drug adsorptivity, containing albumin and dextran sulfate, and preparation method therefor
US20140142689A1 (en) 2012-11-21 2014-05-22 Didier De Canniere Device and method of treating heart valve malfunction
US9999676B2 (en) 2012-11-27 2018-06-19 Utah-Inha Dds & Advanced Therapeutics Research Center Biodegradable microbead comprising anionic polymer for improving adsorptive power to anticancer drugs, and method for preparing same
BR112016005768B1 (pt) 2013-09-19 2021-09-21 Microvention, Inc Películas de polímero
CN110279885B (zh) 2013-09-19 2022-07-26 泰尔茂株式会社 聚合物颗粒
BR112016010067B1 (pt) 2013-11-08 2023-01-10 Terumo Corporation Partículas de polímero e métodos de preparação
US9566443B2 (en) 2013-11-26 2017-02-14 Corquest Medical, Inc. System for treating heart valve malfunction including mitral regurgitation
US10842626B2 (en) 2014-12-09 2020-11-24 Didier De Canniere Intracardiac device to correct mitral regurgitation
JP2016124818A (ja) * 2014-12-26 2016-07-11 日本化薬株式会社 転移性肝癌治療薬及び転移性肝癌の治療方法
US9907880B2 (en) 2015-03-26 2018-03-06 Microvention, Inc. Particles
WO2016203352A2 (en) * 2015-06-14 2016-12-22 Mohan M Alapati Compositions and methods for the treatment of cancer
WO2016203337A2 (en) * 2015-06-14 2016-12-22 Mohan M Alapati Compositions and methods for the treatment of cancer
GB201515602D0 (en) * 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
KR102310696B1 (ko) 2016-09-28 2021-10-12 테루모 가부시키가이샤 색전 조성물
AU2018273988C1 (en) 2017-05-26 2025-11-13 Bruin Biosciences, Inc. Chemoembolization agents
CN107812232A (zh) * 2017-11-08 2018-03-20 华威（深圳）医疗器械有限责任公司 可显影羧基改性聚乙烯醇微球栓塞剂及其制备工艺
JP7198529B2 (ja) * 2018-11-30 2023-01-04 ネクストバイオメディカル カンパニー リミテッド 生分解性高分子を含む化学塞栓用水和ゲル粒子
GB201918300D0 (en) * 2019-12-12 2020-01-29 Extruded Pharmaceuticals Ltd Chemotherapeutic drug implant

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4032561A (en) * 1975-05-27 1977-06-28 The Upjohn Company 17-Phenyl-18,19,20-trinor-cis-4,5-didehydro-PGF1.sub.α compounds
US4224427A (en) 1978-06-01 1980-09-23 Ciba-Geigy Corporation Process for preparing hydrogels as spherical beads of large size
JPS6019790A (ja) 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US4978713A (en) 1987-12-16 1990-12-18 Ciba-Geigy Corporation Polyvinyl alcohol derivatives containing pendant vinylic monomer reaction product units bound through ether groups and hydrogel contact lenses made therefrom
GB9023498D0 (en) 1990-10-29 1990-12-12 Biocompatibles Ltd Soft contact lens material
US5559235A (en) * 1991-10-29 1996-09-24 Glaxo Wellcome Inc. Water soluble camptothecin derivatives
GB9301702D0 (en) 1993-01-28 1993-03-17 Biocompatibles Ltd New materials
GB9301701D0 (en) 1993-01-28 1993-03-17 Biocompatibles Ltd New zwitterionic materials
TW272976B (enExample) 1993-08-06 1996-03-21 Ciba Geigy Ag
GB9415926D0 (en) 1994-08-04 1994-09-28 Biocompatibles Ltd New materials
CA2192725C (en) * 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
ES2212648T3 (es) 1998-11-13 2004-07-16 Biocompatibles Uk Limited Complejo de poliiones anionicos-cationicos que comprenden un componente monomero dipolar.
US6958212B1 (en) * 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
DE19905639A1 (de) * 1999-02-11 2000-08-17 Clariant Gmbh Wasserlösliche oder wasserquellbare Polymerisate
FR2793684B1 (fr) 1999-05-17 2001-08-10 Ethypharm Lab Prod Ethiques Utilisation de microspheres biodegradables liberant un agent anticancereux pour le traitement du glioblastome, procede de preparation de ces microspheres et suspension les contenant
US6191119B1 (en) * 1999-10-15 2001-02-20 Supergen, Inc. Combination therapy including 9-nitro-20(S)-camptothecin
JP2002154963A (ja) * 2000-11-14 2002-05-28 Yakult Honsha Co Ltd 徐放性抗腫瘍剤
US7838699B2 (en) * 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
DE10230991A1 (de) 2002-07-10 2004-02-12 Robert Bosch Gmbh Werkzeugaufnahme für eine Werkzeugmaschine
US20040076582A1 (en) * 2002-08-30 2004-04-22 Dimatteo Kristian Agent delivery particle
US20040161466A1 (en) * 2003-02-14 2004-08-19 Biocompatibles Uk Limited Chemoembolisation
CN103393605B (zh) * 2003-02-12 2018-05-29 生物相容英国有限公司 用于实体瘤的化学栓塞治疗的组合物

Also Published As

Publication number Publication date
WO2006027567A2 (en) 2006-03-16
DE602005027477D1 (de) 2011-05-26
EP1796644B1 (en) 2011-04-13
WO2006027567A3 (en) 2006-05-18
CA2579533A1 (en) 2006-03-16
US20070275991A1 (en) 2007-11-29
EP1796644A2 (en) 2007-06-20
CN103860479A (zh) 2014-06-18
EP2269580A2 (en) 2011-01-05
JP2012236840A (ja) 2012-12-06
JP2008512370A (ja) 2008-04-24
ES2361919T3 (es) 2011-06-24
HK1198691A1 (en) 2015-05-29
CN101052378A (zh) 2007-10-10
US20120276151A1 (en) 2012-11-01
JP2015180625A (ja) 2015-10-15
US20120201867A1 (en) 2012-08-09
JP5792691B2 (ja) 2015-10-14
ATE505185T1 (de) 2011-04-15
JP2017025071A (ja) 2017-02-02
AU2005281483A1 (en) 2006-03-16
CA2579533C (en) 2013-05-21
JP5221134B2 (ja) 2013-06-26
EP3085361A1 (en) 2016-10-26
EP2269580A3 (en) 2011-11-09

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired