JP5221134B2 - 塞栓剤からの薬物送達 - Google Patents

塞栓剤からの薬物送達 Download PDF

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Publication number
JP5221134B2
JP5221134B2 JP2007529390A JP2007529390A JP5221134B2 JP 5221134 B2 JP5221134 B2 JP 5221134B2 JP 2007529390 A JP2007529390 A JP 2007529390A JP 2007529390 A JP2007529390 A JP 2007529390A JP 5221134 B2 JP5221134 B2 JP 5221134B2
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JP
Japan
Prior art keywords
anticancer agent
agent according
group
microspheres
water
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP2007529390A
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English (en)
Japanese (ja)
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JP2008512370A (ja
Inventor
ルイス，アンドリュー，レナード
ストラトフォード，ピーター，ウィリアム
ヴィクトリア ゴンザレス−ファヤルド，マリア
タン，イークィン
Original Assignee
バイオコンパティブルズ ユーケー リミテッド
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432—Inhibitors, antagonists
    • A61L2300/434—Inhibitors, antagonists of enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
JP2007529390A 2004-09-07 2005-09-06 塞栓剤からの薬物送達 Expired - Lifetime JP5221134B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04255411 2004-09-07
EP04255411.3 2004-09-07
PCT/GB2005/003431 WO2006027567A2 (en) 2004-09-07 2005-09-06 Drug delivery from embolic agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012167295A Division JP5792691B2 (ja) 2004-09-07 2012-07-27 塞栓剤からの薬物送達

Publications (2)

Publication Number Publication Date
JP2008512370A JP2008512370A (ja) 2008-04-24
JP5221134B2 true JP5221134B2 (ja) 2013-06-26

Family

ID=34930630

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2007529390A Expired - Lifetime JP5221134B2 (ja) 2004-09-07 2005-09-06 塞栓剤からの薬物送達
JP2012167295A Expired - Lifetime JP5792691B2 (ja) 2004-09-07 2012-07-27 塞栓剤からの薬物送達
JP2015080262A Pending JP2015180625A (ja) 2004-09-07 2015-04-09 塞栓剤からの薬物送達
JP2016159713A Pending JP2017025071A (ja) 2004-09-07 2016-08-16 塞栓剤からの薬物送達

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2012167295A Expired - Lifetime JP5792691B2 (ja) 2004-09-07 2012-07-27 塞栓剤からの薬物送達
JP2015080262A Pending JP2015180625A (ja) 2004-09-07 2015-04-09 塞栓剤からの薬物送達
JP2016159713A Pending JP2017025071A (ja) 2004-09-07 2016-08-16 塞栓剤からの薬物送達

Country Status (11)

Country Link
US (3) US20070275991A1 (enExample)
EP (3) EP3085361A1 (enExample)
JP (4) JP5221134B2 (enExample)
CN (2) CN101052378A (enExample)
AT (1) ATE505185T1 (enExample)
AU (1) AU2005281483B2 (enExample)
CA (1) CA2579533C (enExample)
DE (1) DE602005027477D1 (enExample)
ES (1) ES2361919T3 (enExample)
HK (1) HK1198691A1 (enExample)
WO (1) WO2006027567A2 (enExample)

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EP2034951B2 (en) 2006-06-22 2020-03-25 Biocompatibles UK Limited Rehydratable pharmaceutical product
EP1985286A1 (en) * 2007-04-24 2008-10-29 Biocompatibles UK Limited Microspheres for treatment of brain tumours
ES2706023T3 (es) * 2007-08-16 2019-03-27 Biocompatibles Uk Ltd Administración de combinaciones de fármacos
US20110293672A1 (en) * 2008-12-02 2011-12-01 Biocompatibles Uk Limited Pancreatic tumour treatment
ES2542242T3 (es) * 2010-11-29 2015-08-03 Centre Hospitalier Universitaire Vaudois Composición de quimioembolización que comprende agentes antiangiogénicos
US10314594B2 (en) 2012-12-14 2019-06-11 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
US10307167B2 (en) 2012-12-14 2019-06-04 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
US10813630B2 (en) 2011-08-09 2020-10-27 Corquest Medical, Inc. Closure system for atrial wall
CN102336904B (zh) * 2011-09-29 2013-03-27 成都一平医药科技发展有限公司 一种喜树碱及其衍生物的多价peg修饰物及其用途
CN102397593B (zh) * 2011-11-11 2013-12-18 北京大学 X线下可显影的栓塞微粒及其制备方法和应用
US20150352050A1 (en) * 2012-11-15 2015-12-10 Utah-Inha Dds & Advanced Therapeutics Research Center Biodegradable microbeads with improved anticancer drug adsorptivity, containing albumin and dextran sulfate, and preparation method therefor
US20140142689A1 (en) 2012-11-21 2014-05-22 Didier De Canniere Device and method of treating heart valve malfunction
US9999676B2 (en) 2012-11-27 2018-06-19 Utah-Inha Dds & Advanced Therapeutics Research Center Biodegradable microbead comprising anionic polymer for improving adsorptive power to anticancer drugs, and method for preparing same
BR112016005768B1 (pt) 2013-09-19 2021-09-21 Microvention, Inc Películas de polímero
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US9566443B2 (en) 2013-11-26 2017-02-14 Corquest Medical, Inc. System for treating heart valve malfunction including mitral regurgitation
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JP2016124818A (ja) * 2014-12-26 2016-07-11 日本化薬株式会社 転移性肝癌治療薬及び転移性肝癌の治療方法
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WO2016203352A2 (en) * 2015-06-14 2016-12-22 Mohan M Alapati Compositions and methods for the treatment of cancer
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GB201515602D0 (en) * 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
KR102310696B1 (ko) 2016-09-28 2021-10-12 테루모 가부시키가이샤 색전 조성물
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JP7198529B2 (ja) * 2018-11-30 2023-01-04 ネクストバイオメディカル カンパニー リミテッド 生分解性高分子を含む化学塞栓用水和ゲル粒子
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Also Published As

Publication number Publication date
WO2006027567A2 (en) 2006-03-16
DE602005027477D1 (de) 2011-05-26
EP1796644B1 (en) 2011-04-13
WO2006027567A3 (en) 2006-05-18
CA2579533A1 (en) 2006-03-16
US20070275991A1 (en) 2007-11-29
EP1796644A2 (en) 2007-06-20
CN103860479A (zh) 2014-06-18
EP2269580A2 (en) 2011-01-05
JP2012236840A (ja) 2012-12-06
JP2008512370A (ja) 2008-04-24
ES2361919T3 (es) 2011-06-24
HK1198691A1 (en) 2015-05-29
CN101052378A (zh) 2007-10-10
US20120276151A1 (en) 2012-11-01
JP2015180625A (ja) 2015-10-15
AU2005281483B2 (en) 2008-11-27
US20120201867A1 (en) 2012-08-09
JP5792691B2 (ja) 2015-10-14
ATE505185T1 (de) 2011-04-15
JP2017025071A (ja) 2017-02-02
AU2005281483A1 (en) 2006-03-16
CA2579533C (en) 2013-05-21
EP3085361A1 (en) 2016-10-26
EP2269580A3 (en) 2011-11-09

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